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광선각화증, 각화극세포종과 Bowen's병에서 p53과 p21의 표출 양상
조명구,조현득,양승하,김의한 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2
Background The function of the p53 protein was known to regulate cell proliferation by inhibiting cells entering Sphase. So DNA damaged cell proliferation was inhibited by apoptosis. P21 is a cyclin dependent kinase inhibitor induced by wild type p53, not mutant p53. Thus p21 is thought go mediate the signal of p53 induced by DNA damaged agents to arrest the cell cycle in G1 phase. p53 and p21 were expressed in many malignant tumors, and its role in oncogenesis, tumor progression and prognosis were important. The authors analyzed immunohistochemical expression of mutant p53 and p21 protein in some skin tumors. Method Thirteen cases of actinic keratosis, 7 cases of keratoacanthoma and 8 cases of Bowen's disease were immunohistochemically stained with p53 and p21 monoclonal antibodies. Results; 1. In cases of positive p53 protein and negative p21 protein, the expressed p53 protein was suggested as mutant form. 2. Positive expression of p53 protein and p21 protein in prickle cell layer of actinic keratosis and Bowen's disease was suggesded that the composing cells of prickle cell layer were transformed into the proliferated cell. The p21 protein expression was suggested to be induced by the p53 independent pathway. 3. Negative expression of p53 protein and p21 protein in prickle cell layer of keratoacanthoma was suggested that the composing cells of prickle cell layer were completely mature cells, so the keratoacanthoma had good prognosis.
김의한,정현,이종석,이성열,조명구 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2
Background : The bc1-2 protein, contrast to p53, has been shown to be suppress the apoptosis, and overexpression of the bc1-2 protein has been reported in several malignant tumors. Although how the bc1-2 protein takes part in tumorgenesis has not been proved, the bc1-2 positive tumors appeared to have good prognosis in some malignant tumors. The expression pattern of the bc1-2 in keratinocyte originated skin tumors have not been well known. The authors analyzed immunohistochemically expression of the bc1-2 protein to invastigate the role of the bc1-2 protein in developing skin tumors. Method : 21 squamous cell carcinoma, 19 basal cell carcinoma, 9 keratoacanthoma 11 seborrehic keratosis and 9 Bowen's disease were immunostained with anti-bc1-2 monoclonal antibody. Results : 1. The bc1-2 negative reactions were seen in all cases of sqaumous cell carcinoma, keratoacanthoma and Bowen's disease. The basal layer in keratoacanthoma and Bowen's disease shown to be intense positive reaction in bc1-2, whch suggested of the protected barrier function from tumor cell invasion into the dermis. 2. The bc1-2 were positive in all basal cell carcinoma. 3. In seborreheic keratosis, 9 cases were negative and 2 cases were positive. The positive cases appeared to be resulted from invagination of the basal cells in the epidermis. Conclusion : The bc1-2 protein did not appear to express in full matures cell, but positive reaction are seen in proliferating activity cells. The bc1-2 positive cells are rahter not abnormal cells than have function of protection of tumor cell proliferation by the prolongation of survival time normal cell.
이동환,차학주,조명구,최석민,이상주 순천향대학교 1990 논문집 Vol.13 No.3
Mycoplasma Pneumoniae is a main respiratory pathogen in children and young adults. But, M.Pneumoniae infection may also invlove other organ systems. Clinical manifestations of Mycoplasma infection include pneumonia, hemolytic anemia, myocarditis, pericarditis, hepatitis, pancreatitis and arthritis. And many CNS manifestations have been descrived, including meningitis, meningoencephalitis, cerebellar syndorme, peripheral and cranial neuropathy, cerebral infarction, hydrocephalus, poliomyelitis like syndorme, transverse myelitis, psychosis and Guillain-Barre syndrome. We experienced two cases of meningoencephalitis associated with M. pneumoniae in 6-year old girl and 12-year old boy. There were strong positive reaction with cold agglutinin and M. pneumoniae antibody titer in both of them.