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Designing an Optimal Temperature Profile to Develop Effective Insulation Packaging Materials
배윤성,고대식 아이씨티플랫폼학회 2016 JOURNAL OF PLATFORM TECHNOLOGY Vol.4 No.4
This study seeks to design an optimal temperature profile of distribution channel that is necessary for developing insulation packaging products and verifying their performance in an effective manner. To do this, external and internal temperature of packaging materials of agricultural products that go through domestic major distribution hubs were measured throughout various regions, months, and seasons. After the results compared and analyzed, an optimal temperature profile was designed based on regions, month, and seasons. In order to verify the effectiveness of the temperature profile that was developed in this study, the duration for which the products were refrigerated in August and November was investigated, using popular refrigerants in general pharmaceutical distribution. In other words, refrigeration durability of our temperature profile was examined, using Expandable Poly Styrene (EPS) containers and refrigerants that are commonly used. As a result, temperature desorption started to happen drastically from the temperature zone of 2 to 8 degrees, which is a prerequisite for medical supplies’ refrigeration, after 15 hours were passed since product packaging. This study may attribute to cost reduction and development of an optimal packaging system in developing insulating packaging materials for coldchain products including medical supplies; this is because the suggested temperature profile in this study can help set types and quantities of packaging materials based on various storage conditions.
배윤성,김세훈,정준원,장원석,김세화,오은지 대한병리학회 2013 Journal of Pathology and Translational Medicine Vol.47 No.6
Background: Cerebrospinal fluid (CSF) examination can be used to verify the presence of primary malignancies as well as cases of central nervous system (CNS) metastasis. Because of its importance,there have been several studies concerning the sensitivity of CSF cytology. To determine the practical use and reproducibility of diagnoses based on CSF cytology, we evaluated this test by analyzing cytology results from consecutive CSF samples. Methods: Between July 2010 and June 2013, 385 CSF cytology samples from 42 patients were collected. The samples were gathered using a ventricular catheter and reservoir. CSF cytology of all patients was examined more than two times with immunocytochemistry for cytokeratin. Results: Primary neoplastic sites and histologic types of patients’ metastatic cancer were diverse. The overall sensitivity for detecting malignancy was 41.3%. Even within short-term intervals, diagnoses frequently changed. Conclusions: Our results were inconsistent, with low sensitivity, when compared to the results of previous studies. However, CSF evaluation can still provide valuable diagnostic and prognostic information because adjuvant treatments are now routinely performed in patients with CNS metastasis. Negative CSF cytology results should not be ignored, and continuous CSF follow-up is essential for following the clinical course of patients with metastatic cancer involving the CNS.
배윤성,조정윤,지상미,이영주 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.3
Gene therapy is fundamentally a sophisticated drug delivery technology to cure a disease by the transfer of genetic material to modify living cells, In other words, the gene is used as a therapeutic drug much like a chemical compound is employed in chemotherapy. Currently almost 600 clinical trials are underway worldwide since the first clinical trials carried out in 1990 to treat adenosine deaminase deficiency using retroviral vectors. Despite the great progress still is there no gene therapy product being approved as a new drug. This is partly due to a lack of and ideal gene delivery system that is safe and can provide stable, optimal level production of the therapeutic proteins in the cell. This review covers the current status of several different biological and physico-chemical agents that are being developed as gene delivery vehicles. Although gene therapy promises great hopes toward the cure of a broad spectrum of genetic and acquired diseases, the success of gene therapy heavily asks for the development of vector systems for safe and efficient application in humans.
IgG4-Related Hepatic Inflammatory Pseudotumor Complicated by Actinomycosis during Steroid Therapy
정재원,배윤성,임진홍,이동기,유정식 대한영상의학회 2019 대한영상의학회지 Vol.80 No.2
For a 67-year-old man with diabetes mellitus, a 9-cm liver mass was found on CT during the diagnostic work-up for weight loss and fever. Dynamic CT and MRI showed a layered pattern of contrast enhancement suggesting the imaging features of the solid inflammatory mass. After tissue diagnosis of immunoglobulin G4 (IgG4)-related disease by gun needle biopsy, steroid therapy induced partial shrinkage of the mass on the follow-up CT at 4 weeks. On the 5-month follow-up CT with the maintenance of low-dose oral steroid medication, disease progression with invasion to diaphragm brought surgical intervention of right hemihepatectomy considering the possibility of combined malignancy. In the area of diaphragmatic destruction, focal actinomycosis was complicated in the main mass of IgG4-related disease. We are the first to describe a rare case of IgG4-related inflammatory pseudotumor, complicated by actinomycosis, showing an invasive nature that mimicked malignancy during steroid therapy in a diabetic patient.
항문주위공간의 세포성 혈관섬유종 : 자기공명영상과 병리소견의 연관
백창규,임준석,배윤성 대한자기공명의과학회 2011 Investigative Magnetic Resonance Imaging Vol.15 No.3
A variety of benign and malignant tumor can occur in the perianal space. Among them, cellular angiofibroma is a rare tumor that belongs to fibroblastic/myofibroblastic tumors of the WHO classification,sometimes called as“ angiomyofibroblastoma-like tumor”. Cellular angiofibroma can be found at various anatomic sites such as the vulva, perineum, genital tract, and inguinal regions with approximately equal gender ratio. This tumor is usually a well-circumscribed mass showing isosignal intensity to muscle on T1-weighted images. On T2-weighted images, cellular angiofibroma may show as a mass with inhomogeneous signal intensity depending on amount of composed spindle cell, collagenous stroma, myxoid matrix,and fat tissue; however it is characterized by low signal intensity due to fibrous tissues. This highly vascular mass shows strong enhancement on post contrast images. Recommended treatment is simple local excision and no recurrence or metastasis have been reported up to date. 항문주위 공간에는 다양한 종류의 양성 및 악성 종양이 생기며, 그 중 세포성 혈관섬유종은 WHO 분류상 섬유모세포성/근육섬유모세포성종의 범주에 속하는 매우 드문 종양으로 혈관근육섬유모세포양 종양으로도 알려져 있다. 세포성 혈관섬유종은 음문부, 회음부, 생식기, 서혜부 등에서 발생하는 종양이며, 남녀의 발생 비율은 비슷하다. 이 종양은 경계가 매우 잘 지워지는 종양으로 T1 강조영상에서는 근육과 비슷한 신호강도를 보이며, T2 강조영상에서는 방추형 세포, 콜라겐 기질, 점액성 기질, 그리고 지방 조직 등의 구성 성분에 따라 다양한 신호 강도를 보일 수 있으나, 특히 콜라겐 기질과 방추형 세포의 증식에 의한 저신호강도를 보인다. 조영 증강 후 영상에서는 고혈관성이므로 매우 조영 증강이 잘 되는 양상이다. 치료는 단순국소절제술이며, 치료 후 국소 재발이나, 전이를 보이는 경우는 없었다.