http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
가족기반연구에서 형매정보를 이용한 유전적 연관성 분석방법의비교
정지원,이석훈,김순애,박미라,Jung, Ji-Won,Lee, Suk-Hoon,Kim, Soon-Ae,Park, Mi-Ra 한국통계학회 2010 Communications for statistical applications and me Vol.17 No.5
가족기반 유전연구에서 단일염기다형성(SNP) 및 일배체형(haplotype)을 이용한 질병-유전자간 연관성 분석은 주요 관심부분 중 하나이다. 이진형질인 경우 사용되는 고전적인 TDT(transmission/disequilibrium test)는 부/모/자의 유전정보를 모두 알 수 있을 때에 쓸 수 있다. 그러나 경우에 따라서는 부모의 유전자형에 대한 정보를 사용할 수 없을 수가 있는데, 치매등과 같이 늦게 발병하는 질환에서 이런 경우가 자주 발생한다. 부모의 유전자형을 모를 때 이를 대체할 수 있는 방법으로 형매(sib)의 유전정보를 이용하는 방법이 있다. 본고에서는 가족기반연구에서 형매의 유전정보를 이용하는 분석방법에 대해 고찰하고 모의실험을 통해 이들의 검정력을 비교하였다. Recently, disease-genetic association analyses using single nucleotide polymorphisms(SNPs) and haplotypes in family-based genetic study have come into the spotlight. In binary trait, the classic transmission disequilibrium test(TDT) can only be applied if genetic information of parents and their offspring is available. However, in case of diseases having a late age of onset such as dementia, the TDT cannot be applied due to the fact that parental genotype data are unavailable. For this reason, alternate methods using genetic sib information instead of parental genotype data are proposed. In this study, methods using genetic sib information are reviewed and power of analysis tests is also compared throughout simulation experiment.
Poly (DADM) 고분자 응집제의 합성 및 상수처리 특성
박이순,신준호,최상준,신명철,이석훈 한국환경과학회 1998 한국환경과학회지 Vol.7 No.5
Poly(DADM) was synthesized for the drinking water treatment. Poly(DADM) was produced by the free radical polymerization of diallyldimethylammonium chloride(DADM) monomer and its properties were characterized. The effects of monomer concentration, initiator concentration and reaction time on synthesis of poly(DADM) were investigated. Poly(DADM) flocculant was applied to Nak-dong river water to examine its efficiency in reducing turbidity. The synthesized poly(DADM) was effective as flocculant for drinking water treatment. The addition of 1 ㎎/L.of poly(DADM) flocculant caused the reduction of 50 % PAC(polyaluminium chloride).
Polyamine 고분자 응집제의 합성과 상수처리의 적용
신명철,최상준,이석훈,신준호,박이순 한국환경과학회 1998 한국환경과학회지 Vol.7 No.3
Polyamine was synthesized for the drinking water treatment. Polyamine was produced by the two step polycondensation of dimethylamine(DMA) and epichlorohydrin(EPI) and its properties were characterized. The effects of mole ratio of [DMA],/[EPI], reaction temperature and reaction time on synthesis of polyamine were investigated. Polyamine flocculant was applied to Nak-dong river raw water to examine its efficiency in reducing turbidity. The synthesized polyamine was effective as flocculant for drinking water treatment. The addition of 1 ㎎/L of polyamine flocculant caused the reduction of 50% PAC (polyaluminium chloride).