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Benzoxazolin-2-thione과 PAS의 Alkyl Ester과의 Mannich Base 합성 및 항균력에 관한 연구
정원근(Won Keun Chung),정상헌(Sang Hun Chung),정필근(Pil Keun Chung),윤원영(Won Yung Yoon),이남복(Nam Bok Lee) 대한약학회 1974 약학회지 Vol.18 No.4
Nine benzoxazolin-2-thione derivatives were synthesized as the potential antimicrobial substances. These compounds were tested for the antimicrobial activities using Staphylococcus aureus and Escherichia coli by way of tube dilution method. The three compounds of 1, II and VII inhibited the growth of S. aureus at the concentration of 1mcg/ml, and III, VI, VIII and IX exhibited considerable antimicrobial activities against S. aureus at the concentration of l0mcg/ml. As to the growth of E. Coli, VII VII and VIII inhibited at the concentration of 1mcg/ml. II,III and IV exhibited considerable antimicrobial activities against E. coli at the concentration of 10mcg/ml.