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아세틸콜린이 외유모세포 칼륨 전류 및 길이 변화에 미치는 영향
조형호,이준규,이재홍,장명주,황매,정한성,조용범,박종성 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.2
Background and Objectives:Iner hair cells (IHCs) of the organ of Corti change the external sound stimulus into the elect-rical signal and transmit this signal to the auditory cortex through afferent nerve fibers. Outer hair cels (OHCs) control the sound transmission function of IHC. OHCs respond with a somatic shape change to alterations in their membrane potential and this electromotile response is believed to provide mechanical fedback to the basilar membrane. Eferent nerve fibers which arise from the superior olivary nucleus in the midbrain and transmit to OHCs through medial olivocochlear bundle use acetylcholine (ACh) as a neurotransmiter. The cholinergic response of OHCs α-9 nicotinic ACh receptor increase the Ca2+ influx, which control OHCs electromotility by changing a membrane potential. In this research, the effect of ACh on the K+ current in OHC of guinea pig was studied, and the change of OHC length by ACh was studied. Materials and Methods:Using the extracted change of OHC length when ACh was applied was observed. Results:1) ACh increases voltage-dependent K+ current in OHC. 2) In the condition, which Ca2+-dependent K+ current is blocked by removing Ca2+ from intra-cellular fluid, ACh has no effect on K+ current in OHC. 3) ACh increases OHC length. Conclusion:These experimental results show that ACh from the medial olivocochlear eferent system regulates mobility of OHC, increases the Ca2+-dependent K+ currents in OHC.
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급성 안면신경 손상 모델에서 혈소판 풍부 혈장의 신경재생 효과
조형호,이상철,장수정,김송희,정한성,박종성,이경화,조용범,한재영 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.6
Background and Objectives:The object of this study was to evaluate the effect of platelet rich plasma (PRP) on facial nerve regeneration from an axotomy injury in the guinea pig model. Materials and Method:Experiments involved the transection and repair of right facial nerve. The right facial nerve of 14 albino guinea pigs were completely transected and immediately sutured, followed by fibrin glue only (control group) or fibrin glue +PRP (PRP group). Western blot assay was used to detect neurotrophic factors secreted by PRP. Nerve regeneration was assessed by motor function, electrophysiology, and histology studies. Results: High levels of neurotrophin-3, angiopoietin-1, glial cell line derived neurotrophic factors, nerve growth factors and brain derived neurotrophic factors were demonstrated in PRP. Motor function recovery, compound motor action potentials, and axon count showed significant improvement in guinea pig treated with PRP. Conclusion:There was an improved functional outcome with the use of PRP in comparison with control. The increased nerve regeneration found in this study may be due to the neurotrophic factors secreted by PRP.
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인간 유양돌기 골수 유래 간엽줄기세포의 획득 및 신경세포로의 분화
조형호,정한성,장수정,박종성,조휴채,장철호,조용범 대한이비인후과학회 2008 대한이비인후과학회지 두경부외과학 Vol.51 No.5
Reports of neural differentiation of mesenchymal stem cells suggest the possibility that these cells may serve as a source for stem cell-based regenerative medicine to treat neurological disorders. The purpose of this study was to generate neural cells by differentiation of bone marrow-derived mesenchymal stem cells that isolated from human mastoid process. Materials and Method:Human mesenchymal stem cells (hMSCs) isolated from human mastoid process bone marrow during mastoidectomy for chronic otitis media surgery were characterized using fluorescence-activated cell sorter. Induction of neural differentiation from hMSCs was performed using mitogenic factors (basic fibroblast growth factor, epidermal growth factor, forskolin, isobutylmethylxanthine), and the characterization of differentiated hMSCs was performed using immunohistochemistry, RT-PCR and whole cell patch clamp technique. Results:hMSCs from bone marrow of mastoid process were isolated and cultured. Differentiated cells from hMSCs expressed mRNA transcripts for neuron specific markers, TUJ1 and neurofilament proteins (NF-L, NF-M) as determined by RT-PCR, and neuron specific markers, suhc as NeuN, TUJ1, microtubule- associated protein-2 (MAP2) and glial fibrillary acidic protein by immunohistochemistry. These cells showed voltagedependent sodium currents that was blocked by tetrodotoxin. Conclusion:hMSCs, which were isolated from human mastoid process bone marrow, were one of the good sources for stem cell-based regenerative medicine to treat neurological disorders. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:422-8)
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조형호,조재식,임상철 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.9
Background and Objectives:Laryngotracheal stenosis produces complications of respiratory and phonation difficulties and is one of the most troublesome diseases in the otolaryngological field. The purpose of this study is to determine the therapeutic effectiveness of augmentation laryngotracheoplasty for laryngotracheal stenosis as an operative management. Method:The authors retrospectively studied 16 cases of augmentation laryngotracheoplasty patients for the success rate, graft material, type of stent, number of surgery, and duration of treatment. Results:The sucess rate was 68.7% (1 out of 16 cases). Thre out of 5 cases which failed treatment were under 15 years of age. Decanulation was possible at 8.45 months (2- 45 months) postoperatively on the average and the frequency of surgery was 4.36 times (2- 13 times) on the average. There was no complication such as infection and necrosis. Conclusion:Our results show that augmentation laryngotracheoplasty is an aceptable option for the treatment of laryngotracheal stenosis, but needs multiple surgery and long time to be decannulated. The suces rate of the augmentation laryngotracheoplasty in children is relatively low and a more agresive approach could be selected. We conclude that augmentation laryngotracheoplasty in adult is a safe and effective procedure without major (Korean J Otolaryngol 2003 ;46 :775-9)
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조형호,김창국,조재식,임상철 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.7
Background and Objectives:The cesation of airflow in nasal cavity after total laryngectomy could influence the function and photographs and biopsies. Subjects and Method:Twenty-two laryngectomees were studied and compared with 15 normal con-trols. Inferior turbinate was checked with 0 degree endoscopic photographs, and the RGB (Red,Green,Blue) scale was analysed by a histogram of adobe photoshop 6.0. In thirten patients, inferior turbinate mucosa was taken for microscopic examination.
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