BANA assay를 이용한 치주질환 환자의 세균검출에 관한 연구

염창엽,김병옥,이장희,한경윤,김재덕 朝鮮大學校 口腔生物學硏究所 1992 口腔生物學硏究 Vol.16 No.2

BANA assay 를 이용한 치주질환 환자의 세균검출에 관한 연구

염창엽(Chang Yup Yum),김병옥(Byung Ok Kim),이장희(Zang Hee Lee),한경윤(Kyung Yoon Han),김재덕(Jae Duk Kim) 조선대학교 구강생물학연구소 1992 Oral Biology Research (Oral Biol Res) Vol.16 No.2

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부정교합의 치료를 위해 동반되는 corticotomy : 문헌 고찰

신호범(Ho Beom Shin),염창엽(Chang Yup Yum),노기성(Gi Sung Noh),조세열(Se Yul Cho),김병옥(Byung Ok Kim),한경윤(Kyung Yoon Han) 조선대학교 구강생물학연구소 1999 Oral Biology Research (Oral Biol Res) Vol.23 No.1

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인간의 발치와 내에서 골유도재생술 후의 치유양상

장현선,염창엽,박주철,김수관,김흥중,국중기,김종관,김병옥 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.4

이 연구는 임플란트를 식립하기를 원하는 전신건강상태가 양호하며 구강위생상태가 좋은 14명 환자(남자:8명, 여자:6명, 평균나이 : 44세)의 20개의 발치와 내에 흡수성 차폐막(BioMesh. Sam Yang Corporation, Korea)과 함께 탈회냉동 건조동종 골(dem-ineralized freezedried bone allografts, 250-500μm, Pacific Coast Tissue Bank, U.S.A.)과 이종골(Bovine-Bone, Bio-Oss 0.25-1.0 mm, Geistlich, Biomaterials and Osteohealth, Switzerland)을 1:1(부피)로 혼합하여 이식한 후 그 치유양상을 관찰하고자 조직학적 및 면역조직화학적으로 평가하였다. 이직재가 탈락되는 것을 방지하기 위하여 발치한 후 1개월이 경과된 후에 이식재와 차폐막을 위치시켰다. 표본제작을 위하여 이식술을 시행한 지 약 6개월 후에 임플란트를 식립하기 직전 식립부위에서 trephine bur로 골을 채취하였는데, 20증례 중 7증례에서 임플란트를 식립하기 전에 차폐막이 노출되었다. 차폐막이 노출되지 않은 것을 대조군으로, 노출된 것을 실험군으로 설정하였다. 조직학적인 관찰을 위하여 통상적인 방법에 따라 탈회표본을 제작하였고, alkaline phosphotase(ALP)를 이용하여 면역조직화학적 염색을 시행한 후 골 형성 상태를 평가하여 다음과 같은 결과를 얻었다. 본 연구에서는 발치와내에서 골유도재생술 후 나타나는 치유 형태를 5가지 형태로 분류할 수 있었다. Type I, II와 III는 새로운 골 형성을 나타내지 않았고, 면역조직화학적 검사시 ALP 음성 소견을 나타내었다. Type V는 새로운 골 형성과 ALP 양성 소견을 나타내었으나 염증, 괴사, 결합조직의 증식 등은 없었다. Type IV와 Type V의 차이는 결합조직의 증식여부로 구분되었다. 막이 노출되지않은 증례들 중 7 증례에서는 Type V의 치유 형태를, 2증례에서는 Type IV의 치유 형태를 나타내었다. 막이 노출되었던 증례에서는 Type I, II, III의 다양한 치유 형태를 나타내었다. 본 연구결과, 발치와 내에 골유도재생술을 시행한 후 차폐막의 노출 여부가 신생골 형성에 중요한 영향을 미칠 것으로 사료되며, 본 연구에서 분류한 치유 형태가 향후 골유도재생술 후의 결과 분석에 활용될 수 있을 것으로 사료된다.

Healing patterns after guided bone regeneration in human extraction sockets

장현선,염창엽,박주철,김수관,김흥중,국중기,김종관,김병옥,Jang, Hyun-Seon,Yeom, Chang-Yeob,Park, Joo-Cheol,Kim, Su-Gwan,Kim, Heung-Joong,Kook, Joong-Ki,Kim, Chong-Kwan,Kim, Byung-Ock The Korean Academy of Periodontoloy 2005 Journal of Periodontal & Implant Science Vol.35 No.4

이 연구는 임플란트를 식립하기를 원하는 전신건강상태가 양호하며 구강위생상태가 좋은 14명 환자(남자:8명, 여자:6명, 평균나이 : 44세)의 20개의 발치와 내에 흡수성 차폐막(BioMesh. Sam Yang Corporation, Korea)과 함께 탈회냉동 건조동종 골(dem-ineralized freezedried bone allografts, $250-500{\mu}m$. Pacific Coast Tissue Bank, U.S.A.)과 이종골(Bovine-Bone, Bio-Oss 0.25-1.0 mm, Geistlich, Biomaterials and Osteohealth, Switzerland)을 1:1(부피)로 혼합하여 이식한 후 그 치유양상을 관찰하고자 조직학적 및 면역조직화학적으로 평가하였다. 이직재가 탈락되는 것을 방지하기 위하여 발치한 후 1개윌이 경과된 후에 이식재와 차폐막을 위치시켰다. 표본제작을 위하여 이식술을 시행한 지 약 6개윌 후에 임플란트를 식립하기 직전 식립부위에서 trephine bur로 골을 채취하였는데, 20증례 중 7증례에서 임플란트를 식립하기 전에 차폐막이 노출되었다. 차폐막이 노출되지 않은 것을 대조군으로, 노출된 것을 실험군으로 설정하였다. 조직학적인 관찰을 위하여 통상적인 방법에 따라 탈회 표본을 제작하였고, alkaline phosphotase(ALP)틀 이용하여 면역조직화학적 염색을 시행한 후 골 형성 상태를 평가하여 다음과 같은 결과를 얻었다. 본 연구에서는 발치와내에서 골유도재생술 후 나타나는 치유 형태를 5가지 형태로 분류할 수 있었다. Type I, II와 III는 새로운 골 형성을 나타내지 않았고, 면역조직화학적 검사 시 ALP 음성 소견을 나타내었다. Type V는 새로운 골 형성과 ALP 양성 소견을 나타내었으나 염증, 괴사, 결합조직의 증식 등은 없었다. Type IV와 Type V의 차이는 결합조직의 증식여부로 구분되었다. 막이 노출되지않은 증례들 중 7 증례에서는 Type V의 치유 형태를, 2증례에서는 Type IV의 치유 형태를 나타내었다. 막이 노출되었던 증례에서는 Type I, II, III의 다양한 치유 형태를 나타내었다. 본 연구결과, 발치와 내에 골유도재생술을 시행한 후 차폐막의 노출 여부가 신생골 형성에 중요한 영향을 미칠 것으로 사료되며, 본 연구에서 분류한 치유 형태가 향후 골유도재생술 후의 결과 분석에 활용될 수 있을 것으로 사료된다.

비외과적 치주처치의 선행 유무에 따른 치주 판막술 후 임상적 평가

신호범,염창엽,김상목,김병옥,한경윤,Sinn, Ho-Beom,Yun, Chang-Yup,Kim, Sang-Mok,Kim, Byung-Ock,Han, Kyung-Yoon 대한치주과학회 2001 Journal of Periodontal & Implant Science Vol.31 No.1

In the treatment of chronic adult periodontitis, scaling and root planing have been generally performed prior to periodontal flap surgery. The purpose of this study was to evaluate the clinical significance of nonsurgical periodontal therapy prior to periodontal flap surgery in patients with chronic adult periodontitis. Fifty six molars showing bilateral bony defects and 4-6mm periodontal pocket in twelve patients with chronic adult periodontitis were selected. By randomized split-mouth design, in one side, flap operation was performed 4 weeks after scaling and root planing, in the other group, flap operation was only performed without scaling and root planing. Probing pocket depth, gingival recession, clinical attachment level, gingival index, plaque index, and tooth mobility were measured at baseline, before flap operation and post-operation

불화나트륨 이온도포와 Nd:YAG laser 조사가 치근면 내마모성에 미치는 영향

김진덕,염창엽,김송욱,김병옥,한경윤,Kim, Chin-Dok,Yum, Chang-Yup,Kim, Song-Uk,Kim, Byung-Ock,Han, Kyung-Yoon 대한치주과학회 1997 Journal of Periodontal & Implant Science Vol.27 No.4

The purpose of this study was to evaluate the abrasion-resistance of root surface after NaF iontophoresis, Nd:YAG laser irradiation and combined treatment 50 anterior teeth with flat interproximal root surface that had been extracted due to periodontal destruction were selected. All teeth were treated by the same procedure as conventional periodontal root treatment, such as scaling and root planing, root conditioning with tetracycline HCI(lOOmg/ml, 5min). The pre-treatment weight of each tooth was measured by a dial scale(SHIMADEU Co, LIBROR EB-220HU, capacity 220.000 g, Japan). All teeth were divided into 5 groups as follows: Nd:YAG laser irradiation(group 1, 1 W, 100 mJ, 10Hz, fiberoptic-root surface distance=5mm, $10\;sec.{\times}6times$, EL.EN.EN060, Italy): NaF iontophoresis(group 2, $150{\mu}A$, 4 min}: Nd:YAG laser irradiation following NaF iontophoresis(group 3): NaF iontophoresis following Nd:YAG laser irradiation(group 4): No treatment(control group). Electric toothbrushing (Oral-B, Brown Co, Germany) was conducted during 1 hour($lO\;min.{\times}6\;times$). Subsequently post-treatment weight was remeasured by the same method as pre-treatment weight measurement. The difference of abrasion rate among all groups was statistically analyzed by ANOVA(SAS program). Following results were obtained: 1. The abrasion rate was significantly lower in Nd:YAG laser irradiation group than NaF iontophoresis group(p < 0.001). 2. The abrasion rate was significantly lower in combined groups of Nd:YAG laser irradiation and NaF iontophoresis than either Nd:YAG laser irradiation group or NaF iontophoresis group(p < 0.001). 3. There was no significant difference in abrasion rate according to application order in the combined groups(p > 0.05). 4. The abrasion rate was significantly lower in all experimental groups than control group(p < 0.001). The results suggest that combined treatment of Nd:YAG laser irradiation and NaF iontophoresis on exposed root surface after periodontal therapy can enhance the abrasion-resistance of root surface and may inhibit the root caries development.

치주치료를 받은(1981-1995) 환자들의 연령과 치료술식에 대한 조사 연구

이영석,염창엽,김상목,김병옥,한경윤,Lee, Young-Seok,Yun, Chang-Yup,Kim, Sang-Mok,Kim, Byung-Ock,Han, kyung-Yoon 대한치주과학회 2001 Journal of Periodontal & Implant Science Vol.31 No.1

The aim of this study was to recommend the optimal age for prevention of periodontal disease and to investigate the trend of treatment modality according to different period. From the chart recordings of the patients who had been treated periodontally from Jan. 1981 to Dec. 1995 in the dept .of periodontics, Chosun University Dental Hospital, those of the periodontally treated patients on more than 4 sixtants were selected for the present study. The distribution of the patients was counted according to the age group and the gender. And they were divided into 3 groups(group 1: 1987-1958, group 2: 1985-1990, group 3: 1991-1995) by 5 year interval according to the treated year. The periodontal treatment modalities were classified into non-surgical therapy, pocket elimination surgery, regenerative periodontal surgery, mucoginigival surgery, clinical crown lengthening, and others. The results were as follows; 1.In the distribution of the periodontally treated patients according to the age group, 40's age group was the highest, and 30's, 40's, and 50's age groups occupied more than two thirds(73%). 2.The sexual distribution of the periodontally treated patients showed that males(53.4%) were a little more than females(46.6%). Within 20's group female was higher, but within 40's male was higher. 3.Regardless of the age group and the gender, pocket elimination surgery was the most frequent treatment modality. 4.In group 1 and 2(1987-1990) the main treatment modality was pocket elimination surgery and non-surgical therapy, but in group 3(1991-1995) it was regenerative periodontal surgery and pocket elimination surgery. The above results suggest that the prevention of periodontal disease should be initiated from early twenties, and the most frequent treatment modality may be closely related with development of new material and method.

부정교합의 치료를 위해 동반되는 corticotomy : 문헌고찰 REWIEW ARTICLE

신호범,염창엽,노기성,조세열,김병옥,한경윤 朝鮮大學校 口腔生物學硏究所 1999 Oral Biology Research (Oral Biol Res) Vol.23 No.1

In order to overcome the limit of conventional orthodontic treatment and reduce orthodontic treatment time, corticotomy technique is used to orthodontic treatment. Corticotomy as osteotomy of the cortical bone is useful to obtain faster movement of teeth, since the main resistance to movement is encountered in the cortical layer. The advantage of the corticotomy are many, through leaving the spongiosa intact, prevents injury of the periodonteum, pocket formation, and devitalizing of a single tooth or of a group of teeth. The nutritional function of the bone to e displaced is maintained through the spongiosa, although the bone exposed. It the corticotomy is performed under adequate selection of indication, it can be selected for effective supplemently surgery under orthognathic surgery and conventional orthodontic treatment.

Laser Doppler Flowmetry를 이용한 유리치은이식술 부위의 치은혈류 변화에 관한 연구

전동영,박병기,염창엽,김세훈,김재덕,김병옥,Chun, Dong-Young,Park, Byung-Ki,Yeom, Chang-Yeob,Kim, Se-Hun,Kim, Jae-Deok,Kim, Byung-Ock 대한치주과학회 2002 Journal of Periodontal & Implant Science Vol.32 No.2

In most of the previous studies, invasive and discrete techniques have been used to monitor the healing process of the gingival graft. However, Laser Doppler Flowmetry(LDF, floLAB(R), Moor Instruments Ltd., England) is a non-invasive technique for measurement of blood flow in the tissue and also allows continuous monitoring. Thus, we tested the usefulness of LDF in monitoring the healing process of free gingival graft at gingival recession. Eleven gingival graft site of 7 patients, including 5 males and 2 females, aged between 21 and 41 years (mean age 28.5) were monitored for the blood flow. The blood flow in gingival graft at coronal site, central site, apical site, mesial site and distal site was measured using LDF. Blood flow was measured at 1- week, 2- week, 3- week and 4- week after gingival graft surgery from 10 a.m. to 2 p.m. Time-course of the healing process was evaluated by statistical analysis using repeated ANOVA and Duncan test. The results were as follows : (1) Blood flow stayed increased for 2 weeks, and then, it was a tendency to decrease. (2) The blood flow at distal site had always higher than mesial site during the measuring periods. (3) The blood flow was high orderly after 1 week ; most coronal site, most apical site, central site. But that was high orderly after 2 week, 3 week, 4 week ; most coronal site, central site, most apical site. In conclusion, LDF was a useful and clinically adaptable method to monitor wound healing process. Our study suggested that it was important to protect surgical site to promote initial wound healing.