격자볼츠만방법(LBM)을 이용한 마이크로채널 내의 유동해석

조경진(K. J. Cho),정재택(J. T. Jeong) 한국전산유체공학회 2004 한국전산유체공학회 학술대회논문집 Vol.2004 No.-

As an alternative numerical method. the lattice Boltzmann method (LBM) is used to simulate a 2-dimensional pressure driven microchannel flow which comes from frequently in MEMS problems. The flow is assumed to be isothermal ideal gas flow. The flow field is calculated with various Knudsen numbers, pressure ratios and aspect ratios of the microchannel. The LBM can show the fundamental characteristics in microchannel flow such as velocity slip and nonlinear pressure drop.

고등교육 개혁에 따른 보건계열 전문대학 내실화 방안에 관한 연구

이창규(C. K. Lee),임국환(K. H. Rhim),이동호(D. H. Lee),정운원(W. W. Jung),이승관(S. G. Lee),조경진(K. J. Cho),황선철(S. C. Whang) 고려대학교 보건과학연구소 1998 보건과학논집 Vol.7 No.1

형질 전환 Aspergillus oryzae의 첨가가 산란계의 생산성, 계란 품질 및 장내 미생물 변화에 미치는 영향

정병윤,박세원,백인기,조경진,이상석,Jung, B.Y.,Park, S.W.,Paik, I.K.,Cho, K.J.,Lee, S.S. 한국축산학회 2005 한국축산학회지 Vol.47 No.4

본 연구는 메주에서 순수 분리된 메주곰팡이의 대표적 균종인 황국균(Aspergillus oryzae; AO)으로 만든 AO culture와 Salmonella 병원특이 유전자를 삽입한 형질전환 AO(TAO) culture가 산란계의 생산성, 계란 품질 및 장내 미생물 균총에 미치는 영향을 규명하고자 실시하였다. 39주령 산란계 Hy-line Brown 840수를 공시하여 대조구, AO culture 0.2%와 0.5%, TAO culture 0.2%와 0.5%, UV를 조사하여 단백질 분해효소를 감소시킨 mutant에 Salmonella 병원 특이 유전자를 삽입한 형질전환 AO(TMAO) culture 0.2%와 0.5% 첨가구들을 비교하였다. 각 첨가구는 6반복, 반복당 20수씩, 한 케이지 당 2수씩 배치하여 8주간 사양시험을 실시하였다. 사양시험 결과 모든 산란 생산성 및 계란 품질 관련 조사항목에서 처리간에 유의한(P<0.05) 차이가 있었다. TAO culture 0.2% 첨가구가 산란 생산성에 있어서 유의적으로 가장 높았으며, 난중은 모든 AO 첨가구들이 대조구에 비해 유의적으로 낮거나 낮아지는 경향을 나타내었다. 연파란율은 TMAO culture 0.5% 첨가구가 가장 낮았다. 사료섭취량과 사료요구율은 대조구와 모든 AO 첨가구들간에 유의적 차이가 나타나지 않았다. 난각 강도는 대조구 보다 모든 AO 첨가구들에서 유의적으로 높게 나타났으며, 난황 색도는 TMAO culture 0.5% 첨가구에서 가장 높았다. 난각 색도와 Haugh unit은 대조구와 모든 AO 첨가구들간에 유의적 차이가 나타나지 않았다. 장내 미생물 균총(Salmo- nella spp., E. coli. Lactobacilli spp.)에서는 유의적(P<0.05) 차이가 있었다. AO culture 첨가에 의해서 Lactobacilli spp.의 수는 증가되고, E. coli 및 Salmonella spp.의 수는 감소되었다. 특히 TAO와 TMAO culture 첨가구에서는 AO culture 첨가구보다 Salmonella spp. 및 E. coli 억제효과가 컸으며 첨가수준(0.5% vs 0.2%) 간에는 유의한 차이가 없었다. 결론적으로 TAO culture 0.2% 첨가는 산란 생산성 증가에 효과가 있었으며 TAO 및 TMAO culture 0.2% 첨가는 장내 E. coli 및 Salmonella spp.의 감소에 유의한 효과가 있었다. An experiment was conducted to investigate the dietary effects of a transgenic Aspergillus oryzae(AO) culture on the performance, egg quality and intestinal microflora of layers. A total of 840 Hy-line Brown layers of 39wks old were assigned to one of the following 7 dietary treatments: control(C), C+0.2% AO culture, C+0.5% AO culture, C+0.2% transgenic AO culture, C+0.5% transgenic AO culture, C+0.2% transgenic mutant AO culture, and C+0.5% transgenic mutant AO culture. The transgenic AO was made by inserting Salmonella gallinarum gene to AO. And the transgenic mutant AO was made by inserting Salmonella gallinarum gene to mutant AO which was mutated by UV irradiation. Each treatment was replicated six times with 20 birds housed in 2 bird cage. Twenty birds units were arranged according to completely randomized block design. Feeding trial lasted for 8wks under 16 hour lighting regimen. Laying performance and egg quality were significantly(P<0.05) affected by the treatments. Transgenic AO culture supplementation at the level of 0.2% significantly increased egg production, while its egg weight was significantly decreased compared to that of the control. Feed intake and feed conversion ratio(FCR) were not significantly different among the AO treatments and the control. The eggshell strength of the AO treatments was significantly higher than that of the control. Transgenic mutant AO culture supplemented at the level of 0.5% significantly increased egg yolk color. Intestinal microflora were significantly(P<0.05) affected by the treatments. The cfu of Lactobacilli spp. significantly increased and those of Salmonella species and E. coli decreased in the AO treatments. The transgenic AO and transgenic mutant AO culture were more effective than the AO culture in reducing the cfu of Salmonella species and E. coli. It is concluded that supplementation of the transgenic AO culture at the level of 0.2% could be recommended for the improvement of egg production. Supplementation of transgenic AO or transgenic mutant AO culture at 0.2% level effectively controlled intestinal Salmonella species population.

고등교육 개혁에 따른 보건계열 전문대학 신대학 학위제도연계에 관한 연구

김영환(Y. H. Kim),이창규(C. K. Lee),오세윤(S. Y. Oh),이승관(S. G. Lee),정수경(S. K. Jung),박종성(J. S. Park),유병서(B. S. Ryu),조경진(K. J. Cho) 고려대학교 보건과학연구소 1998 보건과학논집 Vol.7 No.2

CAT(Computer Adaptive Test) 시스템 구축을 위한 문항반응이론(IRT)의 문항분석 비교연구(1)

이창규 ( Chang Kyou Lee ),이승관 ( S. G. Lee ),조경진 ( K. J. Cho ),이은일 ( E. I. Lee ),이숙자 ( S. J. Lee ),박은숙 ( E. S. Park ),박영주 ( Y. J. Park ) 대한임상검사과학회 2000 대한임상검사과학회지(KJCLS) Vol.32 No.3

Prior to CAT, the parameter estimation on executed items should be accomplished by IRT.and the item banking must be build up on the basis of the parameter of difficu1ty. A program developed by Korea ETS, Bilog and Bigsteps were all found to be very powerful to understand the attributes of items. Though multiple true-false type K items have some merits, the items should be examined quantitative1y if they are appropriate or not by IRT. Through the study we have fmally confmned that the new program developed by Korea ETS has its abi1ity to check the validities of items from preparing or scoring to item analysis.

SFDI와 LSI를 이용한 조직 건강 비접촉 모니터링 : 허혈성 조직 괴사 및 MGD 유발 안구건조증 진단으로의 응용

박일용(I. Y. Park),김형범(H. B. Kim),임남규(N. K. Lim),조경진(K. J. Cho),모지훈,정필상 한국재활복지공학회 2022 한국재활복지공학회 학술대회논문집 Vol.2022 No.11

혈청 Creatine Kinase측정 표준화에 관한 연구(Ⅵ)

이창규,이승관,조경진,정수경,박종성,박상숙,류정록,남현철,김상섭,김석수,장철수,최명재 高麗大學校 倂設 保健大學 保健科學硏究所 1998 保健科學論集 Vol.24 No.1

In European countries or Japan they made an attempt for the standardization of assays in AST, ALT, ALP, CK, LD and GGT 10 years ago. For the actualization of the trial, they managed to succeeded in development of certified reference material and enzyme reference material. And they are now forecasting the unification of test results produced differently under the respective situatons. Then, through the highly developed communication system, someone can access any test results whenever or whereever only if they want to. It means that we can expect much greater improvements in medical services through the information exchanges. In this study the authors tried to ascertain the interchangeability comparing the obtained results of the CK tests between two general hospitals. Fortunately, the data got in the internal QC programs came to fall within the normal tolerances. The reference intervals for the CK test were different accarding to the chosen reagents and the results from the pooled serum were also shown differently each other. However, from the two hospitals, we could get glucose K factors, upon which the measurements were obtained and compared. Using K factors we measured the CKs, then we multiply the CK values by correction coefficients. We could found that the two results were showing good coincidence in the comparison. The main purpose of the standardization of enzyme assays is the creation of a new unified value which can be expressed differently otherwise. Using the standardized values we can exploit the data everywhere, reduce the medical costs from repeated or duplicated tests, save the foreign exchanges preventing the diversification of impart connections.

문학반응이론에 의한 보건의학기술계열 국가시험개선방안에 관한 연구

이창규,이승관,조경진,박종성,정수경,유병서,박상숙,윤효숙,황선철,문경환,김정민,함용운,김지환,임국환,김영순,윤경희,황성준 高麗大學校 倂設 保健大學 保健科學硏究所 1998 保健科學論集 Vol.24 No.1

The nationally-governed examinations for certification of allied health professions in Korea have been continued for thirty three years. During that time, there were a lot of managerial improvements in carrying out the examinations, for example, the looking-over the papers converted from manual method to computerized one. Nevertheless, the overall aspects of item management in the national examinations are still remained as obsolete style. In some developed countries they have already tried or adopted computerized system in making questions, executing item analysis, developing item banking, and in overall management of examinations, looking over papers for their national licensure examinations, and have established good reputations. Since the National Health Personnel Licensing Examination Board was established in 1998, now we can expect there would be a lots of improvements in the managerial systems and organizational structures associated with the national licensing examinations suggesting followings. 1. The contents and scope of the licensing examinations based on job analysis should be announced publicaly. 2. Items should be developed based on the scopes and contents of job characteristics. 3. All the developed items for the licensing examinations should be tested quantitatively prior to banking items. 4. All the parameters of the stored items should be fully estimated through item response theory. 5. All the efforts should be given in order to execute the examinations in individual residential areas on behalf of every examinee. 6. To the licensing examination system the Computerized Adaptive Testing system should be introduced in order to enhance the efficiencies. 7. Security enhancement on the stored items should be reminded in order to prevent leaking out the banking items. 8. Much more improvements should be made for the proper job evaluations. 9. Every efforts should be given to prevent cheatings encountable during the examinations. 10. Make the best of professional volunteers from the various fields in the execution of licensing examinations. 11. Consider a new system in that examinations can be executed twice or more in a year. 12. The current methods of presiding over the examinations should be replaced by a more reasonable one. 13. The results of the examinations should be announced as soon as possible in order not to prolong the examinees' unemployment periods. 14. The National Health Personnel Licensing Examination Board should try to rationalize the management keeping step with the information-oriented society.

혈청 LDH 효소분석 검사의 효준화에 관한 연구(Ⅴ)

이창규,이승관,조경진,박종성,정수경,유병서,박상숙,류정록,남현철,김석수,김상섭,김재영,이국성 高麗大學校 倂設 保健大學 保健科學硏究所 1998 保健科學論集 Vol.24 No.1

Since the Korean Association of Quality Assurance for Clinical Laboratory was established in 1976, the numbers of the participating hospitals nowadays were increased from 40 to 450 or more hospitals all over the country. In the early day the both internal and external quality control programs were started at the same time, however, the external QC programs prevailed over the internal ones putting the cart before the horse. The accuracy and the precision of the data are not satisfying in spite of the 20 years experiences of quality control programs. All the daily data should be reported after the validity is assured by the self-evaluation not by third party evaluation. It is regret that the CVs of enzymatic tests in external QC are exceeding 10% and there is no sign of diminishing CVs. One of the major reasons is that the types of anaytical instrurments and reagents are diverisified. Moreover, most of them are subject to the standards of the respective country of manufacturer. Accordingly, we can make a suggestion that the reagents and instruments should be imported or supplied meeting the established requirements for Korean standardization.

Bloodborne Pathogen에 대한 임상병리사의 예방행태학적

조경진,이창규,안승일 高麗大學校 倂設 保健大學 保健科學硏究所 1998 保健科學論集 Vol.24 No.1

에이즈가 널리 전파되면서 임상병리사 들은 혈액유래감염원에 대한 노출에 대하여 보다 커다란 관심을 갖기 시작하였다. 이에 우리는 개인적특성이나 검사실의 체제가 개인의 예방습관이나 보호구착용수준에 얼마만한 영향을 미치는 지를 보기 위한 임상병리사 들의 개인보호를 위한 대책과 형태와 관한 연구를 실시하였는데 보호구착용수준과 예방습관은 낮은 것으로 나타났으며, 예방습관에 영향을 미치는 요인으로는 검사실내 관행과 기본안전관리체제로 나타났다. Occupational exposure to bloodbome pathogens has been the growing concern for the clinical laboratory scientists since the AIDS epidemic was propagated throughout the world. Accordingly we started a survey on the personal protective behaviors of clinical laboratory scientists to ascertain how the socio-economic and institutional characteristics affect to the levels of preventive behaviors or to the levels of PPE compliances. Major factors affecting the protective habits were PPE compliance, institutional customs and basic safety system.