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췌담도 ; 알코올성 췌장염과 간경변환자에서 알코올 대사효소와 사이토카인의 유전자 다형성
김명식 ( Kim Myeong Sig ),정석 ( Jeong Seog ),이진우 ( Lee Jin U ),권계숙 ( Kwon Gye Sug ),이돈행 ( Lee Don Haeng ),김범수 ( Kim Beom Su ),김형길 ( Kim Hyeong Gil ),신용운 ( Sin Yong Un ),김영수 ( Kim Yeong Su ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 만성음주에 의한 장기의 손상의 개인적 감수성의 차이는 알코올 대사효소나 사이토카인의 유전자 다형성에 의해 영향을 받을 것으로 생각된다. 이 연구는 알코올성 췌장염과 알코올성 간경변 환자에서 알코올 탈수소효소2(ADH2), 알코올 탈수소효소3 (ADH3), 알데하이드 탈수소효소2 (ALDH2), 미소체 에탄올 산화계의 사이토크롬 P450 2E1효소(CYP2E1), 4가지 사이토카인(IL-1, IL-6, IL-8, TNF-α)들의 유전자의 유전자형
Measurement of Hepatic Functional Reserve by Functional Liver Imaging
이진우 ( Lee Jin U ),조혜진 ( Jo Hye Jin ),김정은 ( Kim Jeong Eun ),이정일 ( Lee Jeong Il ),정석 ( Jeong Seog ),권계숙 ( Kwon Gye Sug ),이돈행 ( Lee Don Haeng ),김범수 ( Kim Beom Su ),김형길 ( Kim Hyeong Gil ),신용운 ( Sin Yong U 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<Purpose> To evaluate the feasibility of functional liver imaging (FLI) as a new method for measuring hepatic functional reserve (HFR). <Materials and Methods> Twenty-two patients with cirrhotic liver with various functional impairments (Child-Pugh [CP] c
위선암과 파골성 거대세포상 십이지장암이 병발한 원발성 중복암 1 예
김영수,박상준,이준희,신용운,권계숙,이돈행,김범수,김경래,조현근,김형길,김준미,김승연,박현신 대한내과학회 2001 대한내과학회지 Vol.61 No.2
Osteoclast like giant cells (OGCs) are infrequently encountered in a number of malignancies in extraosseous sites, such as the breast, pancreas, liver, stomach, thyroid gland, and other organs. Immunohistochemical stains demonstrate that the OGCs are of monocytic or histiocytic origin and probably represent a distinctive host response to the tumor. The OGCs show strong reactivity with CD68, and no reactivity with cytokeratin or polyclonal antibody to carcinoembryonic antigen (CEA). We experienced a 70 year old man who presented with epigastric pain and weight loss, and found synchronous duodenal carcinoma with OGCs and gastric adenocarcinoma. Histological examination showed an undifferentiated carcinoma with evenly scattered OGCs in the duodenum and liver metastases. OGCs were never seen to undergo mitotic division or exhibit atypia. By immunohistochemistry, neoplastic cells were diffusely positive for vimentin and focally positive for CAM 5.2 (low molecular weight cytokeratin), but OGCs were positive for only vimentin. He underwent palliative gastrojejunostomy for intestinal obstruction due to a large duodenal neoplasm. We report a case of synchronous double primary cancer of gastric adenocarcinoma and duodenal carcinoma with OGCs in a 70 year old man which was proved histopathologically.(Korean J Med 61:156-161, 2001)