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연부조직종괴로 오인된 늑골의 동맥류성 골낭종 - 증례 보고 -
이아원,이연수,조건현,이중달,김병기,Lee, Ah-Won,Lee, Youn-Soo,Jo, Gun-Huyn,Lee, Jung-Dal,Kim, Byung-Kee 대한근골격종양학회 2000 대한골관절종양학회지 Vol.6 No.4
동맥류성 골낭종(aneurysmal bone cyst)은 비종양성 팽륜성 골 병변으로 정확한 병인은 밝혀지지 않았지만 반응성 현상으로 생각되며, 다른 골 병변과 동반되거나 원발성으로 발생한다. 동맥류성 골낭종은 주로 장골과 척추골에 발생하며, 늑골에서 발생하는 경우는 드물다. 저자들은 좌측 첫번째 늑골에서 발생하였으며, 연부조직 악성 종양으로 오인되었던 동맥류성 골낭종 1예를 경험하였기에 보고하는 바이다. 19세 여자 환자가 좌측 견갑부에서 촉진되는 종괴를 주소로 내원하였다. 방사선학적 검사상, 광범위한 연부조직 병소이며 낭성구조로 이루어진 불균일한 양상이었고, 인접한 좌측 첫번째 늑골의 부분적 골소실이 있어, 연부조직에서 발생한 악성 종양 의진하에 절제술을 시행하였다. 절제된 종괴의 육안 소견상, 종괴 변연부를 달걀 껍질같이 얇은 한층의 골조직이 싸고 있는 것이 관찰되어 늑골 기원의 병변이라는 것을 알 수 있었다. 광학 현미경 검사상, 종괴는 큰 동맥류성 공간으로 이루어져 있었고 혈액으로 차 있었다. 동맥류성 공간사이를 피복세포가 없이 섬유성 격이 나누고 있으면서 여기에는 파골세포와 유사한 다핵 거대세포, 단핵세포, 유골과 섬유점액성조직이 관찰되었다. 병리 소견에 따라 재검한 MRI에서, 늑골에서 종괴의 변연부로 이어지는 얇은 골구조가 관찰되어 늑골에서 발생한 동맥류성 골낭종이 연부조직 쪽으로 광범위하게 돌출해 나온 것임을 알 수 있었다. Aneurysmal bone cyst(ABC) is a benign lesion and generally occurs in the long bones and vertebral column. ABC of the rib is an uncommon entity. We reported a case of ABC originating in the left first rib. The patient was a 19-year-old woman and presented with palpable mass on the shoulder. Chest X ray and MRI showed a large expansile mass, with multiple cystic areas, arising from the left first rib and bulging out into retroclavicular and paravertebral soft tissue, so the lesion was initially misdiagnosed as a soft tissue malignant tumor destructing adjacent rib. On histological examination, the mass, which was surrounded by a peripheral band of mature trabecular bone, consisted of multiple anastomosing cavernous blood channels separated by fibrous septa that containing osteoid, myxochondroid material and osteoclast-type giant cells.
타액선 유두상-낭성 선방세포암종의 세침흡인 세포학적 소견 - 1예 보고 -
이아원,유진영,김병기,강석진,Lee, Ah-Won,Yoo, Jin-Young,Kim, Byung-Kee,Kang, Seok-Jin 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.1
Acinic cell carcinoma(ACC) is the third common malignancy in major salivary gland. Fine needle aspiration cytology is a useful tool for the diagnosis of salivary gland lesions. However, some low grade malignancies, such as ACC and mucoepidermoid carcinoma show relatively high false negative rate, mainly due to deceptively benign cytomorphologic appearance. We experienced a papillary-cystic variant of ACC, having different cytopathologic features compared with those of classic ACC. Our case showed monolayered sheets and papillary clusters without any acinic structures or naked nuclei of the tumor cells. Foamy proteinaceous material was seen in the background. The tumor cells had a large amount of granular cytoplasm and eccentric nuclei. Many vacuolated or clear cells were also noted.
유방의 낭내 유두상 암종의 세침흡인 세포학적 소견 - 1예 보고 -
이아원,최영진,이교영,김병기,김선무,심상인,Lee, Ah-Won,Choi, Yeong-Jin,Lee, Kyo-Young,Kim, Byung-Kee,Kim, Sun-Moo,Shim, Sang-In 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.2
Intracystic papillary carcinoma(IPC) of the breast is a distinctive and very rare variant of intrductal carcinoma. The cytologic features of IPC have been rarely reported, and there are difficulties in distinguishing between benign and malignant papillary breast lesions. Herein we report a IPC of the breast in a 80 year-old female. Fine needle aspiration cytology revealed monotonous cuboidal epithelial cells in small clusters and individually scattered on bloody background. The tumor cells did not show overt cytologic atypia. With the histologic features of this case and review of the literature, the cytologic differential points are discussed.
박재현,정재희,이아원,송영택,Park, Jae-Hyun,Jung, Jae-Hee,Lee, Ah-Won,Song, Young-Tack 대한소아외과학회 2001 소아외과 Vol.7 No.2
Clear Cell Sarcoma of the Kidney(CCSK) is a rare malignant childhood tumor with frequent metastasis to the bone. We report a case of right sided in a 5 month-old girl. A radical nephrectomy was performed. It was clinical stage III with renal capsular invasion and lymph node metastasis by the classification of NWTS-5. Histologic examination revealed the classic pattern of CCSK. Postoperative adjuvant chemotherapy with doxorubicin and radiotheraphy were applied.
편평세포암종으로 오인된 와르틴 종양의 세침흡인 세포소견 -증례 보고-
이경지,정찬권,이아원,강창석,이교영,Lee, Kyung-Ji,Jung, Chan-Kwon,Lee, Ah-Won,Kang, Chang-Suk,Lee, Kyo-Young 대한세포병리학회 2005 대한세포병리학회지 Vol.16 No.2
We report a case of Warthin's tumor of the parotid gland in a 53 year old man, which is incorrectly diagnosed as squamous cell carcinoma. Fine needle aspiration cytology(FNAC) smear obtained from the right parotid gland revealed scattered epithelial cell clusters or nests in a diffuse inflammatory and necrotic background. Some epithelial cells had squamoid appearance showing variable sized bizarre shaped nuclei. They had abundant of dense eosinophilic keratinized cytoplasm. Occasionally, parakeratotic cells were also present. These cytologic findings with significant atypia and necrotic background made diagnosis as squamous cell carcinoma. But, the resection specimen from this patient showed classic Warthin's tumor in addition to abundant areas of inflammation and squamous metaplasia. Metaplastic or infarcted Warthin's tumor in the salivary gland may be confused with false positive diagnosis of malignancy on FNAC. Therefore, cytopathologist should have adequate awareness of potential of erroneous diagnosis in FNAC of Warthin's tumor.
질 확대경상 비정상 소견을 보인 환자에서 HPV DNA chip과 Hybrid-Capture II assay의 임상적 유용성 비교
김태정,정찬권,이아원,정은선,최영진,이교영,박종섭,Kim, Tae-Jung,Jung, Chan-Kwon,Lee, Ah-Won,Jung, Eun-Sun,Choi, Young-Jin,Lee, Kyo-Young,Park, Jong-Sup 대한세포병리학회 2008 대한세포병리학회지 Vol.19 No.2
This study was performed to compare the efficacy between a DNA chip method and a Hybrid-Capture II assay (HC-II) for detecting human papillomavirus in patients with intraepithelial lesions of the uterine cervix. From May, 2005, to June, 2006, 192 patients with abnormal colposcopic findings received cervical cytology, HC-II and HPV DNA chip tests, and colposcopic biopsy or conization. We compared the results of HC-II and HPV DNA chip in conjunction with liquid based cervical cytology (LBCC) and confirmed the results of biopsy or conization. The sensitivity of the HPV DNA chip test was higher than HC-II or LBCC. The HPV DNA chip in conjunction with LBCC showed higher sensitivity than any single method and higher sensitivity than HC-II with LBCC. We confirmed that the HPV DNA chip test was more sensitive for detecting HPV in cervical lesions than HC-II, and that it would provide more useful clinical information about HPV type and its multiple infections.
소포성 갑상샘 유두암종의 세침흡인 세포검사의 정확도와 Galectin-3 면역염색의 유용성
정찬권,신정하,이현승,이아원,정은선,최영진,이교영,Jung, Chan-Kwon,Shin, Jung-Ha,Lee, Hyun-Seung,Lee, Ah-Won,Jung, Eun-Sun,Choi, Yeong-Jin,Lee, Kyo-Young 대한세포병리학회 2008 대한세포병리학회지 Vol.19 No.2
The cytologic diagnosis of the follicular variant of papillary thyroid carcinoma (FVPTC) has become one of the common causes of false negative diagnoses when performing fine needle aspiration cytology (FNAC) of the thyroid gland. We retrospectively reviewed all the aspirates for which a diagnosis of FVPTC had been made based on the surgically excised specimens, regardless of the cytologic diagnosis. 145 FNACs was performed in 135 patients. The cytologic diagnoses were categorized as 2 unsatisfactory specimens (1.4%), 16 benign (11.0%), 49 atypical (33.8%) and 78 malignant lesions (53.8%). The tumor cells consistently showed significant nuclear overlapping, irregular nuclei and fine chromatin in all cases; however, nuclear grooves and inclusions were scarce. Galectin-3 immunostaining was performed on the cell blocks of 65 cases and this was positive for 45 cases (69.2%). The results of our study demonstrate that the determination of minimal cytologic criteria is needed to raise the sensitivity of detecting FVPTC by FNAC, and galectin-3 immunostaining is useful to make decisions on the surgical treatment of cytologically atypical thyroid nodules.
조송미,지원희,유이령,이아원,정양국,Cho, Song-Mee,Jee, Won-Hee,Yoo, Ie-Ryung,Lee, Ah-Won,Chung, Yang-Guk The Korean Musculoskeletal Tumor Society 2010 대한골관절종양학회지 Vol.16 No.1
Fibrous dysplasia is a common benign disorder of bone in which normal bone marrow is replaced with fibro-osseous tissue. As PET/CT is increasingly used for the staging of different malignant disease, incidentally found fibrous dysplasia with increased FDG uptake may mimic metastasis. We report on a 46-year-old woman with fibrous dysplasia who underwent PET/CT because of suspected recurrence of breast cancer and was misdiagnosed as a bony metastasis with a focal FDG uptake on left proximal femur. This lesion was interpreted as fibrous dysplasia based on MRI in addition to the plain radiographs. We conclude that MRI in addition to radiography may help to differentiate fibrous dysplasia mimicking metastasis on PET/CT in the patients with malignancy. 섬유형성이상은 골수가 섬유-골성 조직으로 치환되는 흔한 양성 골 질환이다. 암환자에서 병기의 결정과 추적 검사 시 암 전이의 발견에 PET/CT의 역할이 증가됨에 따라 우연히 발견된 FDG 섭취 증가를 보이는 섬유형성이상에서 암 전이와의 감별이 중요하다. PET/CT를 시행한 46세의 유방암 환자에서 좌측 대퇴골에 국소 FDG 섭취를 보여 암 전이로 의심되었으나 단순촬영과 자기공명 영상 소견에서 섬유형성이상으로 진단한 환자의 증례를 보고하고자 한다. 이 환자에서 단순활영과 자기공명영상 소견은 PET/CT에서 유방암 전이로 오인된 섬유형성이상의 감별에 도움이 되었다.
췌장의 점액 낭샘암종의 세침흡인 세포소견 -1예 보고-
이경지,이교영,강창석,심상인,이아원,Lee,, Kyung-Ji,Lee, Kyo-Young,Kang, Chang-Suk,Shim, Sang-In,Lee, Ah-Won 대한세포병리학회 2005 대한세포병리학회지 Vol.16 No.2
Mucious cystic neoplasm of pancreas is a cystic neoplasm composed of columnar, mucin-producing epithelium and is supported by ovarian-type stroma. The key to the cytologic evaluation of pancreatic cystic lesions is to recognize the cytologic components as being diagnostic of a mucin-producing cystic neoplasm, as all of these neoplasms need to be resected. We report the use of fine needle aspiration cytology in the diagnosis of an invasive mucinous cystic carcinoma confirmed by partial pancreatectomy. The cytologic specimen showed a abundant mucin background and sheets or papillae of neoplastic cells. There are mucin-containing columnar cells that show a variable degree of cytologic atypia.
이하선의 상피-근상피암종 - 세침흡인 세포검사에서 다형성선종으로 오진된 1 예 보고 -
김동철,이교영,강창석,심상인,이아원,Kim, Dong-Chul,Lee, Kyo-Young,Kang, Cang-Suk,Shim, Sang-In,Lee, Ah-Won 대한세포병리학회 2002 대한세포병리학회지 Vol.13 No.1
Epithelial-myoepithelial carcinoma(EMC) is a rare, low grade malignant tumor of the salivary glands. The EMC has a distinctive histological appearance comprising ductal structures with an inner epithelial cell component and an outer layer of myoepithelial cells which show plump clear cytoplasm. The cytologic features of the EMC have been rarely described. A correct cytological diagnosis to this rare tumor is difficult with high false negative rate. We report a case of EMC in which fine needle aspiration cytologic findings were misinterpreted as a pleomorphic adenoma.