Poster Session : PS 0831 ; Upper GI Tract : Clinical Factors to Predict Angiographically Detectable Non-Variceal Upper Gastrointestinal Bleeding in Patients Refractory to Endoscopic Treatment

( Tae Hwan Ha ),( Tae Hoon Oh ),( Sung In Yu ),( Min Kim ),( Jong Wook Kim ),( Won Ki Bae ),( Jae Hyung Kim ),( Seung Suk Baek ),( Mi Jin Ryu ),( Ye Na Choi ),( Ji Young Park ),( Eileen L Yoon ),( Tae 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Non-variceal upper GI bleeding (NVUGIB) is a common medical problem that has signifi cant association with morbidity and mortality. Angiographic detection and subsequent transarterial embolization (TAE) is a primary treatment option when medical and endoscopic treatments fail. We investigated clinical factors that could affect the success of the angiographic detection and prognosis after TAE in patients with NVUGIB refractory to endoscopic therapy. Methods: A retrospective analysis of the clinical data was done in patients with failed endoscopic treatment who underwent angiography for the treatment of acute NVUGIB between May 2002 and May 2013. Patients were divided into detection or non-detection groups according to the presence of bleeding stigmata in angiographic fi nding. Rebleeding defi ned as subsequent bleeding event within 7 days and mortality within 30days were analyzed as outcome parameters after TAE following detection in angiography. Results: A total 45 patients 37 (male, mean age, 65.9±14.9 years) were analyzed and classifi ed as a detection group (n=25, 55.5%) and non-detection group (n=20, 44.6%). Peptic ulcers were the most common cause of refractory NVUGIB. Larger transfusion amount (5.7±3.9 unit vs. 3.5±2.8 unit; P=0.03), prolonged aPTT level (34.2±17.3 sec vs. 21.8±13.8 sec; P=0.01) and short time interval between last endoscopy and angiography (17.5±25.9 hours vs. 34.3±59.5 hours; P=0.04) were found to be signifi cant factors for predicting angiographic detection. TAE was performed in all patients detected in angiography. Rebleeding (44%) was significantly associated with higher Rockall score (8.3±1.5 vs. 6.6±2.4; P=0.046) and mortality (12%) was signifi cantly associated with higher Rockall score (9.3±0.6 vs. 7.1±2.2; P=0.002) and higher level of BUN (55.3±47.4 vs. 27.6±17.4; P=0.01). Conclusions: Clinical characteristics associated with angiographic detection in patients with NVUGIB refractory to endoscopic therapy were severe bleeding, bleeding tendency and early angiographic intervention. The Rockall score is useful parameter for predicting rebleeding and mortality after TAE.

신라대학교 주변 백양산의 동물상

노치권(외 6명) 신라대학교 자연과학연구소 2012 自然科學論文集 Vol.22 No.-

To study fauna of Silla University located in Mt. Baek-yang, we conducted six surveys from 29 May 2011 to 28 April 2012. We found five phyla 41 orders 197 species of animals inhabiting in this area: four phyla 27 orders 163 species of invertebrates and in vertebrates one order six species of fishes, three orders nine species of amphibians and reptiles, six orders 14 species of aves, and four orders five species of mammals. Of these species, some Korean endemic species were included: a fish of Rhodeus uyekii in a pond near main gate of this university, a frog of Rana coreana in a creek near a dormitory, and a rabbit of Lepus coreanus and a water deer of Hydropotes inermis in a grass region near a main stadium. A kind of hawk, Falco tinnunculus as a natural monument (animal) of no. 323-8, was observed on a building of medical and life science. A blue frog of Hyla japonica as a variation was found near a spring resort. Therefore, this area is considered an ecologically important area having a high animal diversity.

Guinea pig 단일 심실근 세포의 칼슘전류에 대한 아드레날린성 약물의 효과

백승곤,심태섭,방효원 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.4

In order to investigate the effects of sympathomimetic drugs on the calcium currents, whole cell patch clamp technique was used in ventricular cells of the guinea-pig. Single ventricular cells were isolated by Langedorff perfusion method with collagenase. T-type and L-type Ca-currents were recorded in different holding potentials. T-type Ca-current was activated from more negative membrane potentials(around -50 mV) and was inactivated very rapidly, whereas L-type Ca-current was activated from -30 mV and inactivated with two time constants(fast and slow components). Replacement of calcium with barium increased the activation magnitude of L-type Ca-current and delayed inactivation time course, but did not affect T-type Ca-current significantly. Nifedipine blocked and Bay K 8644 increased L-type Ca-current with voltage-dependent manner. T-type Ca-current, however, was relatively insentive to dihydropyridine compuonds. Isoproterenol which is known to have mainly beta-agonist increased L-and T-type Ca-currents and propranolol reversed the effect of isoproterenol. Phenylephrine(alpha-agonist) and phentolamine(alpha-blocker) have no significant effects on the Ca-currents. From the above results it is suggested that L-type and T-type Ca-currents are present in guineapig ventricular myocytes and very sensitive to beta-agonist or-antagonist, but relatively insensitive to drugs acting on alpha-receptors.

고성능 액체 크로마토그라피에 의한 금은화 추출액중의 Chlorogenic acid의 정량

백승화,양태희 圓光大學校 基礎自然科學硏究所 1993 基礎科學硏究誌 Vol.12 No.1

The method for quantitative determination of chlorogenic acid in Lonicerac Flos extracts by high performance liquid chromatography(HPLC) was established. A reversed-phase system with a μ-Bondapak Cis column using methanol in 1.0% acetic acid (50 : 50) as a mobile phase was developed. Chlorogenic acid was detected at 280㎚ and the analysis was successfully carried out within 30 min.

냉기치료후 슬관절강내의 온도변화

백승석,최기섭,박시복,이상건,김영호,양길태,장윤희 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.2

[논문]여러 용매계에서 Poly(vinylidene fluoride) 의 물리적 젤화에 대한 동력학 및 열역학 연구

백승태,김봉수,이장우 釜山大學校生産技術硏究所 2006 生産技術硏究所論文集 Vol.65 No.-

Poly (vinylidene fluoride) (PVDF) 물리 젤은 각 기 다른 조 건 에 서 v-butyrolactone, cyclohexanone, propylene carbonate와 같은 다양한 유기용매에서 형성된다. 첼 녹는점은 시차주사열량계로 측정하였고 젤화 시간은 시험관 틸팅방법을 통해 측정하였다. 임계 젤 농도는 PVDF의 농도와 젤화 속도로 결정되어진다. 본 연구에서는 젤화 속도는 임계 농도를 얻기 위해 구하였다. 젤화 속도는 온도에 높게 의존한다; 젤화 속도는 젤화 시간의 역수로 분석 가능하며/ 젤화는 낮은 농도에서 투명한 젤이 형성되어지는 것과 젤 형성을 위한 엔탈피 변화가 적기 때문에 낮은농도에서 액-액 상분리에 의해 일어난다. 실온에서 천천히 건조시킨 젤 필름을 주사전자현미경으로 관측하였고 젤 필름에서 많은 구정과 연결 분자 들을 관찰하였다.

교정환자에서 MRI를 이용한 측두하악관절 장애의 연구

김태우,변은선,백승학,장영일,남동석,양원식 대한치과교정학회 2000 대한치과교정학회지 Vol.30 No.2

측두하악관절의 자기공명영상(MRI)은 하악과두와 관절원판(disc)의 관계를 잘 보여주기 때문에 관절내장증(internal derangement)의 진단을 위해 매우 유용하다. 이번 연구의 목적은 서울대학교 치과병원 교정과에 내원한 측두하악관절 장애가 의심되는 환자들의 MRI자료를 평가하여 관절 내장증의 유무, 발생빈도 및 심도를 파악하는 것이다. MRI를 촬영한 표본은 남자 10명, 여자 40명으로 총 50명이었고 평균 나이는 22.9세였다. 전체 50명 중에 43명에서 positive finding이 관찰되었다. Positive finding을 나타낸 환자 중에서 전방관절원판변위 (anterior disc displacement : ADD)는 비정복성이 56%로 가장 많았으며, 양쪽 관절에서 동시에 일어난 경우가 65%로 가장 많았다. Positive finding을 나타낸 환자를 Angle 분류 시, Ⅱ급 1류 부정교합 환자가 39.6%, Ⅱ급 2류 부정교합 환자가 2.3%로 Ⅱ급 부정교합이 41.9%로 가장 많았고, 1급 부정교합 환자는 37.2%, Ⅲ급 부정결합 환자가 18.6%, 확인 안된 경우가 2.3%였다. Positive finding을 나타낸 환자 중에서 안면 비대칭 환자는 8.6%, 개교 환자는 55.8%였다. 결론적으로 측두하악관절의 관절 내장증을 가진 환자에서는 Ⅱ급 부정교합이 차지하는 비율이 매우 크다고 할 수 있다. 개교나 안면 비대칭은 측두하악관절 장애로 인한 보상적 또는 비보상적인 변형에 의해 나타날 수 있으며 퇴행성 관절 질환으로 진행되는 과정 중 안면 골격 개조의 결과로 보인다. 그러므로 개교 및 안면 비대칭이 있는 환자는 교정 치료 시작 전에 측두하악관절의 이상 유무를 MRI로 확인(screening)할 것이 권장된다. 측두하악관절 장애가 있는 경우 교정 치료 후에도 재발의 경향이 크고 측두하악관절에 대한 계속적인 관찰이 필요하므로 감별진단이 필수적이다. Magnetic resonance imaging(MRI) of the temporomandibular joint(TMJ) is very useful method to diagnose internal derangement of the TMJ because of its high specificity for identification of condyle-disc relationships. The purpose of this study was to evaluate the existence, incidence and severity of internal derangement of the TMJ by the MRI of patients who are suspected to leave TMJ disorder. MRI sample was composed of 50 subjects(10 males, 40 females) and the mean age was 22.9 years. 43 subjects of the sample were found to have positive findings. 56% of the subjects with positive findings had ADD(anterior disc displacement) without reduction, and 65% had internal derangement of bilateral joints. Distributions in the types of malocclusion in patients with positive findings, the Angle's classification had shown : the largest 41.9% for Cl II(39.6% for Cl II div 1 and 2.3% for Cl II div 2), 37.2% for Cl I, 18.6% for Cl III, and 2.3% for the unidentified. 8.6% of the subjects with positive findings had facial asymmetry and 55.8% had openbite. We can conclude that the percentage of Cl II is the highest in patients with internal derangement of the TMJ. Openbite or facial asymmetry is considered to be uncompensated or compensated deformity which results from facial skeleton remodeling in the process of degenerative joint disease(DJD) due to TMJ degeneration. Therefore it is recommended to screen the patients with facial asymmetry or openbite by MRI before the beginning of orthodontic treatment. Differential diagnosis is essential because the tendency of relapse is high after the orthodontic treatment and continuous observation of TMJ is needed in patients with TMJ disorder.

암반사면의 안정을 위한 신뢰성 해석에 관한 연구

심태섭,기완서,주승완,백재상 朝鮮大學校 建設技術硏究所 2000 建設技術硏究 Vol.20 No.1

The stability of rock slope is mainly controlled by the engineering properties of discontinuities in the rock mass. Design method for deciding the cutting angle of rock slope must involve the significance of the mechanical and hydraulic characteristics of discontinuities on the shear strength of the rock mass. However most methods consider only rock strength as a prime factor for slope design, which sometimes result in failure. The optimum design of rock slope based on the limit equilibrium theory can vary significantly according to the mechanical characteristics of the discontinuities. Therefore, unless the level of ground water and its seasonal variations are accurately investigated, the reinforcements of any kind must be installed, besides the lowering of cutting angle, to ensure the stability of rock slope. This study is analyzed the stability of rock slopes by computing limit equilibrium theory. By analyzing probability of failure in rock slope, this study is analyzed the probability.

한국인 여성 Ⅱ급 2류 부정교합환자의 측모두부방사선 형태학적 특징

김태우,백승학 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.5

본 연구의 목적은 한국인 여성 Ⅱ급 2류 부정교합 환자의 측모두부 방사선계측사진상의 형태학적 특징을 평가하고, 같은 Ⅱ급 2류 부정교합을 가진 백인과의 형태학적 차이를 비교하는 것이다. 연구자료는 초진시의 연구모형에서 Ⅱ급 2류 부정교합과 4mm이상의 수직피개교합 및 영구치열을 가지는 환자로 제한하여 선정하였다. 그후 인종에 따라서 1군 (16명, 한국인 여성, 평균연령:18세 2개월)과 2군(20명, 백인여성, 평균연령14세 2개월)으로 분류하였다. 각 군의 측모두부 방사선계측사진의 투사도를 작성한 후 38항목을 계측하였고 평균 및 표준편차를 계산하였다. 군간의 비교를 위하여 independent t-test를 시행하여 다음과 같은 결과를 얻었다. 1. 전치부 수직피개 교합량, SN to mandibular plane angle, Palatomandibular plane angle, FMA항목은 1,2구간의 유의한 차이를 보이지 않았다. 그러나 SN to palatal plane angle과 SN to occlusal plane angle 항목은 1군이 크게 나타나서 2군에 비해 구개평면과 교합평면의 전하방 경사를 보였다. 그리고 ODI 항목은 1군이 2군에 비해 과개교합 경향이 낮게 나타났다. 2. 하악체와 하악지의 길이 항목은 1,2군간에 유의한 차이가 존재하지 않았으나, upper gonial angle 항목이 1군이 2군에 비해 현저히 작아서 하악골의 반시계방향 회전 경향이 감소되었음을 나타내었다. 3. 전안면고경의 상하비율과 전후안면고경비율 항목은 1,2군간의 통계적 유의차가 없었다. 4. 전치부 수평피개 교합량과 하악골의 전후방위치 항목은 1,2군간의 차이가 없었으나, 상악골은 1군이 2군에 비해 후방위치되었다. 5. 상하악 기저골에 대한 하악전치의 돌출도 항목이 1군이 더 크게 나타난 것을 제외하고는 상,하악 절치의 기준 평면에 대한 경사도와 거리 및 절치간각 항목은 1,2 군간의 차이가 없었다. 6. 상악구치의 구개평면에 대한 수직거리 항목는 1,2군간의 차이가 없었으나 하악구치의 하악평면에 대한 수직거리항목은 1군이 크게 나타났으며, 이것과 교합평면의 전하방 경사와 감소된 하악골의 반시계방향 회전 경향이 관계있는 것으로 생각된다. 7. Ricketts의 심미선에 대한 상순과 하순의 돌출도 항목은 1군이 모두 크게 나타났다. The purposes of this study were to evaluate the cephalometric characteristics of Korean patients with Class Ⅱ division 2 malocclusion and to compare Korean females with Caucasian females who had same type of malocclusion. All of the samples had Class Ⅱ division 2 malocclusion with deep overbite (more than 4mm) and full permanent dentition. These samples were divided into two groups according to the races: Group 1(N=16; Korean females; average age=18Y 2M) and Group 2 (N=20; Caucasian females; average age=14Y 2M). The pretreatment lateral cephalograms were measured, analyzed and compared by using 38 variables and independent t-test. And the results were as follows:. 1. Although there were no differences in Overbite, SN to mandibular plane angle, Palatomandibular plane angel, and FMA between Group 1 and 2, the other vertical relation variables of maxilla and mandible (SN to palatal plane angle, SN to occlusal plane angle, ODI) of Group 1 showed more clockwise rotation tendency of occlusal plane and less hypodivergency tendency than of Group 2. 2. There were no differences in mandibular body length and ramus height between Group 1 and 2 except small upper gonial angle of Group 1. There was less counterclockwise rotation tendency of mandible in Group 1. 3. There were no statistical significant differences in UAFH/LAFH and PFH/AFH between Group 1 and 2. 4. Although there were no differences of overjet and anteroposterior position of mandible between Group 1 and 2, the position of maxilla of Group 1 was more retropositioned than that of Group 2. 5. Except the more protrusion of lower incisor to A-Pog of Group 1, there were no differences of inclination and distance of upper and lower incisors to basal plane between Group 1 and 2. 6. The distance from upper first molar to palatal plane showed no difference between Group 1 and 2. But the distance from lower first molar to mandibular plane of Group 1 was greater than that of Group 2. So it may be partially related to the clockwise rotation of occlusal plane and the less counterclockwise rotation tendency of mandible of Group 1. 7. Group 1 had more protrusive upper and lower lips than Group 2.

고삼 추출물을 이용한 해독물질의 개발

양희태,정승일,이영철,윤경아,백승화 한국식품영양학회 2002 韓國食品營養學會誌 Vol.15 No.1

고삼 메탄올 추출물로부터 분리한 flavonoids를 IR, NMR등의 분광학적인 방법으로 Leachianone A(LA)과 Sophoraflavanone G(SFG)로 동정하였고, 카드뮴의 세포독성효과를 고삼 및 고삼추출물이 방어할 수 있는 지를 검색하기 위하여 NIG 3T3 세포에 고삼 및 LA와 SFG, LA+SFG를 처리하고 MTT assay 및 광학현미경으로 세포의 생존률을 검색하여 다음과 같은 결론은 얻었다. MIT의 흡광도는 카드뮴의 농도에 의존하여 감소하였으며, IC_50인 MTT50은 12.5??이었으며 카드뮴을 IC_50농도로 처리하고 고삼 및 LA, SFG, LA+SFG를 각 화합물의 자체 세포독성을 갖지 않는 농도로 처리한 후 MTT assay로 세포 생존율을 측정한 결과 LA, SFG, LA+SFG 처리군들은 카드뮴 처리군(MTT_50)에 비해 세포생존률이 증가되었으며 이들은 고삼 및 고삼추출물의 농도에 의존적으로 증가되었고 각각의 단일 화합물보다 두 화합물 LA+SFG 병용처리군에서 수복 효과가 더 좋은 것으로 나타났으며 광학현미경적 소견에서도 세포재생이 뚜렷하게 보였다. 이상과 같이 고삼에서 분리한 flavonoids가 카드뮴 독성에 의하여 손상된 NIH 3T3 섬유아세포의 재생효과에 영향이 있는 것으로 판단된다. The aim of this study was to assess the antitoxic compounds, flavanones (Leachinanone A=LA and Sophora flavanone G=SFG), from Sophora flavescents (S. Flavescens). We investigated the possibility of antitoxicity of LA and SFG against NIH 3T3 fibroblasts cell lines using colorimetric MTT[3-(4-5-dimethylthiazol-2-yl)-2-5diphenyl-2H-tetra-azolium bromide] assay. The results were as follows : After cadmium was treated against NIH 3T3 cell lines, we determined IC_50. Accordingly we have examined the detoxification effects of S. flavescens, LA and SFG under cadmium IC_50=12.5?? and was carried out to observe morphological changes by the light microscopic study. In NIH 3T3 cells, Sophora flavescens, LA, SFG and LA+ SFG showed inhibitory effects on the cytotoxicity of cadmium and these detoxication effects increased in proportion to the concentration of these drugs. These results suggest that LA and SFG from S. flavescens retain a potential antitoxic activity.