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연구논문 : 의약화학 ; MAP kinase 활성화와 액틴 환 형성을 통하여 RANKL 유도된 파골세포 분화와 기능을 억제하는 엘라지탄닌, 후로신
박의균 ( Eui Kyun Park ),김명선 ( Myung Sunny Kim ),이승호 ( Seung Ho Lee ),김경희 ( Kyung Hee Kim ),박주영 ( Ju Young Park ),김태호 ( Tae Ho Kim ),이인선 ( In Seon Lee ),우제태 ( Je Tae Woo ),정재창 ( Jae Chang Jung ),신홍인 ( Ho 영남대학교 약품개발연구소 2005 영남대학교 약품개발연구소 연구업적집 Vol.15 No.-
신홍임,이승희,김승호,Shin, Hong-Im,Lee, Seung-Hee,Kim, Seung-Ho 연세대학교 의과대학 2008 의학교육논단 Vol.10 No.2
Purpose : The establishment of clinical skills centers(CSCs) to facilitate the teaching and assessment of clinical skills is one of the more recent developments occurring in medical schools worldwide. The aim of this study is to review experiences of CSCs in other medical schools and learn how to design a CSC in our school. Methods : This study was undertaken in two steps. In the first step, educational activities of CSCs in 6 medical schools were reviewed. In the second step, a search for articles of journals regarding clinical skills education in CSCs was conducted. Results : The review of CSCs programs reveals variations among centers in teaching and assessment activities. However there are increasing trends of utilizing CSCs in teaching and learning in CSCs. The delivery of clinical skills is expanded by an increasing use of simulated patients and realistic simulators. Through an audio/video technology, availability of more detailed monitoring and feedback. CSCs also provide greater opportunity for assessment of communications skills, physical examination and practical procedures. Conclusions: CSCs contribute to the effectiveness in clinical teaching and assessment. Educational benefits of a CSC can be maximized by utilizing new delivery methods, implementing educational strategies and staff development programmes.
혈관내피성장인자가 사람 지방간엽줄기세포와 골수간엽줄기세포의 골재생 유도에 미치는 영향
임지원 ( Ji Won Lim ),노혜정 ( Hey Jeong Noh ),양정호 ( Jung Ho Yang ),유창국 ( Chang Kook You ),윤희숙 ( Hui Suk Yun ),신홍인 ( Hong In Shin ),김신윤 ( Shin Yoon Kim ),박의균 ( Eui Kyun Park ) 한국조직공학·재생의학회 2013 조직공학과 재생의학 Vol.10 No.1s
Human adipose tissue-derived stromal cells (ATSCs) and human bone marrow stromal cells (BMSCs) are promising stem cell sources for bone regeneration. However, implantation of ATSCs or BMSCs alone induces partial effect on bone formation. Angiogenesis and blood supply are essential in tissue survival after implantation. We investigated effects of vascular endothelial growth factor (VEGF), a well known angiogenic factor, on ATSCand BMSC-induced bone regeneration. In vitro effects of VEGF on the proliferation (MTS assay) and osteogenic differentiation (ALP and Alizarin Red staining) of ATSCs and BMSCs were examined. ATSCs and BMSCs were seeded on biphasic calcium phosphate (BCP), treated with VEGF, and implanted on calvarial defects of nude mice. Bone regeneration was assessed by Micro-CT and histology at 10 weeks after implantation. Proliferation and differentiation of ATSCs and BMSCs was not increased by VEGF in vitro. However, BMSCs and ATSCs treated with VEGF showed increased bone mineral density (BMD) and bone mineral content (BMC) as assessed by micro-CT. In addition, histomorphometric analysis showed that new bone formation was significantly increased in VEGFtreated ATSCs (30%) and BMSCs (21%) groups compared to untreated group. These results demonstrated that adult MSCs (ATSCs and BMSCs) treated with VEGF can promote bone regeneration in calvarial critical-sized defect model. Taken together, VEGF can be a useful factor for bone repair and regeneration.
손정오 ( Jung Oh Sohn ),박의균 ( Eui Kyun Park ),이진호 ( Jin Ho Lee ),신홍인 ( Hong In Shin ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.1s
Bone defects occur in a variety of clinical situation, and their reconstruction to provide mechanical integrity to the skeleton is a necessary step in the patient rehabilitation. Bones can regenerate themselves to repair defects up to a certain size but sometimes the suitable implant materials have to be applied to facilitate the bone repair. As a part of the effort to improve the efficiency of bone repair, we evaluated the hydrophilized asymmetric pore sized polydioxanone membrane for guided bone regeneration. The polydioxanone membrane was fabricated to have different pore size at inner (around 50 nm in diameter) and outer surface (around 50 μm in diameter) with an average 0.4 mm thickness. The cytotoxic effect of it was analyzed in vitro and the histocompatibility and guided bone regeneration effects were evaluated in vivo, respectively. The rat tibia bone defects measuring 7 mm×3 mm in size were treated with polydioxanone membrane with or without application of 10 mM LiCl or 100 μg/ml T-CAM. The defects were evaluated at 3weeks after treatment by radiography and histology. The polydioxanone membrane was relatively resilient with some cushion. It was no cytotoxic and evoked neither an immune nor an inflammatory response. It was gradually absorbed by numerous multinucleated giant cells with time and completely disappeared within 8 weeks at rat subcutaneous pouches. The application of polydioxanone membrane at rat tibia bone defects induced more effective bone repair with matured cortical plate regeneration compared to none membrane applied group. In addition, the treatment of 10 mM LiCl and 100 μg/ml T-CAM within polydioxanone membrane facilitated bony healing. These results suggest that the combined application of bioactive molecules such as 10 mM LiCl or 100 μg/ml T-CAM with hydrophilized sized polydioxanone membrane can facilitate the guided bone regeneration.
여러 종류의 성장인자와 덱사메타손이 골수간엽줄기세포의 증식에 미치는 효과
손민정 ( Min Jung Shon ),이선영 ( Sun Young Lee ),김태호 ( Tae Ho Kim ),김석영 ( Suk Young Kim ),강길선 ( Gil Son Khang ),손영숙 ( Young Sook Son ),신홍인 ( Hong In Shin ),김신윤 ( Shin Yoon Kim ),박의균 ( Eui Kyun Park ) 한국조직공학과 재생의학회 2006 조직공학과 재생의학 Vol.3 No.4
Bone marrow stromal cells(BMSCs) are pluripotent cells capable of differentiating into several types of cells and are thus an attractive cell source for connective tissue engineering. For use of BMSCs in there applications, ex vivo expansion is necessary to obtain sufficient numbers of cells. Various growth factors regulate the recruitment of progenitor cells and their proliferation and differentiation into matured cells. In this study we have investigated the effects of different growth factors and in combination with dexamethasone(Dex) on the proliferation of BMSCs. We found that at a low concentration of growth factors(1 ng/mL) including fibroblast growth factor(FGF)-2, epidermal growth factor(EGF), hepatocyte growth factor(HGF), transforming growth factor-ß(TGF-ß), vescular endothelial growth factor(VEGF) and platelet derived growth factor-BB(PDGF-BB), FGF-2 was most effective in stimulation of proliferation in BMSCs in vitro. In addition, when FGF-2, PDGF and EGF were combined with Dex, proliferation of BMSCs was further stimulated. Among the growth factors, it was shown that FGF-2 in combination with Dex showed most prominent effect on stimulation of BMSCs. These results demonstrate that a low concentration of FGF-2 incombination with Dex may be useful stimulants for ex vivo expansion of BMSCs.