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한병훈,박만기,이은실,Han, Byeong-Hun,Park, Man-Gi,Lee, Eun-Sil 고려인삼학회 1991 Journal of Ginseng Research Vol.15 No.2
The metabolic fate of ginsenosides including gastrointestinat absorption, organ distribution, excretion and metabolism in liver was investigated by tracer studies using the radio-labeled ginsenosides. 3H-ginsenosides were shown to be absorbed from the mouse digestive tract and then to be excreted rapidly into urine and/or bile. Bile juice was concluded to play a significant role in absorption of ginsenosides. The total concentration of radioactivity persisted in tissues 24 hrs after oral administration was less than 1.3% of the administered dose and Rbl showed the highest value. The concentrations of radioactivity were relatively high in the liver and kidney. After administration of Rbl radioactivity was detected in the brain. After oral administration of 8H-ginsenosides, major component excreted into urine was found to be the intact ginsenosides and decomposed and/or metabolized products were found in GIT in the case of Rbl. 3H-ginsenoside Rbl was shown to be metabolized in the liver and the metabolite was suggested to be an acylated compound of Rbl by a certain organic acid.
라미부딘 내성 만성 B형 간염 환자에서의 아데포비어의 치료 효과
이지숙,장리라,이상욱,한병훈,윤병철 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2
Backgrounds/Aims : Adefovir dipivoxil(ADV) has been shown to be effective against lamivudine resistant strain of hepatitis B virus. But continuation of lamivudine therapy or switching to Adefovir dipivoxil in patients with viral breakthrough after long term lamivudine therapy are controversial. To find efficacy of adefovir dipivoxil, we retrospectively assessed clinical course after lamivudine resistance in patients who changed adefovir dipivoxil and continued lamivudine therapy. Methods : 58 patients with lamivudine resistant HBV mutants after at least 6 months of lamivudine treatment were included in this study. 24 of the 58 patients were treated with ADV and rest of them were continued the lamivudine therapy after lamivudine resistance. The continuous lamivudine treatment group (n=34) was divided into two groups according to ALT count (ALT≧40, n=19 vs ALT<40, n=16) The clinical course and the biochemical and virological response of the switching adefovir group were compared with those of continuing lamivudine group. HBV genotypes and YMDD mutation site was anaylzed by TRUGENE HBV Genotyping. Results : At twelve months, the levels of median serum HBV DNA and ALT was decreased and albumin was improved significantly(P<0.01) in adefovir switching group compared with lamivudine sustained group, especially ALT was elevated more than 40. There is no significant differences between adefovir switching group and lamivudine sustained group (ALT<40, n=15). This study showed that adefovir dipivoxil reduces HBV replication and improves not only biochemical markers of disease activity, but also liver function. HBV genotypes of 58 patients were all C and rtM204I/V mutant was the most common. Conclusion : This study provides an evidence that adefovir dipivoxil can be effective in the treatment of lamivudine-resistant HBV mutants, especially ALT elevated.
지방간의 병리학적 소견과 초음파검사의 연관성에 관한 연구
조성환,박이천,박남영,노지훈,윤병철,한병훈,이상욱 KOSIN UNIVERSITY COLLEGE OF MEDICINE 2006 高神大學校 醫學部 論文集 Vol.21 No.1
BACKGROUND Fatty liver is a common disease characterized by diffuse accumulation of neutral fat(triglycerides) more than 5 percent in liver. Ultrasonography has used to be a diagnostic tool for fatty liver, because of cost-effective and non-invasive study. But the sensitivity and specificity of ultrasonography for diagnosis of fatty liver are variable. Thus, we conducted a retrospective study to investigate correlation between histology and sonographic findings of fatty change in liver. METHODS We collected data from 47 patients who were diagnosed as fatty liver by liver biopsy and ultrasonography from January, 1994 to December, 1997. We compared a sonographic finding with the histologic grade of fatty liver and analysed the data retrospectively by SAS program. RESULTS Major cause of fatty liver is alcohol. The mean consumption of alcohol during 1 day is 64.1 gram, and the mean duration of alcohol drinking is 16.5 years. Degree of fatty infiltration in ultrasonography was significantly correlated with degree of fatty accumulation of liver(p=0.001). But, though it was diagnosed as normal by ultrasonography, 19.1% of total patients was fatty liver by needle biopsy. CONCLUSION We think that liver biopsy is needed for further management and follow-up, if liver function test is abnormal, though the finding of ultrasonography is normal.