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김유영,정혁,최귀향 대한의생명과학회 2005 Biomedical Science Letters Vol.11 No.3
Formaldehyde (FA) is an important industrial chemical, but it can cause allergic reactions, sick building syndrome and so on. It has also been observed to cause cancer in scientific studies using laboratory animals, and it even causes cancer in humans. Natural products such as ginseng and pine needle containing complicated mixtures of organic chemicals are widely used in the world, because their effective components are responsible for some pharmacological activities including antioxidative effect, anticancer effect. We investigate the effect of Korean ginseng (GE), pine needle extract (PE) and combined GE and PE (cNPE) on mouse lung injury by FA exposure. GE, PE and cNPE was directly transported to pulmonary cells through respiratory organ by nebulizer inhalation. In the case of FA exposure, the pulmonary structure was damaged and its function became abnormal. However, cNPE-FA, GE-FA, and PE-FA treated groups showed similar with the control group compared with FA group. Among them, GE was proved to be more effective than any other extracts. These results demonstrate that natural product extracts could protect pulmonary structure and function against FA exposure.
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척추동물 망막에서 아연과 저온 효과가 명·암순응에 미치는 영향
박종석,김현정,정혁,김상기,최귀향,김보애,서태수,김상국,김유영,김시열 대한안과학회 2007 대한안과학회지 Vol.48 No.7
Purpose: The purpose of this study was to clarify the effects of zinc treatment and hypothermia on visual adaptation and visual sensitivity in bullfrogs (Rana catesbeiana), which are poikilothermal animals capable of adjusting quickly to environmental temperature changes. Methods: The effects of both zinc treatment and hypothermia on visual sensitivity were studied by using electroretinogram (ERG) recording and absorption spectra scanning before and after zinc and TSQ (N-[6-methoxy-8-quinolyl]-p-toluene sulfonamide) treatment, with or without temperature changes. Results: In spite of malnutrition due to hibernation, the optimal zinc concentration effect was obtained at 10-4 M (10-2 M 200 ㎕ ZnCl2 in 20 ㎖ Ringer’s solution) according to ERG recording. After zinc treatment and hypothermia induction, increments of all ERG components and thresholds were taken by ERG recording. These results showed that both zinc treatment and hypothermia may increase visual sensitivity during visual adaptation. In spectral scans, the absorbance increment due to zinc treatment and hypothermia was shown over the whole spectral range (400~750 nm), and it was especially prominent at α-peak (about 500 nm). In addition, there was a decrease in absorption differences between dark adaptation and light adaptation after zinc treatment. Furthermore, according to the visual sensitivity decrement using TSQ as a zinc specific chelator, this visual sensitivity increase was shown to be caused by zinc. Conclusions: As the results suggest, both zinc treatment and hypothermic effects may improve visual sensitivity by promoting rhodopsin regeneration and inhibiting rhodopsin bleaching induced by light illumination. Zinc may activate the enzyme activity of retinol dehydrogenase and phosphodiesterase, while hypothermic effects may improve precursor transport, which is required for rhodopsin regeneration, by tightening membrane adhesion between retinas and retinal pigment epithelia. In addition, we believe that zinc treatment and hypothermic effects may work synergistically to accelerate visual sensitivity during visual adaptation.
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김유영,김상기,김상국,김보애,최귀향 대한의생명과학회 2006 Biomedical Science Letters Vol.12 No.3
Cigarette smoke causes atypical structure of pulmonary and oxidative damage. Therefore, we carried out to determine if exposure to cigarette smoke alters pulmonary structure and anti-oxidant related enzyme in a animal model, when natural product extracts using by Nebulizer. The rat were divided into four groups: H2O-treated (Control), natural product (Camellia sinensis) extracts-treated (CS), natural product extracts-treated with cigarette smoke-exposed (CS+SM) and cigarette smoke-expose (SM). All groups are similar to Control group in weight, but SM group is lower than the other groups. Microscopic image of the pulmonary structure in SM group showed deleterious alterations in the morphology, but the other groups are maintained in normal structure. In anti-oxidant related enzymes, SOD (superoxide dismutase) and catalase, SM group represents the lowest enzyme activity among all groups. But G6PD (glucose-6-phosphate dehydrogenase) and LPO (lipid peroxidation) is SM group represents the highest enzyme activity among all groups. These result indicate that the natural product extracts is an efficient tissue protective substance against smoke-induced lung injury.
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진달래꽃(Rhododendron mucronulatum Turczaninow) 추출물의항산화, 항암 효과 및 tyrosinase 저해활성
안봉전,손준호,이창언,이진영,최귀향,박태순 한국응용생명화학회 2005 Journal of Applied Biological Chemistry (J. Appl. Vol.48 No.3
Several biological activities of Rhododendron mucronulatum were investigated. The electron donating abilities of ethanol extracts of Rhododendron mucronulatum were more than 90% at 100 ppm, 500 ppm and 1,000 ppm. Xanthine oxidase was inhibition about 46% by the ethanol extracts of R.mucronulatum at 500 ppm 48% of tyrosinase activity relating to skin-whitening was shown at 1,000ppm. Uniquely, the anti-microbial effects of water extract and ethanol extract were shown only on Staphylococcus aureus. The water extract 1 mg/disc showed the higher activity than ethanol extract. The growth inhibition effect of each sample on lung cancer (A549) and melanoma (B16F10) cell lines were over 70% at 1,000 ppm, while the effects on the melanoma (G361) and liver cancer (HepG2) were about 50% at the same concentration.
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