우울증 치료에서 빠른 효과와 적은 부작용을 가진 새로운 N-Methyl-D-Aspartate(NMDA) 수용체 길항제

최범성,이화영,Choi, Bum-Sung,Lee, Hwa-Young 대한생물정신의학회 2015 생물정신의학 Vol.22 No.4

Mood disorder is a common psychiatric illness with a high lifetime prevalence in the general population. Many prescribed antidepressants modulate monoamine neurotransmitters including serotonin, norepinephrine and dopamine. There has been greater focus on the major excitatory neurotransmitter in the human brain, glutamate, in the pathophysiology and treatment of major depressive disorder (MDD). Recently, ketamine, an N-methyl-D-aspartate receptor antagonist, has received attention and has been investigated for clinical trials and neurobiological studies. In this article, we will review the clinical evidence for glutamatergic dysfunction in MDD, the progress with ketamine as a rapidly acting antidepressant, and other N-methyl-D-aspartate receptor antagonist for treatment-resistant depression.

인터넷 중독과 주의력결핍 과잉행동장애 환아 어머니의 양육 스트레스 및 효능감

최범성(Bum-Sung Choi),김봉석(Bongseog Kim) 대한소아청소년정신의학회 2010 소아청소년정신의학 Vol.21 No.2

Objectives:The purpose of this study was to compare levels of parenting stress and efficacy in mothers of children suffering from attention-deficit hyperactivity disorder (ADHD) and internet addiction disorder (IAD), mothers of children with ADHD alone only, and those with normal children. Methods:Participants were composed of 25 mothers of children with ADHD and IAD, 35 mothers of children with ADHD alone, and 50 mothers of normal children. They completed the Parenting Stress Index (PSI) and Parenting Sense of Competence (PSOC). Results:In comparison with the mothers of normal children, the mothers of children with ADHD and IAD and the mothers of children with ADHD alone showed significantly higher levels of parenting stress and lower parenting efficacy. However, a comparison of mothers of children with ADHD and IAD with those of children with ADHD alone did not show any significant differences in their levels of parenting stress or efficacy. Conclusion:Mothers of children with ADHD, regardless of the presence of IAD exhibited a higher level of parenting stress and a lower level of parenting efficacy than mothers of normal children.

ADHD 학생의 동네환경과 특별활동의 경험에 대한 비교연구

이재영,최범성,강동묵,김지훈,Lee, Jae-Young,Choi, Bum-Sung,Kang, Dong-mug,Kim, Ji-Hoon 대한생물정신의학회 2018 생물정신의학 Vol.25 No.3

Objectives The purpose of this study is to investigate the differences between a attention deficit hyperactivity disorder (ADHD) group and a general student group in terms of the perception of the residential environment and periodic activities outside the classroom. Methods The patient group consisted of 62 outpatients or inpatients at the Department of Pediatric Psychiatry, and 49 patients diagnosed with ADHD were selected. For the control group, 3727 youths in elementary schools, middle schools, and high schools of one city were asked to fill out questionnaires. Of the 1717 respondents who responded to the questionnaires, 245 were selected for a patient-controlled study. The differences between the patient group and the control group were compared using the chi-squared test (${\chi}^2$ test). Results There was a significant difference between the patient group and the control group in areas where students responded by "My neighborhood is dirty and littered (p < 0.05)". There was also a significant difference between the patient group and the control group in terms of having more than one club activity per month (p < 0.05). Conclusions It was found that the patients with ADHD are more aware of perceived negative aspects of the area in which they reside, thus reflecting their anxiety. In addition, it was also found that the patient group did not partake in as many social activities as the control group.

텍스트마이닝을 활용한 발달장애 신문기사 분석: 조기선별과 조기중재를 중심으로

이상아 ( Lee Sang-ah ),최범성 ( Choi Bum-sung ),최진혁 ( Choi Jin-hyeok ) 한국특수아동학회 2020 특수아동교육연구 Vol.22 No.1

연구목적: 본 연구에서는 텍스트마이닝을 활용하여 발달장애 조기선별과 조기중재 관련 신문기사를 분석하여 우리 사회의 인식 특성을 파악하는 것을 목적으로 한다. 연구방법: 분석대상은 2014년부터 2019년 9월까지의 신문기사 39건으로 하였다. 분석자료는 뉴스 빅데이터 분석 서비스에서 수집하고, 텍스톰과 UCINET을 활용하여 분석하였다. 연구결과: 첫째, 우리 사회는 발달장애 조기선별과 조기중재와 관련해 지속적인 관심을 보이는 것으로 나타났다. 둘째, 발달장애에 대한 용어는 발달장애인법이 통과된 후 범용적으로 사용된 것을 알 수 있다. 셋째, 주요 단어 중 ‘발달장애’가 가장 높은 빈도로 등장했다. 넷째, N-gram 분석에서 상위의 연관 있는 단어의 관계는 ‘발달장애-아동’, ‘발달장애-가족’, ‘발달장애-뇌’로 나타났다. 다섯째, 의미연결망 분석에서 영향력 있는 단어는 ‘발달장애’, ‘아동’, ‘치료’로 나타났다. 여섯째, CONCOR 분석으로 ‘발달장애 특징과 지원’, ‘조기중재’, ‘정부정책’의 범주별 주요 클러스터가 구분되었다. 결론: 본 연구는 발달장애 조기선별과 조기주재에 대한 전반적인 사회의 인식을 탐색하고, 앞으로 나아갈 방향성을 파악하였다는 것에 의의가 있다. Purpose: The purpose of this study was to analyze newspaper articles related to early screening and early intervention of individuals with developmental disabilities via the text mining method. Method: The analysis targets 39 newspaper articles from Jan. 2014 to Sept. 2019. Newspaper articles were ected through Big KindsⓇ and analyzed through Textom and UCINET. Results: First, it was identified that the interest in early screening and early intervention of developmental disabilities have maintained. Second, the ‘developmental disabilities’ term was commonly used after the activation of the Developmental Disability Support Act. Third, the word ‘developmental disabilities’ appeared with the highest frequency. Fourth, in the N-gram analysis, the relationship of upper related words was shown as ‘developmental disabilities - child’, ‘developmental disabilities - family’ and ‘developmental disabilities - brain’. Fifth, in the semantic network analysis, influential words appeared as ‘developmental disabilities’, ‘child’ and ‘therapy’. Sixth, the CONCOR analysis has divided the major clusters by the categories of ‘characteristics and support of developmental disabilities’, ‘early intervention’ and ‘government policy’. Conclusion: Through this study, we were able to find a way forward.

학술지 소아청소년정신의학의 공저 네트워크 분석

김성완(Soungwan Kim),최범성(Bum-Sung Choi),김봉석(Bongseog Kim),김경민(Kyoung-Min Kim) 대한소아청소년정신의학회 2017 소아청소년정신의학 Vol.28 No.2

Objectives: The purpose of this study is to analyze the co-author networks in the Journal of the Korean Academy of Child and Adolescent Psychiatry, a representative journal published by a branch of the domestic psychiatric academy, in order to present the current state of the co-authoring of and developments in child and adolescent psychiatry. Methods: We visualized and estimated the basic characteristics of the co-author networks shown by 564 authors who wrote 251 papers published in the Journal of the Korean Academy of Child and Adolescent Psychiatry between 2005 and 2015, in order to assess their network characteristics, author centrality, and relevance to research performance. Results: The co-author networks in the Journal of the Korean Academy of Child and Adolescent Psychiatry showed the characteristics of a small world and scale-free network. There was a correlation between the author centrality within the network and the research performance of the authors, but less correlation was shown between the centrality and mean paper citation counts. Conclusion: The network structure in the Journal of the Korean Academy of Child and Adolescent Psychiatry showed similarity to the co-authoring of other branches. However, given that the mean paper citation counts were less correlated with the author centrality than those in other branches, it may be necessary to promote an increase in the mean paper citation counts.

소아청소년기 발병 양극성 장애와 성인기 발병 양극성 장애의 인지 및 임상적 특성에 대한 비교 연구

김현미(Hyeonmi Kim),허성영(Sung-Young Huh),김성곤(Sung-Gon Kim),김지훈(Ji-Hoon Kim),정우영(Woo-Young Jung),유은라(Eun-ra Yu),최범성(Bum-Sung Choi),김대욱(Dae-Wook Kim),윤동욱(Dong-Uk Yoon) 대한생물치료정신의학회 2020 생물치료정신의학 Vol.26 No.2

Objectives:Childhood/adolescent-onset of bipolar disorder presents functional impairments on emotional, academic, and social aspects. These impairments could continue into adulthood. However, there are few studies comparing cognitive function between childhood/adolescent- and adult-onset using psychological test. This study aims to improve understanding of childhood/adolescent-onset of bipolar disorder by comparing differences in cognitive function, clinical and demographic features between the two groups. Methods:This study was conducted on 145 patients diagnosed with bipolar disorder type I, II, and other specified bipolar disorder by DSM 5 at the time of discharge from 2016 to 2019 at the Department of Psychiatry, Pusan National University Yangsan Hospital. Demographic information, clinical data, and results of psychological tests (K-WISC-IV, K-WAIS-IV) were collected and reviewed. Results:Childhood/adolescent-onset group was significantly low in total potential IQ and in language understanding than adult-onset group (p=0.008 and p=0.013). The childhood/adolescent group had significantly more psychiatric comorbidities than the adult group (p<0.001). The average number of prescribed antipsychotic agents was 1.18 (SD=±0.64) in the childhood/adolescent group, and 1.78 (SD=±0.82) in the adult group. The difference was statistically significant (p<0.001). Conclusion:Patients with childhood/adolescent-onset bipolar disorder have lower total potential IQ and language understanding comparing patients with adult-onset bipolar disorder. This highlights the importance of conducting a well-designed prospective study to find out more about the characteristics of childhood/adolescent-onset bipolar disorder.

자폐스펙트럼장애 아동의 치료개입시기에 영향을 미치는 요인 : 후향적 분석

유은라(Yu, Eun-ra),김지훈(Kim, Ji-hoon),민은정(Min, Eun-jeong),서비아(Seo, Bi-A),최진혁(Choi, Jin-Hyeok),최범성(Choi, Bum-Sung) 한국자폐학회 2020 자폐성 장애연구 Vol.20 No.1

본 연구의 목적은 자폐스펙트럼장애 아동의 부모가 자폐증상을 인지한 이후, 보다 빠른 치료적 개입시작에 영향을 미치는 요인을 파악하는 데 있다. 연구대상은 B 대학병원에 내원한 만 2세부터 만 6세 사이의 자폐스펙트럼장애 아동 170명을 대상으로 하였다. 연구방법은 빈도 및 기술통계분석, 독립표본 t-검정, 상관관계분석, 다중회귀분석을 실시하였다. 연구결과, 아동이 다른 아이들과 다름을 인지한 시기는 평균 생후 20개월 시점인 것으로 확인되었고, 치료를 처음 시작한 연령은 35.5개월로 아동의 증상을 인지하고 치료시작까지 걸리는 시간은 평균 14.5개월 소요되는 것으로 확인되었다. 영향요인 분석 결과, 아동의 일상생활능력 중 사회성과 부모상호작용 중 지시성이 낮고, 상동행동적인 문제가 심하며, 모의 학력이 더 높을수록 치료적 개입이 보다 조기에 이뤄지는 것을 확인하였다. 이에 영향을 미치는 요인들이 자폐스펙트럼장애 아동의 원활한 치료를 위해 활용되도록 제언하였다. The purpose of this study was to investigate the factors that affect the initiation of therapeutic intervention after parental awareness of autism symptom in children with autism spectrum disorder(ASD). We studied 170 children with ASD from 2 to 6 years old who visited B National University Hospital. The research methods were frequency, descriptive statistical analysis, independent sample t-test, correlation analysis, and multiple regression analysis. According to the results, when the average age child was about 20.8 months, the parents recognized the child s autism symptoms and the average age of starting intervention was 35.5 months. The average time to start therapeutic intervention after parents recognized the child s autism was 14.5 months on average. The timing of intervention for children with ASD was faster as the less sociality in the daily life area of the children, the lower the direction among the parent interactive behavior scale, the more severe the symptoms of stereotypic behavior patterns and the higher the mother s educational background of the children. It was suggested that the factors affecting the initiation of therapeutic intervention be used for the early intervention of children with ASD.