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세침흡인 세포검사에서 양성 질환을 닮은 폐의 고분화 샘편평 암종 - 1예 보고 -
배종엽,오훈규,박재복,Bae, Jong-Yup,Oh, Hoon-Kyu,Park, Jae-Bok The Korean Society for Cytopathology 2004 대한세포병리학회지 Vol.15 No.2
Fine needle aspiration (FNA) cytological examination is an appropriate method for the evaluation of pulmonary nodules. In major types of lung cancer, Its diagnostic accuracy is quite high. However, it is sometimes difficult, using this technique, to differentiate between some unusual phenotypes including adenosquamous carcinoma, bronchioloalveolar carcinoma (BAC), neuroendocrine tumor, mucoepidermoid carcinoma, and sclerosing hemangioma. Here, we present a case involving extremely well differentiated adenosquamous carcinoma, mimicking benign lesions, such as pulmonary scar and adenomatoid malformation with squamous metaplasia. The patient was a 68-year-old man presenting with a solitary pulmonary nodule$(1.6\times1.6cm)$, which was incidentally found at the periphery of the right lower lobe. FNA revealed some clusters of glandular cells with minimal atypia, in addition to squamous cells at a nearly full maturational state. Histological examination verified the cytological diagnosis on a lobectomy specimen. The tumor exhibited a well differentiated adenocarcinoma component, mimicking the bronchioles in scarred lung tissue. and a well differentiated squamous cell carcinoma component, mimucking the squamous cell nests of adenoacanthoma, in the other organs. In the present case, the possibility of adenosquamous carcinoma should have been considered if squamous cells were seen in the FNA from the peripheral pulmonary nodule, even though they appeared to be benign.
국소진행성 비소세포폐암 환자에서 weekly paclitaxel을 이용한 화학 방사선 동시요법의 효과
배성화 ( Sung Hwa Bae ),김경찬 ( Kyung Chan Kim ),이선아 ( Sun Ah Lee ),김소연 ( So Yeon Kim ),류헌모 ( Hun Mo Ryoo ),현대성 ( Dae Sung Hyun ),이상채 ( Sang Chae Lee ),예지원 ( Ji Won Yei ),배종엽 ( Jong Yup Bae ),정경재 ( Kyung J 대한내과학회 2005 대한내과학회지 Vol.69 No.4
목적 : 절제 불가능한 국소진행성 비소세포폐암 환자에서 paclitaxel을 이용한 화학 방사선 동시요법의 효과를 조사하기 위해 본 연구를 시행하였다. 방법 : 화학 방사선 동시요법 기간동안 paclitaxel을 매주 60㎎/㎡의 용량으로 1시간 동안 정맥으로 투여하였다. 방사선치료는 일일 1회 1.8Gy 분할량으로 주 5회 조사하였으며, 총 63Gy까지 조사하였다. 동시치료 이후 4주기의 paclitaxel/carboplatin 복합화학요법을 시행하였다. 결과 : 28명의 환자가 등록되었고, 남자가 25명, 여자가 3명이었고, 나이의 중앙값은 60세(범위: 41~73세)였다. 19명의 환자에서 계획된 화학 방사선 동시치료를 마쳤다. 완전관해는 5명, 부분관해는 15명으로 전체 관해율은 71.4%이었고, 7명의 환자에서 3도 이상의 폐렴이 발생하였는데 이 중 3명이 치료 관련 사망하였다. 중앙 생존기간은 17.5개월(95% 신뢰구간 12.5~22.5개월)이었고 무진행 생존기간의 중앙값은 8.0개월(95% 신뢰구간 4.1~11.9개월)이었다. 결론 : 국소진행성 비소세포폐암에서 paclitaxel을 포함한 화학 방사선 동시치료는 효과적이지만 폐의 부작용이 문제가 되며 환자 대상 선택과 추적에 주의를 요한다. Background : Combined modality therapy is standard treatment of unresectable, locally advanced stage III non-small cell lung cancer (NSCLC). However, the optimal chemotherapy regimen and duration of chemotherapy remain a matter of debate. We evaluated the efficacy and feasibility of concurrent chemoradiation therapy (CCRT) in patients with locally advanced NSCLC. Methods : PS 0-2 patients with histologically proven inoperable stage III NSCLC were eligible for this trial. The patients received paclitaxel (60㎎/㎡) on days 1, 8, 15, 22, 29, 36 with a concurrent radiotherapy (5days/week, 1.8Gy/day) starting day 1 with a total dose of 63 Gy. After CCRT, four cycles of consolidation chemotherapy with paclitaxel (140㎎/㎡) and carboplatin (AUC 5) was administered to patients with a partial, complete remission or stable disease. Results : Twenty eight patients with locally advanced NSCLC enrolled in this study. The median age of the patients was 60 years. Of the 28 patients, 19 received scheduled CCRT. Overall response rate was 71.4% including 5 complete responses and 15 partial responses. Grade 3 or 4 pulmonary complication was observed in 7 patients and 3 patients died of pneumonitis. The median overall survival was 17.5 months (95% CI, 12.5-22.5). The median progression free survival was 8.0 months (95% CI, 4.1-11.9). Conclusions : CCRT including paclitaxel in patients with locally advanced NSCLC led to an encouraging response rate and survival, but resulted in high incidence of severe pulmonary complication.(Korean J Med 69:379-386, 2005)
갑상선결절의 초음파유도하 세침흡인검사에서 Galectin-3의 진단적 유용성
김현숙 ( Hyun Sook Kim ),조창호 ( Chang Ho Cho ),정의달 ( Eui Dal Jung ),윤현대 ( Hyun Dae Yoon ),배종엽 ( Jong Yup Bae ),손호상 ( Ho Sang Shon ) 대한갑상선학회 2008 International Journal of Thyroidology Vol.1 No.2
Background and Objectives: Fine needle aspiration biopsy (FNAB) is considered as the most feasible preoperative diagnostic tool for thyroid lesions. However, indeterminate results of FNAB are common, so many methods were developed as supportive preoperative diagnostic modalities in indeterminate results of FNAB. In our previous studies, galectin-3 was expressed preferentially in thyroid malignancies of postoperative tissue specimen. In the present study, we evaluated whether galectin-3 immunohistochemistry (IHC) is useful as a preoperative diagnostic tool in thyroid nodules. Materials and Methods: A total of 151 thyroid nodules were performed US-guided FNAC and obtained from patients who underwent thyroidectomy were evaluated using papanicolaou-stained slides and cell blocks with galectin-3 IHC. IHC for Galectin-3 was performed. Cytologic diagnoses were correlated with the results of galectin-3 and categorized into 3 groups (benign, indeterminate, malignancy) and compared with the corresponding histologic diagnoses. Results: Of 151 specimens, 113 (74.8%) were malignant. When the histologic diagnoses were compared with the galectin-3 IHC, there were 14 (9.2%) discrepant cases. In the result of US-guided FNAB, sensitivity, specificity, positive-predictive value, and negative predictive value of galectin-3 IHC were 90.2, 92.1, 97.1, 76.1%. In the indeterminate result of US-guided FNAB, sensitivity, specificity, positive-predictive value, and negative predictive value of galectin-3 were 50, 91.4, 60, 96.9%. Conclusion: Galectin-3 IHC is a supplementary marker for the preoperative diagnoses of thyroid nodules in the US-guided FNAB. In the indeterminate of FNAB, galectin-3 IHC is not a reliable method for diagnosis, but negative staining of galectin-3 may raise the possibility of benign thyroid nodules.
류정선 ( Jeong Seon Ryu ),이원연 ( Won Yeon Lee ),송광선 ( Kwang Seon Song ),용석중 ( Suk Joong Yong ),신계철 ( Kye Chul Shin ),정순희 ( Soon Hee Jung ),배종엽 ( Jong Yup Bae ) 대한류마티스학회 1994 대한류마티스학회지 Vol.1 No.2
Dermatomyositis is a disorder of unknown etiology characterized by an inflammatory myopathy involving striated skeletal muscle and associated characteristic skin lesions. In recent years, there has been increased the awareness of the association of malignant tumor with this disorder. But the relations between dermatomyositis and malignant tumors remains controversial. Comparing to other countries, the incidence rate may be said to be low in Korea. However, we suggest that our concerning makes it`s associated malignant tumors discovered. The cutaneous necrosis, elevated erythrocyte sedimentation rate, older age, or acute onset of symptoms proved to have the predictive value of cancer in dermatomyositis. Therefore, we think that more detailed diagnostic workups for malignant neoplasms are recommended in the patient with this criterion. Here we reported a case of dermatomyositis accompaning by lung cancer with brief review of literatures.