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柳榮海 대한감염학회 1973 감염 Vol.5 No.1
고래로부터 동서양을 막론하고 질병이 인류에게 큰 위협이 되어온 것은 조화의 사실이다. 또한 비록 체계는 다를지언정 동서양의 의학이 질병을 치료함에 있어서 기질병이 발생케된 원인과 경로 및 경과에 대한 추긍에 주력하여 온것도 사실이다. 즉 인체에 있어서 일정한 원인과 조건이 성립되었을때에 특정한 병변이 발생되며 그 결과로 말미암아 주관적 혹은 객관적으로 관찰할 수 있는 증후군이 발현되는 것으로 이해된다.
1971年度 韓國에서 分離 된 살모넬라 菌屬의 同定에 關한 報告
柳榮海,金英子 대한감염학회 1972 감염 Vol.4 No.1
The authors identified 176 Salmonella cultures either isolated from the apparent cases in various epidemic areas or collected from the Seoul infectious diseases hospital, the provincial hygiene laboratories and the county health centers in order to be confirmed bacteriologically during the period from January to December in 1971 since the preparation for establishing Korean National Salmonella Center was on the pavement to provide the diagnostic service over the country. The screening procedures for the morphological and biochemical tests, and the serological determinations for the somatic and flagellar antigens as well as Vi antigen were performed according to the recommendations made by U.S. Center for Disease Control. The results of the laboratory tests were summarized as follows: 1. Of 176 Salmonella cultures, 163 Salmonella typhi with Vi antigen and 13 other Salmonella cultures were confirmed. 2. With 163 S. typhi cultures, all typically showed methyl red positive, motility positive, acid from glucose positive, mannitol positive. 9.2% showed sorbitol positive, 0.6% showed arabinose positive, 61.4% showed arginine dihydrolase positive and 77.3% showed D-tartrate positive as summarized in Table 1. 3. With 13 Salmonella cultures other than S. typhi, 92.3% showed Simmons' citrate positive, and all produced acid and gas from glucose. All showed sorbitol positive, 84.6% showed dulcitol positive, 23.1% showed inositol positive, 92.3% showed arabinose positive, 69.3% showed rhamnose positive, 15.4% showed mucate positive, and all showed lysine decarboxylase and arginine dihyrolase positive as summarized in Table 1, too. 4. Of 13 Salmonella cultures other than S. typhi, one S. paratyphi A, one S. typhimurium, one S. jericho, one S. colorado, one S. bareilly, three S. berta and five S. enteritidis cultures were confirmed as shown in Table 2 and S. jericho was considered not to have ever been reported in the country before. 5. The sensitivity tests, by means of Ericsson's disc method, to eight kinds of antibiotics were carried out, i.e. chloramphenicol, neomycin, erythromycin, colistin, kanamycin, tetracycline, streptomycin, and ampicillin, which were widely in common use in Korea and the result were compared with that of Salmonella cultures isolated during the period from 1967 to 1970 as shown in Table 3. There were three cultures resistant to chloramphenicol and 27 cultures (17%) resistant to ampicillin found among 163 cultures of S. typhi. With 13 cultures of Salmonella other than S. typhi, five cultures were found to be resistant to ampicillin, but none to chloramphenicol. 6. In regards to the multiple resistance to the antibiotics tested, with 163 cultures of S. typhi, all cultures tested showed multiple resistant patterns to more than three kinds of antibiotics in various combinations as shown in Table 4. 152 cultures(ca 93%) showed multiple resistant patterns to more than four kinds of antibiotics in various combinations. 128 cultures (79%) showed that to more than five kinds of antibiotics and 33 cultures (18%) showed that to more than six kinds of antibiotics in various combinations including chloramphenicol. And the results were also compared with the results obtained from the previous study during the period from 1967 to 1970 as shown in Table 4.
최근 우리나라 장내 세균성 질환의 발생양상에 관한 연구
金仁達,盧忍圭,柳榮海 서울대학교 1974 서울대학교 論文集 Vol.24 No.-
The occurrence of enteric bacterial infections such as typhoid fever, paraty-phoid fever, shigellosis, amebiasis and cholera recently occurred in Korea was analyzed in terms of distribution, bacteriology, and the factors. With the data of communicable disease reporting, the distribution was observed on the variables of time, place and personal characteristics and showed on several tables and figures. By reviewing the works of bacteriological and epidemiological investigations for the recent occurrences of the diseases, the illustration was made on the kinds of species and strains of the etiologic agents and factors of the occurrence. A model of infectious process and approach to control measures of fecal-borne diseases was designed as shown on the Fig. 5. For the control measures on the enteric bacterial infections as well as other fecal-borne diseases, the emphasis was given on the sanitary sewage disposal.