복잡성 심실성 부정맥과 좌심실 비후의 상관관계 및 예후에 관한 연구

이광제(Kwang Je Lee),정유석(Yoo Suk Chung),곽미향(Mi Hyang Kwak),김경만(Kyung Man Kim),김치정(Chee Jeong Kim),류왕성(Wang Seong Ryoo),유언호(Un Ho Yoo) 대한내과학회 1997 대한내과학회지 Vol.53 No.1

N/A Objectives: Echocardiographically determined left ventricular hypertrophy is associated with increased risk for sudden cardiae death and for complex ventricular arrhythmias in 24-hour ambulatory electrocardiographic monitoring. In subjects with left ventricular hypertrophy, the presence of asymptomatic complex ventricular arrhythmias is associated with higher incidence of sudden cardiac death and higher cardiovascular mortality. However, their accurate relationship and prognostic significances have been remained to be established. The purpose of this study was to evaluate the relationship between complex ventricular arrhythmias, left ventricular hypertrophy, and sudden cardiac death in Korean patients. Methods: Twenty four hour ambulatory electrocardiographic monitoring, echocardiographic data and medical records were reviewed in 360 subjects from 1991 to 1994. We evaluated the relationship between complex ventricular arrhythmias and left ventricular mass index, and the prognostic values of them. Of the 360 subjects, 187 could be followed up for one to four years. The mean follow-up period was 2.8 years. Results: The incidence of complex ventricular arrhythmias was significantly correlated with left ventricular mass index and ejection fraction in all subjects. During the follow-up periods, seven of 187 subjects died from sudden cardiac death. Six of them had complex ventricular arrhythmias with left ventricular hypertrophy. Conclusion - The incidence of complex ventricular arrhythmias was significantly correlated with echocardiographically determined left ventricular hypertrophy and it is suggested that subjects with complex ventricular arrhythmias combined with left ventricular hypertrophy have higher risk for sudden cardiac death.

폐경후 여성에서 1년간의 호르몬대치요법이 Lp(a)와 지질에 미치는 영향(호르몬대치요법과 Lp(a))

김치정 ( Chee Jeong Kim ),이광제 ( Kwang Je Lee ),정유석 ( Yoo Suk Chung ),민용기 ( Young Ki Min ),유왕성 ( Wang Seong Ryu ),유언호 ( Un Ho Ryoo ) 한국지질동맥경화학회(구 한국지질학회) 1996 韓國脂質學會誌 Vol.6 No.1

폐경후 여성에서 호르몬 대치요법의 투여기간이 지질과 Lipoprotein ( a ) 에 대한 효과에 미치는 영향

김치정(Chee Jeong Kim),곽미향(Mi Hyang Kwak),김경만(Kyung Man Kim),이광제(Kwang Je Lee),정유석(Yoo Suk Chung),민용기(Young Ki Min),유왕성(Wang Seong Ryu),유언호(Un Ho Ryoo) 대한내과학회 1997 대한내과학회지 Vol.52 No.6

N/A Objectievs: Hormone replacement therapy(HRT) in postmenopausal women decreases lipoprotein(a) [Lp(a)]. The influences of progesterone on Lp(a) and lipids, administered with estrogen, are controversial. However, previous studies had variable duration of therapy, and there was no report evaluating the effect of the duration of medication. Methods: A total 246 postmenopausal women were divided into 4 groups: group A; 0.625mg conjugated equine estrogen(CEE)(n=90), group B; 0.625mg CEE plus 5mg medroxyprogesterone acetate(MPA)(n=35), group C; 0.625mg CEE plus 10mg MPA(n=43), and group D; 2mg estradiol valerate(E2) plus 0.5mg norgestrel(N)(n=76). Lp(a) and lipids levels were measured before, 2, 6 and 12 months after HRT. Results: In total subjects, Lp(a) was decreased with medication for 2 months by 20.7%(p<0,0001). Compared with levels at 2 months after medication, levels at 6 and 12 months revealed further reduction(p<0.001) by 5.3% and 9.0% respectively. Medication for 2 months increased HDL-C in group A, not changed in group B and C, and decreased in group D. After 12 months, HDL-C levels were increased in Group A, B, and C, and not changed in group D, In total subjects, low density lipoprotein- cholesterol(LDL-C) was decreased by 12.2% after 2 months(p<0.001). Compared with levels at 2 months after medication, LDL-C level was decreased by 3.4% after 6 months(p<0.001) and there was no further reduction after 12 months. Conclusion: The effect of hormone replacement therapy on Lp(a) and lipids were dependent upon the duration of medication. Inconsistent results in previous studies can be partially explained by the difference in this parameter.

아연이온이 반추위내 미생물의 조성 , 단백질 분해효소의 활력 및 사료단백질 분해에 미치는 영향

하종규,이성실,정유석 한국낙농학회 1993 韓國酪農學會誌 Vol.15 No.4

본 실험은 아연이온이 반추위 내에서 단백질 분해를 억제하는 기작을 알아내기 위하여 수행하였으며, in vitro 실험으로 단백질 분해율, 미생물 성장속도, NH₃-N 방출, pH, 단백질 분해효소의 활성과 박테리아종의 성장속도 등을 측정하였으며, in vivo 실험에서는 단백질 분해율, 미생물 성장속도, NH₃-N 방출, pH, 단백질 분해효소의 활성과 질소 축적량을 측정하였다. 이 실험의 결과를 요약하면 다음과 같다. 1. 금속 이온은 단백질 분해율에 영향을 미쳤으며 농도가 증가함에 따라 감소하였다 (P<0.05). 금속이온이 영향을 미친 순서는 다음과 같았다. mercury> nickel> cupper> cadmium> zinc> cobalt. 2. 미생물 성장속도, NH₃-N 방출과 단백질 분해효소의 활성은 감소하였으며 그 경향은 단백질 분해율과 같았다(P<0.05). 3. 배양액의 pH는 금속 이온에 의해서 영향을 받지 않았다. 4. 세가지의 균주중에서 단지 Bacteroids fibrisolvens만이 아연(zinc)에 의해서 성장이 감소하였다(P<0.05), 5. 단백질 분해균/총균수의 비는 아연의 처리에 의해서 감소하였다. 6. 반추위액내의 가용성 단백질과 미생물태 단백질은 0.4% 아연의 처리에 의해서 증가하였다(P<0.05). 7. 반추위액내의 단백질 분해효소의 활력은 아연 처리시에 증가하였다(P<0.05). 8. 질소 축적량은 아연의 처리에 의해서 개선되었다 (P<0.05). 이 실험의 결과에 의하면 금속이온의 단백질 분해 억제 기작은 미생물의 성장 억제와 효소의 작용감소에 기인한다고 사료되었다. A series of experiments were conducted to find out effects of zinc ion on the ruminal microbial population, proteolytic enzymes and protein degradation. In in vitro experiments, protein degradation, bacterial growth rate, NH₃-N release, pH, proteolytic activity and bacterial growth rate were measured to find out the inhibitory effect of zinc ion. In in vivo experiments, the effect of zinc ion on protein degradation, bacterial growth rate, NH₃-N release, pH and proteolytic activity were determined with nine Corriedale sheep. Results obtained from this study are summerized as follows; 1. Zinc sources affected protein degradability, which was decreased in order of oxide, chloride, acetate and sulfate(P<0.05). 2. Bacterial growth rate, NH₃-N release and proteolytic activity were decreased with higher concentrations of zinc as were in protein degradability(P<0.05). 3. pH was not influenced by zinc ions. 4. The ratio of proteolytic/total viable bacteria in the rumen fluid was decreased by zinc ion treatment. 5. Soluble protein and bacterial protein in the rumen fluid were increased by 0.4% zinc treatment(P<0.05). 6. Adding 1 % and 2 % zinc increased proteolytic activities of rumen fluids (P<0.05). 7. N retention was improved by zinc treatment. (P<0.05). According to the results of present study, inhibitory effects of the zinc ion on the protein degradation were attributed to the depression of microbial growth and decrease of proteolytic enzymes.

천식을 동반한 만성 부비동염의 임상적 특징

동헌종,하병석,정유석,정승규,장병찬 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.5

최근 3 년간 성전파 질환의 추이 : 서울시 11개 보건소 이용자를 중심으로

박정희,권혜석,유선미,정유석,박일환,권선진,김윤수,김인국,박강원,설용한,유명자,이경렬,정봉진,조종희,최규상,허숙조 대한가정의학회 1998 Korean Journal of Family Medicine Vol.19 No.2

금속이온이 반추위내 미생물의 발효 성상 및 단백질 분해효소의 활력에 미치는 영향

김창현,하종규,이성실,정유석 한국낙농학회 1993 韓國酪農學會誌 Vol.15 No.4

본 실험은 금속이온이 단백질 분해 억제에 미치는 기작을 구명하기 위하여 in vitro 실험으로 단백질 분해율, 미생물 성작속도, NH^3-N방출, pH, 단백질 분해효소의 활성과 박테리아의 성장속도 등을 측정하였다. 이 실험의 결과를 요약하면 다음과 같다. 1. 금속 이온의 첨가 농도가 증가함에 따라 단백질 분해율을 감소시켰으며(P<0.05), 감소의 농도는 Cadmiun<Zinc<Cupper<Cobalt<Mercury<Nickel의 순으로 Nickel이 가장 강하게 작용하였다. 2. 미생물 성장속도, NH3-N 방출된 단백질 분해효소의 활성은 금속이온에 의하여 감소되었으며, 그 경향은 단백질 분해율과 같았다(P<0.05). 3. 배양액의 pH는 금속 이온에 의해서 영향을 받지 않았다. 4. 세가지의 균주중에서 Bacteroids fibrisolvens만이 아연에 의해서 성장이 감소하였다(P<0.05). 이 실험의 결과에 의하면 금속이온의 단백질 분해 억제 기작은 미생물의 성장 억제와 효소의 작용감소에 기인하는 것으로 보인다. A series of experiments were conducted to find out the mechanism of effects of metal ions on the ruminal microbial population, proteolytic enzymes and protein degradation. In in vitro experiments, protein degradation, bacterial growth rate, NH₃-N release, pH, proteolytic activity and bacterial growth rate were measured to find out the possible mechanism of inhibitory effect of metal ion. Results obtained from this study are summerized as follows ; 1. Metal ions affected(P<0.05) protein degradability, which was decreased with increased concentration of all metal ions. The inhibitory effects of metal ions were in the order of cadmium<zinc<cupper<cobalt<mercury<nickel. 2. Bacterial growth rate, NH₃-N release and proteolytic activity were decreased as was in protein degradability(P<0.05). 3. pH was not influenced by treatment of metal ions. 4. Among three bacteria species, only Bacteroids fibrisolvens was affected by zinc ion, which decreased the growth rate of the organisms(P<0.05). According to the results of present study, inhibitory effects of the metal ion on the protein degradation were attributed to the depression of microbial growth and decrease of proteolytic enzymes.