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술후 통증조절을 위한 새로운 대안으로서의 Oxycodone
최병문,Choi, Byung Moon 대한치과마취과학회 2013 Journal of Dental Anesthesia and Pain Medicine Vol.13 No.4
Oxycodone is a semi-synthetic opioid synthesized from poppy-derived thebaine. It is a narcotic analgesic generally indicated for relief of moderate to severe pain. Although developed in an attempt to improve on the existing opioids, the adverse effects of oxycodone are those that are typically found in opioids. In recent years, the use of the opioid oxycodone has increased markedly and replacing morphine as the first line choice of opioid in several countries. There are formulations for oral immediate, oral extended release and intravenous use. In 2013, intravenous oxycodone was approved for marketing by Ministry of Food and Drug Safety (MFDS), with the indication of postoperative intravenous patient-controlled analgesia (IV PAC). Simulation study of oxycodone demonstrated that minimum effective analgesic concentration (MEAC) of oxycodone was most quickly reached with higher loading dose and IV PCA with background infusion, which may reduce the necessity of rescue analgesics during immediate postoperative period. Previous studies for postoperative pain management with intravenous oxycodone are limited in sample size, mostly less than 100 patients, which may not be large enough to assess safety of intravenous oxycodone. The effectiveness and tolerability of IV PCA with oxycodone should, therefore, be evaluated in large scale clinical trials in Korean populations.
최병문 ( Byung Moon Choi ),진지현 ( Ji Hyun Chin ),김영국 ( Young Kug Kim ),함경돈 ( Kyung Don Hahm ),심지연 ( Ji Yeon Sim ),최인철 ( In Cheol Choi ),황규삼 ( Gyu Sam Hwang ),한성민 ( Sung Min Han ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.2
An inguinal hernia shows that the protruding viscus exits from the endoabdominal fascial sac through the internal inguinal ring. Because an inguinal hernia is usually associated with incarceration, obstruction and even strangulation, it must be quickly treated whenever observed. Although there are several predisposing factors of the development of inguinal hernia, relatively little is a case report of the inguinal hernia developed by the increased intra-abdominal pressure during general anesthesia. In this case, we report a patient who developed the unexpected recurrence of left inguinal hernia following lumbar spinal surgery in prone position by increasing intra-abdominal pressure. After manual reduction was performed promptly by general surgeon, the patient was discharged without any complication on the eighth postoperative day. (Korean J Anesthesiol 2006; 51: 239~42)
실험연구 : Propofol 미세유탁액을 지속정주하여 진정된 비글견에서 집단 약동력학적 모형화
최병문 ( Byung Moon Choi ),정성문 ( Sung Moon Jung ),배균섭 ( Kyun Seop Bae ),노규정 ( Gyu Jeong Noh ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.50 No.6
Background: Aquafol(R) is a microemulsion formulation of propofol. This study was designed to investigate the population pharmacokinetic and pharmacodynamic modeling in beagle dogs sedated by Aquafol(R). Methods: Electroencephalogram was recorded and venous blood was sampled at preset times in 15 beagle dogs during 3 hours of infusion of Aquafol(R) and subsequently during 3 hours of recovery. Venous blood was sampled at 0, 2, 10, 30, 60, 120, 180, 190, 240 and 360 minutes after infusion. We evaluated the effect of propofol on electroencephalogram by calculating SEF90. In the preliminary analysis, two compartment model best described all data from all subjects. The pharmacodynamics were best described using an effect compartment model and ke0, a first-order elimination rate constant characterizing the effect-site equivalent to estimate the apparent effect-site concentrations. The relationship between propofol effect-site concentration and SEF90 was analyzed using an inhibitory sigmoid Emax model. Results: The final pharmacokinetic model was best described with the followings: V1 = 18.5e0.114*BWT, k10 = 1.86 min-1, k12 = 0.6 min-1, k21 = 0.684 min-1. The final pharmacodynamic model was best described with the followings: t1/2ke0 = 0.62 min, Ce50 = 32.2 ng/ml, Eo = 31.3 Hz, Emax = 20.9 Hz, γ = 1.28. Conclusions: The propofol microemulsion shows different pharmacokinetics and pharmacodynamics compared with the propofol lipid emulsion. (Korean J Anesthesiol 2006; 50: 689~97)
이성낙(Sung Nack Lee),이광훈(Kwang Hoon Lee),김덕현(Duck Hyun Kim),최병문(Byung Moon Choi) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.3
A 44 year-old male without a specific past history demonstrated violaceous colored. angulated flat papules in a zosteriform arrangement along the medial aspect of left arm and upper anterior chest for 3 months. In addition, whitish patches with a lace-like pattern were seen on the buccal mucosa. The histopathologic findings were characteristic of lichen planus. The zosteriform lichen planus is a rare variant of lichen planus, Especially, it has been rarely observed in cases that developed without a previous history of herpes zoster or factors that lead to the Koebner phenoinenon In this context, it piqued our scientific curiousity enough to investigate it.