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노환성,김운자,박건구,조영환,박형섭,Ro, Hwan-Seong,Kim, Oon-Ja,Park, Kun-Ku,Cho, Young-Hwan,Park, Hyung-Sup 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.4
Development of hyperlipidemic animal model is prerequisite for the screening of drugs lowering the blood lipoprotein level. In this study, two kinds of diet regimens were tried for the hyperlipidemic effect. The model will be used for the screening of current prescriptions to a variety of diseases related to hyperlipidemia by practioner of traditional herbal medicine. Fifteen male Wister rats of 200g were divided into three groups, and given normal, or either one of the two high cholesterol diets for up to 2 weeks. Regimen HC-1 and regimen HC-2 contained I% and 2% cholesterol in diet, respectively. Total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL) and lower density lipoprotein cholesterol (LDL) levels in the serum were measured before the start of the diet, at 1 week after the start, and at 2 week point. Both regimens resulted in hyperlipidemia with the typical characteristics of increase in TC and LDL, and reduction in HDL, and showed no observable side effects such as diarrhea. In conclusion, both of HC-1 and HC-2 regimens appeared appropriate as diet regimens for the hyperlipidemic rat model.
노환성,양현옥,김재연,조영환,박형섭 한국병원약사회 2001 병원약사회지 Vol.18 No.4
In our previous report, the water extract of Bupleuri radix showed the lowering effect of total cholesterol level in the experimentally induced hyperlipidemic rats. In order to elucidate the active ingredient(s), the water extract were dialyzed, ad two fractions, high molecule fraction and low molecule fraction, were obtained. These two fractions were tested on the experimentally induced hyperlipidemia in rats for lowering effect of serum lipoprotein contents. Hyperlipidemia was induced on male Wistar rats by feeding high cholesterol diet for 7 days. After oral administration of above samples for 4 weeks, serum lipids profile was monitored by measuring total cholesterol, triglyceride, high density lipoprotein cholesterol and low density lipoprotein cholesterol level. Low molecule fraction decreased total cholesterol and triglyceride levels significantly (p<0.05) at 4 week point when they were compared with the control group.
노환성,송영천,김재연,조영환 한국병원약사회 1996 병원약사회지 Vol.13 No.1
Hospital Pharmacists’ consciousness for pharmacy education was surveyed by questionnaire method to hospital pharmacists who are working at 22 general hospitals in Seoul City. The results are as follows:1. Lectures and trainings for clinical pharmacy should be added to present curricurum of pharmacy education. 2. For adding patient-oriented curricurum, the term of pharmacy education should be extended to 5 or 6 years. 3. The place of clinical practice for pharmacy students will be considered in hospital pharmacy and retail pharmacy, too. 4. Clinical pharmacy and basic medicines e.g. anatomy, pathology and physiology, should be included in the course of study on national examination for pharmacists.
고지혈증 랫트를 이용한 작약의 수종 용매 추출물에 의한 항고지혈 효과
노환성,고우경,양현옥,박건구,조영환,박형섭 ( Hwan Seong Ro,Woo Kyoung Ko,Hyun Ok Yang,Kun Koo Park,Young Hwan Cho,Hyoung Sup Park ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.2
N/A Hexane, chloroform, methanol and water extracts of Paeoniae Radix were tested on the experimentally induced hypercholesterolemia in rats for lowering effect of serum lipoprotein contents. Hyperlipidemia was induced on male Wistar rats by feeding high cholestetrol diet for 7 days. Serum lipid profile was verified on these rats by measuring total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL), and low density lipoprotein cholesterol (LDL). Then, the diet was changed to normal. At the same time, hexane, chloroform, methanol and water extract of Paeoniae Radix were given orally on daily basis, and the changes in the serum lipid profile were assessed for 4 weeks. Methanol extract of Paeoniae radix decreased TC level at 1. 2, and 4 week point significantly, and water extract decreased TC level at 4 week point significantly comparing with the control group.
盧煥成 서울大學校 保健大學院 1969 公衆保健雜誌 Vol.6 No.1
The purpose of this study is to provide data required for the formulation of a pharmacist manpower planning as part of the medical manpower planning. As the result of surveys conducted during the period of May 1. to July 20, 1968, on a total of 10,116 pharmacists regularly registered in 1968 the following conclusion has been reached. 1. The number of pharmacists is broken down by sex into 55.8 per cent of male pharmacist and 44.2 per cent of female pharmacist. 2. The average age of pharmacists is low in as much as the group comprising those at the ages of 26 to 35 years constitutes 75.8 per cent of the total number of pharmacists. 3. A great number of pharmacists are concentrated in Seoul, constituting 47.7% per cent of the total number of pharmacists in the nation. 4. In terms of their present address. 83.3 per cent of pharmacists are in urban areas while 16.7 per cent of them are in rural areas. 5. The urbanization ratio of female pharmacist is 92.4 per cent, and that of male pharmacist 76.3 per cent. 6. In terms of their present addresses, the number of pharmacists in urban areas is broken down by sex into 50.5 per cent of male pharmacists and 49.5 per cent of female pharmacists, while that in rural areas is broken down into 79.6 per cent of male pharmacists and 20.4 per cent of female pharmacists. 7. Pharmacists are broken down by their birth places as follows: Male pharmacist: Urban......48.2 per cent Rural........51.8 per cent Female pharmacist: Urban.......65.8 per cent Rural........34.2 per cent 8. They are broken down by their areas of work as follows: Urban: 82.9 per cent Rural : 17.1 per cent 9. As for their distribution by kind of occupation, those working at pharmcies constitute the greatest proportion of 69.8 per cent. 10. On the basis of the above results, the following recommendation is made: 1) It is necessary to readjust the number of graduate pharmacists. 2) In order to eradicate the excessive supply of pharmacists in urban areas, they should be encouraged to work in rural areas. 3) The scope of the employment of pharmacists should be extended. 4) An adequate policy should be considered to meet the anticipated "vacuum period" in the supply of pharmacists 20 years hence.