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육계 에탄올 추출물이 HT-29 대장암 세포주의 성장 및 COX-2 기전에 미치는 영향
이승연(Seung Youn Lee),김희석(Hee Seok Kim),김정옥(Jeoung Ok Kim),황성완(Sung Wan Hwang),황성연(Sung Yeoun Hwang) 한국식품영양과학회 2006 한국식품영양과학회지 Vol.35 No.9
육계 추출물의 대장암 세포에 미치는 영향을 HT-29 인체 결장암 세포주를 이용하여 조사하였다. 육계 추출물은 대장 정상세포인 CCD-112CoN의 성장에는 크게 영향을 미치지 않았으나, 대장암 세포인 HT-29의 성장은 농도, 시간에 의존적으로 크게 억제하였고, 대장암의 진행 과정에서 매우 중요한 COX-2 mRNA 발현량 및 PGE₂ 생성, cGMP 생성을 농도 의존적으로 억제하였다. 이상의 결과에서 육계 추출물은 정상세포에는 독성 없이 대장암 세포의 COX-2 및 PGE₂, cGMP 생성을 억제함으로써 결과적으로 대장암 세포의 성장을 감소시킨 것으로 판단된다. 따라서 육계는 부작용이 없는 대장암 예방 건강 보조식품으로서 개발 가능성이 있으며, 암세포 사멸에 대한 더욱 정확한 작용기전의 규명과 활성성분의 분리 및 정제, 응용법 등의 연구가 필요할 것으로 사료된다. The effect of cinnamon ethanol extract (CN) on HT-29 cancer cell line has been examined. CN inhibited the growth of HT-29 colon cancer cells in a concentration- and time-dependent manner but not the growth of CCD-112CoN normal colon cells. And CN markedly inhibited the production of PGE₂ and cGMP as well as the mRNA expression of COX-2. These data suggest that non-toxic concentration of CN has a significant inhibition effect on the growth of HT-29 cells, probably through the inhibition of PGE₂ production via COX-2 inhibition, and may have value as a safe chemopreventive agent for colon cancer.
한국인 남자에서 Synapsin III 유전자의 D22S280 표지자와 정신분열병의 연합연구
이유상,박종원,이승연,이석진,박용범,신윤식,유장근,홍경수,양병환,Lee, Yu-Sang,Park, Chong-Won,Lee, Seung-Yeoun,Lee, Suk-Jin,Park, Yong-Bum,Shin, Yoon-Sik,Yoo, Jang-Keun,Hong, Kyung Sue,Yang, Byung-Hwan 대한생물정신의학회 2006 생물정신의학 Vol.13 No.4
Objectives : Synapsin III near VCFS region on chromosome 22q affects. It could be an interesting candidate gene for schizophrenia. D22S280 is a highly polymorphic genetic marker residing in synapsin III. We examined association of D22S280 marker on synapsin III with Korean patients with schizophrenia. Methods : The subjects were 46 male Korean patients with schizophrenia and 60 male normal controls. Using polymerase chain reaction, gel electrophoresis, ABI 310 genetic analyzer, and GeneScan Collection 3.1 software, we confirmed genotypes of D22S280 marker. We examined Hardy-Weinberg equilibrium and case-control association using SAS/Genetic 9.1.3. Results : Genotypes of both schizophrenia and control groups were in Hardy-Weinberg equilibrium. We could not find any significant statistical differences in allele-wise(${\chi}^2$=10.4, df=6, p=0.098) and genotype-wise (${\chi}^2$=22.1 df=19, p=0.258) analyses of D22S280 marker between schizophrenia and normal controls. Individual allele analyses with df=1 showed significant differences in A1(p=0.025) and A7(p=0.034) allele, which were not significant following Bonferroni corrections(A1:p=0.177, A7:p=0.235). Conclusion : We couldn't find any association between schizophrenia and the synapsin III gene. Given the small number of subjects studied, further investigations are needed.
김용규,신재공,박종원,홍경수,이승연,오홍석,이용석,곽용태,장재승,이유상,Kim, Yong-Kyu,Shin, Jae-Kong,Park, Chong-Won,Hong, Kyung Sue,Lee, Seung-Yeoun,Oh, Hong-Seok,Lee, Yong-Suk,Kwak, Yong-Tae,Chang, Jae Seung,Lee, Yu-Sang 대한생물정신의학회 2005 생물정신의학 Vol.12 No.2
Objectives:EEG coherence could imply the connectivity between two different areas of the brain, which is known to be important in the pathophysiology of bipolar I disorder(BPD I) and schizophrenia. The authors investigated EEG coherence in patients with BPD I and schizophrenia to examine the connectivity of the neural circuit. Methods:EEGs were recorded in 15 schizophrenia and 14 bipolar disorder patients, and 14 age-matched normal control subjects from 16 electrodes with linked-ear reference. Spectral parameters and coherence were calculated for the alpha bandwidth(8-13Hz) by a multi-channel autoregressive model using 20 artifact-free 2-seconds epochs and the differences were compared among three groups by two different statistical methods;F-test and Kruskal-Wallis test. Furthermore, when there were significant differences among three groups, Scheffe's multiple comparison tests were provided and Jonckheere-Terpstra tests for the ordered alternative were given. Results:In the intra-hemispheric comparison, left frontal coherence was increased in order of control, BPD I and schizophrenia. In the inter-hemispheric comparison, 1) inter-prefrontal coherence in BPD I was signifi- cantly higher than in normal controls, and 2) inter-prefrontal coherence in schizophrenia was significantly lower than in controls. Conclusion:These results suggest that 1) both schizophrenia and BPD I are diseases having the abnormality of neural circuit connectivity in both frontal and prefrontal lobes, and 2) the abnormality is more severe in schizophrenia than in BPD I. Furthermore, the data support that a common pathogenetic process may reside in both schizophrenia and BPD I.
한국 조현병 환자에서 검지-약지 길이비와 발병 연령 및 대사 장애와의 연관성
김홍래,이중선,주연호,원승희,류승형,홍경수,권준수,이승연,오홍석,최준호,이유상,Kim, Hong Rae,Lee, Jung Sun,Joo, Yeon Ho,Won, Seunghee,Ryu, Seunghyong,Hong, Kyung Sue,Kwon, Jun Soo,Lee, Seung Yeoun,Oh, Hong Seok,Choi, Joon Ho,Lee, Yu Sa 대한생물정신의학회 2017 생물정신의학 Vol.24 No.3
Objectives The ratio of second to fourth digit length (2D : 4D) could be a potential epigenetic marker of sexual dimorphism reflecting prenatal testosterone exposure. Testosterone is known to affect the development of the brain through an epigenetic mechanism. The purpose of this study was to investigate the effects of exposure to fetal testosterone on the metabolic syndrome based on 2D : 4D of schizophrenia patients and the relationship with the age of onset of schizophrenia. Methods A total of 214 schizophrenia patients participated in this study. The participant's physical and blood tests were performed according to the American National Cholesterol Education Program's Third Amendment of the Metabolic Syndrome Diagnostic Criteria, and the 2D : 4D was measured by the method designed by McFadden. Data were statistically analyzed by t-test, Pearson's correlation analysis and multiple regression model analysis. Results 2D : 4D was significantly higher in female than male in both hands, and there was a statistically significant negative correlation between 2D : 4D and the age of onset of schizophrenia in male. However, 2D : 4D did not show statistically significant correlation with metabolic factors. Conclusions Fetal testosterone suggests the possibility of affecting the age of onset of schizophrenia through the epigenetic mechanism, but there is no clear relationship with metabolic factors.
박태성,이용성,이승연,이승묵,이성곤,강성현,최호식,유동현,장미윤 한국보건통계학회 2001 한국보건정보통계학회지 Vol.26 No.1
Microarrays are novel biotechnologies which are being used increasingly in medical research. By allowing the monitoring of expression levels for thousands of genes simultaneously, such a microarray technique may lead to a more complete understanding of the molecular variations and may detect differentially expressed genes. However, except for some basic classification and clustering analyses, and testing procedures, not many sophisticated statistical analysis methods have been developed. In this paper, we consider a regression model approach to detect a differentially expressed genes in a single microarray and compare it with other approaches.