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제암성물질의 합성에 관한 연구 VI. 2,4-Dihydroxy-5-nitropropiophenone 유도체의 합성 및 항종양시험
정원근(Won Keun Chung),이남복(Nam Bok Lee) 대한약학회 1973 약학회지 Vol.17 No.2
Seven beta-substituted-2, 4-dihydroxy-5-nitropropiophenones were synthesized as potential antineoplastic agents, and subjected to the screening test of survival effect and cell decrease effect. Of the synthesized compounds, beta-(1-methyl-1-hydroxymethyl) ethylamino-2,4-dihydroxy-5-nitropropiophenone, beta-(1,1-dihydroxymethyl) ethylamino-2, 4-dihydroxy-5-nitropropiophenone and beta-(1,1-dihydroxymethyl) propylamino-2,4-dihydroxy-5-nitropropiophenone were found to be active against both Ehrlich ascites carcinoma and Sarcoma 180.
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Benzoxazolin-2-thione과 PAS의 Alkyl Ester과의 Mannich Base 합성 및 항균력에 관한 연구
정원근(Won Keun Chung),정상헌(Sang Hun Chung),정필근(Pil Keun Chung),윤원영(Won Yung Yoon),이남복(Nam Bok Lee) 대한약학회 1974 약학회지 Vol.18 No.4
Nine benzoxazolin-2-thione derivatives were synthesized as the potential antimicrobial substances. These compounds were tested for the antimicrobial activities using Staphylococcus aureus and Escherichia coli by way of tube dilution method. The three compounds of 1, II and VII inhibited the growth of S. aureus at the concentration of 1mcg/ml, and III, VI, VIII and IX exhibited considerable antimicrobial activities against S. aureus at the concentration of l0mcg/ml. As to the growth of E. Coli, VII VII and VIII inhibited at the concentration of 1mcg/ml. II,III and IV exhibited considerable antimicrobial activities against E. coli at the concentration of 10mcg/ml.
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이남복 단국사학회 1980 史學志 Vol.14 No.1
Kim Yuk(金堉, 1580-1658) was not only a famous government official and scholar but also an administrator and statesman with both theory and practice. His life underwent so different process that to study it we can divide it into two parts the former and the latter. All through the former part of his life, he lived in obsecurty. He wandered from place to place in his early days on account of the Japanese Invasion in 1592. When he was 32, he became the president of student's association in Sung Kyun Kwan. But he left Seoul and got into Jam-Gok(潛谷) in Ga-Pyung(加平) because of an event of striking the name of Chung In-Hong(鄭仁弘) off the Confucian list. Since then he had personally been engaged in farming nearly for ten years till the enthronement of king In-Jo(仁祖). Through this farming life, he learned by actual experience the real condition of miserable farmers. Due to this experience, in after days when he became a government official, he gave priority to problems of the people's livelihood and stood on his doctrine beneficial to both people and state. His economic policy based on such doctrine was met with opposition by the ruling conservative power in and out of government. But he carried his standpoint powerfully with either persuasion or confrontation. His thought, however, was inclined to have a distinct leaning toward a tone giving priority to state over the people in his latter part of his life. This was closely connected with the fact that he became higrer in bureaucracy and the nobility at that time. In the end, his standpoint was settled to improve partially and maintain the ruling system. His standpoint had considerable limitation in itself, compared with that of the Silhak(實學) scholars, Ban-Gye, Yu Hyung-Won(柳馨遠) and Sung-Ho, Lee Ik(李瀷) whose opinions were to reconstruct radically the system of state and society. But it was greatly enlightening and realistic, compared with that of conservative scholars who set forth empty justice of "the great duty" and misled the people. Thus, his enlightening and progressive opinions like this, must deeply affect the following Silhak scholars.
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李楠福 대구사학회 2005 대구사학 Vol.78 No.-
Kim Gu(金坵) was a fine writer and politician of 13th century. At the beginning of 13th century Mongolia was arising and becoming the new ruler of China continent after destroying the Jin dynasty. The state ruling Yuan empire invaded the Koryo in 1231. The Koryo fiercely continued the anti-Mongol war for 30 years. However, in 1270, a peace treaty was reconciled which resulted in not only a termination of military regime of a century but a restoration of monarchy. Kim Gu was a provincial officer of Boo Ryung(扶寧). Although, his father was also a officer, as a low rank of his father, Kim Gu has not taken advantage of his family. Only his ability, fine literate ability could make him to become a scholar-officer. The intellectual leader of that era, Lee Gyu Bo(李奎報) recommended him to a diplomat document writer after seeing Kim Gu's fine writings. In his early official life, Kim Gu was full of anti-Mongol spirits in his writings and was enthusiastically involved in campaign of engraving Tripitaka Koreana. In 1240, he visited Mongolia as a delegate, thereafter he did not participate in engraving Tripitaka Koreana. He was seeing the Empire itself shedding on its power in a global scale. He adopted a practical stance. The engraving of Tripitaka could not possibly repel the gigantic Mogol invasion. A reconciliation is the better than the anti-Mongol resistance for withdrawal of Mongol to overcome the poverty and the damage of war. His anti-Mongol spirits turned into a practicalism. He volunteerly involved in practical politics along with the royal regime of reconciliation. As for him, the taking parts in practical politics meant writing delicate diplomatic documents concerning Mongol relationship, logically reputing excessive demands of Mongol, and resolving pending problems. Kim Gu was an outstanding writer and diplomat in making diplomatic documents during anti-Mogol resistance and Mongol interfering periods.
ScienceON
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