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김대억 ( Dae-eok Kim ),정대규 ( Dae-kyoo Chung ),김상호 ( Sang-ho Kim ),이원우 ( Won-woo Lee ),이은경 ( Eun-kyung Lee ) 대구한의대학교 제한동의학술원 2016 東西醫學 Vol.41 No.4
Tic disorders are involuntary sudden, rapid, repetitive movements of muscles and sounds. 10 patients who were scheduled to receive herb therapy (Ukgansangagam) after the diagnosis of ticks at the `H` clinic in Suseong-gu, Daegu from March 2013 to August 2015, and 8 patients who did not have tick disease were included in the study. The following conclusions were obtained through comparative analysis. 1. α wave was significantly lower (p <0.05) in the FP2, F3, FZ, F4, FCZ, O1 and OZ channels. 2. β wave was significantly lower (p <0.05) in the tic disorder control group in the 28 channels of the 30 channels, including O1, OZ, and O2, P8, P7, P8, P7, P8, F7, F3, F4, F8, FT7, FC3, FCZ, FC4, FT8, T7, C3, CZ, C4, T8, TP7, CP3, CPZ, CP4, TP8, P7 channels. 3. θ wave was significantly (p <0.05) significantly higher in the tic disorder control group in all 30 channels of FP1, FP2, F7, F3, FZ, F4, F8, FT7, FC3, FCZ, FC4, FT8, T7, C3, CZ, C4, T8, TP7, CP3, CPZ, CP4, TP8, P7, P3, PZ, P4, P8, O1, OZ, O2. 4. δ wave was significantly (p <0.05) significantly higher in the tic disorder control group in the F7, P7, P4, P8, O1, OZ and O2 channels. Based on the present study, we hope to develop therapeutic methods and treatment regimens that have stabilized the EEG close to normal through further study of EEG changes such as herbal medicine and acupuncture treatment in the treatment of tic disorders.
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Scopolamine 유발 기억력손상 흰 쥐에서 笭桂甘棗湯加龍骨牡蠣의 인지기능개선과 항산화 효과
김대억 ( Dae-eok Kim,),한다영 ( Da-young Han,),김상호 ( Sang-ho Kim,),정대규 ( Dae-kyoo Chung ) 대한한방신경정신과학회 2018 동의신경정신과학회지 Vol.29 No.3
Objectives: The purpose of this in vivo study is to observe anti-amnesic effects of Yeongkyekamjotanggayonggolmoryo (YGYM), a novel mixed herbal prescription, Ossis Mastodi and Ostreae Testa added Yeongkyekamjo-tang, on scopolamine induced amnesia in C57BL/6 mice through acetylcholine (ACh) and acetylcholinesterase (AChE) activity, Choline acetyltransferase (ChAT) mRNA expression, and antioxidant effects. Methods: Six groups, total 20 intact or 100 Sco treated mice were used in this study after one week of acclimatization period. Half the animals were used for passive avoidance task tests and hippocampus ACh content, AChE activity, and ChAT mRNA expression were measured. The other half was subjected to an underwater maze test and then the cerebral cortex antioxidant defense system was measured. Results: In the passive avoidance experiment, there was significant decrease in residence time in the bright room and in the underwater maze test, escape latency to escape from the esophagus significantly increased compared with the normal control group. At the final sacrifice, ACh content and ChAT mRNA expression decreased, AChE activity increased, and cerebral cortical MDA increased GSH content, SOD and CAT activity in Sco control mice, as compared to intact vehicle control mice. However, these Sco treatment-related memory loss through AChE activation destroyed the cerebral cortex antioxidant defense system, and was inhibited dose-dependently by 28 days consecutive oral pretreatments of YGYM extracts 500, 250, 125 mg/kg. Conclusions: In the above results, YGYM extract that oral administration of YGYM extracts alleviates the antioxidant defense system, through preservation of ACh mediated by upregulation of ChAT mRNA expression, and increase of AChE inhibition and brain antioxidant defense systems.
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박나은 ( Na-eun Park ),박준현 ( Jun-hyun Park ),김대억 ( Dae-eok Kim ),김상호 ( Sang-ho Kim ),정대규 ( Dae-kyoo Chung ) 대한한방신경정신과학회 2016 동의신경정신과학회지 Vol.27 No.3
Objectives: Schizophrenia is a serious disease that influences not only the patients themselves but also their family and the society. In this case, we employed art therapy and Korean traditional medicine for treating a schizophrenia patient. Methods: The patient was diagnosed with schizophrenia, and the main complaints were hallucination, visual hallucination and catatonic behavior. We treated the patient with art therapy and Korean traditional medicine including acupuncture, moxa and herbal medicine. We used the Brief Psychiatric Rating Scale (BPRS) and the Positive and Negative Syndrome Scale (PANSS) for assessment. Results: After treatment, clinical symptoms were improved and the BPRS and PANSS scores were decreased, especially the scores for anxiety, depression and poor rapport. Conclusions: Combined treatment with art therapy and Korean traditional medicine can be effective for treating chronic schizophrenia.
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