산란계 사료에서 옥수수 주정박의 영양적 가치평가

천영주,이학림,신명호,이봉덕,손찬구 한국가금학회 2006 한국가금학회 정기총회 및 학술발표회 Vol.23 No.-

본 시험은 품질이 양호한 미국산 DDGS를 산란계 사료에 급여시 산란성적, 계란의 품질 및 난황지질의 총지방 함량과 지방산 조성에 미치는 영양적 가치를 평가하기 위해 실시하였다. 24주령의 HyLine Brown 계통의 산란계 900수를 옥수수-대두박 위주로 CP 17.0%, TMEn 2,780 kcal/kg의 동에너지-동단백질로 DDGS를 각각 0%, 10%, 15%, 20%를 첨가하여 4처리 5반복, 반복 당 45수씩 완전임의 배치로 10주간 급이하였다. 사료섭취량, 총난중 및 사료요구율 등의 산란 생산성은 모든 처리구 사이에 유의한 차이가 없었으나, 산란율은 DDGS 첨가구들에서 유의하게 감소하였다(P<0.05). 그러나 DDGS 첨가구들 사이에서는 산란율에 유의한 차이가 없었다. DDGS 첨가는 계란의 난각중, 난각강도, 난각색, 난백고 및 Haugh unit에 유의한 영향을 미치지 않았다. 그러나 난황색도의 경우 DDGS를 첨가하지 않은 대조구에 비해 DDGS의 첨가량이 증가함에 따라 난황색도가 유의적으로 증가하였다(P<0.05). 한편, 난황지질의 총지방 함량은 유의적인 차이가 없었으며, DDGS가 증가함에 따라 난황 oleic acid는 유의하게 감소하였으며, linoleic acid는 증가하였다. DDGS 첨가는 난황지방산의 불포화도에 영향을 미치지 않는 것으로 나타났다. A layer feeding trial was conducted for 10 weeks to investigate the effects of the addition of corn distillers dried grains with solubles: DDGS) to layer diets on the laying performance, egg qualities, and yolk fatty acid composition. Nine hundred Hyline Brown layers, 24 weeks of age, were randomly allotted to 20 replicate laying cages, 45 birdsper replicate. There were four diet treatments (0, 10, 15, and 20% DDGS), and five replicates per treatment. All experimental diets were prepared to contain iso-protein (17%) and iso-calorie (TMEn 2,780 kcal/kg). The addition of DDGS up to 20% level did not exert any influence on feed intake, total egg mass, mean egg weight, and feed conversion ratio. The laying rate decreased in three DDGS treatments (P<0.05) compared to non-DDGS control. However, no difference was found among the three DDGS treatments. DDGS did not exert any influence in weight, breaking strength, and color of eggshell. The albumin height and Haugh unit was not influenced by DDGS addition, The yolk color was significantly increased by DDGS supplementation. As the DDGS level increased, the oleic acid content decreased, and the linoleic acid increased (P<0.05). The degree of saturation of yolk fatty acids was not affected by dietary DDGS.

한국 외래형 국소용 피부 외용제의 사용 현황에 대한 기초 평가

천영주,김숙현,김옥주,홍세화,양진욱,김정태,임성실 대한약학회 2014 약학회지 Vol.58 No.6

Topical agents including of steroids are easily exposed to Korean patients in community setting. Those topical agents must be use cautiously because can cause adverse drug reaction unlike other oral medication. We evaluate the using pattern topical agents of Korean in community setting. We performed a questionnaire survey in three different pharmacies (general community pharmacy, dermatology clinic oriented pharmacy, general hospital oriented pharmacy) and in three uni-versity town. The survey asked necessity of topical agents, the number of applications per day, application period, site, and exist of steroids ingredient, etc. Total 330 people was participated in the survey from May 1st to July 31st, 2014. We ana-lysed the survey by the frequency of each question and cross-analysis of the compliance between general public and phar-macy groups. In results, Korean people used topical agents for sudden skin diseases (66.9%), was gotten by dermatologist’s prescription (89.1%), and did not know their diagnosis (39.2%). The people applied topical agents on face (22.3%), less one half FTU (finger tip unit) per application (61.9%), less than one week (62.9%). Though they was received drug education from pharmacist (52.2%), did not heard about adverse effects (78.4%). And compliance of applied times in pharmacy group was higher than in-non-pharmacy group (56% vs 38%, p=0.002). The highest compliance between 3 pharmacy subgroup was general community pharmacy (76.3% vs 61.6%, 61.2%, p=0.039). Compliance of applied duration was no difference between groups. Majority of respondents did not know diversity of ingredients, potency, application area of topical steroids, and replied to feel some vague reluctance and to think so dangerous about topical steroids. In conclusion, Korean people in community use topical agents well but still some exposed to risk from topical agents.

미국 식품의약국 미승인 두타스테라이드의 국내 남성형 탈모증 약물요법 적용에 대한 후향적 평가

천영주,김정태,임성실 한국임상약학회 2015 한국임상약학회지 Vol.25 No.3

Background: Androgenetic alopecia (AGA), one of alopecias, requires continuous treatment in order to prevent or stop it, and patient’s compliance is very important. Currently, only two drugs (finasteride, minoxidil) have been approved for AGA by Food and Drug Administration of United States (US FDA). However, another α-2 reductase inhibitor, dutasteride, is approved by Korea Ministry of Food and Drug Safety (MFDS) through a phase III trial. For treatment, pharmacotherapy of AGA usually combines topical minoxidil 7% with one of oral α-2 reductase inhibitor. Objectives: We evaluated the comparative efficacy and adverse effect between topical minoxidil 7%/finasteride 1 mg and topical minoxidil 7%/dutasteride 0.5 mg pharmacotherapy for outpatients with AGA. Also we evaluated the relationship between therapeutic effect and regular hospital visit. Method: This study was performed retrospectively based on electronic medical record (EMR) data of total 98 patients (topical minoxidil 7% with dutasteride 0.5 mg (Avodart®) or finasteride 1 mg (Alopecia®, Propecia®) with diagnosis of AGA from department of dermatology at a secondary hospital from January 1st, to May 31st, 2014. Results: The efficacy and adverse event of topical minoxidil 7%/dutasteride 0.5 mg (DUTA group) were 100% and 45.7%, and of topical minoxidil 7%/finasteride 1 mg (FINA group) were 92.1% and 33.3%, respectively. The mean onset time of responses and adverse events in the FINA group were 3.86 months and 4.43 months. Those in the DUTA group were 3.97 months and 5.06 months. Conclusion: Both FINA and DUTA group were highly effective, but the DUTA group showed higher efficacy and adverse effects than those in the FINA group. Dutasteride may be another alternative in AGA treatment

의료기관 조제실의 정제 재사용을 위한 반자동 정제분류기 개발에 대한 연구

천영주,김정태,임성실 한국병원약사회 2016 병원약사회지 Vol.33 No.3

Automatic tablet dispensing & packing system (ATDPS) is becoming essential in the drug management field of the hospital pharmacy and the local pharmacy. The ATDPS device automatically sorts, distributes, and packages in connection with the order communication system (OCS) or electronic medical record (EMR). In the process of using the ATDPS, some pre-packaged drugs cannot be applied to the patient. Such drugs are re-used after disassembling the packaging. However, many problems such as drug contamination, breakage, and mixing with other drugs can arise during the drug re-using process. Therefore, automation is urgently required in the drug re-using process. Automatic sorting device has not yet been introduced to the domestic pharmacy. The aim of this study was to develop a semi-automatic pills sorting device (SPSD) for the purpose of cost-saving, enhancing operation efficiency, and reducing medication errors. The proposed SPSD is affordable and efficient with potential for use in the pharmacy to help drug management.

옥수수주정박의 급여가 산란계 생산성에 미치는 효과

천영주,이학림,신명호,이수기,이봉덕,손찬구 충남대학교 농업과학연구소 2007 농업과학연구 Vol.34 No.1

A layer feeding trial was conducted for 10 weeks to investigate the effects of the addition of corn distillers dried grains with solubles (DDGS) to layer diets on the laying performance, egg qualities, and yolk fatty acid composition. Nine hundred Hyline Brown layers, 24 weeks of age, were randomly allotted to 20 replicate laying cages, 45 birds per replicate. There were four diet treatments (0, 10, 15, and 20% DDGS), and five replicates per treatment. All experimental diets were prepared to contain iso-protein (17%) and iso-calorie (TMEn 2,780 kcal/kg). The use of DDGS up to 20% level in layer diets did not exert any influence on feed intake, laying rate, total egg mass, mean egg weight, and feed conversion ratio. DDGS did not exert any influence in weight of egg, breaking strength, and color of eggshell. The albumen height and Haugh unit was not influenced by DDGS addition. The yolk color was significantly increased by DDGS supplementation. As the DDGS level increased, the oleic acid content decreased, and the linoleic acid increased (P<0.05). The degree of saturation of yolk fatty acids was not affected by dietary DDGS. The inclusion of DDGS up to 20% in layer diets resulted in the decrease of feed cost per kg without any effect in the laying performance. In conclusion, the use of DDGS up to 20% level in layer diets could replace corn and soybean meal without any harmful effect on the laying performances.

지속정맥주입 헤파린의 처방 및 투여 자동화 프로그램 적용을 통한 업무 개선 연구

천영주,예경남,김정옥,윤지은,박미혜,정경주,김정태,임성실 한국병원약사회 2015 병원약사회지 Vol.32 No.1

UFH (unfractionated heparin) has been classified as a high-alert medication by theInstitute for Safe Medication Practices due to its narrow therapeutic range and the risk of seriousadverse effects. To reduce medication errors, improve the patient safety, and simplify UFH relatedwork processes, we developed a UFH computerized system, HOAP (heparin order & administrationprogram). The aim of this study is to determine the safety and effectiveness of HOAP. The availabilityratio of HOAP went from 43% in Feb 2014 to 100% in June 2014. The HOAP reduced the number of steps required to order and administer heparin from 6 to 3 in physicians, and from 9 to 7 steps fornurses. A total of 167 patients were included in this study. Average run time of interventiondecreased significantly from 3-10 minutes to 1-3 minutes in physicians and nurses, respectively(physician: p=0.018, nurse: p=0.014). HOAP reduced the subjective run time per intervention by morethan 5 minutes. The HOAP reduced the prescription related errors from 5.7% to 0.1%, and reducedadministration related errors from 13.5% to 1.0% (p < 0.0001). The HOAP also decreased the timeinterval of the control infusion rate from 9.2 hrs to 5.9 hrs (p = 0.001), but there was no statisticallysignificant difference between the two groups in regards to reaching the target aPTT (42.1% vs39.0%). The difference in the mean bleeding scores was not statistically significant between pre andpost group. We concluded that HOAP is helpful in improving UFH related work processes, preventingmedication errors, and reducing the run time through standardization and automatization. Therefore,additional reserch is needed to demonstrate the clinical effectiveness of HOAP.

그룹처방약품 집계를 이용한 약품 관리 업무 개선

천영주,예경남,김정보,정경주,김정태 한국병원약사회 2017 병원약사회지 Vol.34 No.3

Background : Group-order medicines (GOM) are requirements that have been steadily used in various clinical laboratories at a hospital. Since GOM is not recognized by an individual code, the number of GOM could not be totalized exactly until now. This results in a discrepancy between amount of health insurance claims and purchasing, leads to unreasonable inventory management and associated work, and increases unnecessary cost. We therefore developed a GOM-counting program (GOMP) for three months, from January to March 2016. Methods : The aim of this study was to evaluate a rational GOM-inventory management process through GOMP. We compared the following factors between pre- and post- GOMP application: characteristic value assignment, work process, and registering percentage of GOM-consignment stock. Results : After applying GOMP, the characteristic of GOM was converted from a requisition to prescription medicine. The issuing department was unified, and requisition work was replaced by an automatic electronic process. The amount of claims and purchasing was equalized after implementation of GOMP. The GOM-associated work process reduced to 5 steps compared to previous 8-9 steps. The registering percentage of consignment stock increased greatly, from 17.8% to 91.1%. Conclusion : Accurate aggregation is critical for proper drug inventory management. Application of GOMP in drug inventory management made it possible to streamline the work process, and to properly manage the consignment stock and drug inventory assets.

『빼앗긴 정서 빼앗긴 문화』, 홍양자 지음, 『빼앗긴 정서 빼앗긴 문화』, 서울: 다림, 1997

천영주 한국국악교육연구학회 2009 국악교육연구 Vol.3 No.1

Beers Criteria 및 STOPP 근거에 의거한 한국 노인 환자의 항콜린성제 약물요법의 적절성 평가

천영주,임성실 대한약학회 2014 약학회지 Vol.58 No.5

Anticholinergic drugs are included in the efficacy group of various antidepressants, antihistamines, antis-pasmodics like skeletal muscle relaxants. Elderly patients are often taking anticholinergic drugs due to various iseases such as sleep disorders and dysuria. But the use of anticholinergic drugs is restricted in guidelines such as Beers Criteria or STOPP due to the anticholinergic adverse effects including dry mouth, constipation, difficult urination, delirium, hal- lucinations and especially cognitive impairment. In this study, we investigated the usage of anticholinergic drugs in out-of-hospital prescription of 4,442 elderly patients. Results of the study were obtained that 32% (n=1,421) of overall patients were prescribed with 1~6 products (average 1.37) of anticholinergic drugs. 70.9% of the 1,421 patients (n=1,007) were pre-scribed with one drug, 22.7% (n=323) were two drugs and 4.9% (n=70) were three drugs. 27.1% of the 1,421 patients (n=430) were 70~74 years old patients who were the most commonly prescribed with anticholinergic drugs. Amitriptyline, chlorpheniramine, dimenhydrinate and quetiapine were most frequent component of ACB Score 3 drugs and amantadine, baclofen, carbamazepine, cyproheptadine and oxcarbazepine were most frequent of ACB Score 2 drugs. Anticholinergic Drug Scale (ADS) of individual patients presented one point (48.5%, n=689), 2 points (15.4%, n=219), more than 3 points (36.1%, n=513), and up to maximum 12 point (n=1). More than 2 points were more than half (51.5%, n=732). Therefore, additional prospective study in the use and adverse effects of anticholinergic drugs for elderly patients will be required. And national management such as DUR program will be required for elderly drug administration from now on.

일제 강점기의 음악교과서 연구 : 1931~1945년 관 ·공립학교를 중심으로

천영주 민족음악학회 1997 음악과 민족 Vol.13 No.-