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국내거주 외국인에 발생한 Panton-Valentine leukocidin (PVL) 양성 USA300 지역사회획득 메티실린 내성 황색포도알균 두경부 농양 1예
정동형,배상수,백인엽,김상동,김보연,권기태,고관수,이신원 대한감염학회 2012 Infection and Chemotherapy Vol.44 No.6
The incidence of community-associated, methicillin-resistant, Staphylococcus aureus (CA-MRSA) has increased in North America and Europe. One of most important reasons is the spread of Panton-Valentine leukocidin (PVL) positive CAMRSA strains. On the other hand, CA-MRSA is not associated with the PVL positive strain in South Korea. Few cases of PVL positive CA-MRSA infections were reported in South Korea. We encountered a case of a submandibular abscess caused by MRSA in an otherwise healthy 29-year-old foreign female resident in a military camp. The CA-MRSA infection was confirmed by culture after abscess aspiration. Staphylococcal cassette chromosome mec (SCCmec) typing, multilocus sequence typing and spa typing revealed type IV, ST8 and t008, respectively. The PVL gene was also identified.
백인엽,정윤진,박민규,정동형,신동우,권종규,류현욱,박종훈 대한췌담도학회 2012 대한췌담도학회지 Vol.17 No.2
Mixed adenoneuroendocrine carcinoma occurs rarely in the biliary tract. We report a case of mixed adenoneuroendocrine carcinoma of common bile duct, based on the World Health Organization 2010 classification. A 79-year-old woman complained of right abdominal pain for 2 weeks. ERCP and MRCP revealed a narrow common bile duct with upstream dilatation and biopsy of common bile duct suggested only adenocarcinoma. Pancreaticoduodenectomy was performed, and a tumor was composed of both neuroendocrine carcinoma and adenocarcinoma. Immunohistochemically, neuroendocrine components were reactive for cytokeratin and synaptophysin. The neuroendocrine and exocrine components occurred in separate areas of the same lesion. Liver metastasis was developed at 16 months after surgery. The optimal strategy of management of mixed adenoneuroendocrine carcinoma involving the biliary tract is unknown because it is very unusual. However, more cases will be helpful to demonstrate clinical course and make a decision about management plans
정연관 ( Youn Kwan Jung ),박혜리 ( Hye Ri Park ),이은주 ( Eun Ju Lee ),정동형 ( Dong Hyoung Jeong ),김건우 ( Gun Woo Kim ),최제용 ( Je Yong Choi ),한승우 ( Seung Woo Han ) 대한류마티스학회 2012 대한류마티스학회지 Vol.19 No.4
DICAM, a dual Ig domain containing adhesion molecule, is involved in cell-cell adhesion through direct interaction with αvβ3 integrin. In our previous study showing the inhibitory role of DICAM in osteoclast differentiation, we found that DICAM also has a suppressive role in macrophage, the precursor cell of osteoclast, The role of DICAM in macrophage activation at the inflammatory milieu, however, remains obscure, Methods, Expression pattern of DICAM by inflammatory cytokines and lipopolysaccharide (LPS) was studied with RAW264.7, a murine macrophage cell line, To study the role of DICAM on macrophage activation, we stably transduced DICAM, or empty vector, into RAW264.7, and then compared the LPS-mediated activation such as spreading and TNF-a production, Results, DICAM was abundantly expressed in the synovial tissue of collagen-induced arthritis. When we assessed the expression of DICAM in RAW264.7 cells by mediators of inflammation, inflammatory cytokines, such as TNF-α, IL-1β, and IFN-γ, and M-CSF increased the expression of DICAM; however, LPS decreased. Functionally, DICAM that stably transduced-RAW264.7 cells showed attenuation of LPS-mediated macrophage activation including spreading and TNF-α production. DICAM decreased the phosphorylation of JNK MAP kinase by M-CSF and LPS stimulation, which was corroborated by a decrease in the expression of ITAM-associated receptors including Trem2, Pira1, and Oscar. Finally, a recombinant ectodomain of DICAM suppressed LPS-induced activation of RAW264.7 cells, Conclusion. These results indicate that DICAM acts as a negative regulator of LPS-mediated macrophage activation.