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고대(古代)의 경복진단법(經服診斷法) 중 십이경맥(十二經脈) 맥진(脈診)에 관(關)한 연구(硏究)
임성철,손성철,이경민,황민섭,김갑성,윤종화,Lim, Seong-cheol,Son, Seong-cheol,Lee, Kyung-min,Hwang, Min-seob,Kim, Kap-sung,Yoon, Jong-hwa 대한침구의학회 2002 대한침구의학회지 Vol.19 No.5
Objective : The study of relations between twelve meridians and pulse diagnosis Method : The possiblity of pulse diagnosis on the pulse points(脈動處) of each meridian through the scription of $\ll$Maek beop(脈法)$\gg$ $\ll$Nae kyeong(內經)$\gg$ and $\ll$Nan kyeong(難經$\gg$ Result : The comparative pulse diagnosis method(比較脈診法) in the scription of $\ll$Mack beop$\gg$ progressed to the five Jang bu maek(五臟脈) in the scription of $\ll$Young chu : Sa gi jang bu byeong hyeong(靈樞 邪氣臟腑病形)$\gg$ in accordance with the progress of pulse diagnosis and the theory of medicine. Conclusions : The comparative pulse diagnosis method in the scription of $\ll$Mack beop)$\gg$ progressed to the five Jang bu maek(五臟脈) in the scription of $\ll$Young chu : Sa gi jang bu byeong hyeong$\gg$ and the moxibustion and Pyum bup(貶法) in the scription of $\ll$Mack beop$\gg$ altered to acupuncture therapy on the five shu points(五輸穴)
Sung-Chul Lim(임성철),Cheol Hee Choi(최철희),Song Iy Han(한송이) 한국생명과학회 2009 생명과학회지 Vol.19 No.12
항암제 내성을 획득한 암세포는 많은 경우 다양한 세포 독성 물질에 대해 교차 내성을 나타낸다. 그러나 온열 치료가 내성 획득 종양에 적용 될 때의 종양 세포의 사멸 효과는 알려져 있지 않다. 본 연구는 시스플라틴에 내성을 갖는 위암 세포 주, SNU601/Cis2이 열충격에 반응하는 민감도와 세포 사멸 방식을 조사함으로써 약물 내성 종양의 온열 치료 효과를 예측하고자 하였다. 정상 위암 세포 주 SNU601/WT은 열충격에 매우 민감하게 반응하며 apoptosis로 사멸하지만, 내성 위암 세포 주 SNU601/Cis2는 미열충격에 내성을 나타내었으며 고열충격에 노출되자 necrosis로 사멸하였다. 또한 SNU601/Cis2에서 necrosis의 발생은 열충격에 의한 JNK1/2의 활성화와 HSP27의 발현저하 현상과 관련되어 있었다. Necrosis의 유도는 세포막 파괴에 의해 세포 내부 물질의 방출로 인한 주변 조직의 염증반응을 수반하는데, 이러한 염증 반응은 암의 성장을 촉진하고 암의 성상을 심화시키는 것으로 보고되고 있다. 이러한 관점에서, 온열 치료가 약물 치료와 병행 될 경우에는 교차 내성과 necrosis로 인한 역효과를 방지하기 위하여, 그 적용이 주의 깊게 이루어져야 할 것으로 판단된다. Carcinoma cells that had acquired resistance to a chemotherapeutic drug often show cross-resistance to various other cytotoxic drugs. In the present study, we explored the effect of heat shock in cisplatin-resistant gastric cancer cells SNU601/Cis2 to figure out the efficacy of hyperthermia in drug-resistant carcinoma. While SNU601/WT cells showed a high-sensitivity response to heat shock by dying through apoptosis, SNU601/Cis2 cells were considerably resistant to mild heat shock, but died by necrosis upon treatment with harsh heat shock. The occurrence of necrosis in SNU601/Cis2 cells was linked to the suppression of both JNK1/2 activation and HSP27 induction in response to heat shock. Since necrosis is closely associated with tumor malignancy and poor prognosis through inflammatory responses, our result suggests that hyperthermic treatment should be carefully applied when it is combined with chemotherapy.
Estradiol valerate와 Letrozole에 의해 유발되는 다낭성난소증후군의 난소변화 비교
임성철 ( Sung Chul Lim ),정문진 ( Moon Jin Jeong ),김세은 ( Se Eun Kim ),김승현 ( Seung Hyun Kim ),김삼철 ( Sam Cheol Kim ),서승용 ( Seung Yong Seo ),김탁 ( Tak Kim ),강성수 ( Seong Soo Kang ),배춘식 ( Chun Sik Bae ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.6
목적: 다낭성난소증후군(polycystic ovary syndrome, PCOS)을 estradiol valerate (EV)와 letrozole (LE)로 유발할 수 있는데 인간의 다낭성난소증후군과 가장 유사한 질환동물 모델이 무엇인가를 알아보고자 하였다. 연구방법: EV와 LE를 각각 랫드에 처리하여 PCOS를 유발시킨 후 희생시켜 난소를 적출하였다. 난소를 조직학적으로 관찰하여 다낭성 난소 변화 유발유무, 난소의 크기, 난포낭의 크기 및 수를 측정하고 난포 및 간질세포의 황체화 등을 비교 관찰하였다. 결과: LE처리군은 EV처리군에 비하여 난소의 크기 및 난포낭의 수가 유의하게 증가하고 난포막세포의 황체화가 뚜렷하여 인간의 PCOS와 더유사한 소견을 보였다. 결론: 랫드에서 LE처리에 의한 PCOS는 PCOS질환유발 동물 모델로 더 적합한 것으로 평가된다. Objective: To compare ovarian morphology of the estradiol valerate (EV)-and the letrozole (LE)-induced polycystic ovary syndrome (PCOS) in rat models. Methods: EV were injected (IM) to 10 Sprague-Dawley rats and LE were administered (PO) to the other 10 Sprague-Dawley rats for 21 days. Sixty days after single injection of EV and 21 days after LE administration, the animals were sacrifi ced and the ovaries were sectioned, measured and analyzed histopathologically. Results: LE-treated group showed larger ovary bearing more abundant cystic follicles with luteinized theca cells. These fi ndings were more similar to human PCOS ovarian morphology. Conclusion: LE-induced PCOS model is recommended to conduct PCOS-related animal experiments.
Hirudin 약침(藥鍼)이 중대뇌동맥폐색(中大腦動脈閉塞)으로 유발(誘發)된 흰쥐의 신경손상(神經損傷) 보호(保護) 효과(效果)
석재욱,정태영,임성철,서정철,김미려,양재하,한상원,Suk, Jae-wook,Jung, Tae-young,Lim, Seong-cheol,Seo, Jeong-chul,Kim, Mi-ryeo,Yang, Chae-ha,Han, Sang-won 대한침구의학회 2004 대한침구의학회지 Vol.21 No.4
Objective : In order to prove the effect of Hirudin Herbal-acupuncture this experimental studies were performed by using rats that had neuronal damage due to the Middle Cerebral Artery Occulsion(MCAO). Methods : Microdialysis probes were implanted into the coordinate of striatum of anesthetized rats which consist of sham-operated 8 rats, MCAO-operated 8 rats and Hirudin Herbal-acupuncture administrated 8 rats before MCAO operating. The Hirudin Herbal-acupuncture(0.5mg/kg) was administrated to rats 30 minutes before having an operation causing the MCAO. The surgical excision lead the cross resected brain to the acute ischemic state. The brain was sliced in 2mm thickness and stained with cresyl violet buffer for the measurement of cerebral infarcted area and volume. Results : Based on the result of the tissue inspection for the cerebral ischemic cell, Hirudin Herbal-acupuncture significantly protect neurocytes. Conclusion : We suggest Hirudin Herbal-acupuncture produces protective effects against the neuronal damage induced by MCAO. Therefore, Hirudin Herbal-acupuncture may prevent delayed neuronal death(DND) in selectively vulnerable focal areas of the brain effectively.
고삼(苦參)이 항암제(抗癌劑) cisplatin의 간(肝),신장(腎臟) 부작용(副作用) 감소(減少)에 미치는 영향(影響)
김진철 ( Jin Cheol Kim ),이경민 ( Kyung Min Lee ),변부형 ( Boo Hyeong Byun ),임성철 ( Seong Chul Lim ),정태영 ( Tae Young Jung ),서정철 ( Jung Chul Seo ),한상원 ( Sang Won Han ) 대한경락경혈학회 2005 Korean Journal of Acupuncture Vol.22 No.3
Objective: The objective of this study is to investigate the inhibitor effects of an traditional oriental herb, Sophora flavescens on the hepatic and renal side effects of chemotherapy by using B16-BL6 melanoma-injected C57BL6 mouse tumor model. Methods: In this study, the effects of an traditional oriental herb, Sophora flavescens, on the side effects of chemotherapy were studied using B16 melanoma-injected C57BL6 mouse tumor model. Results: Sophora flavescen has significant effect on the reduction of the side effects of chemotherapy. Sophora flavescen recovered the reduction of WBC and RBC during cisplatin chemotherapy. Water extract of Sophora flavescens significantly inhibited cisplatin-induced increase of serum blood urea nitrogen (BUN) which is a good indicator of renal toxicity. Sophora flavescens extract does not decrease the anti-tumor activity of cisplatin showing that it can selectively inhibit side effects of anticancer drugs preserving beneficial effect. Conclusion: Theses results suggest a possibility that Sophora flavescens extract can be used for cancer patients for the reduction of the side effects and improving the quality of Life during chemotherapy of cancer patients.
황련해독탕 약침, 자하거 약침의 침감에 대한 임상적 연구 - placebo 약침을 위한 기초연구 (2) -
윤종석,서정철,이향숙,임성철,정태영,신임희,한상원,Yoon, Jong-seok,Seo, Jung-chul,Lee, Hyang-sook,Lim, Seong-cheol,Jung, Tae-young,Shin, Leem-hee,Han, Sang-won 대한침구의학회 2004 대한침구의학회지 Vol.21 No.4
Objective : This study was designed to find out whether NS(normal saline) is able to be constituted as an appropriate control group for HHT(Hwangryunhaedoktang herbal acupuncture) and HP(Homnis Placenta herbal acupuncture). Methods : NS and two herbal acupuncture were inserted into Quchi(LI 11) of the subjects. After 5 minutes the subjects completed a questionnaire rating the intensity of 21 kinds of acupuncture sensation; hurting, penetrating, sharp, aching, intense, spreading, radiating, tingling, pricking, stinging, pulling, heavy, dull, numb, electric, shocking, hot, burning, cool, pulsing, and throbbing. We compared the subjective acupuncture sensation between the two groups. Results : As for HHT seven items of the acupuncture sensation were significantly different from NS. In case of HP just two items were significantly different from NS. Conclusion : We found that NS may be able to be an placebo herbal acupuncture for HP. Further study is needed for the appropriate placebo herbal acupuncture.
서로 다른 분엽에 동시에 발생한 유두성과 여포성 갑상선암
정희석(Hi Seok Cheong),임성철(Sung Cheol Lim),조현진(Hyun Jin Cho) 대한두경부종양학회 2001 대한두경부 종양학회지 Vol.17 No.1
We present a case of a mixed papillary and follicular thyroid cancer in a 45-year-old female presented with palpable mass on anterior neck area for 1 week ago. Neck CT and ultrasonogram revealed small solid masses in the both lobes of the thyroid gland. Thyroid scintigraphy presents as a cold nodule in the right lobe of the thyroid gland and FNA cytology demonstrated papillary thyroid cancer. At the time of operation, small sized solid masses were detected in the both lobes, and no cervical lymph nodes enlargement along the mass. Biopsies of the both mass demonstrated papillary cancer on right lobe and follicular cancer on left lobe. Simultaneous papillary and follicular thyroid cancer is an extremely rare clinical entity. We experienced a case of simultaneous papillary and follicular thyroid cancer, so we report it with a review of some articles.