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파목신 캅셀(아목시실린 500 mg)에 대한 곰실린 캅셀의 생물학적동등성
이윤영,최미희,이경률,이희주,Lee, Yun-Young,Choi, Mee-Hee,Lee, Kyung-Ryul,Lee, Hee-Joo 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.4
A bioequivalence study of $Gomcillin^{TM}$ capsules (DAEWOONG Pharmaceutical Co., Korea) to $Famoxin^{TM}$ capsules (Dong Wha Pharm. Ind. Co., Korea) was conducted according to the guideline of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the amoxicillin dose of 500 mg in a $2{\times}2$ crossover study. There was a one-week wash out period between the doses. Plasma concentrations of amoxicillin were monitored by a high-performance liquid chromatography for over a period of 8 hours after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 8 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Gomcillin^{TM}/Famoxin^{TM}$ were $log0.91\;{\sim}\;log1.03$ and $;log0.93\;{\sim}\;log1.10$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80\;{\sim}\;log1.25$. Thus, our study demonstrated the bioequivalence of $Gomcillin^{TM}$ and $Famoxin^{TM}$ with respect to the rate and extent of absorption.
SSL 프로토콜의 CipherSuite 설정 문제점과 해결 방안
이윤영,허순행,박상주,신동휘,원동호,김승주,Lee, Yun-Young,Hur, Soon-Haeng,Park, Sang-Joo,Shin, Dong-Hwi,Won, Dong-Ho,Kim, Seung-Joo 한국정보처리학회 2008 정보처리학회논문지 C : 정보통신,정보보안 Vol.15 No.5
인터넷과 정보통신기술의 사용이 일반화되면서 인터넷 상에서 중요한 데이터를 안전하게 전송해야 함에 따라 SSL 프로토콜의 사용은 필수요소가 되었다. SSL 프로토콜은 메시지 위/변조 공격과 같은 능동적인 공격에 안전하도록 설계가 되었지만 CipherSuite 설정 변경은 별다른 제약 없이 수정이 가능하다. 공격자가 Client의 시스템의 오작동을 유도하여 CipherSuite 설정을 키 길이가 낮은 대칭키 알고리즘으로 변경한다면 도청하여 데이터를 해독할 수 있다. 본 논문은 키 길이가 낮은 대칭키 알고리즘 설정에 대한 국내 웹사이트의 보안세션 생성 조사 및 CipherSuite 설정 문제점에 대한 해결책을 제시한다. As the use of Internet and information communication technology is being generalized, the SSL protocol is essential in Internet because the important data should be transferred securely. While the SSL protocol is designed to defend from active attack such as message forgery and message alteration, the cipher suite setting can be easily modified. If the attacker draw on a malfunction of the client system and modify the cipher suite setting to the symmetric key algorithm which has short key length, he should eavesdrop and cryptanalysis the encrypt data. In this paper, we examine the domestic web site whether they generate the security session through the symmetric key algorithm which has short key length and propose the solution of the cipher suite setting problem.
Trichloroethylideneacetone과 Hydrazine 들의 반응 (Ⅰ)
이윤영,이우영,장세희,Lee, Youn Young,Lee Woo Young,Chang Sae Hee Korean Chemical Society 1972 대한화학회지 Vol.16 No.4
2, 6-Disubstituted-3-pyridazinones were synthesized from the reaction of trichloroethylideneacetone with substituted phenylhydrazines. From the reaction of trichloroethylideneacetone with ο-nitrophenylhydrazine, pyridazinone derivative was not obtained, but ${\gamma},{\gamma}$-dichloro-${\gamma}$-(o-nitrophenylhydrazino)-ethylideneacetone was obtained in 24% yield.
Reactions of $\gamma$,$\gamma$,$\gamma$-Trichloroethylidene-m-Nitroacetophenone with Hydrazines
이윤영,송석주,Youn Young Lee,Suk Zu Song Korean Chemical Society 1973 대한화학회지 Vol.17 No.1
$\gamma$,$\gamma$,$\gamma$-Trichloroethylidene-m-Nitroacetophenone과 phenylhydrazine및 치환된 phenylhydrazine들과의 반응으로 2,6-disubstituted-3-pyridazinone들을 합성하였으며 2,4-dinitrophenylhydrazine과의 반응에서는 hydrazone을 중간체로 분리하였다. hydrazinehydrate와의 반응에서는 3-(mnitrophenyl)-5-trichloromethyl-2-pyrazoline이 좋은 수득률로 얻어졌다. 또한$\gamma$,$\gamma$,$\gamma$-trichloroethylidene-m-nitroacetophenone과 치환된 phenylhydrazine과의 반응에서 phenyl기에 결합된 치환기의 효과를 검토하였다. 2,6-Disubstituted-3-pyridazinones were synthesized by the reactions of $\gamma$,$\gamma$,$\gamma$-trichloroethylidene-m-nitroacetophenone with phenylhydrazine and substituted phenylhydrazines, and hydrazone was isolated as an intermediate from the reaction with 2, 4-dinitrophenylhydrazine. From the reaction with hydrazine hydrate 3-(m-nitrophenyl)-5-trichloromethyl-2-pyrazoline was obtained in good yield. The effect of substituents on phenyl group in the reaction of $\gamma$,$\gamma$,$\gamma$-trichloroethylidene-m-nitroacetophenone with substituted phenylhydrazines was also discussed.
이윤영,이우영,장세희,Lee, Youn-Young,Lee, Woo-Young,Chang, Sae-Hee Korean Chemical Society 1970 대한화학회지 Vol.14 No.1
3-Phenyl-5-trichloromethyl-2-pyrazoline was synthesized from the reaction of trichloroethylideneacetophenone with hydrazine hydrate. Pyridazinone derivatives were synthesized from the reaction of trichloroethylideneacetophenone with phenylhydrazine or substituted phenylhydrazines. trichloroethylideneacetophenone과 hydrazine hydrate의 반응으로 3-phenyl-5-trichloromethyl-2-pyrazoline을 합성하였다. 또한 trichloroethylideneacetophenone과 phenylhydrazine 또는 치환된 phenylhydrazine의 반응으로 pyridazinone 유도체들을 합성하였다.
Cycloaddition of Homophthalic Anhydrides to Azodicarboxylate and Alkylidenecarbamates
이윤영,김호현,구양모,Youn Young Lee,Ho Hyeon Kim,Yang Mo Goo Korean Chemical Society 1986 대한화학회지 Vol.30 No.2
호모프탈산 무수물(1또는 2)과 디에틸 아조디카르복시산 및 에틸 아릴메티리덴카르밤산과의 고리화첨가반응을 검토하였다. 전자의 반응에서는 2,3--디에톡시카르보닐-2,3-디히드로-1-히드록시프탈라진들(3 및 4)이 생성되었으며, 후자의 반응에서는 3-아릴-4카르복시-2-에톡시카르보닐-3,4-디히드로-1(2H)-이소퀴놀린온들(5~10)이 생성되었다. The cycloaddition between homophthalic anhydrides (1 or 2) and diethyl azodicarboxylate and ethyl arylmetbyldenecarbamates was investigated. The former led to 2,3-diethoxycarbonyl-2,3-dihydro-1-hydroxyphthalazines (3 and 4), while the latter gave 3-aryl-4-carboxy-2-ethoxycarbonyl-3,4-dihydro-1(2H) isoquinolinones (5∼10).