전신홍반루푸스 환자의 두개골에 발생한 형질세포육아종

오지선 ( Ji Seon Oh ),권귀영 ( Gui Young Kwon ),소민욱 ( Min Wook So ),최성호 ( Seong Ho Choi ),김용길 ( Yong Gil Kim ),나성수 ( Seong Su Nah ),이창근 ( Chang Keun Lee ),문희범 ( Hee Bom Moon ),유빈 ( Bin Yoo ) 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.4

Plasma cell granuloma, a form of inflammatory pseudotumor, is a rare nonneoplastic lesion that is characterized by cellular proliferation composed predominantly of polyclonal plasma cells with other inflammatory cells in fibrovascular background. We have experienced an unusual case of plasma cell granuloma of skull that developed in a patient with systemic lupus erythematosus (SLE). A 42-year-old female diagnosed with SLE 13 years ago has complained of palpable scalp mass and headache beginning ten days previously. A brain magnetic resonance imaging showed intensely enhanced soft tissue mass with focal bone defect in right parietal bone and whole body positron emission tomography suggested high possibility of malignancy. Surgical tumor removal was performed. Biopsy specimen revealed inflammatory proliferation predominantly with mature plasma cells which were determined to be polyclonal in immunostaining. Currently, 4 months after surgery, the patient are on regular follow-up with oral medications (prednisolone, hydroxychloroquine) for SLE without evidence of recurrence.

지도 기반 위치정보 저장 어플리케이션

오지선 ( Ji-seon Oh ),이수진 ( Su-jin Lee ),현가영 ( Ga-young Hyeon ) 한국정보처리학회 2017 한국정보처리학회 학술대회논문집 Vol.24 No.2

위치 정보의 카테고리 지정 및 메모 추가, 어플리케이션 간의 공유 기능을 통해서 보다 빠른 위치 정보 저장, 현재 위치를 기반으로 하는 장소 추천 기능을 포함하는 위치 정보 저장 어플리케이션을 개발하고자 한다. 본 연구는 미래창조과학부 및 정보통신기술진흥센터의 서울어코드활성화지원사업(IITP-2017-2012-0-00442)의 연구결과로 수행되었음

모바일에서 콘텐츠 제공 유형 차이에 따른 이용자 태도 분석 - 행정기관 정책 홍보 콘텐츠를 중심으로 -

오지선 ( Oh Ji-seon ),김종무 ( Kim Jong-moo ) 커뮤니케이션디자인학회(구 시각디자인학회) 2018 커뮤니케이션 디자인학연구 Vol.65 No.-

인터넷 기술이 발전하고 스마트폰 보급이 확대되면서 손 안에서 필요한 정보를 찾는 이용자들이 늘고 있다. 지난 2017년 언론수용자 의식조사 보고서에 따르면 모바일로 인터넷을 이용한다는 비율이 80%를 넘어섰고 모바일을 통해 콘텐츠를 소비한다는 비율은 6년 만에 무려 53.7% 급상승한 73.2%를 기록하였다. 모바일 콘텐츠는 이동성이 편한 스마트폰이라는 기기를 통해 정보를 제공하기 때문에 편리성이 높고 정보와 오락의 요소가 더해진 인포테인먼트 요소가 강해 쉽게 다가갈 수 있으며, 이용자들 간의 원활한 커뮤니케이션이 가능해 전 연령층에서 소비하고 있다. 이와 같은 장점으로 모바일 콘텐츠의 양이 나날이 방대해지고 있는 가운데 소비자들은 내게 꼭 필요한 콘텐츠를 찾아내기 위해서 콘텐츠 큐레이션(필요한 정보만 수집·분류·구성하는 과정)을 서슴지 않는다. 이런 변화에 따라 콘텐츠 제작자는 이용자들의 마음을 사로잡기 위해서 어떤 내용을 전달하는 것도 중요한 일이지만 그 내용을 어떠한 형태로 전달할지에 대한 고민도 함께 이뤄져야한다. 본 연구에서는 모바일 플랫폼에서 많이 사용되고있는 스토리텔링(텍스트)형, 인포그래픽형, 동영상형 콘텐츠 유형에 대한 이용자 태도에(호감도, 몰입도, 신뢰도, 만족도) 차이가 어떠한지를 알아보고자, 2018년 04월 09일부터 23일까지 15일간 총 400부의 설문지를 배포하였다. 이 중 회수된 설문지는 385부였고, 불성실한 응답을 한 3부를 제외한 총 382부를 최종 결과 분석에 사용했다. 그 결과 호감도, 몰입도, 신뢰도 및 만족도 모두가 유의한 차이가 없는 것으로 나타났다. 이는 모바일에서 행정기관 정책 홍보 콘텐츠 유형이 이용자 태도에 큰 영향을 주지 않는다는 것이다. 본 연구는 모바일 플랫폼에서 행정 기관 정책 콘텐츠 유형에 관한 연구가 많이 이뤄지지 않은 시점에서 정보 제공 형태가 이용자 태도에 크게 영향을 미치지 않는다는 점을 검증한 것에 의의를 둘 수 있으며, 행정기관에서 모바일 콘텐츠를 제작하고 편집하는 실무자들에게 도움이 되었으면 한다. As Internet technology is developed and smart phones become prevalent, people tend to look for information just on the palm of their hands. In 2017, according to media recipient’s recognition analysis report, Internet usage level through mobile already exceeded 80% and contents usage through mobile also recorded to be 73.2% by rising 53.7% in 6 years. Mobile contents are convient to use because of high mobility and it has infotainment characteristics by adding both information and entertainment and it allows people to communicate with each other so all generations are actively consume mobile contents. Based on these strength points, mobile content’s quality is getting better and quantity is also widening. Consumers also would like to go through all kinds of process such as collecting, sorting and analyzing which is contents curation to look for what they would like to find. In this research, analyzed the difference in user’s attitude(favorable impression, immersion in contents, reliability, satisfactory level) based on different types of contents such as story-telling type, info-graphic type and video type. I started survey from 2018. 04. 09 to 2018. 04. 23 for 15 days with 400 pages of survey papers. Among the 400 survey papers, 385 were returned and after excluding half-hearted 3 survey papers, I used 382 survey papers in analysis for final result. In conclusion, there is no difference in recognition level for favorable impression, immersion, reliability and satisfactory level in statistically significance level. Based on this result, it clearly show that there is no significance impact on user’s attitude based on government’s policy promotional contents type. This research is meaningful for verifying that content type has less impact on user’s attitude when there is not many research covering governmental policy content type under mobile based platform. I also hope that this research can help government officers who make and modify mobile contents.

눈 주위 부종으로 발현한 전신홍반루푸스

김종형 ( Jong Hyung Kim ),오지선 ( Ji Seon Oh ),김동민 ( Dong Min Kim ),허성재 ( Seong Jae Huh ),임경훈 ( Kyung Hun Lim ),도기원 ( Gi Won Do ),홍순형 ( Soon Hyung Hong ),최승원 ( Seung Won Choi ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.1

Periorbital edema is a rare manifestation of systemic lupus erythematosus (SLE). We describe here a patient with bilateral periorbital edema as a presenting symptom of SLE. A 23-year-old woman was admitted for a sudden onset of severe periorbital edema that developed 7 days previously. On the basis of the malar rash, arthritis of the right hand and left wrist, leukopenia, proteinuria and the positive anti-nuclear and anti-dsDNA antibodies, she was diagnosed with SLE. Kidney biopsy revealed lupus nephritis (WHO class IV). After treatment with high dose of steroids, intravenous cyclophosphamide and daily hydroxychloroquine, her symptoms resolved, including the periorbital edema. She was discharged with prescriptions for prednisolone and hydroxychloroquine and she remains well.

폐기능검사 해석에 정상하한치 변화와 새 해석흐름도가 미치는 영향

나승원 ( Seung Won Ra ),오지선 ( Ji Seon Oh ),홍상범 ( Sang Bum Hong ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),고윤석 ( Youn Suck Koh ),이상도 ( Sang Do Lee ),김우성 ( Woo Sung Kim ),김동순 ( Dong Soon Kim ),김원동 ( Won D 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.61 No.2

연구 배경: 폐기능검사를 해석하는데 정상하한치(lower limits of normal) 선정과 해석흐름도 합의가 필수적이다. COPD 국제지침은 FEV1/FVC 정상하한치로 0.7을 사용하여 폐쇄성장애를 진단한다. 한편, 미국흉부학회(ATS)와 유럽호흡기학회(ERS) 공동으로 새 해석흐름도를 제시하였다. `FEV1/FVC 정상하한치 0.7`의 정확성과 새 해석흐름도가 실제 폐기능검사 해석에 어떤 영향을 미치는지 알아 보고자 하였다. 방법: 서울 아산병원의 호흡기검사실에서 2005년 7월 1일부터 11월 30일까지 5개월간 폐활량측정법을 시행한 7362명을 대상으로 하여 `FEV1/FVC 정상하한치 0.7`의 정확성을 평가하였고 새로운 ATS/ERS 해석흐름도에 따르면 폐용적검사가 추가로 필요한 경우가 얼마나 증가하는지 평가하였다. 상기 기간 내에 같은 날 폐용적검사를 시행한 1611명을 대상으로 과거 해석흐름도와 비교하여 새로운 ATS/ERS 해석흐름도를 적용하게 되면 폐쇄성장애로 진단되는 경우가 얼마나 증가하는지 알아보았다. 결과: 1) `FEV1/FVC < 0.7`에 의한 폐쇄성장애 진단은 연령이 증가할수록 민감도는 증가하였으나 특이도는 감소하였고 양성예측도는 감소하였으나 음성예측도는 증가하였다. 2) 새 ATS/ERS 해석흐름도를 적용할 경우 34.5% (2540명/7362명)의 환자가 추가로 폐용적검사가 필요하였다. 3) 새 ATS/ERS 해석흐름도를 적용할 경우, 과거에 제한성질환으로 진단되었던 환자 중 30%(205명/681명)가 폐쇄성질환으로 진단되었고 이는 전체 환자의 13%(205명/1611명)에 해당하였다. 결론: 폐쇄성질환 진단기준으로 `FEV1/FVC < 0.7`을 사용하였을 때 연령에 따라서 민감도와 특이도가 변한다. 또한, 새로운 ATS/ERS 해석흐름도를 실제 환자를 진료하는데 적용하면 폐용적검사를 시행해야 하는 경우가 증가하게 되고 폐쇄성장애로 진단되는 경우가 더 증가하게 된다. Background: To interpret lung function tests, it is necessary to determine the lower limits of normal (LLN) and to derive a consensus on the interpretative algorithm. `0.7 of LLN for the FEV1/FVC` was suggested by the COPD International Guideline (GOLD) for defining obstructive disease. A consensus on a new interpretative algorithm was recently achieved by ATS/ERS in 2005. We evaluated the accuracy of `0.7 of LLN for the FEV1/FVC` for diagnosing obstructive diseases, and we also determined the effect of the new algorithm on diagnosing ventilatory defects. Methods: We obtained the age, gender, height, weight, FEV1, FVC, and FEV1/FVC from 7362 subjects who underwent spirometry in 2005 at the Asan Medical Center, Korea. For diagnosing obstructive diseases, the accuracy of `0.7 of LLN for the FEV1/FVC` was evaluated in reference to the 5(th) percentile of the LLN. By applying the new algorithm, we determined how many more subjects should have lung volumes testing performed. Evaluation of 1611 patients who had lung volumes testing performed as well as spirometry during the period showed how many more subjects were diagnosed with obstructive diseases according to the new algorithm. Results: 1) The sensitivity of `0.7 of LLN for the FEV1/FVC` for diagnosing obstructive diseases increased according to age, but the specificity was decreased according to age; the positive predictive value decreased, but the negative predictive value increased. 2) By applying the new algorithm, 34.5% (2540/7362) more subjects should have lung volumes testing performed. 3) By applying the new algorithm, 13% (205/1611) more subjects were diagnosed with obstructive diseases; these subjects corresponded to 30% (205/681) of the subjects who had been diagnosed with restrictive diseases by the old interpretative algorithm. Conclusion: The sensitivity and specificity of `0.7 of LLN for the FEV1/FVC` for diagnosing obstructive diseases changes according to age. By applying the new interpretative algorithm, it was shown that more subjects should have lung volumes testing performed, and there was a higher probability of being diagnosed with obstructive diseases (Tuberc Respir Dis 2006; 61: 129-136)

증례 : 석회화 담낭 1예

소민욱 ( Min Wook So ),김명환 ( Myung Hwan Kim ),오지선 ( Ji Seon Oh ),이상아 ( Sang Ah Lee ),이상수 ( Sang Soo Lee ),서동완 ( Dong Wan Seo ),이성구 ( Sung Koo Lee ) 대한내과학회 2007 대한내과학회지 Vol.72 No.2

석회화 담낭은 비교적 드문 질환으로 아직 정확히 병인이 밝혀지지 않았다. 최근 다소 논란이 있으나 전암성 병변으로 분류되며 담낭암의 경우 광범위한 전이가 되기 전까지 무증상인 경우가 많고 예후가 좋지 않기 때문에 예방적인 담낭 절제술이 최선의 치료로 추천되고 있다. 저자들은 무증상의 석회화 담낭을 단순 복부 촬영과 복부 CT를 통해 진단하였고, 복강경하 담낭 절제술로 치료하였기에 문헌고찰과 함께 보고하고자 한다. Porcelain gallbladder is characterized by extensive deposition of calcium in the wall of the gallbladder. It is commonly associated with gallbladder cancer, but it has been rarely reported in Korea. Porcelain gallbladder is regarded as a precancerous lesion and prophylactic cholecystectomy is the treatment of choice. We report here a case of a patient with porcelain gallbladder. This case showed the typical radiologic and pathologic findings of this disease. The patient was treated by laparoscopic cholecystectomy. (Korean J Med 72:222-225, 2007)

베체트병의 심혈관 침범 환자의 재발에서 면역억제제의 효과

나성수 ( Seong Su Nah ),이창근 ( Chang Keun Lee ),오지선 ( Ji Seon Oh ),김용길 ( Yong Gil Kim ),전찬홍 ( Chan Hong Jeon ),문희범 ( Hee Bom Moon ),고은미 ( Eun Mi Koh ),유빈 ( Bin Yoo ),홍석찬 ( Seok Chan Hong ) 대한류마티스학회 2007 대한류마티스학회지 Vol.14 No.4

Objective: Despite the high risk for disease-related morbidity and mortality in Behcet`s disease (BD) with cardiovascular (CV) manifestations, only a few studies concerning BD with CV involvements are available. We conducted study to evaluate the clinical manifestations of CV BD (cardiovascular Behcet`s disease) and the clinical outcome according to the different treatment modalities, especially focusing on the immunosuppressive agents. Methods: We retrospectively reviewed 1,812 patients diagnosed with BD at tertiary hospital. All patients with vascular involvements were classified into three groups by lesion site. We assessed clinical characteristics, treatments, outcome and recurrence in each group. Results: Of 1,812 patients, 79 patients showed CV involvements. Male to female ratio was 65 (82.3%) to 14 (17.7%). Venous involvements occurred in 57 cases (72.2%), arterial lesions in 22 (27.8%), cardiac involvements 16 (20.3%). In clinical manifestation, only hypertension and arthritis were more frequently found in cardiac lesion than in venous lesion (p=0.01, p=0.01, respectively). CV lesions recurred in 16 patients (20.3%), mostly at the same sites as previous involvements. There was no association of recurrence with site of lesion (p=0.49). Recurrent rate was significant different in three medication group (p=0.028). Recurrences were more frequent in patients treated with no immunosuppressive agent and colchicines only or colchicines with prednisolone than in patients treated with additional immunosuppressive agent (p=0.024, R.R, 7.16 (95% CI, 1.55 to 32.99)). Conclusion: Recurrence rate was lower in patients with aggressive immunosuppressive treatment. Although most of patients improved, more efforts to decrease the relatively high rate of the recurrence (20.3%) would be needed.

전신경화증 환자에서 발생한 창자벽 공기낭증 1예

임재욱 ( Jae Uk Im ),김은혜 ( Eun Hye Kim ),전홍길 ( Hong Gil Jun ),오지선 ( Ji Seon Oh ),최승원 ( Seung Won Choi ),강병성 ( Byeong Seong Kang ) 대한내과학회 2013 대한내과학회지 Vol.84 No.6

The gastrointestinal tract is commonly involved in patients with systemic sclerosis. The manifestations include motility disorder, pseudo-obstruction, malabsorption, bacterial overgrowth, diverticuli, and, less commonly, pneumatosis cystoides intestinalis (PCI). PCI is characterized by the presence of air in the submucosal or subserosal layer of the bowel wall and is often accompanied by pneumoperitoneum. Although PCI is a benign condition that often responds to conservative management, it is a poor prognostic factor of systemic sclerosis. We report a case of PCI in a patient with systemic sclerosis. The chest and abdominal radiographic findings comprised pneumoperitoneum, marked dilation of the bowels, and intramural air, compatible with PCI. The patient`s symptoms improved spontaneously. It is important to recognize PCI as a gastrointestinal manifestation of systemic sclerosis, and physicians should differentiate it from serious complications-such as intestinal perforation-based on clinical manifestations. (Korean J Med 2013;84:868-872)

신이식 후 발생한 Posttransplant Lymphoproliferative Disease

변승운 ( Seung Woon Byun ),박혜원 ( Hye Won Park ),송주형 ( Ju Hyung Song ),오지선 ( Ji Seon Oh ),김은희 ( Eun Hee Kim ),허주령 ( Joo Ryung Huh ),서철원 ( Cheol Won Suh ),박수길 ( Su Kil Park ) 대한신장학회 2006 Kidney Research and Clinical Practice Vol.25 No.5

Posttransplant lymphoproliferative disorders (PTLD) is an infrequent but serious complication of transplantation. Previous studies have suggested the terms of reference, early PTLD (referring to PTLD that occurs within 1 year of transplantation) and late PTLD (PTLD that occurs after 1 year). Early PTLD generally involves a single organ or nodal region and often responds favorably to a decrease in immunosuppression. Late PTLD tends to be disseminated, responds less frequently to a decrease in immunosuppression, and has a dismal prognosis. We encountered a diffuse large B-cell lymphoma in a 44-year-old man who underwent kidney transplantation over 10 years ago, in 1995. In situ hybridization for Epstein-Barr virus showed positive results in tumor cell. With decreased immunosuppressants and chemotheraphy, he is currently in complete remission. Korean J Nephrol 2006;25(5): 871-876)

시클로스포린으로 치료된 피부근염과 연관된 종격동기종

이경훈 ( Kyoung Hoon Rhee ),정창희 ( Chang Hee Jung ),배정호 ( Jung Ho Bae ),소민욱 ( Min Wook So ),오지선 ( Ji Seon Oh ),김세희 ( Sai Hui Kim ),나성수 ( Seong Su Nah ),이창근 ( Chang Keun Lee ),유빈 ( Bin Yoo ),문희범 ( Hee Bom 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.2

Dermatomyositis (DM) is an inflammatory myopathy of unknown etiology, which involves predominantly the muscles and skin, but also produces pulmonary manifestations in approximately 10% of the patients. Increasing attention has been paid to progressive interstitial pneumonitis as an important pulmonary manifestation of DM that can sometimes have a serious influence on the prognosis. Pneumomediastinum has been reported as a rare complication of DM. In this report, we present a case of 40-year-old woman with DM and interstitial lung disease who developed spontaneuous pneumomediastinum and was successfully treated with cyclosporin A.