임신(妊娠) 전반기(前半期)의 정상(正常) 임부(妊婦) 혈청중(血淸中) HPL의 동태(動態)에 대(對)한 방사면역측정(放射免疫測定)에 관(關)한 연구(硏究)

오보훈,신면우,Oh, Bo-Hoon,Shin, Myon-Woo 대한생식의학회 1978 Clinical and Experimental Reproductive Medicine Vol.5 No.1

In order to estimate the human placental lactogen levels and its value as an indicator of placental function during the first half of normal pregnancy, we defermined HPL levels. in normal snbjects (No=40) from the 6th week to the 20th week of gestation For the determination of human placental lactogen in serum of normal pregnant women during the first half of prognancy, radioimmunoassay have been performed using Phadebas HPL Test kit. The range of 25ng to 800ng HPL/ml. were determined by the procedures using Phadbas HPL Test kit, which correspond to levels recorded throughout the first half of normal pregnancy. HPL was detected in the earliest pregnancy samples collected at 6 weeks but was generally present in minute amount during the first trimester of pregnancy, when the HPL level ranged from 25 ng/ml. to 0.86 ${\mu}g$/ml. The mean concentration of HPL increased gradually from only 0.03 ${\mu}g$/ml, at 6 weeks to 0.25 ${\mu}g$/ml, at 12 weeks of gestation, Subsequently the mean HPL value rose steeply from 0.25 ${\mu}g$/ml, at 12 weeks to 1.65 ${\mu}g$/ml, at 20 weeks of gestation.

태아성별(胎兒性別)에 따른 양수중(羊水中) Testosterone과 F.S.H.의 동태(動態)에 관(關)한 연구(硏究)

고민환,신면우,Koh, Min-Whan,Shin, Myon-Woo 대한생식의학회 1979 Clinical and Experimental Reproductive Medicine Vol.6 No.1

To determine whether hormone analysis of amniotic fluid could be used for accurate determination of fetal sex, we measured testosterone(T) and follicle-stimulating hormone in 19 amniotic fluid samples. The mean T in amniotic fluid of 8 women earring male fetuses was 310 pg. per milliliter and of 11 women earring female fetuses was 150 pg. per milliliter (P<0.05${\ast}$). The mean amniotic fluid FSH of 1.16 mI.U. per milliliter for 7 women with male fetuses was over trifold lower than that for subjects with female fetuses. The mean amniotic fluid FSH of female fetuses was 3.85 mI.U. per milliliter (P<0.01${\ast}$) Measurement of T & FSH in amniotic fluid may be an adjunct method for fetal sex determination.

비정상임산부(非正常妊産婦)의 혈청중(血淸中) H.P.L.의 혈구응집조지반응(球凝集阻止反應)에 의한 측정(測定)에 관(關)한 연구(硏究)

김동진,신면우,Kim, Dong-Jin,Shin, Myon-Woo 대한생식의학회 1977 Clinical and Experimental Reproductive Medicine Vol.4 No.1

Serum levels of human placental lactogen were measured by hemagglutination inhibition reaction in 26 normal pregnant state and in patients with 16 toxemia and 6 F.D.I.U. beyond their thirtieth week of gestation to evaluate their clinical usefulness. It was realized that HPL-HAIR Test Kit was easy to use and produced reliable results. The general conclusion were as follows: 1) HPL value was $6{\sim}8$ug/ml in normal pregnancy. 2) The levels in mild toxemia were similar in the normal state. 3) The levels in severe toxemia were similar or slightly lower than in the normal and mild toxemia. 4) The levels in F.D.I.U. were lower than in the normal state.

Radiotherapy of Recurrent Uterine Cervical Cancer

하성환,박찬일,채규영,강순범,이효표,신면우,Ha Sung Whan,Park Charn Il,Chai Kyu Young,Kang Soon Beom,Lee Hyo Pyo,Shin Myon Woo The Korean Society for Radiation Oncology 1987 Radiation Oncology Journal Vol.5 No.2

수술후 골반강내에 국소재발된 자궁경부암의 진단하에 1979년부터 1984년까지 6년 간 서울대학교병원 치료방사선과에서 방사선치료를 시행한 47명의 환자에 대하여 후향적 분석을 시행하여 다음과 같은 결과를 얻었다. 1. 방사선치료 후 완전관해를 보인 환자는 35명으로 완전관해율은 $74.5\%$이었다. 2. 완전관해를 보인 35명중 7명에서 국소재발 또는 원격전이를 보여 전체적으로 19명 $(40.4\%)$의 환자에서 치료실패를 나타내었다. 3. 4년 무병생존을 및 전체생존율은 각각 50.1 및 $55.2\%$이었다. 4. 병소의 범위를 자궁경부암에 적응되는 FIGO병기 결정기준에 의하여 분류한 결과 각 병기에 따른 4년 생존율은 IIa기에서 $80.4\%$, IIb기에서 $73.0\%$, IIIb기에서 $25.0\%$, IVa기에서 $0\%$이었다. 따라서 수술 후 골강내에 국소재발된 자궁경부암의 경우 적절한 방사선치료를 시행함으로써 좋은 결과를 얻을 수 있음을 알 수 있었다. Forty seven patients with locally recurrent uterine cerival cancer after surgery were treated with radiation during the 6 year period from 1979 through 1984 at the Department of Therapeutic Radiology of Seoul National University Hospital. In 30 out of the 47 patients, recurrence was diagnosed within 2 years after surgery. Site of recurrence was vagina in 19 patients, vagina and parametrium in 21 patients and parametrium only in 7 patients. Complete tumor control was achieved in 35 patients $(74.5\%)$; the complete response rates were $94.7\%(18/19)$ in vaginal recurrences, $57.1\%(12/21)$ in combined vaginal and parametrial recurrences and $71.4\%(5/7)$ in parametrial recurrences. Overall and disease free survival rates at 4 years were 55.2 and 50.1 percent, respectively, for entire group. Overall 4 year survival rates were $77.0\%$ for vaginal recurrences, $44.1\%$ for vaginal and parametrial recurrences and $42.9\%$ for parametrial recrrences. When the disease extent was classified in the same way as the staging system of FIGO, the 4 year survival was 80.4, 73.0, 25.0 and 0 percent for stage IIa, IIb, IIIb and IVa, respectively.

Radiotherapy of Recurrent Uterine Cervical Cancer

Sung Whan Ha(하성환),Charn Il Park(박찬일),Kyu Young Chai(채규영),Soon Beom Kang(강순범),Hyo Pyo Lee(이효표),Myon Woo Shin(신면우) 대한방사선종양학회 1987 Radiation Oncology Journal Vol.5 No.2

수술후 골반강내에 국소재발된 자궁경부암의 진단하에 1979년부터 1984년까지 6년 간 서울대학교병원 치료방사선과에서 방사선치료를 시행한 47명의 환자에 대하여 후향적 분석을 시행하여 다음과 같은 결과를 얻었다. 1. 방사선치료 후 완전관해를 보인 환자는 35명으로 완전관해율은 →74.5%이었다. 2. 완전관해를 보인 35명중 7명에서 국소재발 또는 원격전이를 보여 전체적으로 19명 →(40.4%)의 환자에서 치료실패를 나타내었다. 3. 4년 무병생존을 및 전체생존율은 각각 50.1 및 →55.2%이었다. 4. 병소의 범위를 자궁경부암에 적응되는 FIGO병기 결정기준에 의하여 분류한 결과 각 병기에 따른 4년 생존율은 IIa기에서 →80.4%, IIb기에서 →73.0%, IIIb기에서 →25.0%, IVa기에서 →0%이었다. 따라서 수술 후 골강내에 국소재발된 자궁경부암의 경우 적절한 방사선치료를 시행함으로써 좋은 결과를 얻을 수 있음을 알 수 있었다. Forty seven patients with locally recurrent uterine cerival cancer after surgery were treated with radiation during the 6 year period from 1979 through 1984 at the Department of Therapeutic Radiology of Seoul National University Hospital. In 30 out of the 47 patients, recurrence was diagnosed within 2 years after surgery. Site of recurrence was vagina in 19 patients, vagina and parametrium in 21 patients and parametrium only in 7 patients. Complete tumor control was achieved in 35 patients →(74.5%); the complete response rates were →94.7%(18/19) in vaginal recurrences, →57.1%(12/21) in combined vaginal and parametrial recurrences and →71.4%(5/7) in parametrial recurrences. Overall and disease free survival rates at 4 years were 55.2 and 50.1 percent, respectively, for entire group. Overall 4 year survival rates were →77.0% for vaginal recurrences, →44.1% for vaginal and parametrial recurrences and →42.9% for parametrial recrrences. When the disease extent was classified in the same way as the staging system of FIGO, the 4 year survival was 80.4, 73.0, 25.0 and 0 percent for stage IIa, IIb, IIIb and IVa, respectively.

Treatment Result of Postoperative Radiotherapy of Carcinoma of the Uterine Cervix

박찬일(Charn Il Park),김정수(Jun Soo Kim),김일한(Il Han Kim),하성환(Sung Whan Ha),이효표(Hyo Pyo Lee),신면우(Myon Woo Shin) 대한방사선종양학회 1985 Radiation Oncology Journal Vol.3 No.2

조기자궁경부암의 치료에는 환자 개개의 특성에 따라 근치적수술 또는 근치적방사선치료가 행해지고 있으며, 그 치료성적은 비슷한 것으로 보고되고 있다. 그러나 근치적 수술후 병리조직 소견에 따라 원발병소가 크거나, 임파절전이, 혈관 또는 임파관의 종양 침윤이 있으면 이들 소견이 없던 경우에 비해 재발이 현저히 높고, 생존율이 반으로 줄게 되므로, 이를 극복하기 위해 수출후 방사선 치료가 시행되고 있으나 생존율에 대한 기여에는 아직 논란이 많다. 이에 1979년 2월부터 1982년 9월까지 서울대학교병원 치료방사선과에서 자궁경부암으로 수술 후 방사선 치료를 받았던 203예에 대한 치료성적을 분석하여 얻은 결과는 다음과 같다. 모든 환자에 있어 actuarial 3년 생존율은 83.4%이었으며 3년 무병 생존율은 73.4%이었다. 병기에 따른 actuarial 3년 생존율은 I_B, II_A, II_B, 각각 90.7%, 69.6%, 85.2%이었다. 병기별 3년 무병 생존율은 I_B, II_A, II_B 각각 79.8%, 67.8%, 68.3%이었다. 재발은 총 203예중 51예 (25.1%)에서 관찰되었으며 이중 국소재발이 8.4%, 원격전이가 14.3%이었고, 국소재발과 원격전이가 함께 있던 경우가 2.4%이었다. 병기별 재발율은 I_B, II_A, II_B에서 각각 19.8%(18/91예), 29.1%(16/55예), 29.8%(17/57예)이어다. 합병증중 급성으로 나타난 것이 57.6%이었으나 7.4%만이 심한 증상을 보였고, 만성 합병증은 7.9%에서 관찰되었으며, 장폐색, 비뇨기계증상의 악화, 방사선 방광염등의 순이었다. The early carcinoma of the uterine cervix may be treated by either radical surgery or radical radiotherapy according to the patient's characteristics, and the survival is high with either treatment. But, because of the size of the lesion, metastasis to lymph nodes, and vascular space invasion by tumor have all been shown to influence recurrence and survival, postoperative radiotherapy may be considered as their histopathologic finding after radical surgery. However, there are still debates on the increasing survival rates with postoperative radiotherapy. Two hundreds and three patients with carcinoma of the uterine cervix who were treated with postoperative radiotherapy from February 1979 to September 1982 in the Department of Therapeutic Radiology, Seoul National University were analyzed and following results were obtained. 3-year actuarial survival rate and 3-year disease free sruvival rate were 83.4% and 73.4% respectively and 3-year actuarial survival rates by stages were 90.7% for IB, 69.6% for IIA, and 85.2% for IIB. 3-year disease free survival rates by stage IB, IIA, IIB were 79.8%, 07.8%, 68.3% respectively. The overall failure rate was 25.1% (51/203); local recurrence rate was 8.4%, distant metastasis rate was 14.3% and simultaneous local recurrence and distant metastasis was 2.4%. Failure rates by stages were 19.8% (18/19) for IB, 29.1% (16/55) for IIA and 29.8% (17/57) for IIB. The overall acute complication rate was 57.6%; tolerable cases was 50.2% and severe cases was 7.4%. Late complication rate was 7.9% and the major late complication were intestinal obstruction. aggravated urinary symptom, radiation cystitis in order of frequency.

産科出血의 診斷과 處置

申冕雨 대한의학협회 1975 대한의학협회지 Vol.18 No.1

자궁내구 무력증

신면우 중앙대부설한국의과학연구소 1971 한국의과학 Vol.3 No.5

誤診하기 쉬운 産婦人科疾患, 그 鑑別診斷과 治療

신면우 한국의학사 1984 診斷과治療 Vol.4 No.9

産婦人科系腰痛의 最新知見

申冕雨 대한교통의학협회 1976 교통의학 Vol.3 No.2