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6종 식품의 혼합추출물이 사염화탄소로 유도된 흰쥐 간 손상에 미치는 보호효과
황보미향,예춘정,Hwangbo, Mi-Hyang,Yea, Chun-Jung 한국식품영양학회 2018 韓國食品營養學會誌 Vol.31 No.6
The objective of this study was to examine the biochemical parameters of hepatic function such as serum level of ALT (alanine aminotransferase), AST (aspartate aminotransferase), ALP (alkaline phosphatase), LDH (lactate dehydrogenase), and content of TG (triglyceride) and cholesterol, and tissue immunological changes of the $CCl_4$-treated rats with administration of the mixed sample extract (MSE). The liver weight in $CCl_4$-administered experimental control group (EC) was slightly higher than that of normal control (NC) group. Hepatic damage parameters (ALT, AST, ALP, LDH & TG) in serum of the EC group were significantly higher than those in serum of the NC and silymarin-treated positive control (PC) group. On the other hand, these hepatic damage parameters of MSE-treated experimental (E1 & E2) groups were significantly lower than those of EC group. The number of WBC, neutrophils, lymphocytes and platelets, and the contents of hemoglobin, and hematocrit in EC group were significantly higher than those of NC group. However, the number of WBC and lymphocytes in E1 and E2 groups were significantly lower than those of EC group. Also, the collagen developmental areas in the liver of NC and PC groups by hepatic immuno-histological findings were found slightly positive. Whereas, hepatic fibrous developmental tissue of EC group was strongly positive brown color band, those of E1 & E2 groups were decreased. Therefore, it was concluded that the induction of hepatic fibrous tissue activation had a preventive effect of MSE against the $CCl_4$-induced hepatic damage in rats. However, further study is needed in this filed.
고지방 식이에 따른 혈관 주위 지방조직의 혈관 수축 인자 발현에 미치는 영향
황보미향 (사)한국조리학회 2023 한국조리학회지 Vol.29 No.10
. Excessive fat increases risks like hypertension and cardiovascular diseases. This study explored obesity-induced hypertension mechanisms by evaluating vasoconstrictive substances in rat adipose tissues near major arteries. Dahl salt-sensitive (SS) and salt-resistant (SR) rats were fed either a normal or high-fat diet for 12 weeks. When introducing their perivascular adipose tissue (PVAT) to Sprague- Dawley rat aortas, the aortas constricted with PVAT but not with visceral adipose tissue (VAT). This constriction was more pronounced in SS rats on a normal diet. Antioxidant pre-treatment indicated that substances from PVAT might cause constriction via an antioxidant mechanism. In conclusion, SS rats are more prone to hypertension, and high-fat diets in both rat types could potentially lessen vasoconstriction.
염 민감성 쥐에서 안지오텐신 Ⅱ가 고혈압 면역 기전에 미치는 영향
황보미향 한국식품영양학회 2023 韓國食品營養學會誌 Vol.36 No.6
Hypertension caused by high-fat and high-salt diets is is a well-known significant risk factor for cardiovascular and cerebrovascular diseases. In this study, to confirm the relationship between hypertension and immune cells, angiotensin (Ang) II was administered to Dahl salt-sensitive (SS) rats and Dahl salt-resistant (SR) rats. Then the expression of immune cells and the proinflammatory cytokines were compared between the SS and SR rats. It was observed that after administration of Ang II (50ng/kg/min) for three weeks, blood pressure was increased in the SS rats, but there was no significant change in the SR rats. In addition, the expression of T helper (Th) cells and Th 17 cells in the spleen and the expression of Th cell Rorγt and regulatory T regulatory (Treg) cells in the peripheral blood mononuclear cells did not show a significant difference between the two experimental groups even after the administration of Ang II.IL-1β expression was significantly increased in the kidney tissue of the SS rats, while there was no significant difference in the IL-6 expression in all the experimental groups. The results of this study suggest that Ang II induces hypertension by stimulating IL-1β secretion from renal macrophage in SS rats.
Vasopurus의 LDL r(-/-) Mice에서 항동맥경화 효능
황보미향 ( Mi Hyang Hwangbo ),김현정 ( Hyun Jeong Kim ),이인선 ( In Seon Lee ),정태호 ( Tae Ho Chung ),김인겸 ( In Kyeom Kim ),신흥묵 ( Heung Mook Shin ) 대한본초학회 2009 大韓本草學會誌 Vol.24 No.4
Objectives: The protective effect of Vasopurus, a mixture of three medicinal plants, on atherosclerosis induced by dietary cholesterol in low density lipid (LDL) receptor deficient mice was studied. Methods: Experimental groups were divided into three groups of six animals each; a normal group (N); a high cholesterol group (HC), a high cholesterol plus Vasopurus group (HCVA). The experimental groups were fed for 6 months. Results: Vasopurus supplementation significantly lowered plasma total cholesterol and LDL cholesterol conc entrations compared with the high cholesterol (HC) diet group. In addition, supplementation with Vasopurus significantly increased fecal cholesterol contents compared to mice fed a HC diet. Mice whose diet was supplemented by Vasopurus showed considerably fewer atherosclerotic plagues in the aortic values of heart and aortas compared to mice receiving the HC diet. Conclusions: These results indicate that Vasopurus has efficacy in anti atherosclerosis medication.