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어린이에서 O2-Propofol 마취시 Rocuronium 의 근이완효과와 혈압 및 심박수에 미치는 영향
손종찬,김종성,김성덕,김용락,황정원,최준권 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.32 No.2
Background : Rocuronium(ORG 9426) is a new steroid nondepolarizing neuromuscular blocking drug with fast onset and intermittent duration of action. Its effects on vital signs are controversial. We studied onset, clinical duration, recovery index of rocuronium and its effects on blood pressures and heart rates. Methods : We selected thirty healthy children who would receive inguinal herniorrhaphy and allocated them to 2 groups(control and rocuronium group). Without premedication or with oral medication of PocralTM (20 mg/kg), they administrated propofol(2.5 mg/kg) intravenous for loss of consciousness and we maintained anesthetic states with 20 mg/kg/hr of propofol. After 2 minutes, we checked BP(SBP/ DBP/MBP) and HR at every minutes and checked TOF, T1 height compare to control, T4 to T1 at every twenty seconds. We injected intravenously rocuronium(0.8 mg/kg, 2ED95) to rocuronium group and nothing to control group. We determined intubation time(from injection to 90% depression of maximal block), onset time(to maximal depression or T1=0), clinical duration(to T1=25%) and recovery index(from T1=25% to T1=75%). Results : In children, intubation time was 93.8sec, onset time was 146.2sec, clinical duration was 34.6min, recovery index was 15.4min. SBP, DBP, MBP and HR were not changed independent of injection of rocuronium. Conclusion : Rocuronium is a muscle relaxant with rapid onset and intermittent clinical duration in children. It does not affect BP and HR. (Korean J Anesthesiol 1997; 32: 235∼239)
일측폐환기시 환기측폐의 호기말양압이 동맥혈산소화에 미치는 영향
손종찬,황정원,오용석,최락민,곽일용 대한마취과학회 1995 Korean Journal of Anesthesiology Vol.28 No.1
One lung ventilation(OLV) during thoracotomy is frequently used for the purpose of facilitating surgical exposure by collapsing the lung in the operative hemithorax. But severe hypoxemia may occur during OLV inspite of higher inspired oxygen concentration. This study was performed to evaluate the effect of positive end-expiratory pressure(PEEP) level to the ventilated lung on the arterial oxygenation in the thoracotomy patients(n-10) who showed PaO₂ below 100 mmHg during one lung ventilation (OLV) at the F₁O₂ = 1.0. After measuring control value of arterial blood gas(ABGA), peak inspiratory pressure and hemodynamic parameter (mean arterial pressure and heart rate), PEEP device 5 cmH₂O and then 10 cmH₂O was applied to the expiratory breathing circuit for 10 min at each pressure setting. Data of above parameter was collected after 10 min each PEEP application. There were no siginificant changes in the mean arterial pressure and heart rate between control, PEEP 5 cmH₂O and PEEP 10 cmH₂O. Although PaO₂ did not significantly increased with PEEP 5 cmH₂O compared to control value, the application of PEEP 5cmH2O increased PaO₂ in 6 patients and decreased in 4 patients. In the PEEP 10 cmH application, PaO₂ was significantly improved compared to control and PEEP 5 cmH₂O values (78.4±11.6 mmHg, 84.6±19.2 mmHg vs. 95.3±18.5 mmHg). It is concluded that it may be necessary to adjust PEEP level to the ventilated lung to improve oxygenation when hypoxemia occurs during OLV.
손종찬,김종성,김용락,최준권 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.32 No.2
Background : Although blood is very important therapeutic agent in bleeding patients, it may transmit disease, cause an adverse reaction in the recipients, raise the cost of patient care. Since the misuse and inappropriate use of blood is common, we are to review the transfusion practice in our hospital and to reduce unnecessary blood transfusion. Methods : During a 10-month period from June 1994 through March 1995, 347 patients received blood transfusion during the operation. Among them, we reviewed retrospectively the charts of 211 patients available. We analyzed the transfusion pattern of 47 patients whose postoperative hematocrit exceeded 32 percent to determine the magnitude and cause of unnecessary blood transfusion. Results: The patients of postoperative hematocrit over 32 percent were 119 patients out of 211 patients(56.4%). The main cause of overtransfusion was no reevaluation of the patients hematocrit after the prior unit was given. Conclusions : Guidelines for transfusing patients must be constructed based on acceptable intraoperative hematocrits. Unnecessary transfusion can be decreased when the transfusion done according to the guidelines, insisting on each reevaluation of the hematocrit prior to the administration of unit of blood. (Korean J Anesthesiol 1997; 32: 240∼243)
불소용제에 용해성이 증가된 Calixarene 합성 및 그에 대한 응용연구
손종찬,김영태,이진균 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
For photolithography to organic electronic devices, semi-perfluoro Calixarene molecules and 1,8 naphthalic anhydride based photoacidegenater (PAG) are one of excellent materials to introduce orthogonal photolithography. The concept of orthogonal patterning is to use fluorous solvent(eg. Hydrogen Fluoro Ether series) as casting, developing, stripping to photoresist which has no compatibility to organic materials. However, semi-perfluoro calixarene, PAG can’t be fully dissolved in fluorous solvent without help of PGMEA solvent. we introduce perfluoro ether type chain to semi calixarene and PAG to give better solubility to HFE solvent. Without the help of PGMEA solvent, we successfully dissolve new calixarene molecule, new PAG in HFE solvent.
Antracene 단량체를 포함하는 랜덤 불소공중합체의 합성 및 포토레스트로의 활용
손종찬,김영태,이진균 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
Conventional patterning ways for inorganic electronic devices is photolithography using organic solvents for coating, develop, strip. Contrary to Inorganic ones, Organic devices can’t use organic solvents because of compatibility to organic components beneath photoresist film. Furthermore, debris following decomposition reaction by UV irradiation to photo acid generator can cause deterioration of devices’ performance. In order to resolve these problems, we designed a highly fluorinated photoresist polymer [copolymerization of 6-(anthracene-9-yl)hexyl methacrylate (AHMA) and semi-perfluorodecyl methacrylate (FDMA)] taking advantage of orthogonal patterning which minimizes chemical interaction between fluorous solvents and organic devices.