Comparison of controlled ovarian stimulation outcomes for fertility preservation in women with breast cancer according to KI-67, histologic grade, pathologic type, and cancer stage

( Eun Ji Oh ),( Yeon Hee Hong ),( Seul Ki Kim ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: This study aims to analyze that specific prognostic factors such as Ki-67 value, histologic grade, pathology type, and cancer stage can affect controlled ovarian stimulation outcomes(COS) for fertility preservation in women with breast cancer. Methods: This retrospective cohort study included 92 patients with breast cancer aged 21-44 who underwent COS from August 2012 to April 2020, excluding patients with previous gonadotoxic therapy history. All COS cycles were conducted letrozole-combined random start GnRH antagonist protocol. COS outcomes were compared according to prognostic factors;Ki-67 (< 30% vs. ≥ 30%), histologic grade (low vs. high), and pathologic type (intraductal carcinoma(IDC) vs. triple-negative breast cancer(TNBC)), and cancer stage (early (I, II) vs. advanced (III, IV)). Multivariate analysis was also conducted to find any parameter that can impact over 10 mature oocytes acquisition. Results: Among the 92 patients, 42 were Ki-67≥30% compared to 49 of Ki-67<30%. The number of oocytes, and initial mature oocytes were comparable between Ki-67<30% and ≥30 group. The maturation rate was significantly higher in Ki-67≥30% group than Ki-67<30% group (57.4±36.8% vs. 44.8±28.3%, p=0.041). The same results were drawn when divided according to IDC or TNBC. The maturation rate was significantly higher in TNBC than the IDC group (73.0±17.6% vs. 47.0±28.1% p=0.001). However, the histologic grade or stage did not show any difference in COS outcomes between high and low grade or early and advanced stages. With multivariate analysis, age and AMH are parameters associated with the acquisition of over 10 mature oocytes (OR 0.863, 95% CI [0.755-0.987], OR 1.408, 95% CI [1.145-1.732], respectively). Conclusion: Either Ki-67 or pathologic type can be a potential reliable marker for predicting COS outcome, especially maturation rate. Further study with larger sample size with specific conditions is necessary to clarify the correlation between breast cancer prognostic factors and COS outcomes.

Possibility of Empowerment in The Surrendered by Chang-rae Lee

Seul Ki Lee Ewha Institute of English and American Studies 2022 Journal of English and American studies Vol.20 No.1

This paper supports the interpretation that the main characters in Chang-rae Lee’s The Surrendered find liberation in being surrendered. As a novel written by a recognized Korean-American writer about The Korean War, The Surrendered received many reviews concentrating on the author’s writing style and artistry. These early critics stated that the novel’s varying temporal and geographical shifts and the fact that the novel revolves around three different characters make the novel unnecessarily complex. In addition, the scholarly works that do analyze the novel concentrate on the trauma, disability, and post-traumatic stress disorder resulting from the violence. Although prior research touched upon the characters and the symbolism within the setting, I would like to do a more in depth analysis. I use the concept of “abjection” to analyze the symbolism of the three main characters: June, Hector, and Sylvia. All three characters have distinct individuals while also representing others who have survived the social situations they faced. Therefore, it is meaningful to analyze three characters and how they use their status as abjects to find a form of liberation and empowerment.

The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection

Choi, Seul-Ki,Mun, Gil-Im,Choi, Eun,Kim, Seo-Young,Kwon, Youngjoo,Na, Younghwa,Lee, Yun-Sil American Society of Pharmacognosy 2017 Journal of natural products Vol.80 No.8

<P>Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice. These results suggested that the vinyl moiety of 1 and 2 is necessary for inducing HSF1, which may be useful for developing small molecules for cytoprotection of normal cells against damage by cytotoxic drugs and radiation.</P>

초등학교 고학년 학생의 장애아동에 대한 인식 조사

김보람,김호영,손유라,오진주,윤슬기,이효정,장문영 대한감각통합치료학회 2011 대한감각통합치료학회지 Vol.9 No.1

목적 : 초등학교 고학년 학생의 장애아동에 대한 인식을 알아보는 것이다. 연구방법 : 연구 대상은 김해시에 소재한 통합교육을 실시하지 않는 초등학교의 4, 5, 6학년의 비장애 아동이었다. 연구 기간은 2008년 10월 2일부터 10월 17일까지였으며, 설문지를 사용하였다. 설문지의 하위 영역은 사귐, 활 동, 학업 영역의 세 부분으로 각 10문항으로 이루어져 있으며 SPSS 12.0을 사용하여 분석하였다. 결과 : 장애아동에 대한 인식조사 결과 첫째, 성별에 따른 인식은 남학생보다 여학생의 평균 점수가 높았으나 통계 적으로 유의미한 차이는 없었다. 둘째, 학년에 따른 인식은 4학년의 평균 점수가 가장 높았고 6학년이 가장 낮았으 며 통계적으로 유의미한 차이가 있었다(F=3.546, p<0.05). 셋째, 장애인 접촉 유무에 따른 인식은 접촉 경험이 없 는 학생이 있는 학생보다 평균점수가 높았으나 통계적으로 유의미한 차이는 없었다. 결론 : 비장애학생의 장애아동에 대한 인식은 학년에 따라 차이가 있었다. 본 연구는 작업치료사들에게 장애아동에 대한 또래집단의 인식에 대한 정보를 제공함으로써 학교환경에 대한 이해를 도울 수 있을 것이다. Objective : The purpose of this study was to investigate attitude of grade-schoolers toward children with disabilities. Methods : The subjects of this study were grade-schoolers who have not received an inclusive education in Gim-hae. The study was surveyed from October second to 17th in 2008. The survey was categorized into three parts; comradeship, activity, and study. Each part of the survey consists of 10 questions. Data were analyzed by SPSS (version 12.0). Results : The results were as follows; First, the attitude of girls toward disabled students was non-significant compared to boys. Second, the order of attitude degree in grade of students was 4, 6, and 5. The attitude toward children with disabilities showed statistically significant difference according to grade(F=3.546, p<0.05). Third, the attitude of students who have experience of contact with people with disabilities was non-significant compared to non-experienced students. Conclusion : In conclusion, therefore peer groups in lower class levels showed more positive attitude toward the children with disabilities. The result will be useful information for understanding disabled children and making positive attitude. Also it is expected that occupational therapists help disabled children to participate in school life successfully using these information.

Genome-wide screen of human bromodomain-containing proteins identifies Cecr2 as a novel DNA damage response protein

Lee, Seul-Ki,Park, Eun-Jung,Lee, Han-Sae,Lee, Ye Seul,Kwon, Jongbum Springer-Verlag 2012 Molecules and cells Vol.34 No.1

The Clinical Review of the Appendiceal Tumors : Retrospective Study of 3,744 Appendectomies or Right Hemicolectomies

Seul Ki Song,Jung Heum Bak,Seung Ki Min,Keon Kuk Kim,Wun Ki Lee,Wun Ki Lee,Hung Ku Park,Jae Hwan Oho,Min Chung,Sang Tae Choi 대한외과학회 2006 대한외과학회 학술대회 초록집 Vol.2006 No.11

소형 무인 항공기를 이용한 목표물 추적 시스템 및 통신 링크 구현

이우경(Lee Woo Kyung),이슬기(Seul Ki Lee),이보윤(Bo Yun Lee),이융기(Yung Ki Lee),이승호(Seung Ho Lee),감지수(Su Ji Kam) 한국통신학회 2012 한국통신학회 학술대회논문집 Vol.2012 No.2

Negative Affects and Performance of Possibility in Bernardine Evaristo’s Girl, Woman, Other

( Seul Ki Lee ) 한국현대영미소설학회 2022 현대영미소설 Vol.29 No.1

This paper explores the correlation between desire and power in the use of affects as a means to control feminine bodies to find subversive possibilities in the performance of certain affects in Bernardine Evaristo’s Girl, Woman, Other. Sara Ahmed’s concept of “promise of happiness” and the concept of “cruel optimism” by Lauren Berlant, illustrates that while there are systems that oppress through negative affects, there are also positive affects, those that stem from the desire to be loved, accepted, and successful, that can be used to control and manipulate. The girl, woman, and others depicted in the novel are constantly exposed to violence and this vulnerability is taken advantage of, many times through the transmission of certain affects. This paper examines the use of what is generally thought of as positive affects, through the relationship between Nzinga and her environment, and her romantic relationship with Dominique. While the novel does not deny that the systems of affective manipulation in place are too large for one character to overcome, I assert through an analysis of the two central characters Amma and Carole, inspired by Judith Butler’s and Jose Esteban Munoz’s theories on performance, that there are limited possibilities of moving up within the dehumanizing system through performance.

New aromatic compounds from the fruiting body of Hericium erinaceum

Seul Ki Lee,Se Hwan Ryu,Ayman Turk,Jong Hoon Ahn,Sang Won Yeon,Bang Yeon Hwang,Mi Kyeong Lee 한국버섯학회 2018 버섯 Vol.22 No.1

Hericium erinaceum (Hericiaceae), well known as lion’s mane mushroom, is a edible mushroom traditionally used as an herbal medicine in Korea, China and Japan. It has been reported to have anti-inflammatory, anticancer, antibacterial and neurotrophic activities. For the purpose of enhancing the edible or medicinal values of H. erinaceum, it is worthwhile to perform phytochemical research. The isolation of the n-hexane layer of the fruiting bodies of H. erinaceum was conducted through various chromatographic techniques, which yielded fourteen compounds. The structures of isolated compounds were determined based on spectroscopic methods such as 1D-NMR, 2D-NMR and HRESI-TOF-MS. As a result, fourteen compounds were determined as ergostane-type sterols (1-4) and aromatic compounds (5-14). Among the isolated compounds, compounds 8 and 10-14 were first reported from nature. These results provide useful information about the constituents of H. erinaceum.

P044 Efficacy of alitretinoin in various nail disorders

( Seul Ki Lee ),( Jeong Soo Kim ),( Ha Ryeong Ryu ),( Chul Hyun Yoon ),( Jin Ok Baek ),( Jong Rok Lee ),( Joo Young Roh ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Nail disorders are difficult to treat and often frustrating both for patients and clinicians. The efficacy of topical therapies is limited because of a slow growth rate of the nail plate and the difficulty of the drug penetration into the nail tissues. There is no therapeutic standard have been defined and no guidelines on the treatment of Nail Disorders. Objectives: This study evaluated the treatment efficacy of oral alitretinoin (systemic retinoid) on nail disorders. Methods: Seven patients with nail disorder were enrolled, 4 patients with trachyonychia, 2 with nail psoriasis, 1 with onychogryphosis. All patients treated with oral alitretinoin 30mg once daily for at least 3 months. Efficacy was assessed at 3months by Physician``s Global Assessment (PGA) and Patient``s Global Assessment (PaGA). Results: After 3 months of therapy, nail changes showed improvement under oral alitretinoin therapy. The mean PGA score decreased significantly from 4.7 to 3.0 and PaGA score 4.9 to 3.2. Additionally, subungual edema and pruritus are improved after oral alitretinoin therapy. The limitations of this study are small sample size of patients and short term follow-up results of treatment. Conclusion: Our findings suggest that alitretinoin is an effective treatment for nail disorders. We recommend initiation of systemic therapy with alitretinoin to treatment of nail disorders. And further clinical studies are needed to establish reliable therapeutic guidelines for nail disorders.