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신장 허혈 재관류 손상에 미치는 Ethyl Pyruvate의 효과
정구용(Ku-Yong Chung),정규영(Gyu Young Jeong),안형준(Hyung Joon Ahn),주만기(Man Ki Ju),장혜경(Hye Kyung Chang),이우정(Woo Jung Lee),한평림(Pyung-Lim Han),김유선(Yu Seun Kim) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.5
Purpose: Reactive oxygen species (ROS) significantly contribute to ischemia-reperfusion injury, and are also associated with the gradual loss of renal function and renal failure following renal transplantation. Pyruvate is an endogenous antioxidant, but its use as a therapeutic agent for treating conditions mediated by oxidative stress is limited due to its poor stability in solution. However, ethyl pyruvate (EP), a soluble pyruvate derivative, has far greater stability than pyruvate; thus, may serve as a practical pyruvate precursor. Therefore, the ability of EP in the prevention of renal ischemia- reperfusion injury was assessed. Methods: Sprague-Dawley rats (n=54) were subjected to 40 minutes of renal warm ischemia. The animals were divided into three groups: the sham group without warm ischemia (n=18), the EP group (n=18, EP given before ischemia), and the ischemic control (n=18). The serum levels of creatinine and TNF-α were measured 1, 3 and 5 days after induction of ischemia. The expression of high mobility group box-1 (HMGB-1), a delayed inflammatory mediator, was also assessed by Western blot of renal specimens. Results: In the EP group, late improvements in the serum levels of creatinine and TNF-α were observed in comparison with the ischemic control. Based on this delayed effect, the expression of HMGB-1 was assessed in renal tissue. The HMGB-1 expression increased over time during the ischemia process, but EP suppressed this expression 3 and 5 days after renal ischemia-reperfusion injury. Conclusion: These results have demonstrated, for the first time, that EP ameliorates renal ischemia-reperfusion injury. EP attenuates the renal ischemia-reperfusion injury, at least in part, by suppressing the expression of HMGB-1, a late mediator of delayed inflammation.
포장방법에 따른 한우 극상근(Supraspinatus Muscle)의 냉장 저장 중 품질 변화
정구용,정의룡,이현정,Chung, Ku-Young,Chung, Eui-Ryung,Lee, Hyun-Jung 한국축산식품학회 2007 한국축산식품학회지 Vol.27 No.4
본 연구에서는 한우 앞다리살 부위육인 극상근(Supraspinatus m.)의 포장방법(랩포장, 진공포장 및 가스포장)에 따른 냉장 저장 중 품질변화를 살펴보았다. 포장방법에 따른 pH 변화는 차이가 없었으며, VBN가는 가스포장구의 경우 저장 25일에도 17.65 mg%로 다른 포장구에 비해 낮은 수준이었다. 포장감량은 진공포장구, 랩포장구, 가스포장구의 순으로 높았으며, 육색은 가스포장구가 저장기간 동안 안정적 육색 값을 나타내었다. 경도는 포장구 중 가스포장구의 경도가 저장 15일에 1.74 kg으로 랩포장구의 2.57 kg 보다 낮았다. 총균수는 랩포장구에서 저장 20일에 8.50 log CFU/g로 가식권에 벗어났으나, 가스포장구의 경우 저장 25일에도 7.41 log CFU/g로서 다른 포장구에 비해 다소 저장성이 지연됨을 알 수 있다. 또한 진공포장구와 가스포장구는 랩포장구에 비하여 낮은 대장균군수를 나타내었다. 따라서 한우 극상근을 냉장 저장할 경우 가스포장 하는 것이 극상근의 품질 변화 없이 연도를 증진시키는 방법 이라 사료된다. The aim of this study was to investigate the quality changes in Supraspinatus muscle of Hanwoo with different packaging methods, such as wrapped packaging (C), vacuum packaging (V) and modified atmosphere packaging (MA). These samples were stored for 25 days under $5^{\circ}C$. Each sample was evaluated for pH, volatile basic mitrogen (VBN) value, purge loss, hardness, meat color and microbial counts. From the results obtained, no significant differences were observed among treatments at the pH. The VBN values of MA were significantly lower than those of C. Also, MA was enhanced stability of meat color compared with other packaging methods during storage days. The purge loss was the most in the V samples, followed by the C and the MA was the lowest. Total bacteria counts of MA sample were significantly lower than those from C. Therefore, it has been concluded that MA could be used as an effective packaging since it extends the shelf life and improve the quality of Hanwoo supraspinatus m.
정승진(Seung Jin Jung),황보율(Yul Hwangbo),정지훈(Ji Hoon Jung),김지훈(Jihoon Kim),김현우(Hyunwoo Kim),정구형(Ku Hyong Jeong),이동원(Dong Won Lee),조상현(Sang Hyun Cho),김현우(Hyun Woo Kim) 대한임상노인의학회 2018 대한임상노인의학회지 Vol.19 No.1
Background: There is insufficient data to analyze how the vitamin D status of the Koreans has changed over the years. The purpose of this study is to describe the trend of serum vitamin D concentration by using 25-hydroxyvitamin D [25(OH)D] concentrations measured from 2008 to 2014 (the 4th-6th period of KNHANES). Methods: KNHANES conducted a survey on participants who were 10 years old or older and whose blood 25(OH)D concentration was measured from 2008 to 2014. In this study, linear regression analysis was used to assess blood 25(OH)D concentration trends and logistic regression analysis was used to assess prevalence trends. Results: The mean serum 25(OH)D concentration of all age groups showed a statistically significant decrease. The serum 25(OH)D concentration of the twenties was the lowest in all the surveyed years and the serum 25(OH)D concentration of the forties showed the fastest declining trend. There was no significant increase in the prevalence of vitamin D deficiency in the group using dietary supplements. Conclusion: The serum vitamin D level of Koreans has been decreasing for seven years. Vitamin D replacement through dietary supplements is needed in the high risk group of vitamin D deficiency.
장폐쇄에서 나타나는 장점막 손상의 진단에서 내독소의 유용성
이정은(Jeong-Eun Lee),염차경(Cha-Kyong Yom),박재정(Jae-Jung Park),한기환(Ki-Hwan Han),허정원(Jung-Won Huh),성순희(Sun-Hee Sung),정구용(Ku-Yong Chung) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.2
Purpose: The treatment outcome of an intestinal obstruction depends on the early recognition and emergent operation of a strangulated intestinal obstruction. Endotoxin is a lipopolysaccharide component of the cell wall of gram negative bacteria that normally exist in the intestinal lumen. When a strangulated obstruction occurs, the endotoxin passes transluminally into the peritoneal cavity and blood stream. A disruption of the mucosal barrier is an important putative cause in this pathogenesis. This study investigated the relationship between the endotoxin level and progress of an intestinal obstruction to a strangulated obstruction. Methods: 25 adult male Sprague-Dawley rats (200∼250 g) were divided into 3 groups, the control group, simple obstruction group, and closed loop obstruction group. An intestinal obstruction was induced using a silk tie. Blood samples and obstructed bowel wall specimens were obtained at 24, 48 and 72 hours after surgery. The endotoxin and IL-6 levels were examined, and all specimens were reviewed by a pathologist for mucosal damage after H-E staining. Results: In the obstruction groups, dilated bowel loops at the proximal end of the obstruction site was identified but there were no ischemic changes. The endotoxin and IL-6 levels were similar regardless of the obstruction types and times. There were no differences between the three groups in the degree of mucosal damage. However, according to the endotoxin level, the groups with an endotoxin level <0.2 EU/㎖ showed mild mucosal damage. The severity of mucosal damage increased with increasing endotoxin level. Conclusion: There is a positive relationship (r2=0.673, P-value=0.002) between the endotoxin level and mucosal damage. This suggests the possibility of using endotoxin as a predictive factor for the detection of mucosal injury in an intestinal obstruction. However, a larger scale will be needed to confirm the statistical significance.
서울도시철도 3호선 ATC 차상신호장치 시험장치 연구개발
서경수(Kyoung-soo Seo),김영규(Young-gyu Kim),정구인(Ku-in Jung),이동훈(Dong-hun Lee) 한국철도학회 2018 한국철도학회 학술발표대회논문집 Vol.2018 No.10
ATC 차상신호장치는 차량 운행중 차량의 추돌 및 과속을 방지하기 위한 중요 장치로 그 동작 및 운영에 있어 높은 신뢰성이 요구된다. 본 논문에서는 서울교통공사 3호선에서 운영하고 있는 ATC 차상신호장치의 시험을 위한 시험장치의 연구개발 내용을 소개하고 그 결과를 제시하여 도시철도차량 부품의 기능 및 성능을 시험하기 위한 시험장치 연구개발에 시사점을 주고자 하였다.
도시철도차량 객실 혼잡 측정데이터 유효성 검증을 위한 모의테스트
김영규(Young Gyu Kim),김태도(Tae Do Kim),김영수(Young Su Kim),이석흥(Suk Heung Lee),정구인(Ku In Jung),김노중(No Joong Kim),오정애(Joung Ae Oh),신민창(Sin Min Chang) 한국철도학회 2016 한국철도학회 학술발표대회논문집 Vol.2016 No.5
본 연구는 도시철도역사 이용 혼잡관리 기술개발의 전동차 객실 혼잡도 측정시스템, 혼잡도 제어장치와 혼잡도 측정장치 기술 개발과제로 전동차 객실 내 승객의 체감혼잡도를 낮추고자 전동차 객실 내부의 혼잡도 측정데이터를 상용 LTE망에 전송하여 유효성 및 신뢰성 검증을 위한 모의테스트에 대하여 기술하고자 한다. This study sends a congestion measurement data of the train room inside to lower the city railway history using congestion management technologic EMU rooms congestion measuring system, congestion control and congestion measurement experience congestion within the device Development Project Room passengers on a commercial LTE network and to describe the practice test for the validity and reliability test.