5-Fluorouracil 투여가 마우스공장 소낭선세포의 방사선조사 효과에 미치는 영향

허승재,박찬일,장선택 중앙대학교 의과대학 의과학연구소 1985 中央醫大誌 Vol.10 No.3

The interaction of radiation and 5-Fluorouracil(5-FU) on mouse jejunal crypt cells was studied using the microcolony survival assay. 150㎎/㎏ of 5-FU was injected intraperitoneally 15 minutes before irradiation and 6 hours after irradiation. Jejunal crypt cells of mouse survived more when 5-FU was given 15 minutes before irradiation than giving it 6 hours after irradiation. The mean lethal doses(Do) of each of irradiation alone group, 5-FU injection group of 15 minutes preceding irradiation, and 5-FU injection group of 6 hours postirradiation were, 135, 135, and 114 rad respectively. The dose effect factor of each of 5-FU injection groups of 15 minutes preceding irradiation and of 6 hours post irradiation were 1.13 and 1.27.

The role of radiation therapy in rectal cancer

Charn Il park 대한외과학회 1989 대한외과학회 학술대회 초록집 Vol.1989 No.11

Squamous Cell Carcinoma of the Supraglottic Larynx Treated with Radiation Therapy

Charn Il Park,Kwang Hyun Kim 대한방사선종양학회 1989 Radiation Oncology Journal Vol.7 No.1

Sixty-six patients with squamous cell carcinoma of the supraglottic larynx received irradiation with curative intent between 1979 and 1985 were retrospectively analysed. All patients had a minimum follow-up of 4 years. Of the entire group consisting of 73% T3 and T4 lesions and 58% lymph node metastases, a 5-year acturial survival rate was 31.3%. A 5-year acturial survival rates for stage Ⅱ, Ⅲ and Ⅳ were 60.7% respectively (p<0.05). Patients without lymphnode metastases had better survival rate than those with postive lymphnode metastases (54.8% vs 12.2%) (p<0.005). Surgical salvage rate w8s 4/7(57%). Three patients developed distant metastases. Major complications requiring surgery were seen in , Radiation therapy alone with surgical salvage was an effective, voice preserving treatment for stage Ⅰ, Ⅱ and selected Ⅲ carcinoma of the supraglottic carcinoma, however planned combined treatment with surgery and radiation therapy is advised for stage Ⅲ and Ⅳ carcinoma of the supraglottic larynx with resectable neck disease.

Fatigue Characteristics of Five Types of Implant-Abutment Joint Designs

Il Song Park,Sang Yong Won,Tae Sung Bae,Kwang Yeob Song,Charn Woon Park,Tae Gwan Eom,Chang Mo Jeong 대한금속ᆞ재료학회 2008 METALS AND MATERIALS International Vol.14 No.2

Treatment Result of Postoperative Radiotherapy of Carcinoma of the Uterine Cervix

박찬일(Charn Il Park),김정수(Jun Soo Kim),김일한(Il Han Kim),하성환(Sung Whan Ha),이효표(Hyo Pyo Lee),신면우(Myon Woo Shin) 대한방사선종양학회 1985 Radiation Oncology Journal Vol.3 No.2

조기자궁경부암의 치료에는 환자 개개의 특성에 따라 근치적수술 또는 근치적방사선치료가 행해지고 있으며, 그 치료성적은 비슷한 것으로 보고되고 있다. 그러나 근치적 수술후 병리조직 소견에 따라 원발병소가 크거나, 임파절전이, 혈관 또는 임파관의 종양 침윤이 있으면 이들 소견이 없던 경우에 비해 재발이 현저히 높고, 생존율이 반으로 줄게 되므로, 이를 극복하기 위해 수출후 방사선 치료가 시행되고 있으나 생존율에 대한 기여에는 아직 논란이 많다. 이에 1979년 2월부터 1982년 9월까지 서울대학교병원 치료방사선과에서 자궁경부암으로 수술 후 방사선 치료를 받았던 203예에 대한 치료성적을 분석하여 얻은 결과는 다음과 같다. 모든 환자에 있어 actuarial 3년 생존율은 83.4%이었으며 3년 무병 생존율은 73.4%이었다. 병기에 따른 actuarial 3년 생존율은 I_B, II_A, II_B, 각각 90.7%, 69.6%, 85.2%이었다. 병기별 3년 무병 생존율은 I_B, II_A, II_B 각각 79.8%, 67.8%, 68.3%이었다. 재발은 총 203예중 51예 (25.1%)에서 관찰되었으며 이중 국소재발이 8.4%, 원격전이가 14.3%이었고, 국소재발과 원격전이가 함께 있던 경우가 2.4%이었다. 병기별 재발율은 I_B, II_A, II_B에서 각각 19.8%(18/91예), 29.1%(16/55예), 29.8%(17/57예)이어다. 합병증중 급성으로 나타난 것이 57.6%이었으나 7.4%만이 심한 증상을 보였고, 만성 합병증은 7.9%에서 관찰되었으며, 장폐색, 비뇨기계증상의 악화, 방사선 방광염등의 순이었다. The early carcinoma of the uterine cervix may be treated by either radical surgery or radical radiotherapy according to the patient's characteristics, and the survival is high with either treatment. But, because of the size of the lesion, metastasis to lymph nodes, and vascular space invasion by tumor have all been shown to influence recurrence and survival, postoperative radiotherapy may be considered as their histopathologic finding after radical surgery. However, there are still debates on the increasing survival rates with postoperative radiotherapy. Two hundreds and three patients with carcinoma of the uterine cervix who were treated with postoperative radiotherapy from February 1979 to September 1982 in the Department of Therapeutic Radiology, Seoul National University were analyzed and following results were obtained. 3-year actuarial survival rate and 3-year disease free sruvival rate were 83.4% and 73.4% respectively and 3-year actuarial survival rates by stages were 90.7% for IB, 69.6% for IIA, and 85.2% for IIB. 3-year disease free survival rates by stage IB, IIA, IIB were 79.8%, 07.8%, 68.3% respectively. The overall failure rate was 25.1% (51/203); local recurrence rate was 8.4%, distant metastasis rate was 14.3% and simultaneous local recurrence and distant metastasis was 2.4%. Failure rates by stages were 19.8% (18/19) for IB, 29.1% (16/55) for IIA and 29.8% (17/57) for IIB. The overall acute complication rate was 57.6%; tolerable cases was 50.2% and severe cases was 7.4%. Late complication rate was 7.9% and the major late complication were intestinal obstruction. aggravated urinary symptom, radiation cystitis in order of frequency.

Nasopharyngeal Carcinoma

박찬일(Charn Il Park),박우윤(Woo Yoon Park),김종선(Jong Sun Kim) 대한방사선종양학회 1989 Radiation Oncology Journal Vol.7 No.1

1979년부터 1985년까지 서울대학교병원 치료방사선과에서 비인강암으로 확진되어 방사선치료를 시행한 총 환자는 110명이었다. 이중 진단시 원격전이된 5명과, 근치 방사선량을 받지 못한 16명을 제외한 89명의 치료성적을 분석하였다. 생존 환자의 최소 추적기간은 36개월이었다. 전체 환자의 43%가 T4병변, 72%가 제 4병기이었으며, 편평상피암이 40%, 미분화암이 47%이었고 임파상피암은 5%이었다. T1, T2의 초기병변과 경부 임피절 전이는 6,500cGy의 선량으로 대부분이 근치되었다. 추적기간 중 재발된 환자는 42명,(47%)으로, 이중 16명(38%)은 국소재발, 24명(57%)은 원격전이를 일으켰다. 국소재발된 예중 9명에게 재치료를 시행하여 이중 2명에서 장기 생존이 관찰되고 있다. 전체 환자의 5년 생존율 42%, 무병생존율은 38%이었다. T-병기와 조직학적 아형은 생존율에 무관하나, N-병기는 생존율에 유의한 상관관계가 있음이 증명되었다. One hundred and ten patients with carcinoma of the nasopharynx were treated by radiation therapy in Department of Therapeutic Radiology, Seoul National University Hospital between 1979 and 1985. Among these, one hundred and five patients were treated with curative intent and 5 patients with palliative aim. Excluding 16 patients who did not receive a full course of radiation therapy, the remaining 89 patients were reviewed for this analysis. Minimum follow-up period of survivors was 36 months. Forty-three percent of the patients had T4 primary lesions and 72% had stage IV disease. The histology was squamous cell carcinoma in 46% of the patients. undifferentiated carcinoma in 49%, and lymphoepithelioma in 5%. Total radiation dose to the primary site averaged 6,500cCY for T1, T2 lesions and 7500cCY for T3, T4 lesions. Neck node were given boost treatment to a maximum 7,500cCY depending on the extent of disease. Early primary lesion(T1, T2) and neck nodes were successfully controlled in most cases when dose of greater than 6,500cCY was delievered. Forty two patients(47%) had recurred, 16 of whom(38%) received at the primary site and 24(57%) developed distant metastases. Of these. 9 patients received re-irradiation with or without chemotherapy and local control was obtained in 2 patients(22%). Actuarial overall survival and disease-free survival rate was 42% and 38% at 5 years. T-stage and histologic subtype were not correlated with survival. However, N-stage was related to survival significantly(p=0.043).

Echocardiogram의 임상적 응용

박찬일 ( Park Charn Il ) 국군의무사령부 1976 대한군진의학학술지 Vol.7 No.1

聲門上部癌의 治療成績

朴贊一(Charn Il Park),金光顯(Kwang Hyun Kim) 대한방사선종양학회 1984 Radiation Oncology Journal Vol.2 No.1

From March of 1979 through December of 1982, 84 patients with supraglottic carcinoma were seen and evaluated in the Department of Therapeutic Radiology, Seoul National University Hospital. Of these, 58 patients were treated with a curative intent by employing either radiotherapy alone or a combined approach of radiotherapy plus surgery. Sixteen patients refused to complete the treatment program. Seventy-three per cent of patients had T3 and T4 lesions and 63% of patients had lymph node metastasis at the time of diagnosis. Actuarial recurrence-free survival at 3 year was : Stage Ⅰ~Ⅱ 62%, Stage Ⅲ 54%, Stage Ⅳ 18%. For T1-2, T3 and T4 lesions, the actuarial recurrence free survival at 3 years were 50%, 34% and 9% respectively. Of 39 patients with treatment failure, 29 patients (78%) had uncontrol or ultimate recurrence at the primary site while 9 patients having lymph node recurrence, 14 patients(21%) had lymph node recurrence, and 5 patients had distant metastasis. It is suggested that planned combined radiotherapy is indicated for advanced but resectable supraglottic carcinoma.

子宮頸部癌의 放射線治療成績

朴贊一(Charn Il Park) 대한방사선종양학회 1984 Radiation Oncology Journal Vol.2 No.1

超音波를 利用한 溫熱療法時 溫度分布에 關한 硏究

朴贊一(Charn Il Park),高京煥(Kyeong Whan Koh),河星煥(Sung Whan Ha) 대한방사선종양학회 1984 Radiation Oncology Journal Vol.2 No.1

Temperature homogeniety and stationary temperature is the most important thermometric considerations for the clinical use of hyperthermia. A thermal mapping was done in a phantom with thermocouple during hyperthermia which was induced by 1.0 MHz, 0.7~0.8 watts/㎠ ultrasound and unfocused 2.5 cm-diameter transducer. The results were as follows 1. Effective heating range(42.5℃±0.5℃) were obtained 3 cm in width and 4 cm in depth from surface of phantom and temperature distribution was relatively uniform. 2. There was little heating effect more than 2 cm away from transducer axis and more than 5cm in depth. 3. There was hot spots(more than 43℃) in 2.0±0.5 cm depth from transducer along transducer axis.