http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
류마티스 관절염의 활막 섬유모세포에서 Hypoxia/reoxygenation에 의한 종양 억제 인자 PTEN 발현의 조절
이학용 ( Hak Yong Lee ),류완희 ( Wan Hee Yoo ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.4
Objective: The lack of phosphatase and tensin homolgue deleted on chromosome ten (PTEN) expression was described in rheumatoid synovial tissues and synovial fibroblasts, but exact cause of that in RA is not well known. Hypoxic conditions are thought to exist in inflamed arthritic synovium and therefore, this study was designed to investigate the effects of hypoxia/reoxygenation on the expression of PTEN in synovial fibroblasts of rheumatoid arthritis. Methods: Synovial fibroblasts were isolated from synovial tissues of patients suffering from RA and hypoxic culture was performed by incubating cells in 5% CO2 incubator held at 3% oxygen by the addition of nitrogen gas for 24 hours. Then synovial fibroblasts were cultured for 10 min under normoxic condition for reoxygenation. To know the expression of PTEN and phosphorylated Akt (p-Akt) in synovial fibroblasts, Western blotting analysis was performed. The expression of PIP3 kinase and PTEN was analyzed by immunocytochemical staining. Results: There were less PTEN expression in rheumatoid synovial fibroblasts than that of healthy controls. Hypoxic/reoxygenation stimuli induced down-regulation of PTEN expression in the rheumatoid synovial fibroblasts. In contrast, the expression of PIP3 and p-Akt was increased after stimulation with hypoxia/reoxygenation. Conclusion: These studies suggest that hypoxia/reoxygenation could cause the reduced expression of PTEN in rheumatoid synovial fibroblasts and thus it might thereby contribute to the invasive behaviour of rheumatoid synovial fibroblasts by maintaining their aggressive phenotype in RA.
350km/h급 고속전차선로 보호선의 선종결정 기법에 관한 연구
이학표(Hack-Pyo Lee),서기범(Ki-Bum Seo),박재영(Jae-Young Park) 대한전기학회 2015 전기학회논문지 Vol.64 No.12
In this paper, we analyzed the optimal configuration of protection wire that have been installed in the electric railway power supply system. Protection wires are to suppress the ground potential rise when the short circuit fault between contact wire-rail(C-F), and protect the electronics equipments(signalling and communication) that are facility the wayside. The role of protection wires must be feed back quickly the fault current to the substation when a short circuit fault occurs. In this paper, we proposed that only one line to install the protection wire. Comparing how to newly proposed and existing system, most of the performance is similar. The reason is that most of the current flowing in the protection wire near the location where the fault occurred. There is no problem even if in one line for human safe and the low impedance of the return circuit in dimension to ensure the safety of the facility during the fault. To ensure safety during an fault occurs, it is sufficient even by one line. But, In the protection wire of facilities planning it is necessary to design taking into account the potential utility.