알츠하이머병 유발 동물모델에서 한약제재 경구투여가 기억에 미치는 영향에 대한 국내 연구보고 고찰

한다영 ( Da-young Han ),박나은 ( Na-eun Park ),김상호 ( Sang-ho Kim ),정대규 ( Dae-kyoo Chung ) 대한한방신경정신과학회 2017 동의신경정신과학회지 Vol.28 No.4

Objectives: The objective of this study was to review the effect of oral administration of herbal medicines on the improvement of memory in Alzheimer's disease animal model reported in Korean domestic journals. Methods: The Korean databases (Koreantk, KISS) were searched with memory as a popular search term. During the searches, only animal study reports were reviewed. Data of animal models, intervention, observation methods of measuring indicators were extracted from the databases. Results: Typically, 36 articles were reviewed. Twenty-two studies used scopolamine to induce Alzheimer's disease, 24 studies used complex herbal medicines, and 12 studies used simple herbal medicines. Polygalae Radix and Acori Rhizoma were the most frequently used herbal medicines to improve memory in Alzheimer model. To evaluate the effect of herbal medicines, 36 studies used macroscopy, 16 studies used molecular biological analysis, 21 studies used biochemical analysis, 15 studies used histological analysis, and 11 studies used hematological analysis. Each study showed significant improvement with respect to memory indicators. Conclusions: Overall, the results suggest that treatment employing herbal medicines is an effective option to treat memory impairment in Alzheimer’s disease.

Scopolamine 유발 기억력 손상 마우스 모델에서 목향(木香)의 기억력 개선 및 항산화 효과

박나은 ( Na-eun Park ),한다영 ( Da-young Han ),김상호 ( Sang-ho Kim ),정대규 ( Dae-kyoo Chung ) 대한한방신경정신과학회 2017 동의신경정신과학회지 Vol.28 No.2

Objectives: The objective of this study is to investigate the anti-amnesic effects of AR, Aucklandiae Radix, ground powder on scopolamine (Sco)-induced memory impairment in mice (C57BL/6) through its favorable acetylcholine (ACh) and acetylcholinesterase (AChE) activity, Choline acetyltransferase (ChAT) mRNA expression, and antioxidant effect. Methods: Six groups, a total of 20 intact or 100 Sco treated mice, were selected based on their body weights and were used in this study. Half of the mice in each group were used for the passive avoidance task test and the measurements of hippocampus ACh content, AChE activity and ChAT mRNA expression. The remaining half of the mice in each group were used for the Morris water maze test and cerebral antioxidant defense system measurement. Results: Marked decreases in step-through latency times in the passive avoidance task test and increases in escape latency times in the Morris water maze test were observed with decreases in the hippocampus ACh content and ChAT mRNA expression, and increases in the hippocampal AChE activities, as a result of Sco intraperitoneal treatment, in the present study. In addition, destruction of the cerebral cortex antioxidant defense systems was observed in Sco control mice as compared with intact vehicle control mice. However, 28 days of continuous oral pre-treatment with AR ground powder at doses of 400, 200 and 100 mg/kg markedly and dose-dependently inhibited the Sco treatment-related amnesia. Conclusions: The results prove that oral administration of AR ground powder reduces Sco-induced memory impairment. This is because it can preserve ACh, related to ChAT mRNA expression, cause AChE inhibition, and activate the cerebral antioxidant defense system.

Scopolamine 유발 기억력손상 흰 쥐에서 笭桂甘棗湯加龍骨牡蠣의 인지기능개선과 항산화 효과

김대억 ( Dae-eok Kim,),한다영 ( Da-young Han,),김상호 ( Sang-ho Kim,),정대규 ( Dae-kyoo Chung ) 대한한방신경정신과학회 2018 동의신경정신과학회지 Vol.29 No.3

Objectives: The purpose of this in vivo study is to observe anti-amnesic effects of Yeongkyekamjotanggayonggolmoryo (YGYM), a novel mixed herbal prescription, Ossis Mastodi and Ostreae Testa added Yeongkyekamjo-tang, on scopolamine induced amnesia in C57BL/6 mice through acetylcholine (ACh) and acetylcholinesterase (AChE) activity, Choline acetyltransferase (ChAT) mRNA expression, and antioxidant effects. Methods: Six groups, total 20 intact or 100 Sco treated mice were used in this study after one week of acclimatization period. Half the animals were used for passive avoidance task tests and hippocampus ACh content, AChE activity, and ChAT mRNA expression were measured. The other half was subjected to an underwater maze test and then the cerebral cortex antioxidant defense system was measured. Results: In the passive avoidance experiment, there was significant decrease in residence time in the bright room and in the underwater maze test, escape latency to escape from the esophagus significantly increased compared with the normal control group. At the final sacrifice, ACh content and ChAT mRNA expression decreased, AChE activity increased, and cerebral cortical MDA increased GSH content, SOD and CAT activity in Sco control mice, as compared to intact vehicle control mice. However, these Sco treatment-related memory loss through AChE activation destroyed the cerebral cortex antioxidant defense system, and was inhibited dose-dependently by 28 days consecutive oral pretreatments of YGYM extracts 500, 250, 125 mg/kg. Conclusions: In the above results, YGYM extract that oral administration of YGYM extracts alleviates the antioxidant defense system, through preservation of ACh mediated by upregulation of ChAT mRNA expression, and increase of AChE inhibition and brain antioxidant defense systems.

소자강기탕을 투여한 천식환자의 치험 1례

조혜미,길봉훈,이은창,윤혜수,김동원,한다영,정다해,이정은,Jo, Hye-mi,Kil, Bong-hun,Lee, Eun-chang,Youn, Hye-soo,Kim, Dong-won,Han, Da-young,Jung, Da-hae,Lee, Jung-eun 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.5

Objectives: This study aimed to describe the effects of traditional Korean medical treatment on a patient with asthma. Methods: The patient (female, 88) was treated with herbal medicine (Sojaganggi-tang), acupuncture, and moxibustion. The effects of these treatments were evaluated using the Modified Borg Scale (MBS) and Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA). Results: Following treatment, the MBS score decreased from 7 to 4, and the QLQAKA score increased from 45 to 57. Conclusion: The results suggest that traditional Korean medicine can effectively treat patients with asthma.

기저핵-대뇌부챗살 뇌출혈로 인한 반신부전마비에 대한 한·양방 병행 치험 1례

정다해,길봉훈,김동훈,윤혜수,이은창,조혜미,한다영,손아현,Jung, Da-hae,Kil, Bong-hun,Kim, Dong-won,Youn, Hye-soo,Lee, Eun-chang,Jo, Hye-mi,Han, Da-young,Son, Ah-hyun 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.5

Objective: This study examined the case of a 63-year-old man with a history of hypertension and gout who had developed an intracerebral hemorrhage (ICH) of the right basal ganglia of the corona radiata. Methods: The patient was treated with herbal medicine (Boyanghwanoh-tang and powdered Oryeong-san extract), Western medicine (Anticonvulsants, antihypertensive drugs, psychotropic agents, and others), acupuncture, moxibustion, cupping, and rehabilitative therapy. Their effects were evaluated using the Manual Muscle Test (MMT), Korean version of the modified Barthel Index (K-MBI), National Institute of Health's Stroke Scale (NIHSS), and Modified Rankin Scale (mRS). Results: After treatment, the MMT grade improved from 3/3+ to 4+/4+. Additionally, the K-MBI score improved from 62 to 77. Conclusion: The results suggest that combined traditional Korean and Western medicine can effectively treat patients with ICH.

미세먼지와 아동의 신체 및 정신건강 관계 : 빈곤과 녹지지역비율 조절효과

김시아(Kim, Si Ah),박지혜(Park, Ji Hye),한다영(Han, Da Young),정익중(Chung, Ick-Joong) 한국방재학회 2020 한국방재학회논문집 Vol.20 No.1

우리는 주변 환경의 지대한 영향을 받으며 살아가고 있고, 특히 아동은 미세먼지와 같은 기후재난에 취약할 수밖에 없다. 그러나 미세먼지가 아동의 신체건강 및 정신건강에 미치는 다각적인 영향을 확인할 수 있는 연구는 부족하다. 이에 본 연구에서는미세먼지와 아동의 신체 및 정신건강과의 관계를 밝히고, 아동가정의 빈곤과 녹지지역비율의 조절효과를 검증하였다. 그결과, 첫째, 미세먼지는 아동의 신체 및 정신건강에 부정적인 영향을 미침을 확인하였다. 둘째, 미세먼지와 아동의 정신건강간의 관계에서 녹지지역비율의 조절효과를 확인하였다. 본 연구결과를 근거로, 미세먼지로부터 기후변화 취약계층을 보호할수 있는 재난복지 정책을 제안하였다. We live under substantial influence of our surrounding environment, and children are more vulnerable to climate hazards such as fine dust (PM10). However, there is a dearth of research confirming the multifaceted effects of fine dust on children s physical and mental health. This study clarifies the relationship between PM10 and children’s health, examining the moderating effects of poverty and green area ratio. The results were as follows. First, fine dust (PM10) has a negative impact on the physical and mental health of children. Second, the effect of PM10 on children’s mental health is moderated by the green area ratio of the children’s residences. Based on the results of this study, a disaster welfare policy is proposed to protect climate change-vulnerable populations from fine dust.