좌측 악하선에 발생한 상피-근상피암종 1예

이현직,홍종철,나서희,박헌수 대한이비인후과학회 2010 대한이비인후과학회지 두경부외과학 Vol.53 No.9

Epithelial myoepithelial carcinoma is a rare tumor with slightly less than one percent of salivary gland neoplasm. Histologically, the carcinomas are characterized by a mixture of trabecular structure with outer myoepithelial cells and inner ductal cells, which are confirmed by electron microscopy and immunohistochemistry. Although this neoplasm exhibits high degree of cellular differentiation histologically, it is classified into low grade carcinoma because of its locally infiltrative,destructive growth pattern, and tendency to metastasize. We report a 45-year-old woman with epithelial-myoepithelial carcinoma arising from a submandubular gland, one of the most unusual locations. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:582-4

수치지도 및 위성영상을 이용한 지형분석에 관한 연구

이현직 尙志大學校 生産技術硏究所 1998 生産技術論叢 Vol.6 No.-

I While a lot of information are created and changing by the development of today's society yet we need a lot of time and effort to obtain the terrain analyzation. But by using GIS system in analyzing the terrain, the utility factor of time and economy was increased which made it possible to acquire lot more terrain information, yet it shows lots of defect in. In this research we have analyzing the Wonju city's terrain based on data that is needed to analyze terrain using the digital mapping and Landsat image, using MTA and IA Tool that is provided from Intergraph's GIS software MGE for our object. Analyze of terrain by using the digital mapping we abstracted the contour lines and using these lines we created the three dimensions model, and basing on it we executed elevation, aspect, slope, viewshed analyzation, and analyze using the Satellite image took to analyze the use land, soil temperature vegetation, land moisture capacity to contain which based on Landsat TM image.

NGIS구축을 위한 국가기본도 DIGITAL MAPPING에 관한 연구

이현직 尙志大學校 1996 論文集 Vol.17 No.-

Recently, the National Geographic Information System Project is promoted to construct of Database related to topographic and spatial data. This study is purposed to establish the reasonable process of National Basemap Digital Mapping which has been done with the first phase of the NGIS project. As the results of this study, the reasonable process of 1:5,000 scale National Basemap Digital Mapping is established. And, after finding out the problems of Digital Mapping criteria, the optimal method of National Basemap Digital Mapping was suggested.

화상처리기법을 이용한 고해상도 이색 PIV 알고리즘 개발 ( Development of High-Resolution two-color PIV Algorithm using Digital Image Processing Techniques )

이현직,정재우,이기형,이창식 대한기계학회 1997 대한기계학회 춘추학술대회 Vol.- No.-

무지 형성술 및 전내측 대퇴부 천공지 피판의 연속 술기를 이용한 수부 절단 손상의 재건 - 증례 보고 -

이현직,어수락,조상헌,Lee, Hyun-Jic,Eo, Su-Rak,Cho, Sang-Hun 대한미세수술학회 2012 Archives of reconstructive microsurgery Vol.21 No.1

Purpose: Thumb reconstruction plays most important role in hand injuries because total loss of a thumb constitutes about 40% disability in the hand. The reconstruction can be accomplished by pollicization, free toe-to-thumb transfer, wrap around procedure and lengthening extraction. However, we sometimes need consecutive or double free flaps in the reconstruction of mutilating hand injuries. Methods: We reconstructed a mutilating hand injury in a 54-years old man. Because of severe crushing injury of right thumb and index fingers, we reconstructed a thumb with pollicization using nearly amputated middle finger. Although it survived completely, the adjacent soft tissues which had been covered by fillet flap from the space past was necrosed on 1 month. We debrided the necrotic tissues and covered it with anteromedial thigh perforator free flap consecutively because he had an anatomical variation in branches of lateral femoral circumflex artery. Results: He had an uneventful postoperative course without any complication such as infection, dehiscence and flap necrosis. Three months later, he had undergone tenolysis and defatting procedure of flap site. He recovered the some amount of grip function and was happy with the result. Conclusion: In severe hand trauma including thumb amputation, thumb reconstruction using pollicization and perforator free flap could be an alternative option. It provides minimal donor site morbidity and an acceptable functional result.

Arm-up holder의 보조기구 제작에 따른 유용성 평가

이현직,최병기,심재구,김종식,오동균,박영환 대한방사선치료학회 2002 大韓放射線治療技術學會誌 Vol.14 No.1

I. 목적 : arm-up holder는 흉부 및 복부 질환 치료의 환자고정에 유용하게 사용하고 있으나 손잡이 부분과 어깨가 닿는 부분까지 거리 때문에 동일한 자세를 유지하는데 불편함이 있다. 특히 긴장을 많이 하거나 기력이 없는 환자는 방사선 치료 시 자세의 불안정으로 인하여 치료의 정확성이 떨어질 수 있다. 이에 본원에서는 현재 사용하고 있는 arm-up holder에 팔의 지지를 위한 보조기구를 제작하여 유용성을 평가하였다. II. 대상 및 방법 : 기존의 arm-up holder에 어깨받침대를 부착하여 개선된 arm-up holder를 제작하였다. 실험을 위하여 기존의 arm-up holder를 사용하는 환자그룹과 개선된 arm-up holder를 사용하는 그룹으로 구분하여 자세 변화를 평가하였다. 두 그룹의 환자를 대상으로 모의 치료를 실시한 후 치료실에서 L-gram 을 2회 씩 촬영하여 치료하고자 하는 portal film과 isocenter의 변화를 측정했다. 각 그룹 당 10명씩의 환자를 선정하여 반복 조사하였다. III. 결과 : 개선된 arm-up holder를 사용한 그룹의 isocenter 의 변화는 최대 2mm, 최소 0.5mm 평균 1.2mm 이다. 기존의 arm-up folder를 사용한 그룹과 비교하여 평균변화는 약 2배로 나라났고, 최대 변화는 2.5배의 오차범위가 측정되었다. IV. 결론 : 현재 사용하고 있는 arm-up holder는 흉부 및 복부의 사방향 방사선 치료 시 팔에 의한 방사선 감약을 예방할 수 있는 유용한 고정용구이다. 하지만 팔을 올리고 있는 자세는 환자에게 불편함을 야기 시키며 이로 인한 치료의 정확성을 감소시킬 수 있다. 따라서, 기존의 arm-up holder에 보조기구를 제작하여 사용함으로써 환자의 불편함을 개선하고, set-up 의 안정성과 재현성을 향상시킬 수 있었다.

측량기준점 관리를 위한 성과 일원화 방안 제시

이현직,김세열,이동국,유지호 한국측량학회 2015 한국측량학회 학술대회자료집 Vol.2015 No.4

Mitochondrial oxidative stress regulatory approaches for diabetic encephalopathy

이현직,김대현,김혜진,조항효 충북대학교 동물의학연구소 2022 Journal of Biomedical and Translational Research Vol.23 No.4

Diabetic encephalopathy is a major complication with cognitive impairment and neurodegeneration in patients with type 1 or type 2 diabetes mellitus (DM). DM-induced glucolipotoxicity is a risk factor for Alzheimer’s disease–like phenotype, including amyloidogenesis, tau hyperphosphorylation, and neuronal apoptosis. Although the detailed mechanism underlying the pathogenesis of diabetic encephalopathy remains unclear, mitochondrial oxidative stress is emerging as a key factor for diabetic complications and neurodegeneration. A deeper understanding of the regulatory mechanism of mitochondrial oxidative stress under hyperglycemic conditions will provide insights into the development of therapeutic strategies for diabetic encephalopathy. Here, we review the role of mitochondrial oxidative stress in diabetic encephalopathy and the regulatory mechanisms by which high glucose induces the generation of mitochondrial reactive species oxygen species in neuronal cells. This review also summarizes the mitochondrial-dependent and -independent pathways (O-linked-N-acetylglucosaminylation, calcium, and glycogen synthase kinase 3β signaling) that regulate mitochondrial oxidative stress in a DM model.

갑상샘 결절의 수술 전 진단에서 초음파 유도하 심부 생검 면역 조직화학적 검사의 유용성

이현직,홍종철,이재훈,홍숙희,박헌수 대한이비인후과학회 2010 대한이비인후과학회지 두경부외과학 Vol.53 No.9

Background and Objectives The diagnosis of thyroid nodular diseases is critical for clinical management. Because of the histological similarity of follicular patterned thyroid lesions,the differential diagnosis is often difficult to determine, even with permanent sections. For this reason,we assessed the preoperative diagnostic usefulness of immunohistochemical staining for the four potential markers of malignant thyroid nodule, β-galactosil binding lectin (Galectin-3),Hector Battifora Mesothelial cell (HBME-1), cytokeratin-19 (CK-19) and high molecular weight cytokeratin (HMW-CK) in tissues obtained by ultrasound-guided core needle biopsy. Subjects and Method The immunohistochemical expression of Galectin-3, HBME-1, CK-19 and HMW-CK were evaluated in 43 preoperative thyroid lesions obtained to assess their potential as markers in the diagnosis and classification of thyroid malignancy. We compared the preoperative expression of the four markers with the results of postoperative permanent pathology. Results The expression patterns and positive rates of four markers were the variables in 4thyroid lesions; however, all markers were strong in malignant thyroid nodules, especially in papillary carcinoma. There were no significant differences in the expression rates of the four markers between follicular carcinoma and follicular adenoma. The sensitivity of HBME-1 for thyroid malignancy was the highest (86%) among the four markers, but the sensitivity of combinational expression using two markers, especially Galectin-3 or HBME-1 (95%), HBME-1 or HMW-CK (90%), was higher than that of the expression using one marker for thyroid malignancy. Conclusion The four markers were reliable markers for papillary carcinoma. In preoperative differential diagnosis of thyroid nodule, we suggest that the combinational expression using two makers is more useful than a single marker expression. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:564-70

비금속관로 유지관리 개선을 위한 제품 개발

이현직,박현호 商志大學校 生産技術硏究所 2002 生産技術論叢 Vol.11 No.-

Non-metal Pipeline use is trend that is rising go on water supply pipe of waterwork or case of sewage pipe among city's underground facilities, and about 30% of water supply pipeline has been consisted of Non-Metal Pipeline in case of Wonju city. But, it is real condition that exploration is very difficult in this Non-Metal Pipeline's case and much expense is invested when do substantial inquiry that exploration equipment also is high-priced equipment. Through an experiment in this research Electron induction method exploration technology of metal pipeline that depend because have use method to make Non-Metal Pipeline by Metal Pipeline by a low-cost study and proved accuracy of Non-Metal Pipeline exploration that become Metal Pipeline.