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      • KCI등재

        언어표현의 영상도식적 가치 분석

        정상헌(Chung Sang Hun) 현대문법학회 1998 현대문법연구 Vol.12 No.-

        The purpose of this study is to analyze some aspects of value systems reflected in linguistic expressions by means of the image-schematic approach that Mark Johnson has presented, and axiological semantics which studies values with reference to the meaning of various linguistic expressions, and whose task is to describe those values and ways in which they determine both the structure and the functioning of human language as manifested in human communication. The concepts ‘good’ and ‘bad’, and Tischner’s hierarchy of values have been used. The results of the study are as follows; First, image-schemata are primarily based on human bodily experiences. Second, image-schemata which are based on different clusters of experiences are bi-polar. They have a ‘good’ pole and a ‘bad’ pole. Third, center, link, whole, up, front, right are regarded as ‘good’, while periphery, no link, part, down, back, left as ‘bad’. Fourth, ‘bad’ can be defined relative to ‘good’. but not the reverse. Things canbe ‘bad’ only to the extent to which they are ‘not good’, for the experience of ‘bad’ comes from the experience of ‘lack’. Fifth, positively charged concepts are more likely to be unmarked forms, while negatively charged concepts are more likely to be marked forms.

      • KCI등재

        Benzoxazolin-2-thione과 PAS의 Alkyl Ester과의 Mannich Base 합성 및 항균력에 관한 연구

        정원근(Won Keun Chung),정상헌(Sang Hun Chung),정필근(Pil Keun Chung),윤원영(Won Yung Yoon),이남복(Nam Bok Lee) 대한약학회 1974 약학회지 Vol.18 No.4

        Nine benzoxazolin-2-thione derivatives were synthesized as the potential antimicrobial substances. These compounds were tested for the antimicrobial activities using Staphylococcus aureus and Escherichia coli by way of tube dilution method. The three compounds of 1, II and VII inhibited the growth of S. aureus at the concentration of 1mcg/ml, and III, VI, VIII and IX exhibited considerable antimicrobial activities against S. aureus at the concentration of l0mcg/ml. As to the growth of E. Coli, VII VII and VIII inhibited at the concentration of 1mcg/ml. II,III and IV exhibited considerable antimicrobial activities against E. coli at the concentration of 10mcg/ml.

      • SCIESCOPUSKCI등재

        DW2282 의 용매의존성 항암효과 및 약동력학

        문은이(Eun Yi Moon),최청하(Chung Ha Choi),성승규(Seung Kyoo Seong),이진(Jin Lee),유제만(Jei Man Ryu),이문선(Moon Sun Lee),정상헌(Sang Hun Jung),정용호(Yong Ho Chung),이덕근(Dug Keun Lee),윤성준(Sung June Yoon) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.4

        DW2282, (S)-(+)-4-phenyl-1-[N-(4-aminobenzoyl)-indolin-5-sulfonyl]-4,5-dihydro-2-imidazolone hydrochloride, is a novel anticancer agent thought to have an unique mechanism of action on the inhibition of tumor growth. In this study, we estimated in vivo antitumor activities and pharmacokinetics of DW2282 depending on various vehicles. The inhibition rate of tumor growth was increased by 50, 100 and 200 mg/kg of DW2282 in a dose-dependent manner. When DW2282 dissolved in 4 sorts of vehicles was orally single dosed to rats at 50 mg/kg, Cmax of DW2282 in 0.5% CMC.Na was a half as high as those in PG, PG+CP and PG+CP+DW. When DW2282 was orally administered to mice for 5 days, antitumor activity of 130 mg/kg suspended in 0.5% CMC.Na was as effective as that of 65 mg/kg dissolved in the rest of vehicles. Taken together, it is thought that antitumor activities of DW2282 are resulted from the absorption extent of it and related to the vehicle used.

      • KCI등재

        2차와 3차 병원에서 외상 치료의 적정성 비교

        홍석현 ( Suk Hyun Hong ),한갑수 ( Gap Su Han ),정상헌 ( Sang Hun Jung ),전정민 ( Chung Min Chun ),최성혁 ( Sung Hyuk Choi ),이성우 ( Sung Woo Lee ),홍윤식 ( Yun Sik Hong ) 대한외상학회 2005 大韓外傷學會誌 Vol.18 No.1

        본 연구에서는 응급처치 및 중환자 처치 능력의 확충이 중증 외상환자 치료에 미치는 영향을 알아보고자 두 기간 동안 대도시의 3차 병원과 중소도시의 2차 병원에서 외상치료의 적정성을 비교하였다. 응급 및 중환자 처치 능력의 확충 이후, 2차 병원은 타 병원으로의 전원 없이도 중증 외상 환자를 치료할 수 있게 되었으며, 생리학적 외상 치료 능력이 향상되어 보다 정확한 외상 치료가 가능해 졌다. 비록 특별하게 고안된 외상 센터가 아니라 하더라도, 잘 구축된 응급 의료 체계하에서 지역별로 응급 및 중 환자 처치 능력을 강화하면 외상 환자 치료 성적을 향상 시킬 수 있을 것이다. Background: This study compared the performance of trauma care in an urban and a suburban hospital before and after the enhancement of emergency and intensive care. Method: The medical records of patients who were admitted to the intensive care unit following trauma from 1994 to 1995 and from 2002 to 2003 were examined. The standardized W (Ws), the 95% confidence interval (CI) of the Ws, and the predicted survival rate (Ps) were calculated. During each period, each hospital`s actual survival rate was compared with the 95% CI of the Ps according to the revised trauma score (RTS) and injury severity score (ISS). Spell out RTS and ISS. Result: From 1994 to 1995, 225 and 121 records from the urban and the suburban hospitals were reviewed, respectively. The 95% CI`s of the Ws were -2.30 to 2.73 and -11.40 to -5.90, respectively. The actual survival rate of the suburban hospital was significantly lower than the predicted survival rate at all RTS. From 2002 to 2003, 315 and 268 records from the urban and the suburban hospitals were reviewed, respectively. The 95% CI`s of the Ws was -3.56 to 0.24 and -3.73 to 0.26, respectively. There was no difference between the actual survival rate and the predicted survival rate. Conclusion: An enlargement of the capacities of emergency and intensive care may improve the performance of trauma care at a small suburban hospital.

      • 상지의 운동제한을 보이는 소아에서 방사선 검사의 필요성

        이성우,문성우,윤영훈,이베안,정상헌,전정민,홍윤식 대한응급의학회 2002 대한응급의학회지 Vol.13 No.3

        Purpose: The study was designed to identify the necessity of radiographs and to decrease overutilization of radiographs in uncommunicable children who do not move their arms. This study provides clinical guidelines on radiographic evaluation and treatment of children with limited motion in the upper extremity. Methods: The cases of one hundred thirteen pediatric patients under 36 months of age, who had visited the Emergency Center of Korea University Ansan Hospital from January 2000 to December 2001, were retrospectively reviewed. Pediatric patients with upper extremity injuries due to multiple trauma, laceration or motor vehicle accident were excluded. Parameters analyzed were age, sex, mechanism of injury, physical findings, radiographic finding, and injuried upper extremity region. We described focal tenderness and regional edema as physical finding. Each patient without regional edema was classified into an improved or a not-improved group depending on the outcomes after manual reduction. All statistical tests were conducted with two-tailed levels of 0.05. Results: Of the 113 patients, the mean age was 18.6±0.89 months. The most common injury mechanisms were unknown and traction. Minimal edema in the elbow joint was seen in 5 cases, and supracondylar fractures due to short falls were seen in 4 (80%) of those cases (p<0.05). The improved group was finally confined to radial head subluxation in 88 patients. Although all the not-improved-group patients had received radiographs, no abnormal findings were seen in the elbow. However, clavicle fracture due to fall above or from a level surface were seen in 4 cases (20%) of the not-improved group (p<0.05). No difference of injury mechanism existed between the improved and the not-improved groups. Conclusion: Recommand Radiographic evaluations in Children not-used arm with regional edema before manual reduction. But without regional edema, manual reduction of elbow is first. If children without regional edema do not improve after manual reduction of elbow and they are injuried due to fall, children should be assessed for fractures of clavicle.

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