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Case Report of Occupational Asthma Induced by Polyvinyl Chloride and Nickel
송가원,반가영,남영희,박해심,예영민 대한의학회 2013 Journal of Korean medical science Vol.28 No.10
Polyvinyl chloride (PVC) is a widely used chemical for production of plastics. However occupational asthma (OA) caused by PVC has been reported only rarely. We report a 34-yr-old male wallpaper factory worker with OA due to PVC and nickel (Ni) whose job was mixing PVC with plasticizers. He visited the emergency room due to an asthma attack with moderate airflow obstruction and markedly increased sputum eosinophil numbers. A methacholine challenge test was positive (PC20 2.5 mg/mL). Bronchoprovocation tests with both PVC and Ni showed early and late asthmatic responses, respectively. Moreover, the fractional concentration of exhaled nitric oxide (FeNO) was increased after challenge with PVC. To our knowledge, this is the first case of OA in Korea induced by exposure to both PVC and Ni. We suggest that eosinophilic inflammation may be involved in the pathogenesis of PVC-induced OA and that FeNO monitoring can be used for its diagnosis.
S-40 Effects of human adipose-derived stem cells on gastric ulcer in an animal experimental model
김성익,송가원,고원진,조주영 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background/Aims: To investigate the effects of novel treatment using human adipose-derived mesenchymal stem cell(ADMSC) on healing of iatrogenic gastric ulcer in mini pig model. Methods: 8 gastric ulcers sized 1cm in diameter were made by endoscopic mucosal resection in a mini pig. The ulcers? were divided into 4 groups, 2 ulcers on each group: Submucosal injection of (i) ADMSC in normal saline, (ii) ADMSC?in hyaluronic acid(HA) gel (iii) NS alone, (iv) HA gel alone. Healing of gastric ulcers was assessed on day 3,5,9 and 15?macroscopically through an endoscope and the mini pig killed on days 28. Results: Serial endoscopy revealed more rapid growth of regenerated epithelium at ulcer margin in ADMSC-NS and?ADMSC-HA group than NS alone and HA gel alone group. Mean collagen volume fractions of the areas near ulceration?were 24.4% in ADMSC-NS group, 36.1% in ADMSC-HA group, 33.9% in NS alone group and 42.6% in HA alone group (Masson’s trichrome), In Ki-67 immunohistochemical staining, ADMSC-NS and ADMSC-HA group showed more newly-generated muscle particle than NS alone and HA alone group(310.5 and 243.0 vs. 120.5 and 69.3, muscle particle?count per 1 field). Conclusions: Local injection of ADMSC promotes gastric ulcer healing by rapid re-epithelization, enhanced smooth?muscle regeneration and inhibition of extracellular matrix deposition.
Evaluation and Endoscopic Management of Esophageal Submucosal Tumor
고원진,송가원,조주영 대한소화기내시경학회 2017 Clinical Endoscopy Vol.50 No.3
Submucosal tumors (SMTs) originate from tissues that constitute the submucosal layer and muscularis propria, and are covered by normal mucosa. Esophageal SMTs are rare, accounting for <1% of all esophageal tumors. However, the recent widespread use of endoscopy has led to a rapid increase in incidental detection of SMTs in Korea. Esophageal SMTs are benign in ≥90% of cases, but the possibility of malignancies such as gastrointestinal stromal tumor and malignant leiomyosarcoma still exists. Therefore, patients undergo resection in the presence of symptoms or the possibility of a malignant tumor. For resection of esophageal SMTs, surgical resection was the only option available in case of possible malignancy, but minimally invasive surgery by endoscopic resection is becoming more preferable to surgical resection with the development of endoscopic ultrasonography, endoscopic techniques, and other devices.
조기 식도암에서 내시경점막하박리술 시행 후 항암방사선동시요법을 시행한 1예
한규현,신선영,문준일,송가원,고원진,김원희,홍성표,조주영,Kyuhyun Han,Sunyoung Shin,Junil Moon,Gawon Song,Wonjin Koh,Wonhee Kim,Sungpyo Hong,Joo Young Cho 대한소화기암연구학회 2015 Journal of digestive cancer reports Vol.3 No.1
62-year-old patient who had past history of endoscopic submucosal dissection for early gastric cancer at September 2008, underwent endoscopic submucosal dissection of esophagus for early esophageal cancer at mid esophagus during health screening service. Because there was a high risk of lymph node metastasis at biopsy results, concurrent chemoradiotherapy was added to endoscopic submucosal dissection. There was a metachronous cancer at mid-esophagus at March 2013. He underwent endoscopic mucosal resection and photodynamic therapy. Concurrentchemoradiotherapy after endoscopic submucosal dissection is an effective treatment method.
혈청양성 류마티스관절염 환자에서 급성 신부전을 동반한 다발성 골수종
이승경 ( Seung Kyung Lee ),황선혁 ( Sun Hyuk Hwang ),박주한 ( Joo Han Park ),송가원 ( Ga Won Song ),박선영 ( Sun Young Park ),김세란 ( Sei Rhan Kim ),정주양 ( Ju Yang Jung ),배창범 ( Chang Bum Bae ),김현아 ( Hyoun Ah Kim ),정성현 대한류마티스학회 2014 대한류마티스학회지 Vol.21 No.5
It is known that rheumatoid arthritis (RA) patients show increased incidence of multiple myeloma (MM), despite its rarity. Only one case of MM with seronegative RA was reported in Korea, thus far. We report a case of MM with seropositive RA. The patient was a 66 year old female who had been diagnosed with seropositive RA 4 years ago. Over the last 1 month, the patient experienced general weakness and weight loss of 10 kg. It was found that her serum creatinine had increased and her urine analysis showed proteinuria. To evaluate renal failure and proteinuria, renal biopsy, bone marrow biopsy and electrophoresis were carried out. A diagnosis of myeloma cast nephropathy was made. We report this rare case of MM represented as acute renal failure during the treatment for RA, and include a review of the literature.
증례 : 혈액종양; Sclerosing Angiomatoid Nodular Transformation of Spleen 1예: 스포크 휠(Spoke Wheel) 모양의 조영증강
박주한 ( Joo Han Park ),황선혁 ( Sun Hyuk Hwang ),김기찬 ( Ki Chan Kim ),김시연 ( Si Yeon Kim ),송가원 ( Ga Won Song ),한재호 ( Jae Ho Han ),박준성 ( Joon Seong Park ) 대한내과학회 2014 대한내과학회지 Vol.86 No.3
Sclerosing angiomatoid nodular transformation (SANT) is a rare, benign vascular neoplasm. Most patients have no clinical symptoms, and the tumors are usually discovered incidentally on abdominal computed tomography or ultrasonography. Some studies have reported the clinical features and imaging findings of SANT, but the diagnosis is based on histopathologic examination of a tissue specimen obtained at splenectomy. We report herein an incidentally discovered case of SANT and review the related literature.
황선혁 ( Sun Hyuk Hwang ),박선영 ( Sun Young Park ),김기찬 ( Ki Chan Kim ),박주한 ( Joo Han Park ),김시연 ( Si Yeon Kim ),송가원 ( Ga Won Song ),정숙희 ( Jun Goo Kang ),임선교 ( Sook Hee Chung ),이기명 ( Sun Gyo Lim ),이광재 ( Kwa 전북대학교 의과학연구소 2013 全北醫大論文集 Vol.37 No.2
Cavernous hemangioma of the colon is a rare disease. It mostly affects young patients with recurrent painless rectal bleeding. Complete surgical excision with a sphincter saving procedure is the best therapeutic option. A 25-year-old man referred to our hospital because of a chronic anemia and recurrent painless rectal bleeding. In esophagogastroduodenoscopy, there was gastric erosion. In colonoscopy, there were multiple submucosal vessel dilatations on whole colon. Prominent submucosal vessel was noted on cecum and rectum suspicious for cavernous hemangioma. Biopsy was not performed because of the risk of bleeding. Abdomen computer tomography (CT) showed bowel wall thickening in rectum and colon. Multiple small aggregated cystic lesions in omentum and mesentery were seen. Multiple calcifications in the rectum were noted, a finding compatible with phleboliths. We recommended surgery but patient refused and now he is followed up in our outpainet clinic without complication. Cavernous hemangioma is a rare disease but clinicians should be cautious about the occurrence of this malformation in young patients with recurrent rectal bleeding. Suspicion and knowledge of this disease would reduce the misdiagnosis and mismanagement.