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RISS 인기검색어
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- 저자 : 이용우 ( Yong-woo Lee ) (검색결과 468 건)
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이용우,구자현,주충노,Lee, Yong-Woo,Koo, Ja-Hyun,Joo, Chung-No 생화학분자생물학회 1987 한국생화학회지 Vol.20 No.4
Ginsenoside의 고cholesterol혈증 억제작용 메카니즘을 규명하기 위해 고 cholesterol식이를 투여한 쥐의 low density lipoprotein(LDC) 수용체생 합성에 미치는 인삼 (Panax ginseng C.A. Meyer)의 사포닌 분획과 정제된 ginsenoside-$Rh_1$, $-Rb_2$, -Re, $-Rg_1$의 영향을 조사하여 다음과 같은 결과를 얻었다. 고cholesterol식이와 ginsenoside을 함께 투여한 쥐(시험군)의 혈청 cholesterol농도는 고cholesterol식이만으로는 사육한 쥐(대조군)에 비해 현저히 낮았다. 또한, 각 장기 (간, 신장, 정소, 부신피질)의 cholesterol 농도를 조사한 경우에도 위와같은 결과를 얻었다. 쥐 간의 $^{125}I$-LDL에 대한 LDL수용체의 결합활성은 시험군이 대조군에 비해 크게 증가되었으며, 다른 장기 (신장, 정소, 부신피질)의 경우에도 간의 경우와 유사하였다. 이것은 ginsenoside의 혈중 cholosterol 농도저하작용으로 인하여 고농도의 cholesterol에 의한 LDL 수용체의 생합성억제가 완화된 것으로 생각한다. The effect of saponin fraction from Panax ginseng C. A, Meyer and the purified ginsenoside-$Rh_1$, $-Rb_2$, -Re, $-Rg_1$ on LDL receptor biosynthesis in high cholesterol fed rat has been investigated, The cholesterol level of blood serum of high cholesterol diet-ginsenoside administered rat was greatly lower than that of high cholesterol diet administered rat (control) suggesting tbat the ginsenosides have hypocholesterolemic action, Analysis of LDL receptor from various organs such as liver. kidney, adrenal cortex and testis showed that the population of LDL receptors were significantly increased in the above organs suggesting that the hypocholesterolemic action might be brought about by the increase of LDL receptor.
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Alcaligenes eutrophus 균주의 성장과 Ploy-${\beta}$-hydroxybutyrate 생합성에 대한 속도론
이용우,유영제,Lee, Yong-Woo,Yoo, Young-Je 한국미생물 · 생명공학회 1991 한국미생물·생명공학회지 Vol.19 No.2
It is very important to have a good kinetic model which considers the effects of both ammonium and glucose for the control and optimization of the poly-${\beta}$-hydroxybutyrate (PHB) fermentation. A kinetic model for the growth of Alcaligenes eutrophus and the biosynthesis of PHB under both ammonium and glucose limitation was proposed. Growth rate of residual biomass was expressed as a function of concentrations of residual biomass, glucose and ammonium having glucose inhibition. PHB production rate was expressed as a function of concentrations of residual biomass, glucose, ammonium and PHB content having ammonium and product inhibitions. Novel approaches were made to estimate the parameters in the model equations which considered two limiting substrates. Model parameters were evaluated by graphical and simplex methods. The proposed kinetic model fitted the data very well.
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( 1 ) 저밀도 지방단백질 수용체 생합성 억제완화에 미치는 Gisenoside 의 영향
이용우,구자현,주충노 ( Yong Woo Lee,Ja Hyun Koo,Chung No Joo ) 생화학분자생물학회 1987 BMB Reports Vol.20 No.4
The effect of saponin fraction from Panax ginseng C. A. Meyer and the purified ginsenosides-Rb₁, -Rb₂, -Re, -Rg₁ on LDL receptor biosynthesis in high cholesterol fed rat has been investigated. The cholesterol level of blood serum of high cholesterol diet-ginsenoside administered rat was greatly lower than that of high cholesterol diet administered rat (control) suggesting that the ginsenosides have hypocholesterolemic action. Analysis of LDL receptor from various organs such as liver, kidney, adrenal cortex and testis showed that the population of LDL receptors were significantly increased in the above organs suggesting that the hypocholesterolemic action might be brought about by the increase of LDL receptor.
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이용우,김부근,김성한,Lee, Yong-Woo,Khim, Boo-Keun,Kim, Sunghan 한국해양학회 2013 바다 Vol.18 No.4
해수의 염분 및 라돈($^{222}Rn$) 추적자를 이용하여 부산 인근의 동부와 남부 연안해역(문동리, 이천리, 죽성리, 대변리, 연화리, 다대포) 그리고 일광만 내에서 2009년과 2010년에 해저 용천수 유출 가능성을 조사하였다. 해양조사 전에 기본적으로 육상으로부터 해양으로 연장된 선구조 분석을 통하여 해저 용천수의 유출 유망지점을 선정하였다. 선정된 지점들을 포함하여 해안에서 바다쪽으로 약 1~2 km 이내에서 해수의 염분과 라돈을 측정하였다. 부산 인근의 동부 및 남부 연안해역에서 라돈 농도는 연안에서 외양쪽으로 갈수록 낮아지는 경향을 보였다. 또한, 염분의 수직분포에서는 일부 정점의 중간 수층에서 낮은 염분을 가진 수괴의 수평 유입이 관측되었다. 부산 인근의 동부 연안해역에서 유일한 만의 형태를 보이는 일광만 내에서 측정한 염분 수직분포에서도 저층에서 낮은 염분의 수괴가 출현하였다. 이번 조사에서 나타난 연구결과는 부산 인근 연안해역에서 해저 용천수 형태의 담지하수 유출 가능성을 시사하며, 앞으로 해저 용천수 탐사 방법과 미래의 대체 수자원으로서 활용 가능성에 대한 집중적인 연구가 필요할 것으로 판단된다. We measured salinity and $^{222}Rn$ concentration to explore submarine spring along the coastal areas (Mundongri, Icheon-ri, Jukseong-ri, Daebyeon-ri, Yeonhwa-ri, and Dadae-po) including Ilkwang Bay of Busan Metropolitan City in 2009 and 2010. Before field observation, we selected the potential and possible locations of submarine spring based on the lineament distribution and rose diagram analysis. Salinity and radon concentration were measured within the 1~2 km from the coastal lines. Radon activity decreased gradually from onshore to offshore. Vertical profiles of salinity at some stations showed lateral transport of water mass characterized by low salinity. Vertical profiles of salinity in the Ilkwang Bay, which is a unique bay in the south-eastern coastal area of Busan Metropolitan City, also showed the occurrence of low salinity in the bottom seawater. Our results suggest the possible occurrence of submarine discharge of fresh groundwater in the coastal areas around Busan Metropolitan City. In the future, intensive research should be conducted for the exploration methods of submarine spring as well for the possible utility of submarine groundwater as alternative water resources.
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이용우,안천수,신지태,Lee, Yong-Woo,Bui, Toan Duc,Ahn, Chunsoo,Shin, Jitae 대한의용생체공학회 2015 의공학회지 Vol.36 No.2
Osteoarthritis is the most common chronic joint disease in the world. With its progression, cartilage thickness tends to diminish, which causes severe pain to human being. One way to examine the stage of osteoarthritis is to measure the cartilage thickness. When it comes to inter-subject study, however, it is not easy task to compare cartilage thickness since every human being has different cartilage structure. In this paper, we propose a method to assess cartilage defect using MRI inter-subject thickness comparison. First, we used manual segmentation method to build accurate atlas images and each segmented image was labeled as articular surface and bone-cartilage interface in order to measure the thickness. Secondly, each point in the bone-cartilage interface was assigned the measured thickness so that the thickness does not change after registration. We used affine transformation and SyGN to get deformation fields which were then applied to thickness images to have cartilage thickness atlas. In this way, it is possible to investigate pixel-by-pixel thickness comparison. Lastly, the atlas images were made according to their osteoarthritis grade which indicates the degree of its progression. The result atlas images were compared using the analysis of variance in order to verify the validity of our method. The result shows that a significant difference is existed among them with p < 0.001.
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