경찬해동불보 (敬贊海東佛報)

김학산 해동불보사 1941 해동불보 Vol.4 No.-

응급실환자에 대한 통계적 고찰

김학산,김영철,유수웅,김열자,이학중 최신의학사 1982 最新醫學 Vol.25 No.2

아드레나린성 약물이 유문부결찰 백서의 위분비 기능에 미치는 영향

김학산,김예식,김동구,홍사석 大韓消化器病學會 1987 大韓消化器病學會誌 Vol.19 No.1

토끼에서 Trinitrobenzene Sulfonic Acid ( TNBS ) 로 유발시킨 급성 대장 손상에 대한Warfarin의 영향

김학산,김동준,윤윤보,최은수,손행종(Haeng Jong Sohn),전원호(Won Ho Jeon),김광일 대한소화기학회 1994 대한소화기학회지 Vol.26 No.3

Inflammatory bowel disease is a group of chronic inflammatory disorders of unknown etiolo- gy involving the gastrointestinal tract. Wakefield et al suggested that Crohns disease is medi- ated by multifocal gastrointestinal infarction and recently Gaffney reported that marked im- provement in the patients with ulcerative colitis were noticed during treatment with heparin. This study was performed to find out, whether intrarectal infusion of TNBS 50mg into t.he rab- bit causes acute colitis or not, and whether warfarin pretreatment. Prevent.s colonic damage in duced by TNBS or not. The rabbits were randomly assigned to one of two groups, warfar in pretreated(N=6) and non treated(N=6). Warfarin solution was infused through the ear vein of the rabbit and TNBS 50mg was instilled into the colon of the rabbit. The rabbits were sacri ficed and the degree of colonic damage was recorded as visual analogue scale and microscopic findings. The results showed that intrarectal infusion of TNBS 50mg caused acut.e necrotic co litis, but warfarin pretreatment did not prevent TNBS induced acute colitis.(Korean J Gastro- enterol 1994; 26: 458 464)

생콩을 첨가 사육한 흰쥐의 이자 [췌장]외분비 기능 및 구조에 관한 연구

김학산,주일로,안영수,김경환 大韓消化器病學會 1990 大韓消化器病學會誌 Vol.22 No.4

조기위암의 임상적 고찰

김학산,윤윤보,최은수,서정일,손진희,조은경,손행종,전원호 대한소화기학회 1993 대한소화기학회 추계학술대회 Vol.1993 No.-

N/A

肺動脈 팻취利殖에 關한 實驗的硏究 : An Experimental Study

金鶴山 中央醫學社 1969 中央醫學 Vol.16 No.1

Macroscopic and histological studies were done on the patch graft of the main pulmomary artery trunk to expand the arterial lumen, utilizing crimped dacron vessel piece, homologous pericardium preserved in 70% ethlyalcohol, and fresh autogenous pericardium. Thirty dogs were grafted, among which there are one operative death and five short term survivors. The former expired due to laceration of the posterior aspect of pulmonary artery during dissection and most of the immediate post-operative deaths were due to infection, notably empyema. One, two, three, and four months post-operative long-term survivors were sacrificed to obtain specimens in each group respectively. The following observations were made in the long-term survivors. (A) Macroscopic findings: In one month specimens of the each group rough and thin loosely attached membrane on the vascular luminal surface of the patch was noticed but adventitial surface showed dense adhesion to the pericardium. Up to two months the intimal surface of the patch was rather rough in dacron and homopericardium, but in autopericardium it was smooth and glistening. In three months specimens, autopericardium patch showed completely smooth, glistening, and firm intimal surface which could hardly be differentiated from the imtima of the host's pulmonary artery. In dacron and homopericardium groups the above mentioned patch capsule findings were noted in the four months groups. In four months specimens suture materials were conpletely incorporated into the host tissue. No aneurysmal dilatation nor thrombose were noted: .. , Shrinkage of the graft in the long-term survivors were most remarkable in dacron and least in preserved homograft groups. (B) Microscopic findings: One months groups showed acute inflammatory processes, mainly consisting of neutrophile polymorphnuclear leucocyte infection and small necrotic debris with scattered round cells. Two months groups showed mixed findngs of receding inflamatory reactioin and reparing process, with abundant small cells, fibroblasts, and fibrocytes in and around the patch. In three months group reparing process was dominant with many fibroblasts and fibrocytes showing connective tissue proliferation and scattered small round cells and large mononuclear cells. In four months group fibrous connective tissue surrounded the patch completely and incorporated into it firmly. Very slight or almost no cell infiltration was noted. Intimal surface. of this capsule was smooth and showed endothelialization which can not be differentiated from the host's intima. In autopericardium group connective tissue capsule and endothelializaiion was complete in three months group showing the above mentioned findings. Among these three kinds of patch groups dacron showed the most severe and autopericardium showed the least tissue reaction. The autopericardium group required shorter period of time for complete healing than dacron and homopericardium.

기타 : 담즙산으로 유도된 백서의 췌장손상에 대한 Prostaglandin E1의 효과

김학산(Hak San Kim),이봉휘(Bong Hwi Lee),남홍우(Hong Woo Nam),송형운(Hyung Woon Song),지영구(Young Ku Jee),이태광(Tae Kwang Lee),양진석(Jin Suk Yang),한창순(Chang Soo Han),한길로(Kil Ro Han),서정일(Jung Il Suh) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.2

To elucidate the cytoprotective effect of prostaglandin on pancreatic injury, we measured the mortality rate, the degree of pancreatic necrosis, and serum amylase level after prostaglandin E, administration in acute experimental pancreatitis which was induced by the retrograde injection of 5% sodium taurocholate into the biliopancreatic duct of rat. Prostaglandin E, (100 ug/kg Body Weight) were injected subcutaneously after 1 and 6 hour later after taurocholate injection, and normal saline solution (1 ml) to the control group by same method. The obstained results were as follows: 1) The mortality rate upto 72 hour was not different (11%: VS 29 %) in both group, but mortality rate upto 96 hour was significantly reduced in prostaglandin group compared with that of control group (11% vs 58% p<0.05). 2) The mean serum level of anylase of control group was 773 +- 55.2U and that of prostaglanin group was 772 +- 61.1 U, which were not significantly different each other. 3) The degree of pancreatic necrosis was also reduced in prostaglandin group compared with control group. In conclusion, the present study suggest that prostaglandin E, will have a benefical effect on the course of acute pancreatic injury induced by sodium taurocholate.

조기위암의 임상적 고찰

김학산(Hak San Kim),김광일(Kwang Il Kim),손진희(Jin Hee Son),손행종(Haeng Jong Sohn),전원호(Won Ho Jeon),서정일(Jeong Ill Suh),윤윤보(Yoon Bo Yoon),조은경(Eun Kyung Cho),최은수(Eun Soo Choi) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.1

Background/Aims: Stomach cancer is the most common malignancy and one of the leading cause of death in Korea. However, the prognosis of early gastric carcinoma(EGC) has been reported execellent and this is why we emphasize the early diagnosis and treatment of gastric cancer. Methods: We analyzed 109 patients of early gastric carcinoma which had been confirmed by surgery and pathological examination from January 1986 to December 1992 in the National Medical Center. Resluts: The incidence of early gastric carcinoma was 18.5% of gastric resection for stomach cancer. Male to female ratio was 2.0:1 with male predominance. The commonly involved age of patients was 50 to 59 years and mean age was 55.2. The epigastric pain was predominant symptom and followed by epigastric discomfort and indigestion. The macroscopic classification revealed that the most common types were Ilc(31.9%) and its combined types(41.4%). In sixty cases(5l.7%), the lesions extended to the submucosa, while fifty five cases(48.3%) were confined to the mucosa. The incidence of metastases to regional lymph nodes in mucosal carcinoma was in 8.9% and that of submucosal lesions was 28.3%(p<0.05). The most commonly involved sites were antrum(60.3/) and lesser curvature(35.3%) of the stomach. Forty six cases(39.7%) were between 2.1 cm and 4.0cm in diameter and 15 cases less than 1cm. The most common pathologic type was tubular adenocarcinoma(82.8%), followed by signet ring ce11 carcinoma and mucinous adenocarcinoma. Overall 5 year survival rate for the entire group was 9l.6%. Conclusion: The clinical and pathologic features of early gastric carinoma in the National medical Center werc not much different from those of previous reports, except that the incidence was 18.5% in our series and higher than those of previous reports. (Korean J Gastroenterol 1995;27:31-38)

복수의 감별진단에 있어서 복수내 지질의 의의

김학산(Hak San Kim),이은주(Eun Joo Lee),김종순(Jong Soon Kim),최덕주(Duck Joo Choi),김관우(Kwan Woo Kim),김광일(Kwang Il Kim) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.3

N/A To evaluate the diagnostic value of ascitic lipid in liver cirrhosis, malignant neoplasm and tuberculous peritonitis, ascitic fluid concentration of cholesterol, beta-lipoprotein, triglyceride and protein were studied (25 with liver cirrhosis, 12 with malignant neoplasm and 5 with tuberculous peritonitis). The results were as follows: 1) The mean value for cholesterol, beta-lipoprotein, triglycerides and protein were significantly higher in malignant ascites compared to the mean for those in cirrhotics 2) The best discrimination values were 40mg per dl for cholesterol, 75mg per dl for beta-lipoprotein, 40 mg per dl for triglyceride and 2.5 gm per dl for protein. 3) Applying the discrimination value, efficiency were 94.0% for cholesterol, 91.0% for beta-lipoprotein, 75.2% for triglyceride and 86.7% for protein. We conclud that the level of cholesterol in ascitic fluid was the best parameter of differential diagnosis between liver cirrhosis and malignant neoplasm.