나노구조의 template을 이용한 금속산화물 나노튜브 제조에 관한 연구 (초)

유시훈,박영수,명세희,이장식 대한금속ㆍ재료학회 2009 대한금속재료학회 학술대회 개요집 Vol.2009 No.-

조혈모세포이식 환자에서 I.V. Cyclosporine 용량 조절 현황 고찰

유시훈,홍소연,전수정,남궁형욱,이은숙,Eunkyung Euni Lee,방수미 한국병원약사회 2016 病院藥師會誌 Vol.33 No.2

Background and purpose : Cyclosporine A (CsA) is the most used immunosuppressive agent to prevent grafts versus host diseases (GVHD) after allo-HSCT (Hematopoietic Stem Cell Transplantations). However, the pharmacokinetic and pharmacodynamic profiles of CsA are known to show individual variability. Our study is designed to document the CsA blood level and status of dose adjustment, and drug interactions between CsA and antifungal agents including ketoconazole and itraconazole. Methods : A retrospective evaluation of the electronic medical records was conducted including adult patients who received allo-HSCT at Seoul National University Bundang Hospital from August 1, 2013 to August 31, 2015. Results : A total of 30 patients were included in the study. On average, the starting dose of CsA was 4.9 mg/kg/days, 87 % of the patients did not reach the therapeutic goal. In order to reach the target blood level, patients were required up to three dose adjustments and 4.2 days. The proportion of the patients whose blood level was out of the target level was 66.7 %. Initial blood level and T1/2 of CsA among patients who concurrently used antifungal agents were higher than the control group. Conclusion : Reevaluation of initial CsA IV dose and frequent therapeutic dose monitoring for concurrent use of CsA and antifungal agents are required for using the interdisciplinary team approach.

十九世紀初 韓國小農民經營一考

柳時勳 경희사학회 1986 경희사학 Vol.12ㆍ13 No.-

거골 골절에서 체중 부하 관절면의 중요성

정현욱,유시훈,서진수,Chung, Hyun-Wook,Yoo, Si-Hoon,Suh, Jin-Soo 대한족부족관절학회 2009 대한족부족관절학회지 Vol.13 No.2

Purpose: The fracture of talus has critical complications and results in various clinical outcomes. The purpose of this study is to evaluate clinical outcome and influence on involvement of ankle and subtalar joint. Materials and Methods: From December 1999 to December 2008, a total of 66 fractures and dislocations of talus was treated with minimal 9 months follow up period. Ankle-hindfoot scale of the American Orthopedic Foot & Ankle Society (AOFAS) was used to evaluate the clinical outcome. The complications and sequential radiologic findings were also analyzed. Results: There were 28 neck fractures, 11 lateral process fractures, 10 body fractures, 7 osteochondral fractures, 4 posteromedial tubercle fractures and 4 medial process fractures. In 38 cases, there were concomitant injuries. Ipsilateral ankle fracture, which found in 19 cases, was most common. The surgical treatment was performed in 36 cases. Mean AOFAS score was 85.5 (range, 72 to 96). In 13 of 47 cases, one or more fracture lines involving weight bearing surface were confirmed. The involvement of ankle or subtalar joint had resulted in unsatisfied outcome. Complications were developed as follows, post-traumatic arthritis in 8 cases, avascular necrosis in 3 cases, and deep infection in 2 cases. Conclusion: The involvement of ankle or subtalar joint in fractures of talus seemed to be common and to impact the clinical outcome. Meticulous consideration about that will be positively necessary.

IEEE 802.6 MAN을 위한 효율적 대역폭 사용 메카니즘

강문식,유시훈,조명석,이상배 한국통신학회 1993 韓國通信學會論文誌 Vol.18 No.3

본 논문에서는 이중버스 구조의 고속 통신망인 IEEE 802.6 MAN에서 나타나는 대역폭 사용의 비효율성을 해결하여 성능을 향상시키는 메커니즘을 제시한다. MAN 프로토콜은 기존의 LAN보다 다양한 수용능력 및 전송속도 측면에서 우수하나 단방향 버스 구조와 예약비트의 전파지연으로 인하여 상위스테이션일수록 보다 많은 대역폭을 사용하게 되는 불공정성 문제가 발생하여, 이는 스테이션 수가 늘어나거나 스테이션간의 거리가 커질수록 심하게 나타난다. 이의 해결을 위해 각 스테이션에 슬롯의 사용 여부를 구별할 수 있도록 하고, 특별한 스테이션에 목적지 소거기능을 주어, 슬롯의 재사용을 가능케한다. 이와 같이 하여 네트워크의 대역폭을 효율적으로 사용할 수 있으며, 제안된 메카니즘을 사용한 네트워크를 모델링하고, 각 스테이션에서의 카운터값을 상태변수로하여 해석적 방법으로 처리율과 지연시간을 분석하고, 모의실험을 통하여 성능이 향상됨을 보인다. This paper presents a mechanism for improving performance of the IEEE 802.6 MAN(Metropolitan Area Network), a dual-bus structured high-speed communication network, by a more efficient use of bandwidth. The MAN protocol is able to handle various traffic and offers better transmission speed than the conventional LAN, but the unidirectional bus structure and propagation delay of request bits results in unfairness since higher nodes use more bandwidth. As the number of stations and the distances between them are increased, the problem becomes mere serious. As a solution, this paper presents a method that every station enables to identify the used slots, and that a specified class denoted 'erasure station' has with the functions of destination release, slot reuse. As a result, it is export to improve network bandwidth values of each station and the throughput and delay time was analytically analyzed, and it is shown that according to computer simulation results, this mechanism improves the network performance.

B-ISDN/MAN 간의 연동장치에 대한 성능분석

이의택(Eui Take Lee),이상헌(Sang Hun Lee),유시훈(Si Hun Ryu),이상배(Sang bae Lee) 대한전자공학회 1993 대한전자공학회 학술대회 Vol.1993 No.11

36 mm 골두를 사용한 Ceramic - Ceramic 무시멘트 인공 고관절 전치환술 -3년 이상 추시 결과-

주석규 ( Suk Kyu Choo ),오형근 ( Hyoung Keun Oh ),유시훈 ( Si Hoon Yoo ),남지호 ( Ji Ho Nam ) 대한고관절학회 2013 Hip and Pelvis Vol.25 No.2

목적: 36 mm 대퇴골두를 사용한 무시멘트 세라믹-세라믹 관절면 고관절 전치환술을 시행하고 임상적 및 방사선학적 결과를 분석 하였다. 대상 및 방법: 36 mm 대퇴 골두를 사용한 무시멘트 세라믹-세라믹 관절면 고관절 전치환술을 시행 받은 40명, 43예를 대상으로 하였다. 평균 연령은 56세(28-82세)였으며 평균 추시 기간은 5.3년(3-7.5년)이었다. 임상적 추시로서 Harris 고관절 점수와 통증의 정도, 운동범위를 수술 후 3년에 확인 하였고, 방사선학적 추시 및 합병증을 확인하였다. 결과: Harris 고관절 점수는 수술 전 43.4점(21-57점)에서 수술 후 3년에 88.1점(81-95점)으로 상승하였다. 고관절 운동범위는 평균 굴곡 113°, 외전 30°, 내전 24°, 외회전 36°, 내회전 12°였다. 주관적 통증은 전례에서 없거나 미미한 정도였다. 합병증으로 낙상으로 인한 탈구가 발생된 경우는 1예가 있었으며 비관혈적 정복술을 시행하였다. 이외 세라믹의 골절은 없었으며 1예에서 감염이 발생하였다. 결론: 36 mm 대퇴골두를 사용한 무시멘트 세라믹-세라믹 관절면 고관절 전치환술은 최소 3년 추시에서는 임상적, 방사선학적으로 만족한 결과를 보였으며 장기적인 경과관찰이 필요할 것으로 판단된다. Purpose: The purpose of this study was to analyze the results for clinical outcome and radiologic assessment of ceramic on ceramic cementless total hip arthroplasty using a 36 mm diameter femoral head. Materials and Methods: This study included a group of 40 patients of 43 cases who underwent ceramic on ceramic cementless total hip arthroplasty using a 36 mm diameter femoral head. The age range of this group was 28 to 82(mean 56); we monitored them over a period of 5.3 years(3-7.5 years). This clinical evaluation process included monitoring the degree of pain, range of motion, and the Harris hip score after three years since the surgery was performed. Radiographic evaluation and complication were confirmed as well. Results: The preoperative Harris hip score increased from 43.4(21-57) to 88.1(81-95) after the surgery. The average motion range of hip was 113° flexion, 30° abduction, 24° adduction, 36° external rotation, and 12° internal rotation. Subjective pain was zero or minimal in all cases. Among the complications, dislocation occurred in only one case by a fall from a height and was reduced by closed reduction. There was no occurrence of ceramic fracture, even though infection occurred in one hip. Conclusion: The clinical outcome and radiologic assessment of the ceramic on ceramic cementless total hip arthroplasty using a 36 mm diameter femoral head showed a satisfactory result at three-year follow-up. Longerterm follow up is needed for further assessment.

후방 도달법에 의한 족관절 후과 골절의 치료

정현욱 ( Hyun Wook Chung ),김동환 ( Dong Hwan Kim ),유시훈 ( Si Hoon Yoo ),서진수 ( Jin Soo Suh ) 대한골절학회 2010 대한골절학회지 Vol.23 No.1

목적: 족관절의 골절에서 크기가 큰 후과 골절의 정복은 용이하지 않다. 이에 저자는 후방 도달법에 의한 정확한 정복 및 내고정으로 치료 후 그 결과에 대해 보고하고자 한다. 대상 및 방법: 2005년 8월부터 2008년 8월까지 족관절 후과 골절에 대해 후방 도발법으로 최소 9개월 이상 추시가 가능하였던 15명, 15예를 대상으로 평균 추시 기간은 17.6개월이었다. 수술 전후 관절면의 상태, 수술 방법, 수술 후 처치, 골유합 기간, 합병증 등에 대해 분석하였으며 임상 결과는 AOFAS 및 Olerud와 Molander 평가표를 사용하였다. 결과: 15예 중 후외방 도달법으로 수술한 경우가 9예, 후내방 도달법으로 치료한 경우가 6예였다. 골유합 기간은 평균 12.4주(12∼18주)였으며 AOFAS 수치는 평균 90.3점(72∼98점), Olerud와 Molander 평가는 우수 5예, 양호 7예, 보통 1예, 불량 2예였다. 합병증으로 외상성 관절염이 1예, 선형 반흔 구축으로 인한 관절 운동 제한이 1예에서 발생하였다. 결론: 족관절 후과 골절에서 후과 골편의 관절면 회복은 임상결과에 있어 중요한 요소로 감입된 골편이 있거나 분쇄 골편이 동반되어 지지 금속판 고정이 필요할 경우에 후방 도달법을 통하여 후과 골절의 정확한 정복으로 양호한 임상 결과를 얻을 수 있었기에 유용한 술식이라 생각되어 보고하는 바이다. Purpose: For fixation of the large posterior malleolar fracture fragment, indirect anterior fixation with cannulated screw has been widely used, but the anatomical reduction is not always obtained. The purpose of this article is to evaluate the clinical result of posterior malleolar fractures treated with anatomical reduction and internal fixation using posterior approach. Materials and Methods: We have analyzed the 15 patients with posterior malleolar fractures, treated with posterior approach from August 2005 to August 2008. The mean follow up period was 17.6 months, We have reviewed the perioperative joint integrity, method of operation, postoperative care, bony union and complication. A clinical outcome was evaluated by AOFAS (American orthopedic foot and ankle society) scaling system and Olerud & Molander scoring system. Results: Among 15 cases, posterolateral approach and posteromedial approach were chosen in 9 cases and 6 cases respectively. The radiologic unions were achieved at 12.4 (12∼18) weeks. Mean AOFAS score was 90.3 (72∼98), and Olerud & Molander score was "excellent" in 5 cases, "good" in 7 cases, "fair" in 1 case and "poor" in 2 cases. Postoperative complications in 2 cases revealed a posttraumatic arthritis and a scar band contracture respectively. Conclusion: In posterior malleolar fracture of ankle joint, the integrity of joint has closely affected clinical outcomes. We suggest that a posterior approach for posterior malleolar fracture with especially incarcerated fragments and comminuted fractures, can be a useful method for anatomical reduction and stable fixation, and satisfactory clinical results.