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이화영 ( Wha Young Lee ) 한국화학공학회 1979 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.17 No.5
The structure, preparation methods, physical and chemical properties, thermal characteristics and general catalysis of the heteropoly acids and their compounds are introduced. The catalysts of the oxidation of methacrolein to methacrylic acid presented in the recent patents and papers are analyzed and investigated in a fundamental and practical research aspect with emphasis on the bateropoly compounds.
생물전환을 통한 음나무발효물의 지표성분 설정 및 동시분석법 검증
장원희,이화영,이봉진,김진만,박선주,Jang, Won Hui,Lee, Wha Young,Lee, Bong Jin,Kim, Jean Man,Park, Seon Ju 한국식품영양학회 2019 韓國食品營養學會誌 Vol.32 No.2
The aim of this study was to select compounds for the standardization of fermented Kalopanax pictus Nakai (KP-F), to develop the analysis method using HPLC-PDA and to perform method validation. KP-F is a fermented powder developed to improve the original physiological activities and create a new functionality. Eleutheroside E, Acanthoside B, and Syringaresinol were selected as the standard compounds and developed our own method for simultaneous analysis. The analyte was isolated using C18 column with a gradient elution of 0.05 M phosphoric acid in water and methanol as the mobile phase at a flow rate of 1 mL/min and detected at 210 nm. As a result, all standard compounds showed good linearity with an $R^2$ (coefficient of correlation) of 1.000 and for the limit of detection range of $0.710{\sim}0.831{\mu}g/mL$, and the limit of quantification as $2.150{\sim}2.520{\mu}g/mL$. The precision was RSD (%) of less than 4.80%, while the accuracy was 4.70%>RSD (%) for the range 102.44~110.48%. In conclusion, the developed analysis method is suitable for the detection of Eleutheroside E, Acanthoside B, and Syringaresinol in KP-F.
생물전환을 통한 음나무발효물의 LPS에 대한 경쟁적 억제제 효과 및 내독소혈증 억제 효과
김성필,이화영,인수아,성은영,김진만,남석현,Kim, Sung Phil,Lee, Wha Young,In, Su A,Seong, Eun Young,Kim, Jean Man,Nam, Seok Hyun 한국식품영양학회 2019 韓國食品營養學會誌 Vol.32 No.2
The objective of this study was to evaluate the effect of fermented Kalopanax pictus (KP-F) on macrophage activation and its effect as a competitive inhibitor of LPS and inhibitory effect on endotoxemia. The results showed that KP-F could activate macrophage in a dose-dependent manner, and KP-F was confirmed to act as a ligand for TLR4. Also, it was found that KP-F did not exhibit the same biotoxicity as LPS in intraperitoneal injection, and that it could suppress the neutrophil migration induced by LPS administration. In normal mice, the body weight, tissue weight, and amount of nitrite and pro-inflammatory cytokines in serum showed no significant changes with KP-F diet for 2 weeks, confirming that administration of KP-F in normal mice did not lead to over activation of immune response and biotoxicity. In the mouse model of endotoxemia induced by LPS and D-galactosamine(D-GalN) in sub-lethal dose, the diet of KP-F effectively inhibited the amount of nitrite and cytokines in the blood, and thus was found to be able to relieve the hepatic and kidney injury. In addition, in the endotoxemia mouse model induced by LPS and D-GalN of lethal dose, the survival rate was increased by KP-F diet in a dose-dependent manner.