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김현영,이혜승,이성철,정성은,박귀원,김우기,Kim, Hyun-Young,Lee, Hye-Seung,Lee, Seong-Cheol,Jung, Sung-Eun,Park, Kwi-Won,Kim, Woo-Ki 대한소아외과학회 2005 소아외과 Vol.11 No.1
Choledochal cysts have been associated with complications such as cholangitis, pancreatitis, and malignancy of the biliary tract. Recently, the incidence of choledochal cyst in neonate and young infant is increasing due to advances in diagnostic imaging. The aim of this study is to investigate the rationale of excision of choledochal cyst during the neonatal period. The clinical outcome and correlation between age at surgery and the degree of liver fibrosis were reviewed retrospectively. A total of 198 patients with choledochal cyst who were managed surgically between January 1985 and December 2000 at the Department of Surgery, Seoul National University Children's Hospital were included in this study. The overall outcome and the outcome of patients who were managed surgically during the neonatal period were compared. Correlation between age and the degree of liver fibrosis was evaluated by chi-square test and Pearson exact test. The mean age of the patients was 2 years 7 months (ranged from 5 days to 15 years). Mean postoperative follow-up period was 7 years 1 month (7 months to 20 years). The results are as follows. Twelve patients (6%) had postoperative complications, cholangitis (7), bleeding (4) and ileus (1). Eleven patients operated during the neonatal period had no postoperative complications. The positive correlation between age group and degree of liver fibrosis was statistically significant (chi-square: p=0.0165, Pearson exact test: p=0.019). The results support the rationale that excision of choledochal cyst can be performed safely without increasing morbidity in neonates.
흡인성 폐렴을 유발한 미만성 식도경련에 의한 거대 식도게실
송호준 ( Ho June Song ),김나영 ( Na Young Kim ),황진혁 ( Jin Hyeok Hwang ),김진욱 ( Jin Wook Kim ),이동호 ( Dong Ho Lee ),김성은 ( Seong Eun Kim ),이혜승 ( Hye Seung Lee ),이창수 ( Chang Soo Lee ),정현채 ( Hyun Chae Jung ),송인성 대한소화기기능성질환·운동학회 2004 Journal of Neurogastroenterology and Motility (JNM Vol.10 No.1
Esophageal motility disorders have been considered to be important physiologic bases for the development of esophageal diverticulum, and to rarely cause severe complications. We report a case of aspiration pneumonia caused by esophageal diverticula in a patient with diffuse esophageal spasm (DES). A 44-year-old man suffered from cough due to aspiration pneumonia. He experienced intermittent vomiting for one year. Two years prior to admission, 2 large esophageal diverticula were first noticed in a single-contrast, upper gastro-intestinal tract examination, the size of which had increased one year later. Esophageal manometry and 24-hr esophageal pH monitoring were performed to investigate the underlying causes of aspiration pneumonia and he was diagnosed as DES. He underwent esophageal diverticulectomy and esophagomyotomy. Aspiration pneumonia, which had recurred even after operation, was controlled with percutaneous endoscopic gastrostomy. This case shows that serious pulmonary complications can develop in a ptient with esophageal diverticula related with DES. (Kor J Neur ogastr oenterol Motil 2004;10:76-80)
신동우 ( Dong Woo Shin ),최효진 ( Hyo Jin Choi ),기주영 ( Joo Young Kee ),강병수 ( Byoung Soo Kang ),이은영 ( Eun Young Lee ),이윤종 ( Yun Jong Lee ),이은봉 ( Eun Bong Lee ),이혜승 ( Hye Seong Lee ),송영욱 ( Yeong Wook Song ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.2
Intravascular histiocytosis is an unusual cutaneous lesion with massive aggregates mainly composed of histiocytes in markedly dilated dermal vessel and previously reported in associations with rheumatoid arthritis (RA). We report a case of intravascular histiocytosis in RA patient. A 58-year-old woman having 20-year history of RA presented with the right elbow pain and poorly demarcated, indurated erythema in the right forearm. Biopsy revealed vascular proliferation and mononuclear cellular aggregates in the dilated vessels of dermis. Immunohistochemical findings of the intravascular cells were consistent with a histiocytic differentiation. She underwent synovectomy in the right elbow joint and had rapid resolution of cutaneous lesion.
한국인에서 다변성 D12S391 유전좌의 집단유전학적 연구
이용욱,김성민,구태완,이혜린,강일호,한길로,이혜승,황적준 大韓法醫學會 1999 대한법의학회지 Vol.23 No.1
The hypervariable short tandem repeat(STR) locus D12S391 was investigated in a Korean population. A total of 14 alleles were detected by size under denaturing conditions in 517 unrelated individuals. To confirm all of the alleles detected in a Korean population, a total of 34 fragments were sequenced. Prior to allele designation, we constructed the allelic ladders containing 11 alleles sequenced in this study. Allele 18 is the most common with a frequency of 0.281 in Koreans, and one variant allele 19.3 which have been confirmed by sequencing, was detected. The observed heterozygosity, the power of discrimination (PD), and the mean exclusion chance (MEC) for the locus D12S392 is 0.781, 0.946 and 0.652 , respectively. No deviation from Hardy-Weinberg equilibrium was observed in a Korean population (p=0.557). In the 424 meioses in 105 Korean families confirmed using other 17 STR loci, no mutation was detected in locus D12S391. The STR locus D12S391system is useful both for the analysis identification and parternity.