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개소시랑개비 추출물의 RAW264.7대식세포에서 in vitro 항염효과
남정환,김현삼,김병진,유홍섭,장동칠,진용익,유동림,최종근,박희준,이승빈,이경태,박수진,Nam, Jung-Hwan,Kim, Hyun-Sam,Kim, Byoumg-Jin,Yu, Hong-Seob,Chang, Dong-Chil,Jin, Yong-Ik,Yoo, Dong-Lim,Choi, Jong-Keun,Park, Hee-Jhun,Lee, Seung-Bin,Lee 한국식물생명공학회 2017 식물생명공학회지 Vol.44 No.1
본 연구에서는 개소시랑개비 (Potentilla supina)의 전초를 이용하여 세포독성 및 항염증 활성 효과를 평가하였다. 대식세포인 RAW264.7 cell에서 염증 매개 물질인 lipopo-lysacchride(LPS)로 염증을 유발해 nitric oxide (NO), Inducible nitric oxide synthase (iNOS)와 prostaglandin$E_2$($PGE_2$) 같은 염증 유발 인자들의 억제효과를 확인하였다. 개소시랑개비 ethyl acetate 분획물의 염증 유발 인자 억제 시 $IC_{80}$ value를 측정하였을 때 nitric oxide 및 prostaglandin $E_2$ 생성을 농도의존적으로 현저하게 저해하는 농도는 각각 29.34와 $50.75{\mu}g/ml$이었고 Inducible nitric oxide synthase의 양도 $50{\mu}g/ml$ 처리하였을때 농도 의존적으로 발현 감소 하였다. 따라서 본 연구결과는 개소시랑개비의 ethyl acetate 분획물과 같은 비극성용매 분획물들이 유의성 있는 항염증 효과를 나타내었으며, 이러한 효능은 예방의학적 가능성을 충분히 가지고 있기에 염증성질환의 예방을 위한 건강 기능성식품의 개발 가능성을 제시할 수 있을 것으로 기대된다. 또한 염증과 관련된 사이토카인 및 단백질 발현 메커니즘에 대한 추가적인 연구가 필요할 것으로 판단된다. Potentilla supina (Rosaceae) has traditionally been used to treat disorders of hemostasis, dysentery, malaria, bloody discharge and arthritis, and it has antinociceptive and anti-inflammatory properties. However, validity of the anti-inflammatory activity has not been scientifically investigated so far. Therefore, the aim of this study was to investigate the anti-inflammatory potential of P. supina using the ethanolic extract of P. supina and its sub-fractions. To evaluate the anti-inflammatory effects of P. supina, we examined the inflammatory mediators such as nitric oxide (NO), inducible nitric oxide synthase (iNOS) and prostaglandin $E_2$ ($PGE_2$) in RAW 264.7 cells. Our results indicated that ethyl acetate fraction significantly inhibited LPS-induced NO, iNOS and $PGE_2$ production in RAW 264.7 cells. This result showed that ethyl acetate fraction of P. supina is expected to be a good candidate for development into a source of anti-inflammatory agents.
플러그 크기에 따른 고랭지 지배 시클라멘의 生育 및 開化
남춘우,유동림,류승렬,유인철,백기엽 한국화훼연구회 1998 화훼연구 Vol.7 No.1
This study was carried out to clarify the proper plug tray cell sizes by one temporary planting of Cyclamen persicum cv. Daimongi (F1) under rain shelter cultivation in highland (altitude 800m). The seedling quality such as number of leaves, tuber weight and fresh weight tend to be increased by the large plug cell sizes. The duration of growth and flowering by the large cell sizes of plug were reduced, but number of leaves were not different at the flowering time. The commodity rates were 92-93% according to the raising of the different plug tray cell sizes and cultivation costs did not show a great difference in cyclamen for pot flower production in highland. In result the commodity rates and cultivation costs were alike without difference regardless of cell sizes of 72-288 when the price for pot flower were not change as the past. However if the early price for shipping is high, 72, 128 cell may be lucrative than the others and if the late price for shipping is high, 288 cell may be profitable than the others.