http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
급성 신부전이 병발된 Acute Multifocal Bacterial Nephritis 2 예
김인수,김지윤,박현진,문성수,유병희,윤종현,이태광 대한내과학회 1994 대한내과학회지 Vol.46 No.1
Renal bacterial infection spans a continuum of severity from uncomplicated acute pyelonephritis (APN) through progressively worsening stages of interstitial inflammation to frank abscess formation. Acute multifocal bacterial nephritis (AMBN) is a severe form of acute renal infection in which a heavy leukocytic infiltrate occurs throughout the kidney. Clinically, the patients have evidence of a severe urinary tract infection secondary to a gram-negative organism, usually E. coli or Klebsiella. About half of the reported patients have been diabetic, and there are frequently signs of sepsis. AMBN could be diagnosed by clinical manifestations and radiologic grounds including abdominal computed tomography which shows multiple wedge shaped, poorly defined areas of decreased contrast enhancement in multiple renal lobes. In contrast to uncomplicated APN, the presence of AMBN seemed to correlate well with protracted clinical course and the need for prolonged antibiotic treatment. We report two cases of acute bacterial nephritis with the reviews of literatures which showed multifocal involvement of both kidneys and complicated with acute renal insufficiency.
담즙산으로 유도된 백서의 췌장손상에 대한 Prostaglandin E1의 효과
서정일,양진석,김학산,남홍우,이봉휘,송형운,지영구,이태광,한창순,한길로 대한소화기학회 1991 대한소화기학회지 Vol.23 No.2
To elucidate the cytoprotective effect of prostaglandin on pancreatic injury, we measured the mortality rate, the degree of pancreatic necrosis, and serum amylase level after prostaglandin E₂ administration in acute experimental pancreatitis which was induced by the retrograde injection of 5% sodium taurocholate into the biliopancreatic duct of rat. Prostaglandin E₁ (100 ㎍/㎏ Body Weight) were injected subcutaneously after 1 and 6 hour later after taurocholate injection, and normal saline solution (1 ㎖) to the control group by same method. The obstained results were as follows: 1) The mortality rate upto 72 hour was not different (11%: VS 29 %) in both group, but mortality rate upto 96 hour was significantly reduced in prostaglandin group compared with that of control group (11% vs 58% p$lt;0.05). 2) The mean serum level of anylase of control group was 773±55.2U and that of prostaglanin group was 772±61.1 U, which were not significantly different each other. 3) The degree of pancreatic necrosis was also reduced in prostaglandin group compared with control group. In conclusion, the present study suggest that prostaglandin E₂ will have a benefical effect on the course of acute pancreatic injury induced by sodium taurocholate.
정상인에서 단기간의 Indomethacin 경구 투여가 장 투과성에 미치는 영향
최은수,방신호,김학산,양진석,박원,이태광,윤윤보,민경완 대한소화기학회 1992 대한소화기학회지 Vol.24 No.5
The side effects of non-steroidal anti-inflammatory drugs (NSAIDs) involve mainly gastroduodenal mucosal lesions, however, recent studies suggest that NSAIDs ingestion can cause also the small intestinal diseases, which are characterized sequentially by inflammation, ulceration, perforation, and diaphramatic disease. This study examined the change of intestinal permeability after short-term oral administration of indomethacin and co-administration of synthetic prostaglandin E₁ analogue, Misoprostol, in healthy men. The subjects drank test solution containing ^(51)Cr-EDTA(100 μCi), and this was followed by 10 hour urine collection. The amount of ^(51)Cr-EDTA in the urine reflects non-mediated intercellular intestinal permeability. Indomethacin significantly increased intestinal permeability to ^(51)Cr-EDTA, and co-administration of prostaglandin E₁ analogue significantly decreased this detrimental effect of indomethacin. These findings suggest that prostaglandins are involved in maintaining intestinal integrity in man.