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열처리 조건에 따른 Al-Si-Mg계 합금의 표면 젖음성 영향
장호성,최유진,이승원,전종배,박성혁,신선미,Jang, Hosung,Choi, Yoojin,Lee, Seungwon,Jeon, Jongbae,Park, Sunghyuk,Shin, Sunmi 한국표면공학회 2018 한국표면공학회지 Vol.51 No.6
The present study investigated the effect of heat treatment process on the surface wettability of an Al-Si-Mg alloy. After solution-treated at $525^{\circ}C$ and aged at $160^{\circ}C$, the alloy showed high hardness due to the formation of precipitates. In addition, surface wettability was improved in such a way that the contact angle of distilled water droplet on the flat surface decreased to $37.6{\sim}42.1^{\circ}$ after the heat treatment. The surface energy predicted by Owens-Wendt equation also confirmed the increase of surface energy after the heat-treatment. However, when the surface roughness increased, the positive effect of the heat treatment on wettability diminished due to the geometrical factors of the rough surface.
육미지황환(六味地黃丸) 에탄올 추출물이 난소제거 흰쥐의 경골 소주골에 미치는 영향
김정숙,하혜경,이제현,송계용,김혜진,신선미 한국한의학연구원 2000 한국한의학연구원논문집 Vol.6 No.1
Bone is continuously remodeled during adult life with the resorption of old bone by osteoclasts and its subsequent replacement by osteoblast. Bone homeostasis is maintained by a balance between activities of osteoblasts and osteoclast, but an imbalance between resorption and formation results in bone diseases including osteoporosis. Osteoblasts line up on the bone surface, especially regions of new bone formation, lay down bone matrix (osteoid) in orderly lamellac and induce its mineralization. Thus, the increased activity of osteoblast is helpful to treat and prevent osteoporosis. In this study, we examined whether 80% EtOH extract of yukmijiwhang-whan is capable of affecting osteoblast proliferation using human osteoblast-like cell line, MG-63 and Saos-2. In an in vivo experiment, extract of yukmijiwhang-whan was administered for 9 weeks to ovariectonized (OVX) rats. At necropsy, uterus weights were measured, and trabecular bone area (TBAS) of tibia and the sixth lumber vertebra were measured by bone histomorphology. The maximum cell proliferation of MG-63 caused by extract of yukmijiwhang-whan at 5×10-6mg/ml was approximately 11.5% compared with control. In Saos-2 cell proliferation was approximately 145% of control at 5×10-4mg/ml and maximum alkaline phosphatase (ALP) activity was approximately 143% of control at 5×10-5mg/ml. In animal study, however, the tibia and lumbar TBAS of the yukmijiwhang-whan group did not increased than the OVX control group. In conclusion, the 80% EtOH extract yukmijiwhang-whan increased proliferation of osteoblasts but did not prevent bone loss in OVX rats.