http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
신생아 패혈증의 양상을 보인 신생아 루푸스 증례와 문헌 고찰
박혜민 ( Hye Min Park ),전홍길 ( Hong Gil Jun ),박주환 ( Ju Hwan Park ),최승원 ( Seung Won Choi ),오기원 ( Ki Won Oh ),오지선 ( Ji Seon Oh ) 대한류마티스학회 2014 대한류마티스학회지 Vol.21 No.3
저자들은 출생 당시 피부발진을 보인 신생아에서 범혈구 감소증 및 발열과 함께 심한 황달을 포함한 간기능 이상 소견을 보여 신생아 루푸스로 진단된 환아에서 전신적인 고용량의 스테로이드와 면역글로불린 치료 후 완전히 호전된 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Neonatal lupus is an uncommon autoimmune disease that results from transplacental passage of the maternal anti- SSA/Ro and/or anti-SSB/La antibodies. Pancytopenia or severe jaundice is a rare manifestation of neonatal lupus, respectively, and could be misdiagnosed with other neonatal illnesses, such as infection, hematologic disease, or hepatobiliary disease. Here, we report an unusual case of a premature newborn with severe neonatal lupus manifested with skin rash, fever, pancytopenia, and severe jaundice with abnormal liver function tests. His mother had been clinically asymptomatic before delivery; however, she revealed peripheral edema, bilateral pleural effusion, and ascites after delivery and diagnosed with systemic lupus erythematosus based on positive anti-nuclear and anti-cardiolipin antibodies, proteinuria, and serositis. The newborn and his mother had anti-SSA/Ro and anti- SSB/La antibodies. His pancytopenia and jaundice were progressively aggravated, and his illness was confused with neonatal sepsis or biliary obstruction. We decided to treat with high dose of corticosteroid and intravenous immunoglobulin, and he gradually recovered completely with the treatment. His corticosteroid was stopped at 5 months of age without relapse or complication.
임재욱 ( Jae Uk Im ),김은혜 ( Eun Hye Kim ),전홍길 ( Hong Gil Jun ),오지선 ( Ji Seon Oh ),최승원 ( Seung Won Choi ),강병성 ( Byeong Seong Kang ) 대한내과학회 2013 대한내과학회지 Vol.84 No.6
The gastrointestinal tract is commonly involved in patients with systemic sclerosis. The manifestations include motility disorder, pseudo-obstruction, malabsorption, bacterial overgrowth, diverticuli, and, less commonly, pneumatosis cystoides intestinalis (PCI). PCI is characterized by the presence of air in the submucosal or subserosal layer of the bowel wall and is often accompanied by pneumoperitoneum. Although PCI is a benign condition that often responds to conservative management, it is a poor prognostic factor of systemic sclerosis. We report a case of PCI in a patient with systemic sclerosis. The chest and abdominal radiographic findings comprised pneumoperitoneum, marked dilation of the bowels, and intramural air, compatible with PCI. The patient`s symptoms improved spontaneously. It is important to recognize PCI as a gastrointestinal manifestation of systemic sclerosis, and physicians should differentiate it from serious complications-such as intestinal perforation-based on clinical manifestations. (Korean J Med 2013;84:868-872)
Alemtuzumab을 이용한 이차성 순적혈구 빈혈의 치료
박혜민 ( Hye Min Park ),임재욱 ( Jae Uk Im ),박주환 ( Ju Hwan Park ),김은혜 ( En Hye Kim ),전홍길 ( Hong Gil Jun ),박재후 ( Jae Hoo Park ),김혁 ( Hawk Kim ) 대한내과학회 2013 대한내과학회지 Vol.85 No.2
Pure red cell aplasia (PRCA) in adults is usually idiopathic, although some underlying conditions can cause PRCA. Immunosuppressive therapy (IST) is used to treat PRCA, but IST has side effects and may fail. The anti-CD52 monoclonal antibody alemtuzumab (ALM) was recently used to successfully treat therapy-resistant PRCA. We herein report successful treatment of secondary PRCA after erythropoietin therapy using ALM and cyclosporin A (CsA) in one patient. The total dose of ALM was 60 mg over 3 days (10, 20, and 30 mg, respectively) plus CsA for at least 6 months. The patient achieved a complete response 18 months after ALM-CsA treatment and his treatment could be changed to a different erythropoietin stimulating agent. (Korean J Med 2013;85:214-217)