MTHFR 677유전자형과 복합운동이 남자 대학생들의 호모시스테인 농도에 미치는 영향

신윤아 ( Yun A Shin ) 한국스포츠정책과학원(구 한국스포츠개발원) 2010 체육과학연구 Vol.21 No.3

이 연구의 목적은 심폐체력, 심혈관질환 위험요인과 식이섭취가 호모시스테인의 농도에 미치는 영향을 알아보고, MTHFR 유전자 다형성과 복합운동에 따른 호모시스테인의 농도변화를 알아보는 데 있다. 이 연구는 62명의 건강한 남자 대학생(24.50 ± 1.84세)을 대상으로 실시하였으며, 12주간 주 4회의 중,고강도의 유산소운동 (70%VO2R)과 저항운동(8~12RM)을 병행한 복합운동을 실시하였다. 심폐체력, 심혈관질환 위험요인과 식이 섭취는 호모시스테인의 농도에 유의한 영향을 주지 않는 것으로 나타났다. 반면, MTHFR 유전자 다형성에 따른 호모시스테인 농도는 운동 전 유의한 차이를 나타내었으며, TT 유전자형 집단이 CC 유전자형( p<.001)과 CT 유전자형 집단( p<.001)보다 유의하게 높은 혈중 호모시스테인 농도를 나타내었다. 12주간 운동훈련 후체질량지수의 변화가 측정시기와 유전자형 집단의 상호작용 효과를 나타내었으며( p<.05), 호모시스테인의 농도도 유전자형 집단( p<.05) 및 측정시기와 유전자형 집단의 상호작용 효과를 나타내었다( p<.01). 따라서 건강한 남자 대학생들의 경우 심폐체력, 심혈관질환 위험요인 및 식이섭취는 호모시스테인 농도에 유의한 영향을 주지않는 것으로 나타났다. 또한, 호모시스테인 농도는 MTHFR 유전자형에 따라 차이를 나타내는 것으로 나타났으며, 운동훈련에 따른 변화에도 영향을 주는 것으로 나타났다. The purpose of this study was to investigate the association between cardiorespiratory fitness, cardiovascular risk factors, dietary habits and homocysteine level in male college students. Also, this study was to investigate the combined training effects on homocysteine levels in male college students according to MTHFR 677 polymorphism. The subjects who participated in this study were 62 healthy male college students(24.50 ± 1.84yrs). All subjects participated in the supervised training program for 12 weeks(4days a week) consisting of aerobic exercise(70% VO2R, 50minutes a day) and resistance training(8~12 RM, 3sets). We did not find any association among cardiorespiratory fitness, cardiovascular risk factors, dietary habits and homocysteine level. Mean values of plasma homocysteine level were significantly higher in the TT genotype group compared to the CC and CT genotype in baseline(p<.001). After exercise training, it was shown that body mass index(p<.05) and plasma homocysteine levels(p<.001) significantly interaction effect between time and group. No change occurred in total cholesterol, high density lipoprotein cholesterol, or triglycerides. Consequently, there were no significant relationships among plasma homocysteine and cardiovascular risk factor, dietary habits and cariorespiratory fitness. However, our results indicate that MTHFR 677 gene affected plasma homocysteine level at baseline and the changes of homocysteine level after combined exercise training.

신체활동량과 식이소금 및 칼륨 섭취가 대학생들의 혈압과 비만에 미치는 영향

신윤아(Shin, Yun-A) 한국웰니스학회 2016 한국웰니스학회지 Vol.11 No.4

이 연구는 대학생들을 대상으로 신체활동량, 소금과 칼륨의 섭취가 비만과 혈압에 미치는 영향을 총체적으로 알아보고자 실시되었다. 이 연구는 대학교에 재학 중인 남자 대학생(n=221)과 여자 대학생(n=241)을 대상으로 실시되었다. 혈압은 안정 시에 2번 측정하였고, 식이섭취량은 24시간 회상법을 이용하여 주 3일 이상의 식이섭취를 분석하였으며, 신체활동량은 7일간의 신체활동기록을 분석하였다. 통계적 분석을 위하여 성별에 따른 차이는 독립검증(Independent t-test)을 이용하였으며, 신체활동, 식이 나트륨과 칼륨의 섭취에 따른 집단 간 비교는 일원변량분석(One-way ANOVA)을 이용하여 분석하였다. 남성과 여성모두 신체활동량에 따른 고혈압 유병률은 차이가 없었다. 식이 소금과 칼륨의 섭취에 따른 고혈압 유병률은 여성 집단에서 차이를 나타내었다(p=.042). 남성 집단에서는 식이 칼륨섭취와 이완기 혈압사이에 유의한 음의 관련성(r=-.162, p=.017)을 나타내었다. 또한 남성(r=.253, p<.001)과 여성(r=.278, p<.001) 모두 체질량지수와 수축기혈압이 유의한 양의 관련성을 나타내었다. 고혈압 발생 위험률은 소금섭취와 칼륨섭취가 모두 높을 때에는 남성 집단에서는 2배, 여성 집단에서는 3.1배 증가하는 것으로 나타났다. 반면, 소금섭취량은 높고 칼륨섭취가 낮을 때에는 고혈압 유병률이 남성 집단에서 12.배, 여성 집단에서 24.2배 증가하는 것으로 나타났다(남성: t=13.136, 여성: t=19.388, p<001). 따라서 대학생들의 고혈압을 예방하고 건강관리를 위해서는 적절한 소금과 칼륨의 섭취가 필요하며, 비만과도 관련성을 나타내므로 적절한 체중관리가 필요할 것으로 판단된다. The purpose of this study was to investigate the effect of physical activity, and sodium and potassium intakes on blood pressure and obesity in college students. This study aimed to analyzes data from 462 subjects(male: 221, female: 241) who participated in a health and nutrition survey. Blood pressure was measured twice after a 5-min rest at a single visit. Dietary intake was assessed based on data from at least three 24-h dietary records. Physical activity was assessed based on data from 7-day physical activity records. Sex-related differences were analyzed by using an independent t-test and differences according to physical activity, and sodium, and potassium intakes were analyzed by using One-way analysis of variance. Our results showed no significant differences in hypertension prevalence according to physical activity in both the male and female groups. In the hypertension prevalence according to dietary sodium and potassium intakes, a significant difference was found in the female group, but not in the male group(p=.042). A significant negative association was observed between dietary potassium intake and diastolic blood pressure in the male group(r=-.162, p=.017). Moreover, a positive association was found between body mass index and systolic blood pressure in both the male(r=.253, p<.001) and female groups(r=.278, p<.001). Among the participants with high sodium and potassium intakes, hypertension prevalence increased 2 times in the male group and 3.1 times in the female group. Among those with high sodium and low potassium intakes, the hypertension prevalence increased 12.1 and 24.2 times in the male and the female groups(t=13.136 in the male, t=19.388 in the female, p<001). Therefore, we suggest that appropriate dietary sodium and potassium intakes are needed to prevent hypertension and that weight management are needed for prevention of obesity, which was a positively associated with hypertension.

운동훈련과 단백질 섭취에 따른 골격근 단백질 대사: 안정성 동위원소 추적체법을 이용한 연구결과를 중심으로

신윤아 ( Yun-a Shin ),김일영 ( Il-young Kim ) 한국운동생리학회(구 한국운동과학회) 2017 운동과학 Vol.26 No.2

INTRODUCTION: Regulation of skeletal muscle protein mass is implicated not only in exercise performance but in metabolic health. Exercise in combination with nutrition, particularly dietary protein/amino acid intake, are the pragmatic approach that effectively induces muscle anabolic response (i.e., muscle hypertrophy) through regulating protein synthesis and breakdown. PURPOSE: The purpose of this review was to summarize available data on the effect of exercise intervention and amino acids intake on muscle protein synthesis and breakdown and provide an insight into development of an effective exercise intervention and amino acids supplements, applicable to training practice. METHODS: In this review, we have reviewed currently available data mainly from stable isotope tracer studies with respect to the effect of exercise intervention and protein or amino acid supplement on muscle protein anabolic response. CONCLUSIONS: Taken together, exercise alone may not be effective in achieving a positive net muscle protein balance due to the fact that protein breakdown still exceeds protein synthesis until nutrition intake such as protein/amino acids. It appears that muscle anabolic response increases in proportional to the amount of protein intake up to 20 - 35 g depending on quality of protein, age, differences on exercise intensity, duration, and frequency, and individual`s training status

비만여성들의 C-Reactive Protein과 염증반응지표에 미치는 유산소훈련의 효과

신윤아(Yun A Shin),임강일(Kang Il Lim),석민화(Min Hwa Suk) 한국사회체육학회 2007 한국사회체육학회지 Vol.0 No.30

The purpose of this study was investigate the effect of aerobic exercise on high sensitivity C-reactive protein(hs=CRP), inflammatory markers, and cardiovascular risk factors in obese women. Nineteen obese women(body mass indexs≥25) aged 40 to 53 years were randomly assigned to either a training or control group. The training program consisted of 12 weeks of supervised aerobic exercise(60%VO2R, 60min) three times a week on treadmill. Body weight, BMI, percent of body fat, and waist circumference were significantly decreased after training. Aerobic exercise significantly decreased cardiovascular risk factors and inflammatory markers, including fibrinogen, leptin and IL-6 whereas CRP and adiponectin did not change. The reduction of weight after training was positively associated with the decrease of SBP, TC, TC/HDL-C, TG, CRP, leptin, and IL-6. The change of CRP was positively associated with that of fibrinogen and leptin(p<.05), and also a positive correlation between the changes of leptin and IL-6 was observed(p<.01). As a results, a 12-week aerobic exercise intervention improved cardiovascular risk factors as well as inflammatory markers including fibrinogen, IL-6 and leptin, but had no effect on the modification of CRP despite the improvement of body composition in obese women.

중년 남성의 신체활동량과 형태가 백혈구 텔로미어 길이에 미치는 영향

신윤아 ( Yun-a Shin ),김창선 ( Chang-sun Kim ),이상현 ( Sang-hyun Lee ),이용우 ( Yong-woo Lee ),김준수 ( Jun-soo Kim ),박동호 ( Dong-ho Park ) 한국운동생리학회 2021 운동과학 Vol.30 No.4

PURPOSE: Leukocyte telomere length (LTL) is a potential indicator of cellular senescence. However, its relationship with the type and volume of regular exercise is unclear. Therefore, we investigated the effects of the type and volume of long-term regular exercise on the LTL in middle-aged men (N=109, mean age=44.7±4.1 years [range: 40-56 years]). METHODS: For all participants, the volume of physical activity (PA) was evaluated using a self-report questionnaire, and blood samples were collected simultaneously. We cross-sectionally examined the associations among the type and volume of PA, LTL, telomerase activity (TA), mitochondrial DNA copy number (mtDNA), and body composition in three groups: 1) bodybuilders (BBs) with at least 5 years of athletic experience (n=36, mean age: 42.3±3.3 years [40-51 years]), 2) cyclists (CCs) with an athletic career similar to that of the BBs (n=37, mean age: 45.4±4.4 years [range: 40-53 years]), and 3) healthy ordinary people (CON; n=36, mean age: 46.3±3.3 years [range: 40-56 years]). RESULTS: The LTL showed a significant positive correlation with the volume of PA (r=.285, p=.003), regardless of the type of PA. Furthermore, the LTLs were longer in the BB (p=.007) and CC (p=.003) groups (who performed moderate-to-vigorous PA for 150 minutes or more per week) than in the CON group. Conversely, the TA was significantly higher in the BB group (p=.009) than in the CON group; however, it only tended to be high in the CC group (p=.115). There were no intergroup differences in both the mtDNA (p=.127) and 8-hydroxydeoxyguanosine (p=.289) levels. CONCLUSIONS: The TA was found to increase, and thus prevent telomere loss, in middle-aged men who performed PA of moderate-to-vigorous intensity, regardless of the PA type.

뇌병변 장애인의 심폐체력과 염증반응 지표 및 뇌졸중 위험요인의 관련성

신윤아 ( Yun A Shin ),김효중 ( Hyou Jung Kim ),임강일 ( Kang Il Lim ) 한국특수체육학회 2009 한국특수체육학회지 Vol.17 No.4

본 연구의 목적은 뇌병변 장애인 중 뇌졸중 환자들을 대상으로 심폐체력과 염증반응 지표 및 뇌졸중 위험요인과의 관련성을 분석하는데 있다. 본 연구는 80명의 뇌졸중 환자를 대상으로 실시하였다. 여성 뇌졸중 환자는 남성보다 체지방량(p<.001), 총콜레스테롤(p<.05), 고밀도지단백질 콜레스테롤(p<.05)이 높은 것으로 나타났으며, 남성 뇌졸중 환자는 호모시스테인 농도(p<.001)과 hsCRP 수준(p<.05)이 여성보다 높은 것으로 나타났다. 전체적으로 백혈구 수는 체질량지수(p<.05) 및 공복 시 혈당(p<.01)과 유의한 양의 상관관계를 나타내었으며, 고밀도지단백질 콜레스테롤(p<.01)과 유의한 음의 상관관계를 나타내었다. Fibrinogen은 체지방률(p<.01)과 유의한 양의 상관관계를 나타내었다. oxLDL은 총콜레스테롤(p<.01) 및 호모시스테인(p<.05)과 유의한 양의 관련성을 나타내었다. 심폐체력은 체질량지수(p<.05), 체지방량(p=.01)과 음의 관련성을 나타내었다. 이상의 결과를 종합 해보면 본 연구의 뇌졸중 환자들은 염증반응 지표 중 백혈구 수와 혈중 oxLDL 수준이 증가되어 있으며, 이러한 염증지표가 뇌졸중 위험과 관련이 높은 것으로 나타나 염증반응 개선을 통한 뇌졸중 위험요인의 관리가 필요한 것으로 고려된다. The purpose of this study was to investigate the association between cardiorespiratory fitness, inflammation marker and stroke risk factors. The subjects who participated in this study were 80 stroke patients. There was showed that body percent fat(p<.001), total cholesterol(p<.05), and high lipoprotein cholesterol(p<.05) in women were higher than men. On the other hand, homocystein(p<.001) and hsCRP(p<.05) in men were higher than women. White blood cell(WBC) was positively correlated with body mass index(BMI)(p<.05) and fasting blood glucose(FBG) level(p<.01) and negatively correlated with high lipoprotein cholesterol(HDL-C)(p<.01). Fibrinogen was positively correlated with percent body fat(p<.01). OxLDL(oxidative low-density lipoprotein) was positively correlated with total cholesterol(TC)(p<.01) and homocystein(p<.05). Moreover, the cariorespratory fitness was negatively correlated with BMI(p<.05) and body percent fat(p<.01) and positively correlated with HDL-C(p<.05). Consequently, the results of this study demonstrated that the inflammation indices, especially WBC and plasma oxLDL, were up-regulated in stroke patients and these factors have significant relationship with the recurrent stroke events. Therefore, stroke patients in this study were need to manage and treat for the prevention of recurrent stroke events.

복합 트레이닝이 편마비 환자의 뇌졸중 위험요인과 일상활동능력에 미치는 효과

신윤아 ( Yun A Shin ),이형국 ( Hyung Kook Lee ) 한국운동생리학회(구-한국운동과학회) 2005 운동과학 Vol.14 No.3

수중 운동 수행 시 숙련자와 비숙련자의 면역글로불린 A와 코티졸 반응 비교

신윤아(Yun A Shin),유연주(Yeon Joo Yu),석민화(Min Hwa Suk) 한국사회체육학회 2007 한국사회체육학회지 Vol.0 No.30

The purpose of this study was to compare the stress and immune response between aquarobic experts and novices during cardio-aquarobic exercise. Immunogloblin(IgA), cortisol, Rating of Perceived Exertion(RPE), and heart rate were measured to identify the response of stress and immune in accordance with the levels of cardiovascular fitness during cardio-aquarobic exercise. Expert group(n=9) had 56 months of experience and novice group(n=8) had one month of experience in the aquatic exercise field. The heart rate showed significant difference in group(p<.05) and time(p<.001), and RPE showed significant differences in group(p<.05), time(p<.001), and interactions between group and time(p<.001). IgA and cortisol showed significant differences in time(before and after aquarobic exercise)(p<.01, p<.001, respectively). The response of immune and stress did not show any significant difference both rest and post exercise condition between groups. Therefore, we think that aquarobic exercise is the moderate intensity of exercise which reduced the impact of the muscloskeletal system in body and the psychological stress and increased the immune system. Our results demonstrated that the expert group in aquarobic exercise only showed significant differences in the heart rate and RPE. Therefore further study may investigate the response of immune and stress in different intensity, levels, and conditions of aquarobic exercise.

Ucp2 -866 GG Genotype Confers Higher Insulin Sensitivity and Oxidative Stress Defense Following Exercise Training

Shin, Yun-A(신윤아) 한국사회체육학회 2017 한국사회체육학회지 Vol.0 No.67

이 연구의 목적은 UCP2 -866 유전자 다형성이 운동훈련에 따른 심혈관질환 위험요인과 산화스트레스의 개선에 미치는 효과의 차이를 알아보고 실시되었다. 57명의 심혈관질환자가 피험자로 참여하였으며, 피험자들은 60% VO₂R의 강도에서 트레드밀 걷기와 달리기 45분을 주 3회, 6개월간 실시하였다. 6개월간의 유산소운동 후 신체조성, 심혈관질환 위험요인과 산화스트레스 지표들을 측정한 결과는 다음과 같다. 6개월간의 유산소운동 후 체중(p<.001), 체질량지수(p<.001), 허리둘레(p<.001)가 유의하게 감소하고 VO₂max가 GG와 GA+AA 유전자 집단 모두에서 유의하게 증가하였다. 6개월간의 유산소운동 후 -866 GA+AA 유전자형 집단은 HOMA-IR(<p.05)이 유의하게 감소하였고, -866 GG 유전자형 집단은 인슐린 수준(p<.05)과 HOMA-IR(p<.01)이 유의하게 감소하고 중성지방(p=.057)이 감소하는 경향을 나타내었다. 6개월간의 유산소운동 후 -866 GG 유전자형집단은 SOD(p<.05)와 GPx(p<.01)가 유의하게 증가하였고, -866 GA+AA 유전자형집단은 SOD(p<.01)가 유의하게 증가하였다. 결론적으로 -866 GG 유전자형집단이 운동훈련에 따른 심혈관질환자들의 인슐린분비 및 산화 스트레스 개선에 더 효과적인 것으로 나타났다.

복합트레이닝 프로그램이 비만인의 렙틴, 아디포넥틴 농도와 대사증후군 요인에 미치는 영향

신윤아 ( Yun A Shin ),임강일 ( Kang Il Lim ),석민화 ( Min Hwa Suk ) 한국운동생리학회(구-한국운동과학회) 2005 운동과학 Vol.14 No.4