포도당 농도가 망막상피세포의 반응성 산소 생성량과 세포활성에 미치는 영향

양유리,김성일,고재웅 대한안과학회 2006 대한안과학회지 Vol.47 No.7

Purpose: To investigate the effects of glucose concentrations on formation of reactive oxygen products and cellular activity in human retinal pigment epithelial cells. Methods: Human retinal pigment epithelial cells were cultured with high glucose (200 mg/100 ml, 300 mg/100 ml, 400 mg/100 ml) and normal glucose (100 mg/100 ml). The amounts of reactive oxygen products were assayed with dihydroethidium (DHE). Paraquat-induced cellular activity was determined by 3-[4,5-dimethylthiazol-2-yl]-2,5 -diphenyl tetrazolium bromide (MTT) method. Results: Reactive oxygen products of human retinal pigment epithelial cells were increased 120%, 250% and 390% in high glucose (200 mg/100 ml, 300 mg/100 ml, 400 mg/100 ml) media compared to those of normal glucose (100 mg/100 ml) media. Paraquat-induced cell toxicity was increased by high glucose concentrations. Conclusions: High glucose increased formation of reactive oxygen products in human retinal pigment epithelial cells. These results suggest that high glucose can make human retinal pigment epithelial cells more sensitive to oxidative cellular injury.

요로감염(Urinary tract infection)의 병태와 처방예 및 해설

양유리 약업신문사 1998 의약정보 Vol.1998 No.5

국내 중년 여성의 제2형 당뇨병과 우울(PHQ-9)의 관계

양유리 한국간호과학회 2022 한국간호과학회 학술대회 Vol.2022 No.10

약품식별업무의 현황분석 및 program 구축

양유리,김재연,송영천,조영환,노환성 한국병원약사회 1998 병원약사회지 Vol.15 No.1

The Drug Information Service of AMC(Asan Medical Center) has been providing drug discrimination service since 1989. Most patients attending general hospitals, including AMC, have previously been to other clinics, and therefore it is important to know the patients' prior medication. Requests for drug discrimination are increasing every year and they are mostly being discriminated by personal experiences, by reference to Medical Index, PDR, and other databases, and by making inquiries at the prior prescribed clinic or drug store. Recently, we are also consulting the 'actual drug reference' of domestic drugs which was collected by AMC and the database of psychotropic and hypertensive agents produced by KSHP. Yet, the fact that most drugs are indistinctable by appearance and the limitation of data are still the barriers and the necessity of the computerized drug discrimination program is obvious. So we surveyed the results of drug discrimination since we started this service and on the base of this results, we have developed a drug discrimination service analysis program to support the computerization. By the program the consults, the cases of each consults, the frequency of each department, the mainly requested drug, the proportion of out-pateints to hospitalized patients, discrimination rate, whether the disease states are written or not, the rate of failure and classifying the reasons of the failure to 'assumption'(drug effects, product names etc.) and 'unpredictable'(powders, granules, discoloration, crushes, lack of data, no marks etc.) of each case requested for discrimination was analyzed and evaluated. We hope the results could help the computerizing work of drug discrimination and would provide a more qualified service of drug discrimination.

특수교육대상자의 산림치유 서비스 지원에 대한 학부모와 특수교사의 인식 및 요구

양유리,연평식 한국특수교육교과교육학회 2023 특수교육교과교육연구 Vol.16 No.1

The purpose of this study is to find out the awareness of the need for forest healing service support and the demand of parents and special education teachers, who are related subjects, by seeking ways to activate forest healing service support for people eligible for special education. The research tool was a questionnaire based on literature review, and the questionnaire items such as the need for forest healing service support, expectation of help, perception of expected effect, requirements for forest healing service support, and matters necessary for revitalizing forest healing service were derived. The questionnaire was developed for parents of special education recipients and special teachers, and an online survey was conducted targeting 73 parents of special education recipients and 70 special education teachers nationwide. The results of the study were high in recognition of the need to support forest healing services, and the expectation that forest healing services would help special education subjects' language, society, emotion, psychology, cognition, learning, sensation, and motor functions was also positive in both groups. As for the specific requirements of the special education-related subjects for the forest healing service support operation method, a forest healing instructor who majored in forest healing responded in the form of a small group of 1:2 to 3 once a week for 60 minutes in a nearby park or forest. As for the matters necessary for vitalizing forest healing service support, it was found that the government, local governments, and regions want to provide various forest healing programs through the intervention of experts such as forest healing instructors within the school education system along with appropriate budgeting. 본 연구는 특수교육대상자의 산림치유 서비스 지원에 대한 활성화 방안 모색으로 관련 주체인 학부모와 특수교사들의 산림치유 서비스 지원 필요성 인식 및 요구를 알아보는데 목적이 있다. 연구 도구는 문헌조사를 기초로 한 설문지로 산림치유 서비스 지원의 필요성과 도움 기대, 기대효과에 대한 인식, 산림치유 서비스 지원의 요구사항, 산림치유 서비스 활성화를 위해 필요한 사항 등의 설문 문항을 도출하였다. 설문지는 특수교육대상자 학부모용과 특수교사용으로 나누어 개발하였고, 전국 특수교육대상자 학부모 73명과 특수교사 70명을 대상으로 온라인 설문을 진행하였다. 연구 결과는 산림치유 서비스 지원에 대한 필요성 인식에서 두 집단 모두 높게 나타났고, 산림치유 서비스가 특수교육대상자들의 언어, 사회, 정서, 심리, 인지, 학습, 감각, 운동기능에 도움이 될 것이라는 기대 또한 두 집단 모두에서 긍정적으로 나타났다. 산림치유 서비스 지원 운영방식에 대한 특수교육 관련 주체들의 구체적인 요구사항으로는 산림치유를 전공한 산림치유 지도사가 가까운 공원이나 숲에서 주 1회 60분으로 1:2~3의 소그룹 형태의 응답이 높게 나타났다. 산림치유 서비스 지원 활성화를 위해 필요한 사항으로는 정부 및 지자체, 지역의 적절한 예산 편성과 함께 정책적으로 학교 교육체계 안에서 산림치유 지도사와 같은 전문가의 개입을 통해 다양한 산림치유 프로그램으로 제공되길 바라는 것으로 나타났다.

소화제의 제형변경에 따른 전분소화력의 저하

양유리,윤성미,김재연,노환성 한국병원약사회 1999 병원약사회지 Vol.16 No.2

Digestants are made of enteric coated, multistage, or complex-form tablet for protecting against gastric deactivation and allowing delivery of predictable, high levels of biologically active enzyme to the target site for example stomach, duodenum. So when they are crushed, the stability of digestants are decreased evidently. The purpose of this study is to evaluate how much degree does the digestive action decrease especially in starch, when the formulation is changed to powder. The results are follows. Basic digestive potency per gram is little difference between capsules and tablets (3.16±0.09 (IU/g), 3.21±0.12 (IU/g) (P=0.3777, CI=95%) but capsules are more potent in digestion than tablet when they are pretreated by pH 1.2 gastric acids (0.48±0.13, 0.72±0.11, P=0.0055, CI=95%). The rate of decrease indigestive action is higher in tablet than in capsule (84±3.59%, 77.5±2.99% (P=0.0036, CI=95%). There, We made a determination that change of formulation made a greate decrease in digestive action especially enteric coated tablets.

Control of Green Peach Aphid (Myzus Persicae) by Combination of Plant Oil Formulations and Low-dosed Imidacloprid

양유리,김선화,박명렬,김익수,김인선 한국환경농학회 2010 한국환경농학회지 Vol.29 No.3

Aphids are one of the major pests in agricultural crops. A number of synthetic pesticides have been used for control of aphids in agriculture, but increasing public concerns over their adverse effects on the environment have required more environmentally-friendly methods for pest management. In this study, we examined plant oil formulations for the control of green peach aphid (Myzus persicae). Oil formulations were prepared by hydrolyzing the plant oils in ethanolic KOH solution and diluted at the rate of 1:500 for aphid control. The oil formulations showed aphid mortalities ranging from 24.44 to 43.33% in vitro. Significantly increased aphid mortalities were observed by the treatment of oil formulations combined with low-dosed imidacloprid. No significant difference in the aphid mortality was observed between the oil formulations. Mass spectrometry analyses of aphids treated with the low dosed-imidacloprid plus the plant oil formulations detected similar concentrations of imidacloprid between the treatments. In field trial bioassays against aphids, significantly decreased aphid population were observed in the pepper plants treated with soybean oil formulation combined with the low-dosed imidacloprid, while aphid population dramatically increased in the pepper plants treated with the low-dosed imidacloprid alone. These results suggested that the plant oil formulations can be used as an environmentally-friendly method for enhancing the insecticidal effectiveness, which may play a role in reducing the use of synthetic pesticide in agriculture.

병원 외래 이용 환자의 의료 커뮤니케이션 유형, 역량 및 만족도

양유리,오의금 성인간호학회 2015 성인간호학회 학술대회 Vol.2015 No.4

미술치료가 장애아동을 둔 비장애형제의 우울 및 스트레스에 미치는 영향

양유리 한국예술치료학회 2015 한국예술치료학회지 Vol.15 No.2

본 연구는 장애아 형제를 둔 비장애형제자매를 대상으로 미술치료가 장애아동을 둔 비장애형제자매의 우울 및 스트레스에 어떠한 영향을 주는지 알아보는데 목적이 있다. 2014년 5월 12일부터 약 5개월에 걸쳐서 주1회 80분씩 총 15회기 동안 지적장애 1급 형제자매를 둔 초등학교 1학년 비장애아 동 4팀(8명)의 형제자매를 선발하여 미술치료프로그램을 진행하였다. 프로그램의 효과를 알아보기 위하여 양적검사로는 우울척도(CDI척도), 스트레스척도(QRS척도), 장애형제를 대하는 행동평 가 질문지를 사용하였고, 질적 검사로는 KHTP 그림검사, DAS 그림검사, 빗속의 사람검사를 사전·사후검사로 실시하였다. 그 결과 양적검사와 질적검사 모두 미술치료프로그램이 장애아동을 둔 비장애형제자매의 우울 및 스트레스 감소 에 영향을 준 것으로 나타났다. The purpose of this study was to examine how art therapy using drawing test and index test on normal siblings of disabled children affects their depression and stress. For this study, normal siblings of disabled children were subscribed to select a total of 4 teams (8 children) of normal siblings. Each team consisted of one normal child in 1st grade with a sibling who is diagnosed with Class 1 Mental Disability and one disabled child. They participated in 15 sessions of art therapy program in the form of individual therapy at an independent space in the center for about 5 months. Each session took place once of week for 80 minutes. In order to rate the effect of program, depression scale (CID scale), stress scale (QRS scale), and survey of behaviors around disabled siblings were used for quantitative surveys, while KHTP drawing test, DAS drawing test, and person in rain test for qualitative surveys for pre-test and post-test. Therefore, it was concluded that the individual art therapy program can effectively reduce the depression and stress of normal siblings of disabled children.

가토 각막에서 자가 윤부이식 시 성공을 위한 최소 윤부 양에 대한 연구

양유리,최남영,김진형,김만수,Yoo Ri Yang,Nam Young Choi,Jin Hyung Kim,Man Soo Kim 대한안과학회 2006 대한안과학회지 Vol.47 No.4

Purpose: To investigate the minimal requirements of the limbal epithelium for successful limbal stem cell transplantation and the healing process. Methods: Nine rabbits were divided into 4, 6, and 8 clock-hour transplantation groups. Limbal autografts from the healthy fellow eye were transplanted to the iatrogenic damaged eye. The amniotic membrane served as a stem cell niche. Experimental corneas were evaluated by slit lamp examination and immunohistochemistry. Results: In the over 9 hours transplantation group, the healing process of the epithelium from the limbal stem cell was revealed and cornea-specific keratin k3, transcription factor p63, and connexin 43 were detected by immunohistochemistry. The normal corneal epithelium was regenerated after 60 days postoperatively in the fellow donor eye. Conclusions: Limbal cell transplantation of over 9 hours seems to be a safe and effective method in the treatment of severe ocular surface disorders. In addition, the donation of limbal epithelium for up to 8 hours did not affect the normal corneal regenerating capability.