Comparison of controlled ovarian stimulation outcomes for fertility preservation in women with breast cancer according to KI-67, histologic grade, pathologic type, and cancer stage

( Eun Ji Oh ),( Yeon Hee Hong ),( Seul Ki Kim ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: This study aims to analyze that specific prognostic factors such as Ki-67 value, histologic grade, pathology type, and cancer stage can affect controlled ovarian stimulation outcomes(COS) for fertility preservation in women with breast cancer. Methods: This retrospective cohort study included 92 patients with breast cancer aged 21-44 who underwent COS from August 2012 to April 2020, excluding patients with previous gonadotoxic therapy history. All COS cycles were conducted letrozole-combined random start GnRH antagonist protocol. COS outcomes were compared according to prognostic factors;Ki-67 (< 30% vs. ≥ 30%), histologic grade (low vs. high), and pathologic type (intraductal carcinoma(IDC) vs. triple-negative breast cancer(TNBC)), and cancer stage (early (I, II) vs. advanced (III, IV)). Multivariate analysis was also conducted to find any parameter that can impact over 10 mature oocytes acquisition. Results: Among the 92 patients, 42 were Ki-67≥30% compared to 49 of Ki-67<30%. The number of oocytes, and initial mature oocytes were comparable between Ki-67<30% and ≥30 group. The maturation rate was significantly higher in Ki-67≥30% group than Ki-67<30% group (57.4±36.8% vs. 44.8±28.3%, p=0.041). The same results were drawn when divided according to IDC or TNBC. The maturation rate was significantly higher in TNBC than the IDC group (73.0±17.6% vs. 47.0±28.1% p=0.001). However, the histologic grade or stage did not show any difference in COS outcomes between high and low grade or early and advanced stages. With multivariate analysis, age and AMH are parameters associated with the acquisition of over 10 mature oocytes (OR 0.863, 95% CI [0.755-0.987], OR 1.408, 95% CI [1.145-1.732], respectively). Conclusion: Either Ki-67 or pathologic type can be a potential reliable marker for predicting COS outcome, especially maturation rate. Further study with larger sample size with specific conditions is necessary to clarify the correlation between breast cancer prognostic factors and COS outcomes.

正弦波 出力 PAM形 IGBT 인버터에 관한 硏究

서기영,이현우 慶南大學校 附設 工業技術硏究所 1992 硏究論文集 Vol.10 No.-

본 논문에서는 전력용 IGBT를 사용한 새로운 PAM형 PWM 인버터를 제안한다. 제안된 PAM형 PWM 인버터의 출력파형을 이론과 실험적으로 연구 확인 하였다. 선간전압파형은 기본파 성분과 캐리어주파수의 사이 드밴드로 집중되며 저차고조파는 출력파형에 포함지 않았으며, 각 인버터 아암은 2/3주기동안 휴지시간을 설정하므로서 소자의 발열도 줄어든다. 그러므로 방열판의 감소에 의하여 인버터 시스템의 크기도 작아진다. n this paper an new PAM type PWM inverter using IGBT is described. The output waveforms in the proposed PAM type PWM inverter are investigated both theoretically and experimentally. The line-voltage waveform is composed of fundamental component and the sidebands of carrier frequency. The lower order harmonics are not included in the output waveform. As each inverter arm does not operate during two-thirds period, the heats, generated in the devices are reduced. That is the size of the inverter system can be minimized because of the reduction in the heat dissipating equipment.

비만 여성을 대상으로 한 해조류 추출물의 국부처치와 운동 병행을 통한 지방분해 효과의 임상적 검정

서태수,이인숙,변재철,김규호,박승한,김유영,김상국,김현정,김상기,신동철,성미영,박종석,김종기,박언휘 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.3

This study was carried out to test the body fat breakdown during topical seaweed extract treatment and in combination with the aerobic exercise. Of 20 female obesity subjects, ten treated a cream types of seaweed extract(control group) and ten treated a placebo cream(placebo group). Topical treatment of each sample was designed for 4 weeks, and treated with 2 times a day about 10ml on the abdomen and the thigh, respectively. All subjects were participated aerobic dance half hour a day and four times a week. After 4 weeks of topical treatment and exercise, they were measured body fat, skinfold thickness, body circumference. Then venous blood samples were taken and analyzed blood cells, serum enzymes, and serum lipids. There were reduction of body weight, % of body fat, antebrachium, brachium, chest, waist, thigh circumference and abdomen thickness between pre and post treatment in both group. Especially, body weight and % of body fat significantly reduced in the subjects treating the seaweed extract than those treating the placebo. There were significant decrement in total cholesterol and LDL whereas increment in HDL and TBIL in the control group, but no significant difference in the placebo group. In conclusion, there were 7.6% of body fat reduction during 4 weeks of aerobic exercise and 21% of body fat reducement in combination of topical seaweed treatment and exercise, respectively. These results suggest that the topical treatment of seaweed extract should be very effective for fat breakdown. Especially, the body fat breakdown maximized in the combination with the topical seaweed extracts treatment and the aerobic exercise.

2석식 포워드 컨버터방식 저압대전류 직류전원장치

서기영,구헌회,이현우 慶南大學校 附設 工業技術硏究所 1997 硏究論文集 Vol.15 No.1

저압대전류전원장치의 소형경량화와 효율향상을 위한 요구가 지속적으로 되어오고 있으며 적합한 전력변환방식에 대한 연구도 계속되고 있다. 2석식 포워드 컨버터는 브릿지방식 등에 비해서 변압기 구조가 간단하고 신뢰성있는 동작이 가능하고 고주파화에 적합한 방식이다. 본 연구에서는 2석식 포워드 컨버터방식의 동작모드를 해석하고 DC 30V 1000A의 직류전원장치의 주회로를 설계하고 컨버터의 안정한 동작을 위하여 보상회로를 설계하여 Simulation을 통하여 동작특성을 확인하였다. Efforts to improve low voltage high current DC power supply currently are forcused on increasing efficiency and decreasing size and weight. The two transistor forward converter features simplicity in power transformer sturucture and drive circuit as well as high reliability compare with bridge type converter. In this paper, operation mode of two transitor forward converter is analysis and DC 30V 1000 A power supply is designed and verified the operation characteristics of converetr through simulation.

電力節減裝置를 이용한 變壓器의 特性硏究

徐基永,李鉉雨,權純杰 慶南大學校 附設 工業技術硏究所 1984 硏究論文集 Vol.2 No.-

變壓器는 無負荷에서도 電源이 걸린 상태로 運轉되는 경우가 많이 있기 때문에 無負荷損을 節減하면 그 效果는 크다. 그래서 電力을 節減하는 裝置를 만들어 變壓器의 特性을 調査하였다. Transformers are often operated in charged state even in case of no-load, therefore the efficiency of transformer can be increased if no-load loss is saved. This paper is aimed to observe the characteristics of a transformer with a power saving equipment.

폐렴으로 병발된 범발성 혈관내 응고증의 Antithrombin III 치험 1례

서중산,최호열,김현수,이록윤,오흥국,박영석,정기석,박근칠,선덕제 한림대학교의료원 1994 人間科學 Vol.18 No.9

브러시리스 DC 모터의 코킹토크 저감 대책

서기영,이현우,문상필,강욱중 慶南大學校 附設 工業技術硏究所 1999 硏究論文集 Vol.17 No.-

본 연구에서는 정밀, 소형제동에 사용되는 브러시리스 DC모터의 정밀 운전시 문제가 되는 코킹 토크의 저감을 위하여 코킹 토크 형성에 관한 특정식을 유도하여 그 성질을 파악하고 특정식을 토대로 코킹 토크저감을 위한 설계법을 제안하였다. The Paper characteristics equation of cogging torque is induced to learn this characteristics and on the ground of this equation, the design method is proposed for reducing cogging torque which is the problem to precisely drive DC brushless motor used in precise control system.

Silibinin Inhibits Tumor Growth through Downregulation of Extracellular Signal-Regulated Kinase and Akt <i>in Vitro</i> and <i>in Vivo</i> in Human Ovarian Cancer Cells

Cho, Hyun Jin,Suh, Dong Soo,Moon, Soo Hyeon,Song, Yong Jung,Yoon, Man Soo,Park, Do Yoon,Choi, Kyung Un,Kim, Yong Keun,Kim, Ki Hyung American Chemical Society 2013 Journal of agricultural and food chemistry Vol.61 No.17

<P>Anticancer activity of silibinin, a flavonoid, has been demonstrated in various cancer cell types. However, the underlying mechanisms were not elucidated in human ovarian cancer cells. The present study was undertaken to examine the effect of silibinin <I>in vitro</I> and <I>in vivo</I> on tumor growth in human ovarian cancer cells. Silibinin decreased cell viability in a dose- and time-dependent manner. Silibinin caused an increase in reactive oxygen species (ROS) generation, and the silibinin-induced cell death was prevented by the antioxidant <I>N</I>-acetylcysteine (NAC). Western blot analysis showed silibinin-induced downregulation of extracellular signal-regulated kinase (ERK) and Akt. Transfection of constitutively active forms of MEK and Akt prevented the silibinin-induced cell death. Oral administration of silibinin in animals with subcutaneous A2780 cells reduced tumor volume. Subsequent tumor tissue analysis showed that silibinin treatment induced a decrease in Ki-67-positive cells, an increase in transferase-mediated dUTP nick end labeling (TUNEL)-positive cells, activation of caspase-3, and inhibition of p-ERK and p-Akt. These results indicate that silibinin reduces tumor growth through inhibition of ERK and Akt in human ovarian cancer cells. These data suggest that silibinin may serve as a potential therapeutic agent for human ovarian cancers.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2013/jafcau.2013.61.issue-17/jf400192v/production/images/medium/jf-2013-00192v_0008.gif'></P>

부안 유천리 도자기의 과학적 분석

강현삼,이한형,박기철,김건한,서만철,서정호,최기영 공주대학교 문화재보존과학연구소 2003 문화재과학기술 Vol.2 No.1

전북 부안 유천리 청자요지에서 수습된 청자편 11점의 태토 및 유약에 대하여 화학조성을 분석하고, 기 발표되어진 문헌의 청자데이터들을 종합하여, 이와 비교함으로써 본 시료의 도자특성과 및 산지에 대한 정보를 유추하였다. 태토의 주요산화물 분석에는 XRF를 이용하였으며, 유약의 주요산화물분석에는 EPMA를 이용하였다. 태토 중 17개 미량성분의 분석에는 ICP-MS를 이용하였고, 자료의 비교분석에는 Seger식에 의한 방법과 주성분분석법에 의한 통계처리방법을 병행하였다. 태토의 주요산화물에 대한 비교분석결과 유천리 청자는 Seger 식과 주성분분석에서 RO_(2)와 RO+R_(2)O가 6~8 및 0.3~0.38 mole로, 또 높은 SiO_(2)함량과 낮은 Na_(2)O, CaO의 함량으로 전북지역의 데이터 범위에 분포함을 볼 수 있었다. 유약의 주요산화물에 대한 비교분석결과에서는 Seger식과 주성분분석에서 모두 명확한 지역구분이 나타나지 않았으며, 따라서 유천리 청자 역시 명확한 지역적 특성을 구분하기 어려웠다. 태토중 미량성분의 주성분분석에 의한 통계처리결과 광주 충효동 도편들을 제외하고는 뚜렷한 지역간의 구분을 관찰하기 어려웠다. The characterization of chemical properties and analogy of manufactured origin for the eleven celadon sherds collected in Yuchunri, Buan were performed by analyzing their body and glaze compositions and compared with previous data reported. The chemical compositions of the body and glaze were determined by XRF and EPMA, respectively. The trace elements of the body were also determined by ICP-MS. The Seger analysis and PCA were used to compare the major compositions of body and glaze of the potteries we found with previous data. The Celadon sherds from Yuchunri are distributed in a range of Chonnam potteries considering RO_(2) and RO+R_(2)O are 6~ 8 and 0.3 ~O.38mole, respectively and also high in SiO_(2) and low in Na_(2)O and CaO concentrations in the comparison between the potteries for the major compositions of the body. Differences of the chemical characteristics of those potteries between the provinces were not clear in comparison of the glaze compositions and trace element of the body.

信用狀統一規則 海上船荷證券條項의 運用上 障碍要因에 관한 硏究 : Marine/Ocean Bill of Lading

金基宣,徐百鉉 군산대학교 지역개발연구소 1997 地域開發硏究 Vol.9 No.-